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Restoration of visual function by transplantation of optogenetically engineered photoreceptors.

Garita-Hernandez M, Lampič M, Chaffiol A, Guibbal L, Routet F, Santos-Ferreira T, Gasparini S, Borsch O, Gagliardi G, Reichman S, Picaud S, Sahel JA, Goureau O, Ader M, Dalkara D, Duebel J.

Nat Commun. 2019 Oct 4;10(1):4524. doi: 10.1038/s41467-019-12330-2.


Tissue engineering of retina through high resolution 3-dimentional inkjet bioprinting.

Masaeli E, Forster V, Picaud S, Karamali F, Nasr-Esfahani MH, Marquette CA.

Biofabrication. 2019 Oct 2. doi: 10.1088/1758-5090/ab4a20. [Epub ahead of print]


Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation.

Losada PG, Rousseau L, Grzeskowiak M, Valet M, Nguyen D, Dégardin J, Dubus E, Picaud S, Lissorgues G.

Front Neurosci. 2019 Aug 27;13:885. doi: 10.3389/fnins.2019.00885. eCollection 2019.


β-alanine supplementation induces taurine depletion and causes alterations of the retinal nerve fiber layer and axonal transport by retinal ganglion cells.

García-Ayuso D, Di Pierdomenico J, Valiente-Soriano FJ, Martínez-Vacas A, Agudo-Barriuso M, Vidal-Sanz M, Picaud S, Villegas-Pérez MP.

Exp Eye Res. 2019 Aug 29;188:107781. doi: 10.1016/j.exer.2019.107781. [Epub ahead of print]


Evaluation of linker length effects on a BET bromodomain probe.

Traquete R, Henderson E, Picaud S, Cal PMSD, Sieglitz F, Rodrigues T, Oliveira R, Filippakopoulos P, Bernardes GJL.

Chem Commun (Camb). 2019 Aug 20;55(68):10128-10131. doi: 10.1039/c9cc05054j.


Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.

Chen Z, Picaud S, Filippakopoulos P, D'Angiolella V, Bullock AN.

Structure. 2019 Sep 3;27(9):1395-1404.e4. doi: 10.1016/j.str.2019.06.005. Epub 2019 Jul 3.


Evidence for functional GABAA but not GABAC receptors in mouse cone photoreceptors.

Deniz S, Wersinger E, Picaud S, Roux MJ.

Vis Neurosci. 2019 Jan;36:E005. doi: 10.1017/S0952523819000038.


Carotenoid composition and conformation in retinal oil droplets of the domestic chicken.

Arteni AA, LaFountain AM, Alexandre MTA, Fradot M, Mendes-Pinto MM, Sahel JA, Picaud S, Frank HA, Robert B, Pascal AA.

PLoS One. 2019 May 31;14(5):e0217418. doi: 10.1371/journal.pone.0217418. eCollection 2019.


A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex.

Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A.

Cell Rep. 2019 Apr 9;27(2):387-399.e7. doi: 10.1016/j.celrep.2019.03.061.


Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma.

Song Y, Park PMC, Wu L, Ray A, Picaud S, Li D, Wimalasena VK, Du T, Filippakopoulos P, Anderson KC, Qi J, Chauhan D.

Leukemia. 2019 Apr 8. doi: 10.1038/s41375-019-0467-z. [Epub ahead of print]


Functional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates.

Dizeux A, Gesnik M, Ahnine H, Blaize K, Arcizet F, Picaud S, Sahel JA, Deffieux T, Pouget P, Tanter M.

Nat Commun. 2019 Mar 28;10(1):1400. doi: 10.1038/s41467-019-09349-w.


Adsorption of Formamide at the Surface of Amorphous and Crystalline Ices under Interstellar and Tropospheric Conditions. A Grand Canonical Monte Carlo Simulation Study.

Kiss B, Picaud S, Szőri M, Jedlovszky P.

J Phys Chem A. 2019 Apr 4;123(13):2935-2948. doi: 10.1021/acs.jpca.9b00850. Epub 2019 Mar 20.


A biophysical model explains the spontaneous bursting behavior in the developing retina.

Matzakos-Karvouniari D, Gil L, Orendorff E, Marre O, Picaud S, Cessac B.

Sci Rep. 2019 Feb 12;9(1):1859. doi: 10.1038/s41598-018-38299-4.


Bioluminescence calcium imaging of network dynamics and their cholinergic modulation in slices of cerebral cortex from male rats.

Tricoire L, Drobac E, Tsuzuki K, Gallopin T, Picaud S, Cauli B, Rossier J, Lambolez B.

J Neurosci Res. 2019 Apr;97(4):414-432. doi: 10.1002/jnr.24380. Epub 2019 Jan 3.


[UHSI in the somatic care system for prisoners].

Sudre E, Lévêque É, Kandji M, Brun P, Picaud S, Bédry R.

Rev Infirm. 2018 Dec;67(246):24-25. doi: 10.1016/j.revinf.2018.10.005. French.


Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC.

