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Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.

Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs AP, Philpott M, Uyulur F, Morova T, Dunford JE, Göklemez S, Arı Ş, Oppermann U, Önder TT.

Nat Chem Biol. 2019 May;15(5):519-528. doi: 10.1038/s41589-019-0264-z. Epub 2019 Apr 8.


Commercial determinants of health: advertising of alcohol and unhealthy foods during sporting events.

Ireland R, Bunn C, Reith G, Philpott M, Capewell S, Boyland E, Chambers S.

Bull World Health Organ. 2019 Apr 1;97(4):290-295. doi: 10.2471/BLT.18.220087. Epub 2019 Feb 25.


Correction: The effect of a programme to improve men's sedentary time and physical activity: The European Fans in Training (EuroFIT) randomised controlled trial.

Wyke S, Bunn C, Andersen E, Silva MN, van Nassau F, McSkimming P, Kolovos S, Gill JMR, Gray CM, Hunt K, Anderson AS, Bosmans J, Jelsma JGM, Kean S, Lemyre N, Loudon DW, Macaulay L, Maxwell DJ, McConnachie A, Mutrie N, Sanden MN, Pereira HV, Philpott M, Roberts GC, Rooksby J, Røynesdal ØB, Sattar N, Sørensen M, Teixeira PJ, Treweek S, van Achterberg T, van de Glind I, van Mechelen W, van der Ploeg HP.

PLoS Med. 2019 Mar 14;16(3):e1002772. doi: 10.1371/journal.pmed.1002772. eCollection 2019 Mar.


The effect of a programme to improve men's sedentary time and physical activity: The European Fans in Training (EuroFIT) randomised controlled trial.

Wyke S, Bunn C, Andersen E, Silva MN, van Nassau F, McSkimming P, Kolovos S, Gill JMR, Gray CM, Hunt K, Anderson AS, Bosmans J, Jelsma JGM, Kean S, Lemyre N, Loudon DW, Macaulay L, Maxwell DJ, McConnachie A, Mutrie N, Nijhuis-van der Sanden M, Pereira HV, Philpott M, Roberts GC, Rooksby J, Røynesdal ØB, Sattar N, Sørensen M, Teixeira PJ, Treweek S, van Achterberg T, van de Glind I, van Mechelen W, van der Ploeg HP.

PLoS Med. 2019 Feb 5;16(2):e1002736. doi: 10.1371/journal.pmed.1002736. eCollection 2019 Feb. Erratum in: PLoS Med. 2019 Mar 14;16(3):e1002772.


Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Vazquez-Rodriguez S, Wright M, Rogers CM, Cribbs AP, Velupillai S, Philpott M, Lee H, Dunford JE, Huber KVM, Robers MB, Vasta JD, Thezenas ML, Bonham S, Kessler B, Bennett J, Fedorov O, Raynaud F, Donovan A, Blagg J, Bavetsias V, Oppermann U, Bountra C, Kawamura A, Brennan PE.

Angew Chem Int Ed Engl. 2019 Jan 8;58(2):515-519. doi: 10.1002/anie.201810179. Epub 2018 Dec 7.


Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells.

Fang L, Trigiante G, Kousseff CJ, Crespo-Otero R, Philpott MP, Watkinson M.

Chem Commun (Camb). 2018 Aug 23;54(69):9619-9622. doi: 10.1039/c8cc05425h.


Rapid differentiation of epithelial cell types in aged biological samples using autofluorescence and morphological signatures.

Brocato ER, Philpott MK, Connon CC, Ehrhardt CJ.

PLoS One. 2018 May 17;13(5):e0197701. doi: 10.1371/journal.pone.0197701. eCollection 2018.


MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma.

Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA, Philpott MP, Ezra DG.

Sci Rep. 2018 May 14;8(1):7531. doi: 10.1038/s41598-018-25900-z.


Culture of the human pilosebaceous unit, hair follicle and sebaceous gland.

Philpott MP.

Exp Dermatol. 2018 May;27(5):571-577. doi: 10.1111/exd.13669. Review.


Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling.

Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT.

J Cell Sci. 2018 May 16;131(10). pii: jcs215780. doi: 10.1242/jcs.215780.


Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer: Evaluation in a porcine model.

