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Items: 1 to 50 of 182

1.

PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes.

Lattanzio R, Iezzi M, Sala G, Tinari N, Falasca M, Alberti S, Buglioni S, Mottolese M, Perracchio L, Natali PG, Piantelli M.

BMC Cancer. 2019 Jul 30;19(1):747. doi: 10.1186/s12885-019-5949-x.

2.

High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma.

Curia MC, Fantini F, Lattanzio R, Tavano F, Di Mola F, Piantelli M, Battista P, Di Sebastiano P, Cama A.

BMC Cancer. 2019 May 14;19(1):452. doi: 10.1186/s12885-019-5616-2.

3.

Secreted Gal-3BP is a novel promising target for non-internalizing Antibody-Drug Conjugates.

Giansanti F, Capone E, Ponziani S, Piccolo E, Gentile R, Lamolinara A, Di Campli A, Sallese M, Iacobelli V, Cimini A, De Laurenzi V, Lattanzio R, Piantelli M, Ippoliti R, Sala G, Iacobelli S.

J Control Release. 2019 Jan 28;294:176-184. doi: 10.1016/j.jconrel.2018.12.018. Epub 2018 Dec 13.

4.

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.

Ferro R, Adamska A, Lattanzio R, Mavrommati I, Edling CE, Arifin SA, Fyffe CA, Sala G, Sacchetto L, Chiorino G, De Laurenzi V, Piantelli M, Sansom OJ, Maffucci T, Falasca M.

Oncogene. 2018 Dec;37(49):6368-6382. doi: 10.1038/s41388-018-0390-1. Epub 2018 Jul 30.

PMID:
30061636
5.

The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non-muscle-Invasive Bladder Cancer.

Bielli P, Panzeri V, Lattanzio R, Mutascio S, Pieraccioli M, Volpe E, Pagliarulo V, Piantelli M, Giannantoni A, Di Stasi SM, Sette C.

Clin Cancer Res. 2018 Nov 1;24(21):5422-5432. doi: 10.1158/1078-0432.CCR-17-3850. Epub 2018 Jul 16.

6.

Vav1 downmodulates Akt in different breast cancer subtypes: a new promising chance to improve breast cancer outcome.

Grassilli S, Brugnoli F, Lattanzio R, Marchisio M, Perracchio L, Piantelli M, Bavelloni A, Capitani S, Bertagnolo V.

Mol Oncol. 2018 Jun;12(7):1012-1025. doi: 10.1002/1878-0261.12203. Epub 2018 May 16.

7.

The role of phospholipase Cγ1 in breast cancer and its clinical significance.

Emmanouilidi A, Lattanzio R, Sala G, Piantelli M, Falasca M.

Future Oncol. 2017 Aug 22. doi: 10.2217/fon-2017-0125. [Epub ahead of print]

PMID:
28829192
8.

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.

Corda G, Sala G, Lattanzio R, Iezzi M, Sallese M, Fragassi G, Lamolinara A, Mirza H, Barcaroli D, Ermler S, Silva E, Yasaei H, Newbold RF, Vagnarelli P, Mottolese M, Natali PG, Perracchio L, Quist J, Grigoriadis A, Marra P, Tutt AN, Piantelli M, Iacobelli S, De Laurenzi V, Sala A.

J Pathol. 2017 Feb;241(3):350-361. doi: 10.1002/path.4841. Epub 2016 Dec 29.

9.

p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading.

Guerra E, Cimadamore A, Simeone P, Vacca G, Lattanzio R, Botti G, Gatta V, D'Aurora M, Simionati B, Piantelli M, Alberti S.

BMC Cancer. 2016 Aug 18;16:649. doi: 10.1186/s12885-016-2713-3.

10.

Comment on "Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice".

Guerra E, Piantelli M, Alberti S.

Sci Transl Med. 2016 Aug 3;8(350):350le2. doi: 10.1126/scitranslmed.aaf4379.

