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Items: 1 to 50 of 211

1.

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CR.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8668-E8677. doi: 10.1073/pnas.1810498115. Epub 2018 Aug 27.

PMID:
30150413
2.

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M.

EMBO J. 2018 Sep 3;37(17). pii: e99372. doi: 10.15252/embj.201899372. Epub 2018 Jul 19.

3.

A TFEB nuclear export signal integrates amino acid supply and glucose availability.

Li L, Friedrichsen HJ, Andrews S, Picaud S, Volpon L, Ngeow K, Berridge G, Fischer R, Borden KLB, Filippakopoulos P, Goding CR.

Nat Commun. 2018 Jul 11;9(1):2685. doi: 10.1038/s41467-018-04849-7.

4.

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ.

Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15.

5.

The C-terminal extension landscape of naturally presented HLA-I ligands.

Guillaume P, Picaud S, Baumgaertner P, Montandon N, Schmidt J, Speiser DE, Coukos G, Bassani-Sternberg M, Filippakopoulos P, Gfeller D.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5083-5088. doi: 10.1073/pnas.1717277115. Epub 2018 Apr 30.

PMID:
29712860
6.

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration.

García-Ayuso D, Di Pierdomenico J, Hadj-Said W, Marie M, Agudo-Barriuso M, Vidal-Sanz M, Picaud S, Villegas-Pérez MP.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1396-1409. doi: 10.1167/iovs.17-23258.

PMID:
29625463
7.

A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo.

Yger P, Spampinato GL, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O.

Elife. 2018 Mar 20;7. pii: e34518. doi: 10.7554/eLife.34518.

8.

Adsorption of Methylamine on Amorphous Ice under Interstellar Conditions. A Grand Canonical Monte Carlo Simulation Study.

Horváth RA, Hantal G, Picaud S, Szőri M, Jedlovszky P.

J Phys Chem A. 2018 Apr 5;122(13):3398-3412. doi: 10.1021/acs.jpca.8b01591. Epub 2018 Mar 23.

PMID:
29537265
9.

Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells.

Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, Fouquet S, Villette T, Sahel JA, Lenaers G, Picaud S.

Cell Death Dis. 2018 Feb 19;9(3):287. doi: 10.1038/s41419-018-0331-5.

10.

Cone degeneration is triggered by the absence of USH1 proteins but prevented by antioxidant treatments.

Trouillet A, Dubus E, Dégardin J, Estivalet A, Ivkovic I, Godefroy D, García-Ayuso D, Simonutti M, Sahly I, Sahel JA, El-Amraoui A, Petit C, Picaud S.

Sci Rep. 2018 Jan 31;8(1):1968. doi: 10.1038/s41598-018-20171-0.

11.

Noninvasive gene delivery to foveal cones for vision restoration.

Khabou H, Garita-Hernandez M, Chaffiol A, Reichman S, Jaillard C, Brazhnikova E, Bertin S, Forster V, Desrosiers M, Winckler C, Goureau O, Picaud S, Duebel J, Sahel JA, Dalkara D.

JCI Insight. 2018 Jan 25;3(2). pii: 96029. doi: 10.1172/jci.insight.96029. [Epub ahead of print]

12.

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.

Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE.

J Mol Biol. 2018 Mar 2;430(5):722-736. doi: 10.1016/j.jmb.2017.12.018. Epub 2017 Dec 29.

PMID:
29291391
13.

Multiplexed computations in retinal ganglion cells of a single type.

Deny S, Ferrari U, Macé E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O.

Nat Commun. 2017 Dec 6;8(1):1964. doi: 10.1038/s41467-017-02159-y.

14.

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.

Michel V, Booth KT, Patni P, Cortese M, Azaiez H, Bahloul A, Kahrizi K, Labbé M, Emptoz A, Lelli A, Dégardin J, Dupont T, Aghaie A, Oficjalska-Pham D, Picaud S, Najmabadi H, Smith RJ, Bowl MR, Brown SD, Avan P, Petit C, El-Amraoui A.

EMBO Mol Med. 2017 Dec;9(12):1711-1731. doi: 10.15252/emmm.201708087.

15.

Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface.

Peynshaert K, Devoldere J, Forster V, Picaud S, Vanhove C, De Smedt SC, Remaut K.

Drug Deliv. 2017 Nov;24(1):1384-1394. doi: 10.1080/10717544.2017.1375578.

PMID:
28925755
16.

Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina.

Ameline B, Tshilenge KT, Weber M, Biget M, Libeau L, Caplette R, Mendes-Madeira A, Provost N, Guihal C, Picaud S, Moullier P, Pichard V, Cronin T, Isiegas C.

Gene Ther. 2017 Nov;24(11):735-741. doi: 10.1038/gt.2017.63. Epub 2017 Sep 7.

PMID:
28880021
17.

Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation.

Hadj-Saïd W, Fradot V, Ivkovic I, Sahel JA, Picaud S, Froger N.

Adv Exp Med Biol. 2017;975 Pt 2:687-701. doi: 10.1007/978-94-024-1079-2_54.

PMID:
28849492
18.

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.

Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, Duhamel L, Macé E, Marre O, Benoit P, Hantraye P, Bemelmans AP, Bamberg E, Duebel J, Sahel JA, Picaud S, Dalkara D.

Mol Ther. 2017 Nov 1;25(11):2546-2560. doi: 10.1016/j.ymthe.2017.07.011. Epub 2017 Jul 20.

19.

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub 2017 Jun 22.

20.

Usher syndrome type 1-associated cadherins shape the photoreceptor outer segment.

Schietroma C, Parain K, Estivalet A, Aghaie A, Boutet de Monvel J, Picaud S, Sahel JA, Perron M, El-Amraoui A, Petit C.

J Cell Biol. 2017 Jun 5;216(6):1849-1864. doi: 10.1083/jcb.201612030. Epub 2017 May 11.

21.

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.

Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC.

Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3.

22.

LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.

Neuillé M, Cao Y, Caplette R, Guerrero-Given D, Thomas C, Kamasawa N, Sahel JA, Hamel CP, Audo I, Picaud S, Martemyanov KA, Zeitz C.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1768-1778. doi: 10.1167/iovs.16-20745.

23.

Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy.

Martens TF, Peynshaert K, Nascimento TL, Fattal E, Karlstetter M, Langmann T, Picaud S, Demeester J, De Smedt SC, Remaut K, Braeckmans K.

Eur J Pharm Sci. 2017 May 30;103:27-35. doi: 10.1016/j.ejps.2017.02.027. Epub 2017 Feb 20.

PMID:
28223236
24.

3D functional ultrasound imaging of the cerebral visual system in rodents.

Gesnik M, Blaize K, Deffieux T, Gennisson JL, Sahel JA, Fink M, Picaud S, Tanter M.

Neuroimage. 2017 Apr 1;149:267-274. doi: 10.1016/j.neuroimage.2017.01.071. Epub 2017 Feb 3.

25.

Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome.

Trouillet A, Lorach H, Dubus E, El Mathari B, Ivkovic I, Dégardin J, Simonutti M, Paques M, Guillonneau X, Sennlaub F, Sahel JA, Ronco P, Plaisier E, Picaud S.

Neurobiol Dis. 2017 Apr;100:52-61. doi: 10.1016/j.nbd.2016.12.014. Epub 2017 Jan 3.

PMID:
28057519
26.

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.

Navratilova I, Aristotelous T, Picaud S, Chaikuad A, Knapp S, Filappakopoulos P, Hopkins AL.

ACS Med Chem Lett. 2016 Sep 20;7(12):1213-1218. eCollection 2016 Dec 8.

27.

Emerging therapies for inherited retinal degeneration.

Scholl HP, Strauss RW, Singh MS, Dalkara D, Roska B, Picaud S, Sahel JA.

Sci Transl Med. 2016 Dec 7;8(368):368rv6. Review.

PMID:
27928030
28.

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P.

Cell Rep. 2016 Dec 6;17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014.

29.

Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.

Sengupta A, Chaffiol A, Macé E, Caplette R, Desrosiers M, Lampič M, Forster V, Marre O, Lin JY, Sahel JA, Picaud S, Dalkara D, Duebel J.

EMBO Mol Med. 2016 Nov 2;8(11):1248-1264. doi: 10.15252/emmm.201505699. Print 2016 Nov.

30.

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P.

Sci Adv. 2016 Oct 12;2(10):e1600760. eCollection 2016 Oct.

31.

Monitoring the evolution of boron doped porous diamond electrode on flexible retinal implant by OCT and in vivo impedance spectroscopy.

Hébert C, Cottance M, Degardin J, Scorsone E, Rousseau L, Lissorgues G, Bergonzo P, Picaud S.

Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:77-84. doi: 10.1016/j.msec.2016.06.032. Epub 2016 Jun 10.

PMID:
27612691
32.

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion.

Hadj-Saïd W, Froger N, Ivkovic I, Jiménez-López M, Dubus É, Dégardin-Chicaud J, Simonutti M, Quénol C, Neveux N, Villegas-Pérez MP, Agudo-Barriuso M, Vidal-Sanz M, Sahel JA, Picaud S, García-Ayuso D.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4692-703. doi: 10.1167/iovs.16-19535.

PMID:
27607415
33.

Probing the functional impact of sub-retinal prosthesis.

Roux S, Matonti F, Dupont F, Hoffart L, Takerkart S, Picaud S, Pham P, Chavane F.

Elife. 2016 Aug 23;5. pii: e12687. doi: 10.7554/eLife.12687.

34.

Study of retinal alterations in a high fat diet-induced type ii diabetes rodent: Meriones shawi.

Hammoum I, Mbarek S, Dellaa A, Dubus E, Baccouche B, Azaiz R, Charfeddine R, Picaud S, Ben Chaouacha-Chekir R.

Acta Histochem. 2017 Jan;119(1):1-9. doi: 10.1016/j.acthis.2016.05.005. Epub 2016 Jun 2.

PMID:
27265809
35.

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.

Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR.

J Med Chem. 2016 May 26;59(10):4800-11. doi: 10.1021/acs.jmedchem.6b00012. Epub 2016 May 3.