Boussy T, Vandecasteele T, Vera L, Schauvliege S, Philpott M, Clement E, van Loon G, Willenz U, Granada JF, Stone GW, Reddy VY, Van Langenhove G.

Pacing Clin Electrophysiol. 2018 Jun;41(6):603-610. doi: 10.1111/pace.13345. Epub 2018 May 4.


A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.

Rahman MM, Hazan A, Selway JL, Herath DS, Harwood CA, Pirzado MS, Atkar R, Kelsell DP, Linton KJ, Philpott MP, Neill GW.

Cancer Res. 2018 May 15;78(10):2577-2588. doi: 10.1158/0008-5472.CAN-17-2897. Epub 2018 Feb 20.


Analysis of hedgehog signaling in periocular sebaceous carcinoma.

Bladen JC, Moosajee M, Tracey-White D, Beaconsfield M, O'Toole EA, Philpott MP.

Graefes Arch Clin Exp Ophthalmol. 2018 Apr;256(4):853-860. doi: 10.1007/s00417-018-3900-5. Epub 2018 Feb 8.


A preliminary study of pulmonary vein implant applicability and safety as a potential ablation platform in a follow-up study in pigs.

Vandecasteele T, Schauvliege S, Philpott M, Clement E, van Loon G, Vera L, Boussy T, van Bergen T, Van Den Broeck W, Cornillie P, Van Langenhove G.

Pacing Clin Electrophysiol. 2018 Feb;41(2):167-171. doi: 10.1111/pace.13272. Epub 2018 Jan 24.


Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

Cribbs A, Hookway ES, Wells G, Lindow M, Obad S, Oerum H, Prinjha RK, Athanasou N, Sowman A, Philpott M, Penn H, Soderstrom K, Feldmann M, Oppermann U.

J Biol Chem. 2018 Feb 16;293(7):2422-2437. doi: 10.1074/jbc.RA117.000698. Epub 2018 Jan 4.


Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model.

Asadi K, Ferguson LR, Philpott M, Karunasinghe N.

J Cancer Prev. 2017 Sep;22(3):135-146. doi: 10.15430/JCP.2017.22.3.135. Epub 2017 Sep 30.


Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis.

Caton PW, Evans EA, Philpott MP, Hannen RF.

Curr Opin Pharmacol. 2017 Dec;37:59-64. doi: 10.1016/j.coph.2017.08.011. Epub 2017 Oct 3. Review.


Ulna Autograft for Wrist Arthrodesis: A Novel Approach in Failed Wrist Arthoplasty.

Sargazi N, Philpott M, Malik A, Waseem M.

Open Orthop J. 2017 Aug 21;11:768-776. doi: 10.2174/1874325001711010768. eCollection 2017.


Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis.

Hannen R, Udeh-Momoh C, Upton J, Wright M, Michael A, Gulati A, Rajpopat S, Clayton N, Halsall D, Burrin J, Flower R, Sevilla L, Latorre V, Frame J, Lightman S, Perez P, Philpott M.

J Invest Dermatol. 2017 Aug;137(8):1630-1637. doi: 10.1016/j.jid.2017.02.984. Epub 2017 Mar 28.


In vitro skin models to study epithelial regeneration from the hair follicle.

Ojeh N, Akgül B, Tomic-Canic M, Philpott M, Navsaria H.

PLoS One. 2017 Mar 28;12(3):e0174389. doi: 10.1371/journal.pone.0174389. eCollection 2017.


GLI2 Is a Regulator of β-Catenin and Is Associated with Loss of E-Cadherin, Cell Invasiveness, and Long-Term Epidermal Regeneration.

Pantazi E, Gemenetzidis E, Teh MT, Reddy SV, Warnes G, Evagora C, Trigiante G, Philpott MP.

J Invest Dermatol. 2017 Aug;137(8):1719-1730. doi: 10.1016/j.jid.2016.11.046. Epub 2017 Mar 11.


Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM.

Nat Commun. 2017 Mar 8;8:14694. doi: 10.1038/ncomms14694.


Flow cytometry dataset for cells collected from touched surfaces.

Kwon YJ, Stanciu CE, Philpott MK, Ehrhardt CJ.

Version 2. F1000Res. 2016 Mar 23 [revised 2016 Jan 1];5:390. doi: 10.12688/f1000research.8338.2. eCollection 2016.