PMID:
27488894
11.

Overexpression of PY1289-HER3 in sporadic pulmonary carcinoid from patients bearing MEN1 gene variants.

Lattanzio R, Veschi S, Aceto GM, Curia MC, Cama A, DE Lellis L, Fantini F, Angelucci D, Iacobelli S, Piantelli M, Battista P.

Oncol Lett. 2016 Jul;12(1):453-458. Epub 2016 Jun 1.

12.

Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors.

Guerra E, Trerotola M, Tripaldi R, Aloisi AL, Simeone P, Sacchetti A, Relli V, D'Amore A, La Sorda R, Lattanzio R, Piantelli M, Alberti S.

Clin Cancer Res. 2016 Aug 15;22(16):4197-205. doi: 10.1158/1078-0432.CCR-15-1701. Epub 2016 Mar 28.

13.

Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression.

Chikh A, Ferro R, Abbott JJ, Piñeiro R, Buus R, Iezzi M, Ricci F, Bergamaschi D, Ostano P, Chiorino G, Lattanzio R, Broggini M, Piantelli M, Maffucci T, Falasca M.

Oncotarget. 2016 Apr 5;7(14):18325-45. doi: 10.18632/oncotarget.7761.

14.

Lymph Node Micrometastases Do Influence Breast Cancer Outcome.

Antolini L, Biganzoli E, Querzoli P, Piantelli M, Alberti S.

J Clin Oncol. 2015 Nov 20;33(33):3977-8. doi: 10.1200/JCO.2015.63.0962. Epub 2015 Aug 17. No abstract available.

PMID:
26282637
15.

Prognostic relevance of LGALS3BP in human colorectal carcinoma.

Piccolo E, Tinari N, D'Addario D, Rossi C, Iacobelli V, La Sorda R, Lattanzio R, D'Egidio M, Di Risio A, Piantelli M, Natali PG, Iacobelli S.

J Transl Med. 2015 Jul 30;13:248. doi: 10.1186/s12967-015-0606-x.

16.

miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance.

De Cola A, Volpe S, Budani MC, Ferracin M, Lattanzio R, Turdo A, D'Agostino D, Capone E, Stassi G, Todaro M, Di Ilio C, Sala G, Piantelli M, Negrini M, Veronese A, De Laurenzi V.

Cell Death Dis. 2015 Jul 16;6:e1823. doi: 10.1038/cddis.2015.192.

17.

Features of endothelial dysfunction in umbilical cord vessels of women with gestational diabetes.

Di Fulvio P, Pandolfi A, Formoso G, Di Silvestre S, Di Tomo P, Giardinelli A, De Marco A, Di Pietro N, Taraborrelli M, Sancilio S, Di Pietro R, Piantelli M, Consoli A.

Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1337-45.

PMID:
25438716
18.

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.

Isopi E, Granzotto A, Corona C, Bomba M, Ciavardelli D, Curcio M, Canzoniero LM, Navarra R, Lattanzio R, Piantelli M, Sensi SL.

Neurobiol Dis. 2015 Sep;81:214-24. doi: 10.1016/j.nbd.2014.11.013. Epub 2014 Nov 28.

PMID:
25434488
19.

Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells.

Giuliani C, Bucci I, Di Santo S, Rossi C, Grassadonia A, Mariotti M, Piantelli M, Monaco F, Napolitano G.

PLoS One. 2014 Sep 24;9(9):e107936. doi: 10.1371/journal.pone.0107936. eCollection 2014.

20.

Membranous Nectin-4 expression is a risk factor for distant relapse of T1-T2, N0 luminal-A early breast cancer.

Lattanzio R, Ghasemi R, Brancati F, Sorda RL, Tinari N, Perracchio L, Iacobelli S, Mottolese M, Natali PG, Piantelli M.

Oncogenesis. 2014 Sep 1;3:e118. doi: 10.1038/oncsis.2014.32.

21.

