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Items: 42


DNA-PKc deficiency drives pre-malignant transformation by reducing DNA repair capacity in concert with reprogramming the epigenome in human bronchial epithelial cells.

Teneng I, Picchi MA, Leng S, Dagucon CP, Ramalingam S, Tellez CS, Belinsky SA.

DNA Repair (Amst). 2019 Jul;79:1-9. doi: 10.1016/j.dnarep.2019.04.006. Epub 2019 Apr 27.


p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer.

Filipczak PT, Leng S, Tellez CS, Do KC, Grimes MJ, Thomas CL, Walton-Filipczak SR, Picchi MA, Belinsky SA.

Cancer Res. 2019 Apr 15;79(8):1758-1768. doi: 10.1158/0008-5472.CAN-18-1234. Epub 2019 Jan 8.


Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers.

Tessema M, Rossi MR, Picchi MA, Yingling CM, Lin Y, Ramalingam SS, Belinsky SA.

Lung Cancer. 2018 Sep;123:99-106. doi: 10.1016/j.lungcan.2018.07.011. Epub 2018 Jul 11.


Gene Promoter Hypermethylation Detected in Sputum Predicts FEV1 Decline and All-Cause Mortality in Smokers.

Leng S, Diergaarde B, Picchi MA, Wilson DO, Gilliland FD, Yuan JM, Siegfried JM, Belinsky SA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):187-196. doi: 10.1164/rccm.201708-1659OC.


Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico.

Leng S, Picchi MA, Tesfaigzi Y, Wu G, Gauderman WJ, Xu F, Gilliland FD, Belinsky SA.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 30;12:3171-3181. doi: 10.2147/COPD.S142237. eCollection 2017.


Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers.

Leng S, Picchi MA, Kang H, Wu G, Filipczak PT, Juri DE, Zhang X, Gauderman WJ, Gilliland FD, Belinsky SA.

Cancer Prev Res (Phila). 2018 Feb;11(2):93-102. doi: 10.1158/1940-6207.CAPR-17-0196. Epub 2017 Nov 8.


Gene methylation biomarkers in sputum as a classifier for lung cancer risk.

Leng S, Wu G, Klinge DM, Thomas CL, Casas E, Picchi MA, Stidley CA, Lee SJ, Aisner S, Siegfried JM, Ramalingam S, Khuri FR, Karp DD, Belinsky SA.

Oncotarget. 2017 Jul 15;8(38):63978-63985. doi: 10.18632/oncotarget.19255. eCollection 2017 Sep 8.


ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status.

Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA.

Cancer Lett. 2017 Dec 1;410:191-200. doi: 10.1016/j.canlet.2017.09.038. Epub 2017 Sep 29.


Gene Methylation Biomarkers in Sputum and Plasma as Predictors for Lung Cancer Recurrence.

Belinsky SA, Leng S, Wu G, Thomas CL, Picchi MA, Lee SJ, Aisner S, Ramalingam S, Khuri FR, Karp DD.

Cancer Prev Res (Phila). 2017 Nov;10(11):635-640. doi: 10.1158/1940-6207.CAPR-17-0177. Epub 2017 Sep 13.


A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania.

Leng S, Weissfeld JL, Picchi MA, Styn MA, Claus ED, Clark VP, Wu G, Thomas CL, Gilliland FD, Yuan J, Siegfried JM, Belinsky SA.

Int J Mol Epidemiol Genet. 2016 Jun 1;7(2):95-104. eCollection 2016.


miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis.

Tellez CS, Juri DE, Do K, Picchi MA, Wang T, Liu G, Spira A, Belinsky SA.

Cancer Res. 2016 Aug 15;76(16):4741-51. doi: 10.1158/0008-5472.CAN-15-3367. Epub 2016 Jun 14.


Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners.

Leng S, Thomas CL, Snider AM, Picchi MA, Chen W, Willis DG, Carr TG, Krzeminski J, Desai D, Shantu A, Lin Y, Jacobson MR, Belinsky SA.

Environ Health Perspect. 2016 Apr;124(4):445-51. doi: 10.1289/ehp.1409437. Epub 2015 Sep 15.


Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.

Tessema M, Yingling CM, Picchi MA, Wu G, Liu Y, Weissfeld JL, Siegfried JM, Tesfaigzi Y, Belinsky SA.

J Thorac Oncol. 2015 Aug;10(8):1181-8. doi: 10.1097/JTO.0000000000000592.


Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.

