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Nod-like receptors are critical for gut-brain axis signalling in mice.

Pusceddu MM, Barboza M, Keogh CE, Schneider M, Stokes P, Sladek JA, Kim HJD, Torres-Fuentes C, Goldfild LR, Gillis SE, Brust-Mascher I, Rabasa G, Wong KA, Lebrilla C, Byndloss MX, Maisonneuve C, Bäumler AJ, Philpott DJ, Ferrero RL, Barrett KE, Reardon C, Gareau MG.

J Physiol. 2019 Dec;597(24):5777-5797. doi: 10.1113/JP278640. Epub 2019 Nov 27.


Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.

Shutinoski B, Hakimi M, Harmsen IE, Lunn M, Rocha J, Lengacher N, Zhou YY, Khan J, Nguyen A, Hake-Volling Q, El-Kodsi D, Li J, Alikashani A, Beauchamp C, Majithia J, Coombs K, Shimshek D, Marcogliese PC, Park DS, Rioux JD, Philpott DJ, Woulfe JM, Hayley S, Sad S, Tomlinson JJ, Brown EG, Schlossmacher MG.

Sci Transl Med. 2019 Sep 25;11(511). pii: eaas9292. doi: 10.1126/scitranslmed.aas9292.


High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.

Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO.

Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23.


The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.

Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE.

Science. 2019 Jul 5;365(6448). pii: eaaw4144. doi: 10.1126/science.aaw4144.


Canonical and noncanonical inflammasomes in intestinal epithelial cells.

Winsor N, Krustev C, Bruce J, Philpott DJ, Girardin SE.

Cell Microbiol. 2019 Nov;21(11):e13079. doi: 10.1111/cmi.13079. Epub 2019 Jul 22.


Primed PMNs in healthy mouse and human circulation are first responders during acute inflammation.

Fine N, Barzilay O, Sun C, Wellappuli N, Tanwir F, Chadwick JW, Oveisi M, Tasevski N, Prescott D, Gargan M, Philpott DJ, Dror Y, Glogauer M.

Blood Adv. 2019 May 28;3(10):1622-1637. doi: 10.1182/bloodadvances.2018030585.


VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1.

Capurro MI, Greenfield LK, Prashar A, Xia S, Abdullah M, Wong H, Zhong XZ, Bertaux-Skeirik N, Chakrabarti J, Siddiqui I, O'Brien C, Dong X, Robinson L, Peek RM Jr, Philpott DJ, Zavros Y, Helmrath M, Jones NL.

Nat Microbiol. 2019 Aug;4(8):1411-1423. doi: 10.1038/s41564-019-0441-6. Epub 2019 May 20.


Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models.

Robertson SJ, Lemire P, Maughan H, Goethel A, Turpin W, Bedrani L, Guttman DS, Croitoru K, Girardin SE, Philpott DJ.

Cell Rep. 2019 May 7;27(6):1910-1919.e2. doi: 10.1016/j.celrep.2019.04.023.


Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress.

Molinaro R, Mukherjee T, Flick R, Philpott DJ, Girardin SE.

J Biol Chem. 2019 May 31;294(22):9007-9015. doi: 10.1074/jbc.RA119.007997. Epub 2019 Apr 17.


Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance.

Tsalikis J, Abdel-Nour M, Farahvash A, Sorbara MT, Poon S, Philpott DJ, Girardin SE.

Mol Cell Biol. 2019 Apr 30;39(10). pii: e00489-18. doi: 10.1128/MCB.00489-18. Print 2019 May 15.


NLRC5 deficiency has a moderate impact on immunodominant CD8+ T-cell responses during rotavirus infection of adult mice.

Sun T, Ferrero RL, Girardin SE, Gommerman JL, Philpott DJ.

Immunol Cell Biol. 2019 Jul;97(6):552-562. doi: 10.1111/imcb.12244. Epub 2019 Mar 29.


Acute and Delayed Deaths after West Nile Virus Infection, Texas, USA, 2002-2012.

Philpott DCE, Nolan MS, Evert N, Mayes B, Hesalroad D, Fonken E, Murray KO.

Emerg Infect Dis. 2019 Feb;25(2). doi: 10.3201/eid2502.181250.


Nod2 influences microbial resilience and susceptibility to colitis following antibiotic exposure.

Goethel A, Turpin W, Rouquier S, Zanello G, Robertson SJ, Streutker CJ, Philpott DJ, Croitoru K.

Mucosal Immunol. 2019 May;12(3):720-732. doi: 10.1038/s41385-018-0128-y. Epub 2019 Jan 16.


NOD1 and NOD2 in inflammation, immunity and disease.

Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE.

