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Items: 41


Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Lazzari L, Corti G, Picco G, Isella C, Montone M, Arcella P, Durinikova E, Zanella ER, Novara L, Barbosa F, Cassingena A, Cancelliere C, Medico E, Sartore-Bianchi A, Siena S, Garnett MJ, Bertotti A, Trusolino L, Di Nicolantonio F, Linnebacher M, Bardelli A, Arena S.

Clin Cancer Res. 2019 Aug 2. doi: 10.1158/1078-0432.CCR-18-3440. [Epub ahead of print]


Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.

Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ.

Nat Commun. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1.


Cellular response to glutamine and/or glucose deprivation in in vitro transformed human fibroblasts.

Chiodi I, Picco G, Martino C, Mondello C.

Oncol Rep. 2019 Jun;41(6):3555-3564. doi: 10.3892/or.2019.7125. Epub 2019 Apr 17.


Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.

Nature. 2019 Apr;568(7753):511-516. doi: 10.1038/s41586-019-1103-9. Epub 2019 Apr 10.


Correction: Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.

Hadjialirezaei S, Picco G, Beatson R, Burchell J, Stokke BT, Sletmoen M.

PLoS One. 2018 Jan 2;13(1):e0190814. doi: 10.1371/journal.pone.0190814. eCollection 2018.


A Road Map for Precision Cancer Medicine Using Personalized Models.

Picco G, Garnett MJ.

Cancer Discov. 2017 May;7(5):456-458. doi: 10.1158/2159-8290.CD-17-0268.


Association of GSTT1 null, XPD 751 CC and XPC 939 CC genotypes with increased levels of genomic damage among hospital pathologists.

Santovito A, Delsoglio M, Manitta E, Picco G, Meschiati G, Chiarizio M, Gendusa C, Cervella P.

Biomarkers. 2017 Sep;22(6):557-565. doi: 10.1080/1354750X.2017.1322147. Epub 2017 May 4.


Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.

Hadjialirezaei S, Picco G, Beatson R, Burchell J, Stokke BT, Sletmoen M.

PLoS One. 2017 Apr 17;12(4):e0175323. doi: 10.1371/journal.pone.0175323. eCollection 2017. Erratum in: PLoS One. 2018 Jan 2;13(1):e0190814.


Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.

Picco G, Petti C, Centonze A, Torchiaro E, Crisafulli G, Novara L, Acquaviva A, Bardelli A, Medico E.

EMBO Mol Med. 2017 Mar;9(3):293-303. doi: 10.15252/emmm.201606773.


The RNA-binding protein ESRP1 promotes human colorectal cancer progression.

Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfò I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F.

Oncotarget. 2017 Feb 7;8(6):10007-10024. doi: 10.18632/oncotarget.14318.


Targeting of Tumor-Associated Glycoforms of MUC1 with CAR T Cells.

Maher J, Wilkie S, Davies DM, Arif S, Picco G, Julien S, Foster J, Burchell J, Taylor-Papadimitriou J.

Immunity. 2016 Nov 15;45(5):945-946. doi: 10.1016/j.immuni.2016.10.014.


Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.

Picco G, Petti C, Sassi F, Grillone K, Migliardi G, Rossi T, Isella C, Di Nicolantonio F, Sarotto I, Sapino A, Bardelli A, Trusolino L, Bertotti A, Medico E.

J Natl Cancer Inst. 2016 Oct 22;109(2). pii: djw209. Print 2017 Feb.


The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.

Beatson R, Tajadura-Ortega V, Achkova D, Picco G, Tsourouktsoglou TD, Klausing S, Hillier M, Maher J, Noll T, Crocker PR, Taylor-Papadimitriou J, Burchell JM.

Nat Immunol. 2016 Nov;17(11):1273-1281. doi: 10.1038/ni.3552. Epub 2016 Sep 5.


Relationships between cytokine (IL-6 and TGF-β1) gene polymorphisms and chromosomal damage in hospital workers.

Santovito A, Cervella P, Chiarizio M, Meschiati G, Delsoglio M, Manitta E, Picco G, Delpero M.

