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Items: 1 to 50 of 103


Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers.

Mattox TE, Chen X, Maxuitenko YY, Keeton AB, Piazza GA.

Int J Mol Sci. 2019 Dec 24;21(1). pii: E141. doi: 10.3390/ijms21010141. Review.


Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins.

Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI.

Drug Des Devel Ther. 2019 Aug 27;13:3069-3078. doi: 10.2147/DDDT.S208241. eCollection 2019.


Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.

Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG, Linton KJ, Di Sebastiano P, Chen X, Keeton AB, Ramirez-Alcantara V, Maxuitenko Y, Piazza GA, De Laurenzi V, Sala G, Falasca M.

J Exp Clin Cancer Res. 2019 Aug 5;38(1):312. doi: 10.1186/s13046-019-1308-7.


Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity.

Abd El-Aleam RH, George RF, Lee KJ, Keeton AB, Piazza GA, Kamel AA, El-Daly ME, Hassan GS, Abdel-Rahman HM.

Arch Pharm (Weinheim). 2019 Aug;352(8):e1900002. doi: 10.1002/ardp.201900002. Epub 2019 Jul 29.


Influence of hydroclimatic variations on solute concentration dynamics in nested subtropical catchments with heterogeneous landscapes.

Piazza GA, Dupas R, Gascuel-Odoux C, Grimaldi C, Pinheiro A, Kaufmann V.

Sci Total Environ. 2018 Sep 1;635:1091-1101. doi: 10.1016/j.scitotenv.2018.03.394. Epub 2018 Apr 24. Review.


Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents.

Eldehna WM, Al-Wabli RI, Almutairi MS, Keeton AB, Piazza GA, Abdel-Aziz HA, Attia MI.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):867-878. doi: 10.1080/14756366.2018.1462802.


Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.

El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH.

Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018. Epub 2018 Apr 14.


Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.

Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, Valiyaveettil J, Chen X, Keeton AB, Piazza GA.

Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19.


Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI.

Drug Des Devel Ther. 2017 Aug 9;11:2333-2346. doi: 10.2147/DDDT.S140164. eCollection 2017.


New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.

Attia MI, Eldehna WM, Afifi SA, Keeton AB, Piazza GA, Abdel-Aziz HA.

PLoS One. 2017 Jul 25;12(7):e0181241. doi: 10.1371/journal.pone.0181241. eCollection 2017.


Validation of PDE5 as a Chemoprevention Target.

Piazza GA.

Cancer Prev Res (Phila). 2017 Jul;10(7):373-376. doi: 10.1158/1940-6207.CAPR-17-0136. Epub 2017 Jun 9. No abstract available.


Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion.

Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA.

J Biomed Res. 2016 Mar;30(2):120-133. doi: 10.7555/JBR.30.20150108. Epub 2015 Nov 20.


Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.

Tombline G, Millen JI, Polevoda B, Rapaport M, Baxter B, Van Meter M, Gilbertson M, Madrey J, Piazza GA, Rasmussen L, Wennerberg K, White EL, Nitiss JL, Goldfarb DS.

Aging (Albany NY). 2017 Jan 5;9(1):68-97. doi: 10.18632/aging.101114.


The RAS-Effector Interaction as a Drug Target.

Keeton AB, Salter EA, Piazza GA.

Cancer Res. 2017 Jan 15;77(2):221-226. doi: 10.1158/0008-5472.CAN-16-0938. Epub 2017 Jan 6. Review.


Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.

Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, Sorscher EJ.

PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.


Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells.

Prasain JK, Rajbhandari R, Keeton AB, Piazza GA, Barnes S.

Food Funct. 2016 Sep 14;7(9):4012-4019.


Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α.

Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips JB, Schmitt DC, Vu T, McClellan S, Lin Y, Lin W, Piazza GA, Fodstad O, Tan M.

Cancer Res. 2016 Apr 15;76(8):2231-42. doi: 10.1158/0008-5472.CAN-15-1538. Epub 2016 Apr 5.


Inhibition of breast cancer cell motility with a non-cyclooxygenase inhibitory derivative of sulindac by suppressing TGFβ/miR-21 signaling.

Yi B, Chang H, Ma R, Feng X, Li W, Piazza GA, Xi Y.

Oncotarget. 2016 Feb 16;7(7):7979-92. doi: 10.18632/oncotarget.6888.


Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex.

Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA, Abadi AH.

Chem Pharm Bull (Tokyo). 2016;64(1):34-41. doi: 10.1248/cpb.c15-00608.


β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG.

Lee K, Lindsey AS, Li N, Gary B, Andrews J, Keeton AB, Piazza GA.

Oncotarget. 2016 Feb 2;7(5):5353-65. doi: 10.18632/oncotarget.6705.


Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors.

Abdel-Rahman HM, Abdel-Aziz M, Tinsley HN, Gary BD, Canzoneri JC, Piazza GA.

Arch Pharm (Weinheim). 2016 Feb;349(2):104-11. doi: 10.1002/ardp.201500363. Epub 2015 Dec 20.


Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer.

Somasagara RR, Tripathi K, Spencer SM, Clark DW, Barnett R, Bachaboina L, Scalici J, Rocconi RP, Piazza GA, Palle K.

Biochem Biophys Res Commun. 2016 Jan 15;469(3):449-55. doi: 10.1016/j.bbrc.2015.11.134. Epub 2015 Dec 8.


Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach.

Hassaan EA, Sigler SC, Ibrahim TM, Lee KJ, Cichon LK, Gary BD, Canzoneri JC, Piazza GA, Abadi AH.

Med Chem. 2016;12(5):472-7.


Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.

