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Items: 1 to 50 of 69


Regulation of food intake by astrocytes in the brainstem dorsal vagal complex.

MacDonald AJ, Holmes FE, Beall C, Pickering AE, Ellacott KLJ.

Glia. 2019 Dec 27. doi: 10.1002/glia.23774. [Epub ahead of print]


Evaluation of a primary care-based opioid and pain review service: a mixed-methods evaluation in two GP practices in England.

Scott LJ, Kesten JM, Bache K, Hickman M, Campbell R, Pickering AE, Redwood S, Thomas K.

Br J Gen Pract. 2020 Jan 30;70(691):e111-e119. doi: 10.3399/bjgp19X707237. Print 2020 Feb.


Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture.

Chandler DJ, Jensen P, McCall JG, Pickering AE, Schwarz LA, Totah NK.

J Neurosci. 2019 Oct 16;39(42):8239-8249. doi: 10.1523/JNEUROSCI.1164-19.2019.


Acceptability of a primary care-based opioid and pain review service: a mixed-methods evaluation in England.

Kesten JM, Thomas K, Scott LJ, Bache K, Hickman M, Campbell R, Pickering AE, Redwood S.

Br J Gen Pract. 2020 Jan 30;70(691):e120-e129. doi: 10.3399/bjgp19X706097. Print 2020 Feb.


On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat.

Farmer DGS, Pracejus N, Dempsey B, Turner A, Bokiniec P, Paton JFR, Pickering AE, Burguet J, Andrey P, Goodchild AK, McAllen RM, McMullan S.

J Physiol. 2019 Jul;597(13):3407-3423. doi: 10.1113/JP277661. Epub 2019 Jun 2.


Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

Davies AJ, Kim D, Park J, Lee JY, Vang H, Pickering AE, Oh SB.

Pain. 2019 May;160(5):1059-1069. doi: 10.1097/j.pain.0000000000001482.


Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.

Chakrabarty B, Ito H, Ximenes M, Nishikawa N, Vahabi B, Kanai AJ, Pickering AE, Drake MJ, Fry CH.

Br J Pharmacol. 2019 Jul;176(13):2227-2237. doi: 10.1111/bph.14669. Epub 2019 May 11.


Assessing Long-term Neurodevelopmental Outcome Following General Anesthesia in Early Childhood: Challenges and Opportunities.

Walkden GJ, Pickering AE, Gill H.

Anesth Analg. 2019 Apr;128(4):681-694. doi: 10.1213/ANE.0000000000004052. Review.


Behavioral correlates of activity of optogenetically identified locus coeruleus noradrenergic neurons in rats performing T-maze tasks.

Xiang L, Harel A, Gao H, Pickering AE, Sara SJ, Wiener SI.

Sci Rep. 2019 Feb 4;9(1):1361. doi: 10.1038/s41598-018-37227-w.


Platelet dysfunction after Out of Hospital Cardiac Arrest. Results from POHCAR: A prospective observational, cohort study.

Skorko A, Mumford A, Thomas M, Pickering AE, Greenwood R, Griffiths E, Johnson T, Benger J.

Resuscitation. 2019 Mar;136:105-111. doi: 10.1016/j.resuscitation.2019.01.025. Epub 2019 Feb 1.


Modulation of Bladder Wall Micromotions Alters Intravesical Pressure Activity in the Isolated Bladder.

Chakrabarty B, Bijos DA, Vahabi B, Clavica F, Kanai AJ, Pickering AE, Fry CH, Drake MJ.

Front Physiol. 2019 Jan 10;9:1937. doi: 10.3389/fphys.2018.01937. eCollection 2018.


Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.

Davies AJ, Kim D, Park J, Lee JY, Vang H, Pickering AE, Oh SB.

Pain. 2019 Jan 11. doi: 10.1097/j.pain.0000000000001482. [Epub ahead of print]


Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice.

Ito H, Chakrabarty B, Drake MJ, Fry CH, Kanai AJ, Pickering AE.

BJU Int. 2019 Jul;124(1):163-173. doi: 10.1111/bju.14664. Epub 2019 Feb 17.


Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model.

Sales AC, Friston KJ, Jones MW, Pickering AE, Moran RJ.

PLoS Comput Biol. 2019 Jan 4;15(1):e1006267. doi: 10.1371/journal.pcbi.1006267. eCollection 2019 Jan.


Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.

Swift KM, Gross BA, Frazer MA, Bauer DS, Clark KJD, Vazey EM, Aston-Jones G, Li Y, Pickering AE, Sara SJ, Poe GR.

Curr Biol. 2018 Nov 19;28(22):3599-3609.e4. doi: 10.1016/j.cub.2018.09.054. Epub 2018 Nov 1.


Ultrasound-guided, open-source microneurography: Approaches to improve recordings from peripheral nerves in man.

