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Items: 13

1.

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model.

Viswanathan GK, Shwartz D, Losev Y, Arad E, Shemesh C, Pichinuk E, Engel H, Raveh A, Jelinek R, Cooper I, Gosselet F, Gazit E, Segal D.

Cell Mol Life Sci. 2019 Sep 27. doi: 10.1007/s00018-019-03312-0. [Epub ahead of print]

PMID:
31562564
2.

Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles.

Elias R, Benhamou RI, Jaber QZ, Dorot O, Zada SL, Oved K, Pichinuk E, Fridman M.

Eur J Med Chem. 2019 Oct 1;179:779-790. doi: 10.1016/j.ejmech.2019.07.003. Epub 2019 Jul 2.

PMID:
31288127
3.

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation.

Laor D, Sade D, Shaham-Niv S, Zaguri D, Gartner M, Basavalingappa V, Raveh A, Pichinuk E, Engel H, Iwasaki K, Yamamoto T, Noothalapati H, Gazit E.

Nat Commun. 2019 Jan 8;10(1):62. doi: 10.1038/s41467-018-07966-5.

4.

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity.

Massalha W, Markovits M, Pichinuk E, Feinstein-Rotkopf Y, Tarshish M, Mishra K, Llado V, Weil M, Escriba PV, Kakhlon O.

Biosci Rep. 2019 Jan 18;39(1). pii: BSR20181661. doi: 10.1042/BSR20181661. Print 2019 Jan 31.

5.

Targeting cell-bound MUC1 on myelomonocytic, monocytic leukemias and phenotypically defined leukemic stem cells with anti-SEA module antibodies.

Guillaume T, Dehame V, Chevallier P, Peterlin P, Garnier A, Grégoire M, Pichinuk E, Rubinstein DB, Wreschner DH.

Exp Hematol. 2019 Feb;70:97-108. doi: 10.1016/j.exphem.2018.12.002. Epub 2018 Dec 26.

PMID:
30593830
6.

Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils.

Haj E, Losev Y, Guru KrishnaKumar V, Pichinuk E, Engel H, Raveh A, Gazit E, Segal D.

Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1565-1575. doi: 10.1016/j.bbagen.2018.04.001. Epub 2018 Apr 7.

PMID:
29634991
7.

A differential autophagy-dependent response to DNA double-strand breaks in bone marrow mesenchymal stem cells from sporadic ALS patients.

Wald-Altman S, Pichinuk E, Kakhlon O, Weil M.

Dis Model Mech. 2017 May 1;10(5):645-654. doi: 10.1242/dmm.027938. Epub 2017 Feb 16.

8.

MUC1-ARF-A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA.

Chalick M, Jacobi O, Pichinuk E, Garbar C, Bensussan A, Meeker A, Ziv R, Zehavi T, Smorodinsky NI, Hilkens J, Hanisch FG, Rubinstein DB, Wreschner DH.

PLoS One. 2016 Oct 21;11(10):e0165031. doi: 10.1371/journal.pone.0165031. eCollection 2016.

9.

Antibody targeting of cell-bound MUC1 SEA domain kills tumor cells.

Pichinuk E, Benhar I, Jacobi O, Chalik M, Weiss L, Ziv R, Sympson C, Karwa A, Smorodinsky NI, Rubinstein DB, Wreschner DH.

Cancer Res. 2012 Jul 1;72(13):3324-36. doi: 10.1158/0008-5472.CAN-12-0067. Epub 2012 Apr 16.

10.

Endogenous RNA cleavages at the ribosomal SRL site likely reflect miRNA (miR) mediated translational suppression.

Pichinuk E, Broday L, Wreschner DH.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):706-11. doi: 10.1016/j.bbrc.2011.09.140. Epub 2011 Oct 6.

PMID:
22001924
11.

Similarities between Argonautes and the alpha-sarcin-like ribotoxins: Implications for microRNA action.

Pichinuk E, Wreschner DH.

Protein Sci. 2010 Jun;19(6):1272-8. doi: 10.1002/pro.391.

12.

The MUC1 oncoprotein as a functional target: immunotoxin binding to alpha/beta junction mediates cell killing.

Rubinstein DB, Karmely M, Pichinuk E, Ziv R, Benhar I, Feng N, Smorodinsky NI, Wreschner DH.

Int J Cancer. 2009 Jan 1;124(1):46-54. doi: 10.1002/ijc.23910.

13.

PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.

Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH.

J Biol Chem. 2008 Jun 13;283(24):16928-39. doi: 10.1074/jbc.M801454200. Epub 2008 Apr 3.

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