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Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives.

Zhu WJ, Cui BW, Wang HM, Nan JX, Piao HR, Lian LH, Jin CH.

Eur J Med Chem. 2019 Jul 5;180:15-27. doi: 10.1016/j.ejmech.2019.07.013. [Epub ahead of print]


ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1.

Zhang J, Guo S, Piao HY, Wang Y, Wu Y, Meng XY, Yang D, Zheng ZC, Zhao Y.

J Physiol Biochem. 2019 Jul 9. doi: 10.1007/s13105-019-00690-8. [Epub ahead of print]


One-step synthesized magnetic MIL-101(Cr) for effective extraction of triazine herbicides from rice prior to determination by liquid chromatography-tandem mass spectrometry.

Jiang Y, Piao H, Qin Z, Li X, Ma P, Sun Y, Wang X, Song D.

J Sep Sci. 2019 Jul 4. doi: 10.1002/jssc.201900345. [Epub ahead of print]


Packed hybrids of gold nanoparticles and halloysite nanotubes for dispersive solid phase extraction of triazine herbicides, and their subsequent determination by HPLC.

Qin Z, Jiang Y, Piao H, Tao S, Sun Y, Wang X, Ma P, Song D.

Mikrochim Acta. 2019 Jul 2;186(8):489. doi: 10.1007/s00604-019-3578-3.


Downregulation of miR-485-3p promotes glioblastoma cell proliferation and migration via targeting RNF135.

Zhang Y, Sui R, Chen Y, Liang H, Shi J, Piao H.

Exp Ther Med. 2019 Jul;18(1):475-482. doi: 10.3892/etm.2019.7600. Epub 2019 May 23.


Effects of somatic alterations at pathway level are more mechanism-explanatory and clinically applicable to quantity of liver metastases of colorectal cancer.

Zhang ZG, Ma F, Zhao S, Yang X, Liu F, Xue C, Liu L, Gu J, Piao H.

Cancer Med. 2019 Jun 20. doi: 10.1002/cam4.2368. [Epub ahead of print]


Potential prognostic factors for predicting the chemotherapeutic outcomes and prognosis of patients with metastatic colorectal cancer.

Zhang L, Zhang J, Wang Y, Dong Q, Piao H, Wang Q, Zhou Y, Ding Y.

J Clin Lab Anal. 2019 Jun 19:e22958. doi: 10.1002/jcla.22958. [Epub ahead of print]


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.

Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC.

Cell Metab. 2019 Jun 10. pii: S1550-4131(19)30258-X. doi: 10.1016/j.cmet.2019.05.018. [Epub ahead of print]


A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.

Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL.

iScience. 2019 Jun 28;16:177-191. doi: 10.1016/j.isci.2019.05.033. Epub 2019 May 27.


Identification of a long non‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma.

He H, Chen D, Cui S, Piao H, Tang H, Wang X, Ye P, Jin S.

Oncol Rep. 2019 Jun 3. doi: 10.3892/or.2019.7181. [Epub ahead of print]


A Novel Surfactant-Free O/O Paclitaxel Ointment for the Topical Treatment of Psoriasis.

Yin X, Cao X, Li J, Cheng X, Cheng G, Zou M, Piao H.

AAPS PharmSciTech. 2019 Jun 4;20(5):212. doi: 10.1208/s12249-019-1413-0.


Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone.

Lee SH, Piao H, Cho YC, Kim SN, Choi G, Kim CR, Ji HB, Park CG, Lee C, Shin CI, Koh WG, Choy YB, Choy JH.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11664-11672. doi: 10.1073/pnas.1906931116. Epub 2019 May 23.


Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease.

Wang W, Wang Y, Piao H, Li B, Huang M, Zhu Z, Li D, Wang T, Xu R, Liu K.

PeerJ. 2019 May 8;7:e6831. doi: 10.7717/peerj.6831. eCollection 2019.


Poor management of hypertension is an important precipitating factor for the development of acute aortic dissection.

Dong N, Piao H, Li B, Xu J, Wei S, Liu K.

J Clin Hypertens (Greenwich). 2019 Jun;21(6):804-812. doi: 10.1111/jch.13556. Epub 2019 May 20.