Dunham JP, Sales AC, Pickering AE.

Clin Neurophysiol. 2018 Nov;129(11):2475-2481. doi: 10.1016/j.clinph.2018.07.011. Epub 2018 Jul 29.


Characterization of mouse neuro-urological dynamics in a novel decerebrate arterially perfused mouse (DAPM) preparation.

Ito H, Drake MJ, Fry CH, Kanai AJ, Pickering AE.

Neurourol Urodyn. 2018 Apr;37(4):1302-1312. doi: 10.1002/nau.23471. Epub 2018 Jan 15.


Muro-Neuro-Urodynamics; a Review of the Functional Assessment of Mouse Lower Urinary Tract Function.

Ito H, Pickering AE, Igawa Y, Kanai AJ, Fry CH, Drake MJ.

Front Physiol. 2017 Feb 6;8:49. doi: 10.3389/fphys.2017.00049. eCollection 2017. Review.


Single Electrode Deep Brain Stimulation with Dual Targeting at Dual Frequency for the Treatment of Chronic Pain: A Case Series and Review of the Literature.

Hollingworth M, Sims-Williams HP, Pickering AE, Barua N, Patel NK.

Brain Sci. 2017 Jan 13;7(1). pii: E9. doi: 10.3390/brainsci7010009. Review.


Resolving the Brainstem Contributions to Attentional Analgesia.

Brooks JC, Davies WE, Pickering AE.

J Neurosci. 2017 Mar 1;37(9):2279-2291. doi: 10.1523/JNEUROSCI.2193-16.2016. Epub 2017 Jan 17.


Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia.

Farmer DG, Dutschmann M, Paton JF, Pickering AE, McAllen RM.

J Physiol. 2016 Dec 15;594(24):7249-7265. doi: 10.1113/JP273164.


Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans.

Sims-Williams H, Matthews JC, Talbot PS, Love-Jones S, Brooks JC, Patel NK, Pickering AE.

Neuroimage. 2017 Feb 1;146:833-842. doi: 10.1016/j.neuroimage.2016.08.038. Epub 2016 Aug 21.


Characterising the Analgesic Effect of Different Targets for Deep Brain Stimulation in Trigeminal Anaesthesia Dolorosa.

Sims-Williams HP, Javed S, Pickering AE, Patel NK.

Stereotact Funct Neurosurg. 2016;94(3):174-81. doi: 10.1159/000446608. Epub 2016 Jun 21.


Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea.

Cerritelli S, Hirschberg S, Hill R, Balthasar N, Pickering AE.

PLoS One. 2016 Apr 14;11(4):e0153187. doi: 10.1371/journal.pone.0153187. eCollection 2016.


Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector.

Li Y, Hickey L, Perrins R, Werlen E, Patel AA, Hirschberg S, Jones MW, Salinas S, Kremer EJ, Pickering AE.

Brain Res. 2016 Jun 15;1641(Pt B):274-90. doi: 10.1016/j.brainres.2016.02.023. Epub 2016 Feb 19.


Influence of age on respiratory modulation of muscle sympathetic nerve activity, blood pressure and baroreflex function in humans.

Shantsila A, McIntyre DB, Lip GY, Fadel PJ, Paton JF, Pickering AE, Fisher JP.

Exp Physiol. 2015 Sep;100(9):1039-51. doi: 10.1113/EP085071. Epub 2015 Aug 18.


Modelling the vascular response to sympathetic postganglionic nerve activity.

Briant LJ, Paton JF, Pickering AE, Champneys AR.

J Theor Biol. 2015 Apr 21;371:102-16. doi: 10.1016/j.jtbi.2015.01.037. Epub 2015 Feb 16.


Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone.

Hughes S, Hickey L, Donaldson LF, Lumb BM, Pickering AE.

Pain. 2015 Feb;156(2):328-34. doi: 10.1097/01.j.pain.0000460313.73358.31.


Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats.

Briant LJ, Stalbovskiy AO, Nolan MF, Champneys AR, Pickering AE.

J Neurophysiol. 2014 Dec 1;112(11):2756-78. doi: 10.1152/jn.00350.2014. Epub 2014 Aug 13.


Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.

Stalbovskiy AO, Briant LJ, Paton JF, Pickering AE.

J Physiol. 2014 May 15;592(10):2215-36. doi: 10.1113/jphysiol.2014.270769. Epub 2014 Mar 24.


Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats.

Hickey L, Li Y, Fyson SJ, Watson TC, Perrins R, Hewinson J, Teschemacher AG, Furue H, Lumb BM, Pickering AE.

J Neurosci. 2014 Mar 19;34(12):4148-60. doi: 10.1523/JNEUROSCI.4835-13.2014.


Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms.

Funai Y, Pickering AE, Uta D, Nishikawa K, Mori T, Asada A, Imoto K, Furue H.