Arch Biochem Biophys. 2019 Jul 30;670:69-81. doi: 10.1016/ Epub 2018 Dec 19. Review.


Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.

Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA.

Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071.


Innate Immune Influences on the Gut Microbiome: Lessons from Mouse Models.

Robertson SJ, Goethel A, Girardin SE, Philpott DJ.

Trends Immunol. 2018 Dec;39(12):992-1004. doi: 10.1016/ Epub 2018 Oct 28. Review.


The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1.

Killackey SA, Rahman MA, Soares F, Zhang AB, Abdel-Nour M, Philpott DJ, Girardin SE.

Mol Cell Biochem. 2019 Mar;453(1-2):187-196. doi: 10.1007/s11010-018-3444-3. Epub 2018 Sep 6.


The interplay between microbes and the immune response in inflammatory bowel disease.

Goethel A, Croitoru K, Philpott DJ.

J Physiol. 2018 Sep;596(17):3869-3882. doi: 10.1113/JP275396. Epub 2018 Jul 17. Review.


Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria.

Sorbara MT, Foerster EG, Tsalikis J, Abdel-Nour M, Mangiapane J, Sirluck-Schroeder I, Tattoli I, van Dalen R, Isenman DE, Rohde JR, Girardin SE, Philpott DJ.

Cell Host Microbe. 2018 May 9;23(5):644-652.e5. doi: 10.1016/j.chom.2018.04.008.


Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia.

Costford SR, Tattoli I, Duan FT, Volchuk A, Klip A, Philpott DJ, Woo M, Girardin SE.

J Endocr Soc. 2018 Feb 21;2(4):336-347. doi: 10.1210/js.2017-00360. eCollection 2018 Apr 1.


Environmental temperature and exercise modality independently impact central and muscle fatigue among people with multiple sclerosis.

Grover G, Ploughman M, Philpott DT, Kelly LP, Devasahayam AJ, Wadden K, Power KE, Button DC.

Mult Scler J Exp Transl Clin. 2017 Dec 21;3(4):2055217317747625. doi: 10.1177/2055217317747625. eCollection 2017 Oct-Dec.


ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.

Lopes F, Keita ÅV, Saxena A, Reyes JL, Mancini NL, Al Rajabi A, Wang A, Baggio CH, Dicay M, van Dalen R, Ahn Y, Carneiro MBH, Peters NC, Rho JM, MacNaughton WK, Girardin SE, Jijon H, Philpott DJ, Söderholm JD, McKay DM.

J Biol Chem. 2018 Mar 2;293(9):3073-3087. doi: 10.1074/jbc.RA117.000809. Epub 2018 Jan 9.


The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition.

Lemire P, Robertson SJ, Maughan H, Tattoli I, Streutker CJ, Platnich JM, Muruve DA, Philpott DJ, Girardin SE.

Cell Rep. 2017 Dec 26;21(13):3653-3661. doi: 10.1016/j.celrep.2017.12.026.


The effect of rolling massage on the excitability of the corticospinal pathway.

Aboodarda SJ, Greene RM, Philpott DT, Jaswal RS, Millet GY, Behm DG.

Appl Physiol Nutr Metab. 2018 Apr;43(4):317-323. doi: 10.1139/apnm-2017-0408. Epub 2017 Oct 30.


Enrichment of magnetic particles using temperature and magnetic field gradients induced by benchtop fabricated micro-electromagnets.

Hosseini A, Philpott DN, Soleymani L.

Lab Chip. 2017 Nov 21;17(23):4097-4104. doi: 10.1039/c7lc00825b.


Maximal Voluntary Activation of the Elbow Flexors Is under Predicted by Transcranial Magnetic Stimulation Compared to Motor Point Stimulation Prior to and Following Muscle Fatigue.

Cadigan EWJ, Collins BW, Philpott DTG, Kippenhuck G, Brenton M, Button DC.

Front Physiol. 2017 Sep 20;8:707. doi: 10.3389/fphys.2017.00707. eCollection 2017.


Design and Validation of a Platform to Evaluate mHealth Apps.

Philpott D, Guergachi A, Keshavjee K.

Stud Health Technol Inform. 2017;235:3-7.


Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance.

Chan KL, Tam TH, Boroumand P, Prescott D, Costford SR, Escalante NK, Fine N, Tu Y, Robertson SJ, Prabaharan D, Liu Z, Bilan PJ, Salter MW, Glogauer M, Girardin SE, Philpott DJ, Klip A.

Cell Rep. 2017 Mar 7;18(10):2415-2426. doi: 10.1016/j.celrep.2017.02.027.


The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility.

Escalante NK, Lemire P, Cruz Tleugabulova M, Prescott D, Mortha A, Streutker CJ, Girardin SE, Philpott DJ, Mallevaey T.