HNRNPAB-regulated lncRNA-ELF209 inhibits the malignancy of hepatocellular carcinoma.

Yang Y, Chen Q, Piao HY, Wang B, Zhu GQ, Chen EB, Xiao K, Zhou ZJ, Shi GM, Shi YH, Wu WZ, Fan J, Zhou J, Dai Z.

Int J Cancer. 2019 May 15. doi: 10.1002/ijc.32409. [Epub ahead of print]


Long noncoding RNA MT1JP inhibits proliferation, invasion, and migration while promoting apoptosis of glioma cells through the activation of PTEN/Akt signaling pathway.

Zhang Y, Sui R, Chen Y, Liang H, Shi J, Piao H.

J Cell Physiol. 2019 May 7. doi: 10.1002/jcp.28553. [Epub ahead of print]


Experience of the management of coronary artery bypass graft only on moderate ischemic mitral regurgitation: A single-center retrospective study.

Wang W, Li B, Wang Y, Piao H, Zhu Z, Xu R, Li D, Liu K.

Medicine (Baltimore). 2019 Apr;98(17):e14969. doi: 10.1097/MD.0000000000014969.


[Study on the Metabolic Reprogramming of Lung Cancer Cells Regulated by Docetaxel Based on Metabolomics].

Sun H, Piao H, Qi H, Yan M, Liu H.

Zhongguo Fei Ai Za Zhi. 2019 Apr 20;22(4):208-215. doi: 10.3779/j.issn.1009-3419.2019.04.02. Chinese.


Synthesis and evaluation of the HIF-1α inhibitory activities of novel ursolic acid tetrazole derivatives.

Zhang LH, Zhang ZH, Li MY, Wei ZY, Jin XJ, Piao HR.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1440-1445. doi: 10.1016/j.bmcl.2019.04.028. Epub 2019 Apr 17.


Matrix solid-phase dispersion coupled with hollow fiber liquid phase microextraction for determination of triazine herbicides in peanuts.

Piao H, Jiang Y, Li X, Ma P, Wang X, Song D, Sun Y.

J Sep Sci. 2019 Jun;42(12):2123-2130. doi: 10.1002/jssc.201801213. Epub 2019 May 7.


Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.

Liu H, Sun D, Du H, Zheng C, Li J, Piao H, Li J, Sun L.

Eur J Med Chem. 2019 Jun 15;172:163-173. doi: 10.1016/j.ejmech.2019.03.059. Epub 2019 Mar 30.


Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.

Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC.

Cell Res. 2019 Jun;29(6):460-473. doi: 10.1038/s41422-019-0163-6. Epub 2019 Apr 4.


Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.

Sun L, Wang P, Xu L, Gao L, Li J, Piao H.

Bioorg Med Chem Lett. 2019 May 15;29(10):1187-1193. doi: 10.1016/j.bmcl.2019.03.023. Epub 2019 Mar 20.


On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy.

Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, Wu X, Chen Y, Piao H, Lu L, Jiang W, Xu Y, Feng B, Nan Y, Xie W, Chen G, Zheng H, Li H, Ding H, Liu H, Wang T, Ou X, Wu S, Kong Y, Wang P, Cong M, Zhang Y, You H, Jia J.

J Med Virol. 2019 Aug;91(8):1499-1509. doi: 10.1002/jmv.25465. Epub 2019 Apr 16.


Improved Oral Absorption of Poorly Soluble Curcumin via the Concomitant Use of Borneol.

Gao Y, Chen G, Luan X, Zou M, Piao H, Cheng G.

AAPS PharmSciTech. 2019 Mar 22;20(4):150. doi: 10.1208/s12249-019-1364-5.


A new inclusion technique through an upper partial sternotomy for complicated Stanford B-type aortic dissection with an aberrant right subclavian artery: A case report.

Huang M, Piao H, Li B, Wang Y, Wang T, Zhu Z, Li D, Liu K.

Medicine (Baltimore). 2019 Mar;98(11):e14727. doi: 10.1097/MD.0000000000014727.


Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents.