Mol Cell. 2019 Feb 7;73(3):621-638.e17. doi: 10.1016/j.molcel.2018.11.006. Epub 2018 Dec 13.


Panton-Valentine Leucocidin Proves Direct Neuronal Targeting and Its Early Neuronal and Glial Impacts a Rabbit Retinal Explant Model.

Liu X, Roux MJ, Picaud S, Keller D, Sauer A, Heitz P, Prévost G, Gaucher D.

Toxins (Basel). 2018 Nov 4;10(11). pii: E455. doi: 10.3390/toxins10110455.


Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells.

Shiota H, Barral S, Buchou T, Tan M, Couté Y, Charbonnier G, Reynoird N, Boussouar F, Gérard M, Zhu M, Bargier L, Puthier D, Chuffart F, Bourova-Flin E, Picaud S, Filippakopoulos P, Goudarzi A, Ibrahim Z, Panne D, Rousseaux S, Zhao Y, Khochbin S.

Cell Rep. 2018 Sep 25;24(13):3477-3487.e6. doi: 10.1016/j.celrep.2018.08.069.


BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.

Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CR.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8668-E8677. doi: 10.1073/pnas.1810498115. Epub 2018 Aug 27.


Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M.

EMBO J. 2018 Sep 3;37(17). pii: e99372. doi: 10.15252/embj.201899372. Epub 2018 Jul 19.


A TFEB nuclear export signal integrates amino acid supply and glucose availability.

Li L, Friedrichsen HJ, Andrews S, Picaud S, Volpon L, Ngeow K, Berridge G, Fischer R, Borden KLB, Filippakopoulos P, Goding CR.

Nat Commun. 2018 Jul 11;9(1):2685. doi: 10.1038/s41467-018-04849-7.


BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ.

Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15.


The C-terminal extension landscape of naturally presented HLA-I ligands.

Guillaume P, Picaud S, Baumgaertner P, Montandon N, Schmidt J, Speiser DE, Coukos G, Bassani-Sternberg M, Filippakopoulos P, Gfeller D.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5083-5088. doi: 10.1073/pnas.1717277115. Epub 2018 Apr 30.


Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration.

García-Ayuso D, Di Pierdomenico J, Hadj-Said W, Marie M, Agudo-Barriuso M, Vidal-Sanz M, Picaud S, Villegas-Pérez MP.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1396-1409. doi: 10.1167/iovs.17-23258.


A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo.

Yger P, Spampinato GL, Esposito E, Lefebvre B, Deny S, Gardella C, Stimberg M, Jetter F, Zeck G, Picaud S, Duebel J, Marre O.

Elife. 2018 Mar 20;7. pii: e34518. doi: 10.7554/eLife.34518.


Adsorption of Methylamine on Amorphous Ice under Interstellar Conditions. A Grand Canonical Monte Carlo Simulation Study.

Horváth RA, Hantal G, Picaud S, Szőri M, Jedlovszky P.

J Phys Chem A. 2018 Apr 5;122(13):3398-3412. doi: 10.1021/acs.jpca.8b01591. Epub 2018 Mar 23.


Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells.

Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, Fouquet S, Villette T, Sahel JA, Lenaers G, Picaud S.

Cell Death Dis. 2018 Feb 19;9(3):287. doi: 10.1038/s41419-018-0331-5.


Cone degeneration is triggered by the absence of USH1 proteins but prevented by antioxidant treatments.

Trouillet A, Dubus E, Dégardin J, Estivalet A, Ivkovic I, Godefroy D, García-Ayuso D, Simonutti M, Sahly I, Sahel JA, El-Amraoui A, Petit C, Picaud S.

Sci Rep. 2018 Jan 31;8(1):1968. doi: 10.1038/s41598-018-20171-0.


Noninvasive gene delivery to foveal cones for vision restoration.

Khabou H, Garita-Hernandez M, Chaffiol A, Reichman S, Jaillard C, Brazhnikova E, Bertin S, Forster V, Desrosiers M, Winckler C, Goureau O, Picaud S, Duebel J, Sahel JA, Dalkara D.

JCI Insight. 2018 Jan 25;3(2). pii: 96029. doi: 10.1172/jci.insight.96029. eCollection 2018 Jan 25.


Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.

Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE.

J Mol Biol. 2018 Mar 2;430(5):722-736. doi: 10.1016/j.jmb.2017.12.018. Epub 2017 Dec 29.


Multiplexed computations in retinal ganglion cells of a single type.

Deny S, Ferrari U, Macé E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O.

Nat Commun. 2017 Dec 6;8(1):1964. doi: 10.1038/s41467-017-02159-y.


CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.

Michel V, Booth KT, Patni P, Cortese M, Azaiez H, Bahloul A, Kahrizi K, Labbé M, Emptoz A, Lelli A, Dégardin J, Dupont T, Aghaie A, Oficjalska-Pham D, Picaud S, Najmabadi H, Smith RJ, Bowl MR, Brown SD, Avan P, Petit C, El-Amraoui A.