Dual targeting of ErbB-2/ErbB-3 results in enhanced antitumor activity in preclinical models of pancreatic cancer.

Ghasemi R, Rapposelli IG, Capone E, Rossi C, Lattanzio R, Piantelli M, Sala G, Iacobelli S.

Oncogenesis. 2014 Aug 18;3:e117. doi: 10.1038/oncsis.2014.31.

22.

A unique four-hub protein cluster associates to glioblastoma progression.

Simeone P, Trerotola M, Urbanella A, Lattanzio R, Ciavardelli D, Di Giuseppe F, Eleuterio E, Sulpizio M, Eusebi V, Pession A, Piantelli M, Alberti S.

PLoS One. 2014 Jul 22;9(7):e103030. doi: 10.1371/journal.pone.0103030. eCollection 2014.

23.

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process.

Grassilli S, Brugnoli F, Lattanzio R, Rossi C, Perracchio L, Mottolese M, Marchisio M, Palomba M, Nika E, Natali PG, Piantelli M, Capitani S, Bertagnolo V.

Oncotarget. 2014 Jun 30;5(12):4320-36.

24.

Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study.

Lattanzio R, La Sorda R, Facciolo F, Sioletic S, Lauriola L, Martucci R, Gallo E, Palmieri G, Evoli A, Alessandrini G, Ruco L, Rendina EA, Truini M, Chiarle R, Barreca A, Pich A, Ascani S, Remotti D, Tunesi G, Granone P, Ratto GB, Puma F, Pescarmona E, Piantelli M, Marino M; Thymic Epithelial Tumor Working Group, Carlini S, Cerasoli V, Corzani F, Melis E, Filippetti M, Canalini P, Palestro G, Lalle M, Ruffini E, Ceribelli A, Rinaldi M.

Lung Cancer. 2014 Aug;85(2):191-6. doi: 10.1016/j.lungcan.2014.05.010. Epub 2014 May 22.

25.

Trop-2 is a determinant of breast cancer survival.

Ambrogi F, Fornili M, Boracchi P, Trerotola M, Relli V, Simeone P, La Sorda R, Lattanzio R, Querzoli P, Pedriali M, Piantelli M, Biganzoli E, Alberti S.

PLoS One. 2014 May 13;9(5):e96993. doi: 10.1371/journal.pone.0096993. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110606.

26.

Inhibition of tumor growth and angiogenesis by SP-2, an anti-lectin, galactoside-binding soluble 3 binding protein (LGALS3BP) antibody.

Traini S, Piccolo E, Tinari N, Rossi C, La Sorda R, Spinella F, Bagnato A, Lattanzio R, D'Egidio M, Di Risio A, Tomao F, Grassadonia A, Piantelli M, Natoli C, Iacobelli S.

Mol Cancer Ther. 2014 Apr;13(4):916-25. doi: 10.1158/1535-7163.MCT-12-1117. Epub 2014 Feb 19.

27.

The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function.

Giuliani C, Bucci I, Di Santo S, Rossi C, Grassadonia A, Piantelli M, Monaco F, Napolitano G.

Food Chem Toxicol. 2014 Apr;66:23-9. doi: 10.1016/j.fct.2014.01.016. Epub 2014 Jan 18.

PMID:
24447974
28.

Role of phospholipase C in cell invasion and metastasis.

Lattanzio R, Piantelli M, Falasca M.

Adv Biol Regul. 2013 Sep;53(3):309-18. doi: 10.1016/j.jbior.2013.07.006. Epub 2013 Jul 18. Review.

PMID:
23925006
29.

Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.

Bomba M, Ciavardelli D, Silvestri E, Canzoniero LM, Lattanzio R, Chiappini P, Piantelli M, Di Ilio C, Consoli A, Sensi SL.

Cell Death Dis. 2013 May 2;4:e612. doi: 10.1038/cddis.2013.139.

30.

mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/β-catenin.

Guerra E, Lattanzio R, La Sorda R, Dini F, Tiboni GM, Piantelli M, Alberti S.