J Immunotoxicol. 2016 May;13(3):314-23. doi: 10.3109/1547691X.2015.1076547. Epub 2015 Sep 3.


Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions.

Haugstad KE, Hadjialirezaei S, Stokke BT, Brewer CF, Gerken TA, Burchell J, Picco G, Sletmoen M.

Glycobiology. 2016 Dec;26(12):1338-1350. Epub 2016 Jun 9.


A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells.

Picco G, Petti C, Trusolino L, Bertotti A, Medico E.

Sci Rep. 2015 Sep 30;5:14721. doi: 10.1038/srep14721.


The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.

Beatson R, Maurstad G, Picco G, Arulappu A, Coleman J, Wandell HH, Clausen H, Mandel U, Taylor-Papadimitriou J, Sletmoen M, Burchell JM.

PLoS One. 2015 May 7;10(5):e0125994. doi: 10.1371/journal.pone.0125994. eCollection 2015.


The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, Buscarino M, Isella C, Lamba S, Martinoglio B, Veronese S, Siena S, Sartore-Bianchi A, Beccuti M, Mottolese M, Linnebacher M, Cordero F, Di Nicolantonio F, Bardelli A.

Nat Commun. 2015 Apr 30;6:7002. doi: 10.1038/ncomms8002.


MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

Cantini L, Isella C, Petti C, Picco G, Chiola S, Ficarra E, Caselle M, Medico E.

Nat Commun. 2015 Nov 17;6:8878. doi: 10.1038/ncomms9878.


Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

Petti C, Picco G, Martelli ML, Trisolini E, Bucci E, Perera T, Isella C, Medico E.

Oncotarget. 2015 Jan 1;6(1):221-33.


Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas.

Picco G, Beatson R, Taylor-Papadimitriou J, Burchell JM.

Eur J Immunol. 2014 Jul;44(7):1947-55. doi: 10.1002/eji.201344076. Epub 2014 Apr 17.


Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

Ferrero GB, Picco G, Baldassarre G, Flex E, Isella C, Cantarella D, Corà D, Chiesa N, Crescenzio N, Timeus F, Merla G, Mazzanti L, Zampino G, Rossi C, Silengo M, Tartaglia M, Medico E.

Hum Mutat. 2012 Apr;33(4):703-9. doi: 10.1002/humu.22026. Epub 2012 Feb 14.


Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.

Julien S, Ivetic A, Grigoriadis A, QiZe D, Burford B, Sproviero D, Picco G, Gillett C, Papp SL, Schaffer L, Tutt A, Taylor-Papadimitriou J, Pinder SE, Burchell JM.

Cancer Res. 2011 Dec 15;71(24):7683-93. doi: 10.1158/0008-5472.CAN-11-1139. Epub 2011 Oct 24.


Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation.

Pinto R, Carvalho AS, Conze T, Magalhães A, Picco G, Burchell JM, Taylor-Papadimitriou J, Reis CA, Almeida R, Mandel U, Clausen H, Söderberg O, David L.

J Cell Mol Med. 2012 Jul;16(7):1474-84. doi: 10.1111/j.1582-4934.2011.01436.x.


Over-expression of ST3Gal-I promotes mammary tumorigenesis.

Picco G, Julien S, Brockhausen I, Beatson R, Antonopoulos A, Haslam S, Mandel U, Dell A, Pinder S, Taylor-Papadimitriou J, Burchell J.

Glycobiology. 2010 Oct;20(10):1241-50. doi: 10.1093/glycob/cwq085. Epub 2010 Jun 8.


Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model.

Julien S, Picco G, Sewell R, Vercoutter-Edouart AS, Tarp M, Miles D, Clausen H, Taylor-Papadimitriou J, Burchell JM.

Br J Cancer. 2009 Jun 2;100(11):1746-54. doi: 10.1038/sj.bjc.6605083. Epub 2009 May 12.


Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian renal infection study 1.

Montini G, Zucchetta P, Tomasi L, Talenti E, Rigamonti W, Picco G, Ballan A, Zucchini A, Serra L, Canella V, Gheno M, Venturoli A, Ranieri M, Caddia V, Carasi C, Dall'amico R, Hewitt I.