Retaining in-gel zymographic activity of cysteine proteases via a cysteine-supplemented running buffer.

Vootukuri Reddy S, Philpott MP, Trigiante G.

Electrophoresis. 2016 Oct;37(20):2644-2648. doi: 10.1002/elps.201600188. Epub 2016 Aug 23.


Study protocol of European Fans in Training (EuroFIT): a four-country randomised controlled trial of a lifestyle program for men delivered in elite football clubs.

van Nassau F, van der Ploeg HP, Abrahamsen F, Andersen E, Anderson AS, Bosmans JE, Bunn C, Chalmers M, Clissmann C, Gill JM, Gray CM, Hunt K, Jelsma JG, La Guardia JG, Lemyre PN, Loudon DW, Macaulay L, Maxwell DJ, McConnachie A, Martin A, Mourselas N, Mutrie N, Nijhuis-van der Sanden R, O'Brien K, Pereira HV, Philpott M, Roberts GC, Rooksby J, Rost M, Røynesdal Ø, Sattar N, Silva MN, Sorensen M, Teixeira PJ, Treweek S, van Achterberg T, van de Glind I, van Mechelen W, Wyke S.

BMC Public Health. 2016 Jul 19;16:598. doi: 10.1186/s12889-016-3255-y.


A Preclinical Study of an Implanted Device in the Pulmonary Veins, Intended for the Treatment of Atrial Fibrillation in an Ovine Model.

Vandecasteele T, Boussy T, Philpott M, Clement E, Schauvliege S, VAN DEN Broeck W, VAN Loon G, Cornillie P, VAN Langenhove G.

Pacing Clin Electrophysiol. 2016 Aug;39(8):822-9. doi: 10.1111/pace.12899. Epub 2016 Jun 23.


Structural analysis of human KDM5B guides histone demethylase inhibitor development.

Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess-Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U.

Nat Chem Biol. 2016 Jul;12(7):539-45. doi: 10.1038/nchembio.2087. Epub 2016 May 23.


Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia.

Chew EGY, Tan JHJ, Bahta AW, Ho BS, Liu X, Lim TC, Sia YY, Bigliardi PL, Heilmann S, Wan ACA, Nöthen MM, Philpott MP, Hillmer AM.

J Invest Dermatol. 2016 Aug;136(8):1559-1567. doi: 10.1016/j.jid.2016.03.032. Epub 2016 Apr 7.


Constitutive Autophagy and Nucleophagy during Epidermal Differentiation.

Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP, Harwood CA, Byrne C, O'Shaughnessy RFL, Bergamaschi D.

J Invest Dermatol. 2016 Jul;136(7):1460-1470. doi: 10.1016/j.jid.2016.03.016. Epub 2016 Mar 25.


Frapid: achieving full automation of FRAP for chemical probe validation.

Yapp C, Rogers C, Savitsky P, Philpott M, Müller S.

Biomed Opt Express. 2016 Jan 11;7(2):422-41. doi: 10.1364/BOE.7.000422. eCollection 2016 Feb 1.


Optical characterization of epidermal cells and their relationship to DNA recovery from touch samples.

Stanciu CE, Philpott MK, Kwon YJ, Bustamante EE, Ehrhardt CJ.

F1000Res. 2015 Nov 26;4:1360. doi: 10.12688/f1000research.7385.1. eCollection 2015.


Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S.

Sci Adv. 2015 Nov 13;1(10):e1500723. doi: 10.1126/sciadv.1500723. eCollection 2015 Nov.


Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S.

Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9.


Human hair follicle organ culture: theory, application and perspectives.

Langan EA, Philpott MP, Kloepper JE, Paus R.

Exp Dermatol. 2015 Dec;24(12):903-11. doi: 10.1111/exd.12836. Review.


Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Chen P, Chaikuad A, Bamborough P, Bantscheff M, Bountra C, Chung CW, Fedorov O, Grandi P, Jung D, Lesniak R, Lindon M, Müller S, Philpott M, Prinjha R, Rogers C, Selenski C, Tallant C, Werner T, Willson TM, Knapp S, Drewry DH.

J Med Chem. 2016 Feb 25;59(4):1410-24. doi: 10.1021/acs.jmedchem.5b00209. Epub 2015 Apr 6.


Separation of uncompromised whole blood mixtures for single source STR profiling using fluorescently-labeled human leukocyte antigen (HLA) probes and fluorescence activated cell sorting (FACS).