PLoS One. 2012;7(11):e49302. doi: 10.1371/journal.pone.0049302. Epub 2012 Nov 28. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/4336e050-68c3-48ef-869e-80c2232b7e65.

31.

Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer.

Alberti S, Ambrogi F, Boracchi P, Fornili M, Querzoli P, Pedriali M, La Sorda R, Lattanzio R, Tripaldi R, Piantelli M, Biganzoli E, Coradini D.

Jpn J Clin Oncol. 2012 Dec;42(12):1128-37. doi: 10.1093/jjco/hys159. Epub 2012 Oct 16.

PMID:
23072840
32.

LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis.

Piccolo E, Tinari N, Semeraro D, Traini S, Fichera I, Cumashi A, La Sorda R, Spinella F, Bagnato A, Lattanzio R, D'Egidio M, Di Risio A, Stampolidis P, Piantelli M, Natoli C, Ullrich A, Iacobelli S.

J Mol Med (Berl). 2013 Jan;91(1):83-94. doi: 10.1007/s00109-012-0936-6. Epub 2012 Aug 5.

PMID:
22864925
33.

Overexpression of activated phospholipase Cγ1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy.

Lattanzio R, Marchisio M, La Sorda R, Tinari N, Falasca M, Alberti S, Miscia S, Ercolani C, Di Benedetto A, Perracchio L, Melucci E, Iacobelli S, Mottolese M, Natali PG, Piantelli M; CINBO (Consorzio Interuniversitario Nazionale per Bio-Oncologia).

Int J Cancer. 2013 Mar 1;132(5):1022-31. doi: 10.1002/ijc.27751. Epub 2012 Sep 1.

34.

Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids.

Veschi S, Lattanzio R, Aceto GM, Curia MC, Magnasco S, Angelucci D, Cama A, Piantelli M, Battista P.

Int J Oncol. 2012 Oct;41(4):1221-8. doi: 10.3892/ijo.2012.1563. Epub 2012 Jul 20.

35.

The Trop-2 signalling network in cancer growth.

Guerra E, Trerotola M, Aloisi AL, Tripaldi R, Vacca G, La Sorda R, Lattanzio R, Piantelli M, Alberti S.

Oncogene. 2013 Mar 21;32(12):1594-600. doi: 10.1038/onc.2012.151. Epub 2012 May 7.

PMID:
22562244
36.

The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.

Esposito DL, Aru F, Lattanzio R, Morgano A, Abbondanza M, Malekzadeh R, Bishehsari F, Valanzano R, Russo A, Piantelli M, Moschetta A, Lotti LV, Mariani-Costantini R.

PLoS One. 2012;7(4):e36190. doi: 10.1371/journal.pone.0036190. Epub 2012 Apr 27.

37.

Upregulation of Trop-2 quantitatively stimulates human cancer growth.

Trerotola M, Cantanelli P, Guerra E, Tripaldi R, Aloisi AL, Bonasera V, Lattanzio R, de Lange R, Weidle UH, Piantelli M, Alberti S.

Oncogene. 2013 Jan 10;32(2):222-33. doi: 10.1038/onc.2012.36. Epub 2012 Feb 20.

PMID:
22349828
38.

An ErbB-3 antibody, MP-RM-1, inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3/Akt signaling.

Sala G, Traini S, D'Egidio M, Vianale G, Rossi C, Piccolo E, Lattanzio R, Piantelli M, Tinari N, Natali PG, Muraro R, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia.

Oncogene. 2012 Mar 8;31(10):1275-86. doi: 10.1038/onc.2011.322. Epub 2011 Aug 8.

PMID:
21822299
39.

Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.

Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL.

PLoS One. 2011 Mar 15;6(3):e17971. doi: 10.1371/journal.pone.0017971.

40.

Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction.