Zhang TY, Zheng CJ, Wu J, Sun LP, Piao HR.

Bioorg Med Chem Lett. 2019 May 1;29(9):1079-1084. doi: 10.1016/j.bmcl.2019.02.033. Epub 2019 Feb 28.


Design and Synthesis of Novel Anti-Proliferative Emodin Derivatives and Studies on their Cell Cycle Arrest, Apoptosis Pathway and Migration.

Yang K, Jin MJ, Quan ZS, Piao HR.

Molecules. 2019 Mar 2;24(5). pii: E884. doi: 10.3390/molecules24050884.


Early and Medium Outcomes of On-Pump Beating-Heart versus Off-Pump CABG in Patients with Moderate Left Ventricular Dysfunction.

Wang W, Wang Y, Piao H, Li B, Wang T, Li D, Zhu Z, Xu R, Liu K.

Braz J Cardiovasc Surg. 2019 Jan-Feb;34(1):62-69. doi: 10.21470/1678-9741-2018-0207.


Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites.

Zeng J, Wang Z, Huang X, Eckstein SS, Lin X, Piao H, Weigert C, Yin P, Lehmann R, Xu G.

Chemistry. 2019 Apr 11;25(21):5427-5432. doi: 10.1002/chem.201900539. Epub 2019 Mar 25.


MicroRNA-374a Governs Aggressive Cell Behaviors of Glioma by Targeting Prokineticin 2.

Zhang Y, Zhang R, Sui R, Chen Y, Liang H, Shi J, Piao H.

Technol Cancer Res Treat. 2019 Jan 1;18:1533033818821401. doi: 10.1177/1533033818821401.


Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA.

Xian Z, Jin G, Li H, Jiang J, Wang C, Zhu L, Jin Z, Li L, Piao H, Zheng M, Yan G.

Biomed Res Int. 2019 Jan 20;2019:7823761. doi: 10.1155/2019/7823761. eCollection 2019.


Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer.

Meng Y, Sun J, Wang X, Hu T, Ma Y, Kong C, Piao H, Yu T, Zhang G.

Technol Cancer Res Treat. 2019 Jan 1;18:1533033818821421. doi: 10.1177/1533033818821421. Review.


Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway.

Wu J, Zhang ZH, Zhang LH, Jin XJ, Ma J, Piao HR.

Bioorg Med Chem Lett. 2019 Mar 15;29(6):853-858. doi: 10.1016/j.bmcl.2018.12.060. Epub 2018 Dec 28.


Alendronate-Anionic Clay Nanohybrid for Enhanced Osteogenic Proliferation and Differentiation.

Piao H, Kim MH, Cui M, Choi G, Choy JH.

J Korean Med Sci. 2019 Jan 25;34(5):e37. doi: 10.3346/jkms.2019.34.e37. eCollection 2019 Feb 4.


The biological macromolecule Nocardia rubra cell-wall skeleton as an avenue for cell-based immunotherapy.

Meng Y, Sun J, Wang X, Ma Y, Kong C, Zhang G, Dou H, Nan N, Shi M, Yu T, Piao H.

J Cell Physiol. 2019 Jan 29. doi: 10.1002/jcp.28182. [Epub ahead of print]


A 2.08 Å resolution structure of HLB5, a novel cellulase from the anaerobic gut bacterium Parabacteroides johnsonii DSM 18315.

Chang C, Brooke C, Piao H, Mack J, Babnigg G, Joachimiak A, Hess M.

Protein Sci. 2019 Apr;28(4):794-799. doi: 10.1002/pro.3582. Epub 2019 Feb 18.


Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.

Wang J, Ren XR, Piao H, Zhao S, Osada T, Premont RT, Mook RA Jr, Morse MA, Lyerly HK, Chen W.

Biochem J. 2019 Feb 8;476(3):535-546. doi: 10.1042/BCJ20180385.


Early steep decline of liver stiffness predicts histological reversal of fibrosis in chronic hepatitis B patients treated with entecavir.