Leng S, Wu G, Collins LB, Thomas CL, Tellez CS, Jauregui AR, Picchi MA, Zhang X, Juri DE, Desai D, Amin SG, Crowell RE, Stidley CA, Liu Y, Swenberg JA, Lin Y, Wathelet MG, Gilliland FD, Belinsky SA.

Cancer Res. 2015 Aug 1;75(15):3108-17. doi: 10.1158/0008-5472.CAN-15-0243. Epub 2015 Jul 16.


15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

Leng S, Liu Y, Weissfeld JL, Thomas CL, Han Y, Picchi MA, Edlund CK, Willink RP, Gaither Davis AL, Do KC, Nukui T, Zhang X, Burki EA, Van Den Berg D, Romkes M, Gauderman WJ, Crowell RE, Tesfaigzi Y, Stidley CA, Amos CI, Siegfried JM, Gilliland FD, Belinsky SA.

J Natl Cancer Inst. 2015 Feb 23;107(5). pii: djv035. doi: 10.1093/jnci/djv035.


GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer.

Tessema M, Yingling CM, Snider AM, Do K, Juri DE, Picchi MA, Zhang X, Liu Y, Leng S, Tellez CS, Belinsky SA.

J Thorac Oncol. 2014 Jun;9(6):784-93. doi: 10.1097/JTO.0000000000000165.


SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.

Tellez CS, Grimes MJ, Picchi MA, Liu Y, March TH, Reed MD, Oganesian A, Taverna P, Belinsky SA.

Int J Cancer. 2014 Nov 1;135(9):2223-31. doi: 10.1002/ijc.28865. Epub 2014 Apr 5.


Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.

Teneng I, Tellez CS, Picchi MA, Klinge DM, Yingling CM, Snider AM, Liu Y, Belinsky SA.

Oncogene. 2015 Jan 29;34(5):621-30. doi: 10.1038/onc.2013.580. Epub 2014 Jan 27.


Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model.

Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, March TH, Kuehl PJ, Belinsky SA.

Br J Cancer. 2013 Oct 1;109(7):1775-81. doi: 10.1038/bjc.2013.575. Epub 2013 Sep 17.


Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico.

Leng S, Liu Y, Thomas CL, Gauderman WJ, Picchi MA, Bruse SE, Zhang X, Flores KG, Van Den Berg D, Stidley CA, Gilliland FD, Belinsky SA.

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1110-6. doi: 10.1164/rccm.201305-0925OC.


Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.

Leng S, Picchi MA, Liu Y, Thomas CL, Willis DG, Bernauer AM, Carr TG, Mabel PT, Han Y, Amos CI, Lin Y, Stidley CA, Gilliland FD, Jacobson MR, Belinsky SA.

Carcinogenesis. 2013 May;34(5):1044-50. doi: 10.1093/carcin/bgt024. Epub 2013 Jan 25. Erratum in: Carcinogenesis. 2013 Jul;34(7):1698.


Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

Flores KG, Stidley CA, Mackey AJ, Picchi MA, Stabler SP, Siegfried JM, Byers T, Berwick M, Belinsky SA, Leng S.

Carcinogenesis. 2012 Aug;33(8):1542-7. doi: 10.1093/carcin/bgs194. Epub 2012 Jun 4.


Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.

Leng S, Do K, Yingling CM, Picchi MA, Wolf HJ, Kennedy TC, Feser WJ, Baron AE, Franklin WA, Brock MV, Herman JG, Baylin SB, Byers T, Stidley CA, Belinsky SA.

Clin Cancer Res. 2012 Jun 15;18(12):3387-95. doi: 10.1158/1078-0432.CCR-11-3049. Epub 2012 Apr 17.


Methylated Genes in Sputum Among Older Smokers With Asthma.

Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y.

Chest. 2012 Aug;142(2):425-431. doi: 10.1378/chest.11-2519.


Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.

Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, Landi MT, Thun M, Picchi MA, Bruse SE, Crowell RE, Van Den Berg D, Caporaso NE, Amos CI, Siegfried JM, Tesfaigzi Y, Gilliland FD, Belinsky SA.

Cancer Res. 2012 Feb 1;72(3):707-15. doi: 10.1158/0008-5472.CAN-11-3194. Epub 2011 Dec 2.


Discovery of common SNPs in the miR-205/200 family-regulated epithelial to mesenchymal transition pathway and their association with risk for non-small cell lung cancer.

Leng S, Bernauer AM, Zhai R, Tellez CS, Su L, Burki EA, Picchi MA, Stidley CA, Crowell RE, Christiani DC, Belinsky SA.