36.

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB.

Sci Adv. 2016 Feb 5;2(2):e1501257. doi: 10.1126/sciadv.1501257. eCollection 2016 Feb.

37.

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S.

Sci Adv. 2015 Nov 13;1(10):e1500723. doi: 10.1126/sciadv.1500723. eCollection 2015 Nov.

38.

Molecular Dynamics Simulations of the Interaction between Water Molecules and Aggregates of Acetic or Propionic Acid Molecules.

Radola B, Picaud S, Vardanega D, Jedlovszky P.

J Phys Chem B. 2015 Dec 24;119(51):15662-74. doi: 10.1021/acs.jpcb.5b08110. Epub 2015 Dec 10.

PMID:
26601716
39.

Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons.

Kim HT, Kim SJ, Sohn YI, Paik SS, Caplette R, Simonutti M, Moon KH, Lee EJ, Min KW, Kim MJ, Lee DG, Simeone A, Lamonerie T, Furukawa T, Choi JS, Kweon HS, Picaud S, Kim IB, Shong M, Kim JW.

Cell Rep. 2015 Nov 3;13(5):990-1002. doi: 10.1016/j.celrep.2015.09.075. Epub 2015 Oct 22.

40.

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S.

Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9.

41.

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma.

Roubeix C, Godefroy D, Mias C, Sapienza A, Riancho L, Degardin J, Fradot V, Ivkovic I, Picaud S, Sennlaub F, Denoyer A, Rostene W, Sahel JA, Parsadaniantz SM, Brignole-Baudouin F, Baudouin C.

Stem Cell Res Ther. 2015 Sep 16;6:177. doi: 10.1186/s13287-015-0168-0.

42.

Structure and Conformation of the Carotenoids in Human Retinal Macular Pigment.

Arteni AA, Fradot M, Galzerano D, Mendes-Pinto MM, Sahel JA, Picaud S, Robert B, Pascal AA.

PLoS One. 2015 Aug 27;10(8):e0135779. doi: 10.1371/journal.pone.0135779. eCollection 2015.

43.

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.

Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, Tralhão P, Gøtzsche CR, Cavadas C, Castelo-Branco M, Woldbye DP, Picaud S, Santiago AR, Ambrósio AF.

ASN Neuro. 2015 Aug 26;7(4). pii: 1759091415598292. doi: 10.1177/1759091415598292. Print 2015 Jul-Aug.

44.

Synthetic 3D diamond-based electrodes for flexible retinal neuroprostheses: Model, production and in vivo biocompatibility.

Bendali A, Rousseau L, Lissorgues G, Scorsone E, Djilas M, Dégardin J, Dubus E, Fouquet S, Benosman R, Bergonzo P, Sahel JA, Picaud S.

Biomaterials. 2015 Oct;67:73-83. doi: 10.1016/j.biomaterials.2015.07.018. Epub 2015 Jul 14.

PMID:
26210174
45.

Genotypic and phenotypic characterization of P23H line 1 rat model.

Orhan E, Dalkara D, Neuillé M, Lechauve C, Michiels C, Picaud S, Léveillard T, Sahel JA, Naash MI, Lavail MM, Zeitz C, Audo I.

PLoS One. 2015 May 26;10(5):e0127319. doi: 10.1371/journal.pone.0127319. eCollection 2015.

46.

The effect of anaesthetics on the properties of a lipid membrane in the biologically relevant phase: a computer simulation study.

Fábián B, Darvas M, Picaud S, Sega M, Jedlovszky P.

Phys Chem Chem Phys. 2015 Jun 14;17(22):14750-60. doi: 10.1039/c5cp00851d.

PMID:
25975364
47.

3D-nanostructured boron-doped diamond for microelectrode array neural interfacing.

Piret G, Hébert C, Mazellier JP, Rousseau L, Scorsone E, Cottance M, Lissorgues G, Heuschkel MO, Picaud S, Bergonzo P, Yvert B.

Biomaterials. 2015 Jun;53:173-83. doi: 10.1016/j.biomaterials.2015.02.021. Epub 2015 Mar 13.

48.

Sildenafil Acutely Decreases Visual Responses in ON and OFF Retinal Ganglion Cells.

Martins J, Kolomiets B, Caplette R, Sahel JA, Castelo-Branco M, Ambrósio AF, Picaud S.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2639-48. doi: 10.1167/iovs.14-15964.

PMID:
25814000
49.

Methane clathrates in the solar system.

Mousis O, Chassefière E, Holm NG, Bouquet A, Waite JH, Geppert WD, Picaud S, Aikawa Y, Ali-Dib M, Charlou JL, Rousselot P.

Astrobiology. 2015 Apr;15(4):308-26. doi: 10.1089/ast.2014.1189. Epub 2015 Mar 16. Review.

PMID:
25774974
50.

9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain.

Picaud S, Strocchia M, Terracciano S, Lauro G, Mendez J, Daniels DL, Riccio R, Bifulco G, Bruno I, Filippakopoulos P.

J Med Chem. 2015 Mar 26;58(6):2718-36. doi: 10.1021/jm501893k. Epub 2015 Mar 5.

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