Pediatrics. 2009 Feb;123(2):e239-46. doi: 10.1542/peds.2008-1003. Epub 2009 Jan 12.


[Outbreak of Mediterranean exanthematic fever due to tick bites in a public square].

Godoy P, Picco G, Clotet C, Gómez F, Peralba MA.

Aten Primaria. 2008 Jul;40(7):371-3. Spanish. No abstract available.


Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor.

Wilkie S, Picco G, Foster J, Davies DM, Julien S, Cooper L, Arif S, Mather SJ, Taylor-Papadimitriou J, Burchell JM, Maher J.

J Immunol. 2008 Apr 1;180(7):4901-9.


Immunisation with 'naïve' syngeneic dendritic cells protects mice from tumour challenge.

Grimshaw MJ, Papazisis K, Picco G, Bohnenkamp H, Noll T, Taylor-Papadimitriou J, Burchell J.

Br J Cancer. 2008 Feb 26;98(4):784-91. doi: 10.1038/sj.bjc.6604221. Epub 2008 Feb 5.


Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells.

Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M.

Cancer Res. 2007 Sep 1;67(17):8358-67.


[Bowel lavage solutions: are senosidos A+B harmless?].

Picco G, de Dios Romero A, Romera B, Badía J.

Med Clin (Barc). 2006 Nov 11;127(18):716-7. Spanish. No abstract available.


[Regular intake of seaweed and hyperthyroidism].

Picco G, de Dios-Romero A, Albanell N, Badia J.

Med Clin (Barc). 2006 Jul 1;127(5):199. Spanish. No abstract available.


[Chagas disease and AIDS: coinfection to consider].

Picco G.

Med Clin (Barc). 2005 Nov 12;125(17):679. Spanish. No abstract available.


Cardiac troponin I in asphyxiated neonates.

Trevisanuto D, Picco G, Golin R, Doglioni N, Altinier S, Zaninotto M, Zanardo V.

Biol Neonate. 2006;89(3):190-3. Epub 2005 Nov 17.


Successful treatment with the monoclonal antibody rituximab in two children with refractory autoimmune thrombocytopenia.

Pusiol A, Cesaro S, Nocerino A, Picco G, Zanesco L, Bisogno G.

Eur J Pediatr. 2004 Jun;163(6):305-7.


Recombinant MUC1 mucin with a breast cancer-like O-glycosylation produced in large amounts in Chinese-hamster ovary cells.

Bäckström M, Link T, Olson FJ, Karlsson H, Graham R, Picco G, Burchell J, Taylor-Papadimitriou J, Noll T, Hansson GC.

Biochem J. 2003 Dec 15;376(Pt 3):677-86.


Granulocyte transfusions from G-CSF-stimulated donors for the treatment of severe infections in neutropenic pediatric patients with onco-hematological diseases.

Cesaro S, Chinello P, De Silvestro G, Marson P, Picco G, Varotto S, Pittalis S, Zanesco L.

Support Care Cancer. 2003 Feb;11(2):101-6. Epub 2002 Nov 12.


[Fever of unknown origin in patients with HIV infection].

Riera M, Altés J, Homar F, Picco G, Salas A, Leyes M, Cifuentes C, Artigues A, Villalonga C.

Enferm Infecc Microbiol Clin. 1996 Dec;14(10):581-5. Spanish.


[Changes in the natural history of AIDS in patients from Mallorca and Ibiza: 1986-1992].

Riera M, Altés J, Villalonga C, Salas A, Homar F, Picco G, Leyes M, Rifà J.

Med Clin (Barc). 1995 May 27;104(20):765-70. Spanish.


[Report on 700 liver biopsies performed in a division of medicine and in- and outpatients].

Ajolfi C, Bassi F, Bautz C, Bongiorni G, Buscarini L, Fornari F, Picco GM, Regolisti M.

Minerva Dietol Gastroenterol. 1979 Oct-Dec;25(4):417-9. Italian. No abstract available.


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