Int J Mol Epidemiol Genet. 2011;2(2):145-55. Epub 2011 Apr 1.


The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.

Leng S, Bernauer AM, Hong C, Do KC, Yingling CM, Flores KG, Tessema M, Tellez CS, Willink RP, Burki EA, Picchi MA, Stidley CA, Prados MD, Costello JF, Gilliland FD, Crowell RE, Belinsky SA.

Clin Cancer Res. 2011 Apr 1;17(7):2014-23. doi: 10.1158/1078-0432.CCR-10-3026. Epub 2011 Feb 25.


Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.

Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, Channell MM, Liu Y, Casero RA Jr, Baylin SB, Reed MD, Tellez CS, March TH.

Cancer Res. 2011 Jan 15;71(2):454-62. doi: 10.1158/0008-5472.CAN-10-3184. Epub 2011 Jan 11.


Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.

Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y.

Am J Respir Crit Care Med. 2010 Nov 1;182(9):1098-104. doi: 10.1164/rccm.201002-0222OC. Epub 2010 Jul 1.


Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers.

Stidley CA, Picchi MA, Leng S, Willink R, Crowell RE, Flores KG, Kang H, Byers T, Gilliland FD, Belinsky SA.

Cancer Res. 2010 Jan 15;70(2):568-74. doi: 10.1158/0008-5472.CAN-09-3410. Epub 2010 Jan 12.


Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers.

Sood A, Stidley CA, Picchi MA, Celedón JC, Gilliland F, Crowell RE, Belinsky SA, Tesfaigzi Y.

COPD. 2008 Oct;5(5):274-81. doi: 10.1080/15412550802363345.


Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers.

Leng S, Bernauer A, Stidley CA, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Crowell RE, Belinsky SA.

Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2062-9. doi: 10.1158/1055-9965.EPI-08-0308.


Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers.

Leng S, Stidley CA, Bernauer AM, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Crowell RE, Belinsky SA.

Carcinogenesis. 2008 Jul;29(7):1380-5. doi: 10.1093/carcin/bgn121. Epub 2008 May 21.


Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation.

Leng S, Stidley CA, Willink R, Bernauer A, Do K, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Zima C, Crowell RE, Belinsky SA.

Cancer Res. 2008 Apr 15;68(8):3049-56. doi: 10.1158/0008-5472.CAN-07-6344.


Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer.

Machida EO, Brock MV, Hooker CM, Nakayama J, Ishida A, Amano J, Picchi MA, Belinsky SA, Herman JG, Taniguchi S, Baylin SB.

Cancer Res. 2006 Jun 15;66(12):6210-8. Erratum in: Cancer Res. 2007 Jan 1;67(1):427.


Gene promoter methylation in plasma and sputum increases with lung cancer risk.

Belinsky SA, Klinge DM, Dekker JD, Smith MW, Bocklage TJ, Gilliland FD, Crowell RE, Karp DD, Stidley CA, Picchi MA.

Clin Cancer Res. 2005 Sep 15;11(18):6505-11.


Predicting the costs of managing patients with chronic obstructive pulmonary disease.

Mapel DW, McMillan GP, Frost FJ, Hurley JS, Picchi MA, Lydick E, Spencer MD.

Respir Med. 2005 Oct;99(10):1325-33. Epub 2005 Apr 22.


Health care utilization in chronic obstructive pulmonary disease. A case-control study in a health maintenance organization.

Mapel DW, Hurley JS, Frost FJ, Petersen HV, Picchi MA, Coultas DB.

Arch Intern Med. 2000 Sep 25;160(17):2653-8.


Utilization in COPD: patient characteristics and diagnostic evaluation.

Mapel DW, Picchi MA, Hurley JS, Frost FJ, Petersen HV, Mapel VM, Coultas DB.

Chest. 2000 May;117(5 Suppl 2):346S-53S.


Asthma in a Vietnamese refugee population.

Ries AL, Picchi MA, Nguyen LH, Moser RJ, Molgaard CA, Wasserman SI.

Am J Respir Crit Care Med. 1997 Jun;155(6):1895-901.


Murine complement component C4 and sex-limited protein: identification of amino acid residues essential for C4 function.

Ogata RT, Cooper NR, Bradt BM, Mathias P, Picchi MA.

Proc Natl Acad Sci U S A. 1989 Jul;86(14):5575-9.


Transfected cDNA directs expression of hemolytically active murine C4 in cultured mouse and monkey cells.

Picchi MA, Bradt BM, Cooper NR, Ogata RT.

Complement Inflamm. 1989;6(6):442-52.


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