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Discovery of Novel Small Molecules that Block Myofibroblast Formation: Implications for Capsular Contracture Treatment.

Park RH, Pollock SJ, Phipps RP, Langstein HN, Woeller CF.

Plast Reconstr Surg Glob Open. 2019 Sep 30;7(9):e2430. doi: 10.1097/GOX.0000000000002430. eCollection 2019 Sep.


Exposure to Heptachlorodibenzo-p-dioxin (HpCDD) Regulates microRNA Expression in Human Lung Fibroblasts.

Woeller CF, Thatcher TH, Thakar J, Cornwell A, Smith MR, Jones DP, Hopke PK, Sime PJ, Krahl P, Mallon TM, Phipps RP, Utell MJ.

J Occup Environ Med. 2019 Dec;61 Suppl 12:S82-S89. doi: 10.1097/JOM.0000000000001691.


Machine Learning Approach for Predicting Past Environmental Exposures From Molecular Profiling of Post-Exposure Human Serum Samples.

Khan A, Thatcher TH, Woeller CF, Sime PJ, Phipps RP, Hopke PK, Utell MJ, Krahl PL, Mallon TM, Thakar J.

J Occup Environ Med. 2019 Dec;61 Suppl 12:S55-S64. doi: 10.1097/JOM.0000000000001692.


Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards.

Thatcher TH, Woeller CF, Thakar J, Khan A, Hopke PK, Smith MR, Uppal K, Walker DI, Go YM, Jones DP, Krahl PL, Mallon TM, Sime PJ, Phipps RP, Utell MJ.

J Occup Environ Med. 2019 Dec;61 Suppl 12:S45-S54. doi: 10.1097/JOM.0000000000001715.


Advances in Comprehensive Exposure Assessment: Opportunities for the US Military.

Krahl PL, Benchoff E, Go YM, Jones DP, Smith MR, Walker DI, Uppal K, Woeller CF, Thatcher TH, Thakar J, Phipps RP, Hopke P, Utell MJ, Mallon TM.

J Occup Environ Med. 2019 Dec;61 Suppl 12:S5-S14. doi: 10.1097/JOM.0000000000001677.


Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor.

Hammond CL, Roztocil E, Phipps RP, Feldon SE, Woeller CF.

PLoS One. 2019 Sep 19;14(9):e0222779. doi: 10.1371/journal.pone.0222779. eCollection 2019.


The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.

Heffer AM, Proaño J, Roztocil E, Phipps RP, Feldon SE, Huxlin KR, Sime PJ, Libby RT, Woeller CF, Kuriyan AE.

PLoS One. 2019 Sep 17;14(9):e0222596. doi: 10.1371/journal.pone.0222596. eCollection 2019.


Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.

Pietropaoli AP, Henrichs KF, Cholette JM, Spinelli SL, Phipps RP, Refaai MA, Blumberg N.

Transfusion. 2019 Jun;59(6):2007-2015. doi: 10.1111/trf.15218. Epub 2019 Feb 27.


Thy1 (CD90) expression is regulated by DNA methylation during adipogenesis.

Flores EM, Woeller CF, Falsetta ML, Susiarjo M, Phipps RP.

FASEB J. 2019 Mar;33(3):3353-3363. doi: 10.1096/fj.201801481R. Epub 2018 Oct 30.


Lipoxin B4 Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression.

Kim N, Lannan KL, Thatcher TH, Pollock SJ, Woeller CF, Phipps RP.

J Immunol. 2018 Dec 1;201(11):3343-3351. doi: 10.4049/jimmunol.1700503. Epub 2018 Oct 22.


Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Antifibrotic Prostaglandins.

Lacy SH, Woeller CF, Thatcher TH, Pollock SJ, Small EM, Sime PJ, Phipps RP.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):269-278. doi: 10.1165/rcmb.2017-0248OC.


Key roles for lipid mediators in the adaptive immune response.

Duffney PF, Falsetta ML, Rackow AR, Thatcher TH, Phipps RP, Sime PJ.

J Clin Invest. 2018 Jul 2;128(7):2724-2731. doi: 10.1172/JCI97951. Epub 2018 Jul 2. Review.


In Vitro Methods to Characterize the Effects of Tobacco and Nontobacco Products on Human Platelet Function.

Loelius SG, Spinelli SL, Lannan KL, Phipps RP.

Curr Protoc Toxicol. 2018 May;76(1):e46. doi: 10.1002/cptx.46.


The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro.

Loelius SG, Lannan KL, Blumberg N, Phipps RP, Spinelli SL.

Thromb Res. 2018 Sep;169:96-104. doi: 10.1016/j.thromres.2018.07.003. Epub 2018 Jul 6.


In Vitro Characterization of Variable Porosity Wound Dressing With Anti-Scar Properties.

Woeller CF, Woodroof A, Cottler PS, Pollock SJ, Haidaris CG, Phipps RP.

Eplasty. 2018 May 25;18:e21. eCollection 2018.


Evaluating a Variable Porosity Wound Dressing With Anti-Scar Properties in a Porcine Model of Wound Healing.