Dean L, Kwon YJ, Philpott MK, Stanciu CE, Seashols-Williams SJ, Dawson Cruz T, Sturgill J, Ehrhardt CJ.

Forensic Sci Int Genet. 2015 Jul;17:8-16. doi: 10.1016/j.fsigen.2015.03.003. Epub 2015 Mar 12.


Surface-Roughness-Based Virtual Textiles: Evaluation Using a Multi-Contactor Display.

Philpott M, Summers IR.

IEEE Trans Haptics. 2015 Apr-Jun;8(2):240-4. doi: 10.1109/TOH.2015.2412551. Epub 2015 Mar 13.


Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M, Akhtar W, Hayes A, Raynaud F, Müller S, Knapp S, Hoelder S.

J Med Chem. 2015 Mar 12;58(5):2553-9. doi: 10.1021/jm501963e. Epub 2015 Feb 26.


Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.

Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP.

J Invest Dermatol. 2015 May;135(5):1244-1252. doi: 10.1038/jid.2015.28. Epub 2015 Feb 3.


Towards a social and context-aware multi-sensor fall detection and risk assessment platform.

De Backere F, Ongenae F, Van den Abeele F, Nelis J, Bonte P, Clement E, Philpott M, Hoebeke J, Verstichel S, Ackaert A, De Turck F.

Comput Biol Med. 2015 Sep;64:307-20. doi: 10.1016/j.compbiomed.2014.12.002. Epub 2014 Dec 10.


Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.

Philpott M, Rogers CM, Yapp C, Wells C, Lambert JP, Strain-Damerell C, Burgess-Brown NA, Gingras AC, Knapp S, Müller S.

Epigenetics Chromatin. 2014 Jul 13;7:14. doi: 10.1186/1756-8935-7-14. eCollection 2014.


Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains.

Hay DA, Fedorov O, Martin S, Singleton DC, Tallant C, Wells C, Picaud S, Philpott M, Monteiro OP, Rogers CM, Conway SJ, Rooney TP, Tumber A, Yapp C, Filippakopoulos P, Bunnage ME, Müller S, Knapp S, Schofield CJ, Brennan PE.

J Am Chem Soc. 2014 Jul 2;136(26):9308-19. doi: 10.1021/ja412434f. Epub 2014 Jun 19.


A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.

Rooney TP, Filippakopoulos P, Fedorov O, Picaud S, Cortopassi WA, Hay DA, Martin S, Tumber A, Rogers CM, Philpott M, Wang M, Thompson AL, Heightman TD, Pryde DC, Cook A, Paton RS, Müller S, Knapp S, Brennan PE, Conway SJ.

Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6126-30. doi: 10.1002/anie.201402750. Epub 2014 May 12.


Process evaluation of European 'Healthy Stadia' program.

Roncarolo F, Lanati N, Philpott M, Drygas W, Ruszkowska J, Ireland R, Tenconi MT.

Health Promot Int. 2015 Dec;30(4):881-90. doi: 10.1093/heapro/dau025. Epub 2014 Apr 25.


Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

Jung M, Philpott M, Müller S, Schulze J, Badock V, Eberspächer U, Moosmayer D, Bader B, Schmees N, Fernández-Montalván A, Haendler B.

J Biol Chem. 2014 Mar 28;289(13):9304-19. doi: 10.1074/jbc.M113.523019. Epub 2014 Feb 4.


GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis.

Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh MT, Lu YJ, Philpott MP.

Cell Death Dis. 2014 Jan 30;5:e1028. doi: 10.1038/cddis.2013.535.


[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.

Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I, Marsden BD, Filippakopoulos P, Müller S, Knapp S, Brennan PE.

J Med Chem. 2014 Jan 23;57(2):462-76. doi: 10.1021/jm401568s. Epub 2013 Dec 30.


Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.

Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A.

J Med Chem. 2013 Dec 27;56(24):10183-7. doi: 10.1021/jm401582c. Epub 2013 Dec 13.


Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.

Fisher K, Gee F, Wang S, Xue F, Knapp S, Philpott M, Wells C, Rodriguez M, Snoek LB, Kammenga J, Poulin GB.

Biol Open. 2013 Dec 15;2(12):1354-63. doi: 10.1242/bio.20136007.

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