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Developmental immunotoxicity (DIT) testing of pharmaceuticals: current practices, state of the science, knowledge gaps, and recommendations.
Collinge M, Burns-Naas LA, Chellman GJ, Kawabata TT, Komocsar WJ, Piccotti JR, Shenton J, Wierda D.
J Immunotoxicol. 2012 Apr-Jun;9(2):210-30. doi: 10.3109/1547691X.2012.661486. Epub 2012 Mar 19. Review.
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Summary of a workshop on nonclinical and clinical immunotoxicity assessment of immunomodulatory drugs.
Piccotti JR, Lebrec HN, Evans E, Herzyk DJ, Hastings KL, Burns-Naas LA, Gourley IS, Wierda D, Kawabata TT.
J Immunotoxicol. 2009 Mar;6(1):1-10. doi: 10.1080/15476910802656440.
T-cell-dependent antibody response: assay development in cynomolgus monkeys.
Piccotti JR, Alvey JD, Reindel JF, Guzman RE.
J Immunotoxicol. 2005 Oct 1;2(4):191-6. doi: 10.1080/15476910500362838.
Use of an ex vivo local lymph node assay to assess contact hypersensitivity potential.
Piccotti JR, Kawabata TT.
J Immunotoxicol. 2008 Jul;5(3):271-7. doi: 10.1080/15376510802311961.
Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo.
Cheng L, Stewart BJ, You Q, Petersen DR, Ware JA, Piccotti JR, Kawabata TT, Ju C.
Mol Pharmacol. 2008 Jun;73(6):1769-75. doi: 10.1124/mol.107.043273. Epub 2008 Mar 11.
Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison.
Piccotti JR, Knight SA, Gillhouse K, Lagattuta MS, Bleavins MR.
J Appl Toxicol. 2006 Jul-Aug;26(4):333-40.
Induction of apoptosis by cationic amphiphilic drugs amiodarone and imipramine.
Piccotti JR, LaGattuta MS, Knight SA, Gonzales AJ, Bleavins MR.
Drug Chem Toxicol. 2005;28(1):117-33.
Tissue-specific consequences of the anti-adenoviral immune response: implications for cardiac transplants.
Chan SY, Li K, Piccotti JR, Louie MC, Judge TA, Turka LA, Eichwald EJ, Bishop DK.
Nat Med. 1999 Oct;5(10):1143-9.
Cytokine regulation of chronic cardiac allograft rejection: evidence against a role for Th1 in the disease process.
Piccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK.
Transplantation. 1999 Jun 27;67(12):1548-55.
Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo: requirement for beta1 subunit of the IL-12 receptor.
Transplantation. 1999 Jun 15;67(11):1453-60.
Genetic vaccination-induced immune responses to the human immunodeficiency virus protein Rev: emergence of the interleukin 2-producing helper T lymphocyte.
Chan SY, Louie MC, Piccotti JR, Iyer G, Ling X, Yang ZY, Nabel GJ, Bishop DK.
Hum Gene Ther. 1998 Oct 10;9(15):2187-96.
Alloantigen-reactive Th1 development in IL-12-deficient mice.
Piccotti JR, Li K, Chan SY, Ferrante J, Magram J, Eichwald EJ, Bishop DK.
J Immunol. 1998 Feb 1;160(3):1132-8.
Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?
Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK.
Transplantation. 1997 Mar 15;63(5):619-24. Review. No abstract available.
Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells.
Piccotti JR, Chan SY, Li K, Eichwald EJ, Bishop DK.
J Immunol. 1997 Jan 15;158(2):643-8.
Suppression of splenic T lymphocyte proliferation by acute cocaine administration.
Piccotti JR, Brissette-Storkus CS, Chambers WH, Bricker JD.
Life Sci. 1997;61(10):967-76.
IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity.
Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK.
J Immunol. 1996 Sep 1;157(5):1951-7.
Regulation of cardiac allograft rejection by T lymphocytes.
Debruyne LA, Piccotti JR, Bishop DK.
Trends Cardiovasc Med. 1996 Jul;6(5):168-73. doi: 10.1016/1050-1738(96)00052-7.
Effect of cocaine administration on concanavalin A-stimulated T-lymphocyte proliferation in rats.
Piccotti JR, Bricker JD.
Immunopharmacol Immunotoxicol. 1995 Feb;17(1):81-90.
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