Woeller CF, Woodroof A, Lacy SH, Cottler PS, Gui JL, Piñeros-Fernandez A, Pollock SJ, Phipps RP.

Eplasty. 2018 May 24;18:e20. eCollection 2018.


Decreased Hemolysis and Improved Platelet Function in Blood Components Washed With Plasma-Lyte A Compared to 0.9% Sodium Chloride.

Refaai MA, Conley GW, Henrichs KF, McRae H, Schmidt AE, Phipps RP, Spinelli SL, Masel D, Cholette JM, Pietropaoli A, Eaton MP, Blumberg N.

Am J Clin Pathol. 2018 Jul 3;150(2):146-153. doi: 10.1093/ajcp/aqy036.


Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.

Judge JL, Nagel DJ, Owens KM, Rackow A, Phipps RP, Sime PJ, Kottmann RM.

PLoS One. 2018 May 24;13(5):e0197936. doi: 10.1371/journal.pone.0197936. eCollection 2018.


Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections.

Bhat TA, Kalathil SG, Bogner PN, Miller A, Lehmann PV, Thatcher TH, Phipps RP, Sime PJ, Thanavala Y.

J Immunol. 2018 Apr 15;200(8):2927-2940. doi: 10.4049/jimmunol.1701417. Epub 2018 Mar 19.


Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.

Paine A, Woeller CF, Zhang H, de la Luz Garcia-Hernandez M, Huertas N, Xing L, Phipps RP, Ritchlin CT.

FASEB J. 2018 Jun;32(6):3174-3183. doi: 10.1096/fj.201701379R. Epub 2018 Jan 17.


Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage.

Duffney PF, McCarthy CE, Nogales A, Thatcher TH, Martinez-Sobrido L, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L505-L513. doi: 10.1152/ajplung.00406.2017. Epub 2017 Dec 14.


Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2.

Lacy SH, Epa AP, Pollock SJ, Woeller CF, Thatcher TH, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L569-L582. doi: 10.1152/ajplung.00565.2016. Epub 2017 Dec 20.


Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia.

Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Piekna-Przybylska D, Maggirwar SB, Haidaris CG, Phipps RP.

J Low Genit Tract Dis. 2018 Jan;22(1):52-57. doi: 10.1097/LGT.0000000000000364.


Haem is associated with thrombosis in neonates and infants undergoing cardiac surgery for congenital heart disease.

Stolla M, Henrichs K, Cholette JM, Pietropaoli AP, Phipps RP, Spinelli SL, Blumberg N.

Vox Sang. 2018 Jan;113(1):72-75. doi: 10.1111/vox.12606. Epub 2017 Oct 16.


Development of an accurate and sensitive method for lactate analysis in exhaled breath condensate by LC MS/MS.

Jackson TC, Zhang YV, Sime PJ, Phipps RP, Kottmann RM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:468-473. doi: 10.1016/j.jchromb.2017.07.041. Epub 2017 Jul 24.


Thy1 (CD90) Expression Is Elevated in Radiation-Induced Periprosthetic Capsular Contracture: Implication for Novel Therapeutics.

Hansen TC, Woeller CF, Lacy SH, Koltz PF, Langstein HN, Phipps RP.

Plast Reconstr Surg. 2017 Aug;140(2):316-326. doi: 10.1097/PRS.0000000000003542.


Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor γ Ligands in Corneal Fibroblasts Are Mediated by β-Catenin-Regulated Pathways.

Jeon KI, Phipps RP, Sime PJ, Huxlin KR.

Am J Pathol. 2017 Aug;187(8):1660-1669. doi: 10.1016/j.ajpath.2017.04.002. Epub 2017 Jun 10.


Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung.

McCarthy CE, Duffney PF, Wyatt JD, Thatcher TH, Phipps RP, Sime PJ.

Toxicol In Vitro. 2017 Sep;43:76-86. doi: 10.1016/j.tiv.2017.05.021. Epub 2017 May 30.


Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Blumberg N, Cholette JM, Schmidt AE, Phipps RP, Spinelli SL, Heal JM, Pietropaoli AP, Refaai MA, Sime PJ.

Transfus Med Rev. 2017 Oct;31(4):252-257. doi: 10.1016/j.tmrv.2017.04.002. Epub 2017 May 4. Review.


The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.

Judge JL, Lacy SH, Ku WY, Owens KM, Hernady E, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM.

Radiat Res. 2017 Jul;188(1):35-43. doi: 10.1667/RR14620.1. Epub 2017 May 2.


In Vitro and Ex Vivo Approaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood Platelets.

Spinelli SL, Lannan KL, Loelius SG, Phipps RP.

Appl In Vitro Toxicol. 2017 Mar 1;3(1):110-120. doi: 10.1089/aivt.2016.0034.


NF-κB Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets.

Damien P, Cognasse F, Payrastre B, Spinelli SL, Blumberg N, Arthaud CA, Eyraud MA, Phipps RP, McNicol A, Pozzetto B, Garraud O, Hamzeh-Cognasse H.