EMBO Mol Med. 2017 Dec;9(12):1711-1731. doi: 10.15252/emmm.201708087.


Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface.

Peynshaert K, Devoldere J, Forster V, Picaud S, Vanhove C, De Smedt SC, Remaut K.

Drug Deliv. 2017 Nov;24(1):1384-1394. doi: 10.1080/10717544.2017.1375578.


Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina.

Ameline B, Tshilenge KT, Weber M, Biget M, Libeau L, Caplette R, Mendes-Madeira A, Provost N, Guihal C, Picaud S, Moullier P, Pichard V, Cronin T, Isiegas C.

Gene Ther. 2017 Nov;24(11):735-741. doi: 10.1038/gt.2017.63. Epub 2017 Sep 7.


Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation.

Hadj-Saïd W, Fradot V, Ivkovic I, Sahel JA, Picaud S, Froger N.

Adv Exp Med Biol. 2017;975 Pt 2:687-701. doi: 10.1007/978-94-024-1079-2_54.


A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.

Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, Duhamel L, Macé E, Marre O, Benoit P, Hantraye P, Bemelmans AP, Bamberg E, Duebel J, Sahel JA, Picaud S, Dalkara D.

Mol Ther. 2017 Nov 1;25(11):2546-2560. doi: 10.1016/j.ymthe.2017.07.011. Epub 2017 Jul 20.


Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub 2017 Jun 22.


Usher syndrome type 1-associated cadherins shape the photoreceptor outer segment.

Schietroma C, Parain K, Estivalet A, Aghaie A, Boutet de Monvel J, Picaud S, Sahel JA, Perron M, El-Amraoui A, Petit C.

J Cell Biol. 2017 Jun 5;216(6):1849-1864. doi: 10.1083/jcb.201612030. Epub 2017 May 11.


MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.

Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC.

Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3.


LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.

Neuillé M, Cao Y, Caplette R, Guerrero-Given D, Thomas C, Kamasawa N, Sahel JA, Hamel CP, Audo I, Picaud S, Martemyanov KA, Zeitz C.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1768-1778. doi: 10.1167/iovs.16-20745.


Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy.

Martens TF, Peynshaert K, Nascimento TL, Fattal E, Karlstetter M, Langmann T, Picaud S, Demeester J, De Smedt SC, Remaut K, Braeckmans K.

Eur J Pharm Sci. 2017 May 30;103:27-35. doi: 10.1016/j.ejps.2017.02.027. Epub 2017 Feb 20.


3D functional ultrasound imaging of the cerebral visual system in rodents.

Gesnik M, Blaize K, Deffieux T, Gennisson JL, Sahel JA, Fink M, Picaud S, Tanter M.

Neuroimage. 2017 Apr 1;149:267-274. doi: 10.1016/j.neuroimage.2017.01.071. Epub 2017 Feb 3.


Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome.

Trouillet A, Lorach H, Dubus E, El Mathari B, Ivkovic I, Dégardin J, Simonutti M, Paques M, Guillonneau X, Sennlaub F, Sahel JA, Ronco P, Plaisier E, Picaud S.

Neurobiol Dis. 2017 Apr;100:52-61. doi: 10.1016/j.nbd.2016.12.014. Epub 2017 Jan 3.


Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.

Navratilova I, Aristotelous T, Picaud S, Chaikuad A, Knapp S, Filappakopoulos P, Hopkins AL.

ACS Med Chem Lett. 2016 Sep 20;7(12):1213-1218. eCollection 2016 Dec 8.


Emerging therapies for inherited retinal degeneration.

Scholl HP, Strauss RW, Singh MS, Dalkara D, Roska B, Picaud S, Sahel JA.

Sci Transl Med. 2016 Dec 7;8(368):368rv6. Review.


Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P.

Cell Rep. 2016 Dec 6;17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014.


Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.

Sengupta A, Chaffiol A, Macé E, Caplette R, Desrosiers M, Lampič M, Forster V, Marre O, Lin JY, Sahel JA, Picaud S, Dalkara D, Duebel J.

EMBO Mol Med. 2016 Nov 2;8(11):1248-1264. doi: 10.15252/emmm.201505699. Print 2016 Nov.


Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P.

Sci Adv. 2016 Oct 12;2(10):e1600760. eCollection 2016 Oct.


Monitoring the evolution of boron doped porous diamond electrode on flexible retinal implant by OCT and in vivo impedance spectroscopy.

Hébert C, Cottance M, Degardin J, Scorsone E, Rousseau L, Lissorgues G, Bergonzo P, Picaud S.

Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:77-84. doi: 10.1016/j.msec.2016.06.032. Epub 2016 Jun 10.


Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion.

Hadj-Saïd W, Froger N, Ivkovic I, Jiménez-López M, Dubus É, Dégardin-Chicaud J, Simonutti M, Quénol C, Neveux N, Villegas-Pérez MP, Agudo-Barriuso M, Vidal-Sanz M, Sahel JA, Picaud S, García-Ayuso D.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4692-703. doi: 10.1167/iovs.16-19535.


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