Corona C, Masciopinto F, Silvestri E, Viscovo AD, Lattanzio R, Sorda RL, Ciavardelli D, Goglia F, Piantelli M, Canzoniero LM, Sensi SL.

Cell Death Dis. 2010 Oct 28;1:e91. doi: 10.1038/cddis.2010.73.

41.

p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features.

Biganzoli E, Coradini D, Ambrogi F, Garibaldi JM, Lisboa P, Soria D, Green AR, Pedriali M, Piantelli M, Querzoli P, Demicheli R, Boracchi P, Nenci I, Ellis IO, Alberti S.

Jpn J Clin Oncol. 2011 Feb;41(2):172-9. doi: 10.1093/jjco/hyq227. Epub 2011 Jan 2.

PMID:
21199790
42.

Immunohistochemistry of thymic epithelial tumors as a tool in translational research.

Marino M, Piantelli M.

Thorac Surg Clin. 2011 Feb;21(1):33-46, vi. doi: 10.1016/j.thorsurg.2010.08.014. Review.

PMID:
21070985
43.

An immunohistochemically positive E-cadherin status is not always predictive for a good prognosis in human breast cancer.

Querzoli P, Coradini D, Pedriali M, Boracchi P, Ambrogi F, Raimondi E, La Sorda R, Lattanzio R, Rinaldi R, Lunardi M, Frasson C, Modesti F, Ferretti S, Piantelli M, Iacobelli S, Biganzoli E, Nenci I, Alberti S.

Br J Cancer. 2010 Dec 7;103(12):1835-9. doi: 10.1038/sj.bjc.6605991. Epub 2010 Nov 9.

44.

A dietary tomato supplement prevents prostate cancer in TRAMP mice.

Pannellini T, Iezzi M, Liberatore M, Sabatini F, Iacobelli S, Rossi C, Alberti S, Di Ilio C, Vitaglione P, Fogliano V, Piantelli M.

Cancer Prev Res (Phila). 2010 Oct;3(10):1284-91. doi: 10.1158/1940-6207.CAPR-09-0237. Epub 2010 Aug 17.

45.

CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells.

Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR.

Am J Transl Res. 2010 Mar 15;2(2):135-44.

46.

Phospholipase Cgamma1 is required for metastasis development and progression.

Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M, Lattanzio R, Piantelli M, Iacobelli S, Broggini M, Falasca M.

Cancer Res. 2008 Dec 15;68(24):10187-96. doi: 10.1158/0008-5472.CAN-08-1181.

47.

High expression of 90K (Mac-2 BP) is associated with poor survival in node-negative breast cancer patients not receiving adjuvant systemic therapies.

Tinari N, Lattanzio R, Querzoli P, Natoli C, Grassadonia A, Alberti S, Hubalek M, Reimer D, Nenci I, Bruzzi P, Piantelli M, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO).

Int J Cancer. 2009 Jan 15;124(2):333-8. doi: 10.1002/ijc.23970.

48.

Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer.

Rossi C, Di Lena A, La Sorda R, Lattanzio R, Antolini L, Patassini C, Piantelli M, Alberti S.

Eur J Cancer. 2008 Nov;44(17):2696-704. doi: 10.1016/j.ejca.2008.08.021. Epub 2008 Oct 14.

PMID:
18926695
49.

A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer.

Guerra E, Trerotola M, Dell' Arciprete R, Bonasera V, Palombo B, El-Sewedy T, Ciccimarra T, Crescenzi C, Lorenzini F, Rossi C, Vacca G, Lattanzio R, Piantelli M, Alberti S.

Cancer Res. 2008 Oct 1;68(19):8113-21. doi: 10.1158/0008-5472.CAN-07-6135.

50.

Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts.

Cumashi A, Tinari N, Rossi C, Lattanzio R, Natoli C, Piantelli M, Iacobelli S.

Cancer Lett. 2008 Nov 8;270(2):229-33. doi: 10.1016/j.canlet.2008.05.007. Epub 2008 Jun 30.

PMID:
18586384

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