Pain. 2014 Mar;155(3):617-28. doi: 10.1016/j.pain.2013.12.018. Epub 2013 Dec 16.


A functional analysis of the influence of β3-adrenoceptors on the rat micturition cycle.

Sadananda P, Drake MJ, Paton JF, Pickering AE.

J Pharmacol Exp Ther. 2013 Nov;347(2):506-15. doi: 10.1124/jpet.113.207340. Epub 2013 Sep 5.


Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.

Hughes SW, Hickey L, Hulse RP, Lumb BM, Pickering AE.

Pain. 2013 Sep;154(9):1680-90. doi: 10.1016/j.pain.2013.05.010. Epub 2013 May 14.


Prolonged ketamine infusion as a therapy for complex regional pain syndrome: synergism with antagonism?

Pickering AE, McCabe CS.

Br J Clin Pharmacol. 2014 Feb;77(2):233-8. doi: 10.1111/bcp.12157. No abstract available.


In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem.

Sugiyama D, Hur SW, Pickering AE, Kase D, Kim SJ, Kawamata M, Imoto K, Furue H.

J Physiol. 2012 May 15;590(10):2225-31. doi: 10.1113/jphysiol.2011.226407. Epub 2012 Feb 27.


Processing of central and reflex vagal drives by rat cardiac ganglion neurones: an intracellular analysis.

McAllen RM, Salo LM, Paton JF, Pickering AE.

J Physiol. 2011 Dec 1;589(Pt 23):5801-18. doi: 10.1113/jphysiol.2011.214320. Epub 2011 Oct 17.


An exploration of the control of micturition using a novel in situ arterially perfused rat preparation.

Sadananda P, Drake MJ, Paton JF, Pickering AE.

Front Neurosci. 2011 May 13;5:62. doi: 10.3389/fnins.2011.00062. eCollection 2011.


Deep brain stimulation relieves refractory hypertension.

Patel NK, Javed S, Khan S, Papouchado M, Malizia AL, Pickering AE, Paton JF.

Neurology. 2011 Jan 25;76(4):405-7. doi: 10.1212/WNL.0b013e3182088108. No abstract available.


Is augmented central respiratory-sympathetic coupling involved in the generation of hypertension?

Simms AE, Paton JF, Allen AM, Pickering AE.

Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):89-97. doi: 10.1016/j.resp.2010.07.010. Epub 2010 Jul 30. Review.


TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord.

Uta D, Furue H, Pickering AE, Rashid MH, Mizuguchi-Takase H, Katafuchi T, Imoto K, Yoshimura M.

Eur J Neurosci. 2010 Jun;31(11):1960-73. doi: 10.1111/j.1460-9568.2010.07255.x. Epub 2010 May 24.


Analgesia in conjunction with normalisation of thermal sensation following deep brain stimulation for central post-stroke pain.

Pickering AE, Thornton SR, Love-Jones SJ, Steeds C, Patel NK.

Pain. 2009 Dec 15;147(1-3):299-304. doi: 10.1016/j.pain.2009.09.011. Epub 2009 Oct 14.


Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats.

Howorth PW, Thornton SR, O'Brien V, Smith WD, Nikiforova N, Teschemacher AG, Pickering AE.

J Neurosci. 2009 Oct 14;29(41):12855-64. doi: 10.1523/JNEUROSCI.1699-09.2009.


The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances.

Dutschmann M, Waki H, Manzke T, Simms AE, Pickering AE, Richter DW, Paton JF.

Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2611-23. doi: 10.1098/rstb.2009.0076.


Homotopic stimulation can reduce the area of allodynia in patients with neuropathic pain.

Love-Jones SJ, Besson M, Steeds CE, Brook P, Chizh BA, Pickering AE.

Eur J Pain. 2009 Oct;13(9):942-8. doi: 10.1016/j.ejpain.2008.11.018. Epub 2008 Dec 30.


Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension?

Simms AE, Paton JF, Pickering AE, Allen AM.

J Physiol. 2009 Feb 1;587(3):597-610. doi: 10.1113/jphysiol.2008.165902. Epub 2008 Dec 8.


Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo.

Howorth PW, Teschemacher AG, Pickering AE.

J Comp Neurol. 2009 Jan 10;512(2):141-57. doi: 10.1002/cne.21879.


Dominant role of aortic baroreceptors in the cardiac baroreflex of the rat in situ.

Pickering AE, Simms AE, Paton JF.

Auton Neurosci. 2008 Nov 3;142(1-2):32-9. doi: 10.1016/j.autneu.2008.03.009. Epub 2008 May 13.


Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity.

Zoccal DB, Simms AE, Bonagamba LG, Braga VA, Pickering AE, Paton JF, Machado BH.

J Physiol. 2008 Jul 1;586(13):3253-65. doi: 10.1113/jphysiol.2008.154187. Epub 2008 May 1.

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