Front Immunol. 2017 Feb 6;8:85. doi: 10.3389/fimmu.2017.00085. eCollection 2017.


Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients.

Kim N, Thatcher TH, Sime PJ, Phipps RP.

JCI Insight. 2017 Feb 9;2(3):e88588. doi: 10.1172/jci.insight.88588.


Maresin 1 induces a novel pro-resolving phenotype in human platelets.

Lannan KL, Spinelli SL, Blumberg N, Phipps RP.

J Thromb Haemost. 2017 Apr;15(4):802-813. doi: 10.1111/jth.13620. Epub 2017 Feb 25.


The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye Disease.

Woeller CF, Roztocil E, Hammond CL, Feldon SE, Phipps RP.

Am J Pathol. 2016 Dec;186(12):3189-3202. doi: 10.1016/j.ajpath.2016.08.017. Epub 2016 Nov 11.


Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

McCarthy CE, Duffney PF, Gelein R, Thatcher TH, Elder A, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1222-L1233. doi: 10.1152/ajplung.00183.2016. Epub 2016 Nov 11.


Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner.

Lacy SH, Woeller CF, Thatcher TH, Maddipati KR, Honn KV, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L855-L867. doi: 10.1152/ajplung.00272.2016. Epub 2016 Sep 9.


A Role for Bradykinin Signaling in Chronic Vulvar Pain.

Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Haidaris CG, Phipps RP.

J Pain. 2016 Nov;17(11):1183-1197. doi: 10.1016/j.jpain.2016.07.007. Epub 2016 Aug 18.


MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.

Woeller CF, Thatcher TH, Van Twisk D, Pollock SJ, Croasdell A, Hopke PK, Xia X, Thakar J, Sime PJ, Mallon TM, Utell MJ, Phipps RP.

J Occup Environ Med. 2016 Aug;58(8 Suppl 1):S89-96. doi: 10.1097/JOM.0000000000000769.


Detection of Serum microRNAs From Department of Defense Serum Repository: Correlation With Cotinine, Cytokine, and Polycyclic Aromatic Hydrocarbon Levels.

Woeller CF, Thatcher TH, Van Twisk D, Pollock SJ, Croasdell A, Kim N, Hopke PK, Xia X, Thakar J, Mallon CT, Utell MJ, Phipps RP.

J Occup Environ Med. 2016 Aug;58(8 Suppl 1):S62-71. doi: 10.1097/JOM.0000000000000742.


Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.

Walker DI, Pennell KD, Uppal K, Xia X, Hopke PK, Utell MJ, Phipps RP, Sime PJ, Rohrbeck P, Mallon CT, Jones DP.

J Occup Environ Med. 2016 Aug;58(8 Suppl 1):S44-52. doi: 10.1097/JOM.0000000000000772.


Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan.

Mallon CT, Rohrbeck MP, Haines MK, Jones DP, Utell M, Hopke PK, Phipps RP, Walker DI, Thatcher T, Woeller CF, Baird CP, Pollard HB, Dalgard CL, Gaydos JC.

J Occup Environ Med. 2016 Aug;58(8 Suppl 1):S3-S11. doi: 10.1097/JOM.0000000000000775.


A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation.

Falsetta ML, Foster DC, Bonham AD, Phipps RP.

BJOG. 2017 Jan;124(2):210-218. doi: 10.1111/1471-0528.14157. Epub 2016 Jun 17. Review.


Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes.

Croasdell A, Sime PJ, Phipps RP.

FASEB J. 2016 Sep;30(9):3181-93. doi: 10.1096/fj.201600375R. Epub 2016 Jun 2.


Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic.

Lind L, Lind PM, Lejonklou MH, Dunder L, Bergman Å, Guerrero-Bosagna C, Lampa E, Lee HK, Legler J, Nadal A, Pak YK, Phipps RP, Vandenberg LN, Zalko D, Ågerstrand M, Öberg M, Blumberg B, Heindel JJ, Birnbaum LS.

Environ Health Perspect. 2016 May 1;124(5):A81-3. doi: 10.1289/ehp.1511115. No abstract available.


Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae.

Croasdell A, Lacy SH, Thatcher TH, Sime PJ, Phipps RP.

J Immunol. 2016 Mar 15;196(6):2742-52. doi: 10.4049/jimmunol.1502331. Epub 2016 Feb 3.


PPARγ and the Innate Immune System Mediate the Resolution of Inflammation.

Croasdell A, Duffney PF, Kim N, Lacy SH, Sime PJ, Phipps RP.

PPAR Res. 2015;2015:549691. doi: 10.1155/2015/549691. Epub 2015 Dec 2. Review.


Resveratrol preserves the function of human platelets stored for transfusion.

Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL.

Br J Haematol. 2016 Mar;172(5):794-806. doi: 10.1111/bjh.13862. Epub 2015 Dec 18.


Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.

Thatcher TH, Williams MA, Pollock SJ, McCarthy CE, Lacy SH, Phipps RP, Sime PJ.

Immunology. 2016 Jan;147(1):41-54. doi: 10.1111/imm.12540. Epub 2015 Nov 10.

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