Kong Y, Sun Y, Zhou J, Wu X, Chen Y, Piao H, Lu L, Ding H, Nan Y, Jiang W, Xu Y, Xie W, Li H, Feng B, Shi G, Chen G, Li H, Zheng H, Cheng J, Wang T, Liu H, Lv F, Shao C, Mao Y, Sun J, Chen T, Han T, Han Y, Wang L, Ou X, Zhang H, Jia J, You H.

J Viral Hepat. 2019 May;26(5):576-585. doi: 10.1111/jvh.13058. Epub 2019 Feb 14.


Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.

Zhou L, Wang Z, Hu C, Zhang C, Kovatcheva-Datchary P, Yu D, Liu S, Ren F, Wang X, Li Y, Hou X, Piao H, Lu X, Zhang Y, Xu G.

J Proteome Res. 2019 Mar 1;18(3):960-969. doi: 10.1021/acs.jproteome.8b00663. Epub 2019 Jan 9.


Recombinant pyrin domain protein attenuates allergic inflammation by suppressing NF-κB pathway in asthmatic mice.

Piao H, Choi YH, Li H, Wang C, Xian Z, Ogasawara M, Jiang J, Li L, Yamauchi K, Yan G.

Scand J Immunol. 2019 Jan;89(1):e12720. doi: 10.1111/sji.12720. Epub 2018 Nov 20.


Synthesis and Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as TGF-β Type I Receptor Kinase Inhibitors.

Zhao LM, Guo Z, Xue YJ, Min JZ, Zhu WJ, Li XY, Piao HR, Jin CH.

Molecules. 2018 Dec 19;23(12). pii: E3369. doi: 10.3390/molecules23123369.


A Trace Carbon Monoxide Sensor Based on Differential Absorption Spectroscopy Using Mid-Infrared Quantum Cascade Laser.

Chen C, Ren Q, Piao H, Wang P, Wang Y.

Micromachines (Basel). 2018 Dec 18;9(12). pii: E670. doi: 10.3390/mi9120670.


Long-Term Outcomes of Hybrid Technique of Complicated Type B Aortic Dissection.

Wang W, Piao H, Wang Y, Li B, Wang T, Xu R, Li D, Zhu Z, Huang M, Liu K.

Ann Thorac Surg. 2019 May;107(5):1319-1325. doi: 10.1016/j.athoracsur.2018.11.023. Epub 2018 Dec 13.


Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype.

Mook RA Jr, Wang J, Ren XR, Piao H, Lyerly HK, Chen W.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):317-321. doi: 10.1016/j.bmcl.2018.11.022. Epub 2018 Nov 12.


Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells.

Lu Y, Xu X, Jiang T, Jin L, Zhao XD, Cheng JH, Jin XJ, Ma J, Piao HN, Piao LX.

Int Immunopharmacol. 2019 Feb;67:119-128. doi: 10.1016/j.intimp.2018.12.011. Epub 2018 Dec 10.


MicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma.

Sun D, Mu Y, Piao H.

Biol Res. 2018 Dec 11;51(1):56. doi: 10.1186/s40659-018-0203-6.


A New Aortic Arch Inclusion Technique With Frozen Elephant Trunk for Type A Aortic Dissection.

Liu K, Zhu C, Zheng X, Wang T, Xu R, Zhu Z, Li D, Piao H, Li B, Wang Y, Zhang S, Sun W.

Ann Surg. 2018 Dec 10. doi: 10.1097/SLA.0000000000003122. [Epub ahead of print]


Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.

Yan M, Qi H, Xia T, Zhao X, Wang W, Wang Z, Lu C, Ning Z, Chen H, Li T, Tekcham DS, Liu X, Liu J, Chen D, Liu X, Xu G, Piao HL.

Metabolism. 2019 Feb;91:18-29. doi: 10.1016/j.metabol.2018.11.010. Epub 2018 Nov 20.


Aloperine suppresses allergic airway inflammation through NF-κB, MAPK, and Nrf2/HO-1 signaling pathways in mice.

Wang C, Choi YH, Xian Z, Zheng M, Piao H, Yan G.

Int Immunopharmacol. 2018 Dec;65:571-579. doi: 10.1016/j.intimp.2018.11.003. Epub 2018 Nov 8.


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