Elhady AK, Sigler SC, Noureldin N, Canzoneri JC, Ahmed NS, Piazza GA, Abadi AH.

Sci Pharm. 2015 Sep 26;84(3):428-446. doi: 10.3390/scipharm84030428.


Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.

Li N, Chen X, Zhu B, Ramírez-Alcántara V, Canzoneri JC, Lee K, Sigler S, Gary B, Li Y, Zhang W, Moyer MP, Salter EA, Wierzbicki A, Keeton AB, Piazza GA.

Oncotarget. 2015 Sep 29;6(29):27403-15. doi: 10.18632/oncotarget.4741.


Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs.

Ma R, Yi B, Piazza GA, Xi Y.

Curr Pharmacol Rep. 2015 Jun 1;1(3):154-160.


Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention.

Fajardo AM, Piazza GA.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G59-70. doi: 10.1152/ajpgi.00101.2014. Epub 2015 May 28. Review.


Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation.

Tripathi K, Hussein UK, Anupalli R, Barnett R, Bachaboina L, Scalici J, Rocconi RP, Owen LB, Piazza GA, Palle K.

Oncotarget. 2015 Mar 10;6(7):5237-52.


Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention.

Aboul-Fadl T, Al-Hamad SS, Lee K, Li N, Gary BD, Keeton AB, Piazza GA, Abdel-Hamid MK.

Med Chem Res. 2014 Sep;23(9):4177-4188.


Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies.

Abdel-Rahman HM, Abdel-Aziz M, Canzoneri JC, Gary BD, Piazza GA.

Arch Pharm (Weinheim). 2014 Sep;347(9):650-7. doi: 10.1002/ardp.201400083. Epub 2014 Jul 1.


Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer.

Arora R, Yates C, Gary BD, McClellan S, Tan M, Xi Y, Reed E, Piazza GA, Owen LB, Dean-Colomb W.

PLoS One. 2014 Jun 4;9(6):e98370. doi: 10.1371/journal.pone.0098370. eCollection 2014.


Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Li N, Lee K, Xi Y, Zhu B, Gary BD, Ramírez-Alcántara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP, Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA.

Oncogene. 2015 Mar 19;34(12):1499-509. doi: 10.1038/onc.2014.94. Epub 2014 Apr 7.


The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.

Fajardo AM, Piazza GA, Tinsley HN.

Cancers (Basel). 2014 Feb 26;6(1):436-58. doi: 10.3390/cancers6010436.


NSAIDs inhibit tumorigenesis, but how?

Gurpinar E, Grizzle WE, Piazza GA.

Clin Cancer Res. 2014 Mar 1;20(5):1104-13. doi: 10.1158/1078-0432.CCR-13-1573. Epub 2013 Dec 5. Review.


Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

Awadallah FM, Piazza GA, Gary BD, Keeton AB, Canzoneri JC.

Eur J Med Chem. 2013;70:273-9. doi: 10.1016/j.ejmech.2013.10.003. Epub 2013 Oct 9.


Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH.

Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1.


MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells.

Wang ZM, Du WJ, Piazza GA, Xi Y.

Acta Pharmacol Sin. 2013 Nov;34(11):1374-80. doi: 10.1038/aps.2013.134. Epub 2013 Oct 14. Review.


COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs.

Gurpinar E, Grizzle WE, Piazza GA.

Front Oncol. 2013 Jul 11;3:181. doi: 10.3389/fonc.2013.00181. eCollection 2013.


6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Abadi AH, Hartmann RW, Engel M.

ChemMedChem. 2013 Sep;8(9):1495-504. doi: 10.1002/cmdc.201300147. Epub 2013 Jul 11.


Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.

Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA.

Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26.


An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4.

Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, Piazza GA, Grizzle WE, Owen LB, Singh AP.

J Biol Chem. 2013 Jul 19;288(29):21197-207. doi: 10.1074/jbc.M113.484576. Epub 2013 Jun 5.


Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.

Arafa RK, Hegazy GH, Piazza GA, Abadi AH.

Eur J Med Chem. 2013 May;63:826-32. doi: 10.1016/j.ejmech.2013.03.008. Epub 2013 Mar 16.


MicroRNA and cancer chemoprevention.

Yi B, Piazza GA, Su X, Xi Y.

Cancer Prev Res (Phila). 2013 May;6(5):401-9. doi: 10.1158/1940-6207.CAPR-13-0032. Epub 2013 Mar 26. Review.


Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.

Tinsley HN, Piazza GA.

Curr Colorectal Cancer Rep. 2012 Dec;8(4):325-330.


A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.

Gurpinar E, Grizzle WE, Shacka JJ, Mader BJ, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA.

Mol Cancer Ther. 2013 May;12(5):663-74. doi: 10.1158/1535-7163.MCT-12-0785. Epub 2013 Feb 26.


Hypoxia-regulated microRNAs in human cancer.

Shen G, Li X, Jia YF, Piazza GA, Xi Y.

Acta Pharmacol Sin. 2013 Mar;34(3):336-41. doi: 10.1038/aps.2012.195. Epub 2013 Feb 4. Review.


Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

El-Gamil DS, Ahmed NS, Gary BD, Piazza GA, Engel M, Hartmann RW, Abadi AH.

Arch Pharm (Weinheim). 2013 Jan;346(1):23-33. doi: 10.1002/ardp.201200334.


Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

Ahmed NS, Ali AH, El-Nashar SM, Gary BD, Fajardo AM, Tinsley HN, Piazza GA, Negri M, Abadi AH.

Eur J Med Chem. 2012 Nov;57:329-43. doi: 10.1016/j.ejmech.2012.09.029. Epub 2012 Sep 29.

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