J Exp Med. 2016 Dec 12;213(13):2841-2850. Epub 2016 Nov 11.


Irreversible splenic atrophy following chronic LCMV infection is associated with compromised immunity in mice.

Mbanwi AN, Wang C, Geddes K, Philpott DJ, Watts TH.

Eur J Immunol. 2017 Jan;47(1):94-106. doi: 10.1002/eji.201646666. Epub 2016 Nov 3.


NKT Cell-Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis.

Selvanantham T, Lin Q, Guo CX, Surendra A, Fieve S, Escalante NK, Guttman DS, Streutker CJ, Robertson SJ, Philpott DJ, Mallevaey T.

J Immunol. 2016 Dec 1;197(11):4464-4472. Epub 2016 Oct 31.


Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.

Alphonse MP, Duong TT, Shumitzu C, Hoang TL, McCrindle BW, Franco A, Schurmans S, Philpott DJ, Hibberd ML, Burns J, Kuijpers TW, Yeung RS.

J Immunol. 2016 Nov 1;197(9):3481-3489. Epub 2016 Sep 30.


Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.

Sun T, Rojas OL, Li C, Ward LA, Philpott DJ, Gommerman JL.

Mucosal Immunol. 2017 May;10(3):775-788. doi: 10.1038/mi.2016.79. Epub 2016 Sep 7.


The transcriptional and splicing landscape of intestinal organoids undergoing nutrient starvation or endoplasmic reticulum stress.

Tsalikis J, Pan Q, Tattoli I, Maisonneuve C, Blencowe BJ, Philpott DJ, Girardin SE.

BMC Genomics. 2016 Aug 26;17:680. doi: 10.1186/s12864-016-2999-1.


Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.

Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Philpott DJ, Rosenstiel P, Inohara N, Núñez G.

Nat Med. 2016 Aug 4;22(8):961. doi: 10.1038/nm0816-961. No abstract available.


The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy.

Zanello G, Goethel A, Rouquier S, Prescott D, Robertson SJ, Maisonneuve C, Streutker C, Philpott DJ, Croitoru K.

J Immunol. 2016 Jul 1;197(1):345-55. doi: 10.4049/jimmunol.1600185. Epub 2016 May 20.


The Bugs Within Our Body: The Human Microbiota.

Philpott DJ, Piquette-Miller M.

Clin Pharmacol Ther. 2016 Jun;99(6):570-4. doi: 10.1002/cpt.371.


Resilience of the intestinal microbiota following pathogenic bacterial infection is independent of innate immunity mediated by NOD1 or NOD2.

Robertson SJ, Geddes K, Maisonneuve C, Streutker CJ, Philpott DJ.

Microbes Infect. 2016 Jul-Aug;18(7-8):460-71. doi: 10.1016/j.micinf.2016.03.014. Epub 2016 Apr 12.


Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.

Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Chamaillard M, Philpott DJ, Rosenstiel P, Inohara N, Núñez G.

Nat Med. 2016 May;22(5):524-30. doi: 10.1038/nm.4075. Epub 2016 Apr 11. Erratum in: Nat Med. 2016 Aug 4;22(8):961.


Differences in corticospinal excitability to the biceps brachii between arm cycling and tonic contraction are not evident at the immediate onset of movement.

Forman DA, Philpott DT, Button DC, Power KE.

Exp Brain Res. 2016 Aug;234(8):2339-49. doi: 10.1007/s00221-016-4639-z. Epub 2016 Apr 1.


NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation.

Tattoli I, Killackey SA, Foerster EG, Molinaro R, Maisonneuve C, Rahman MA, Winer S, Winer DA, Streutker CJ, Philpott DJ, Girardin SE.

Cell Rep. 2016 Mar 22;14(11):2576-86. doi: 10.1016/j.celrep.2016.02.065. Epub 2016 Mar 10.


Arm-cycling sprints induce neuromuscular fatigue of the elbow flexors and alter corticospinal excitability of the biceps brachii.

Pearcey GE, Bradbury-Squires DJ, Monks M, Philpott D, Power KE, Button DC.

Appl Physiol Nutr Metab. 2016 Feb;41(2):199-209. doi: 10.1139/apnm-2015-0438. Epub 2015 Nov 3.


Hematopoietic LTβR deficiency results in skewed T cell cytokine profiles during a mucosal viral infection.

Sun T, Rojas OL, Li C, Philpott DJ, Gommerman JL.

J Leukoc Biol. 2016 Jul;100(1):103-10. doi: 10.1189/jlb.4MAB0715-294R. Epub 2015 Dec 10.


New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection.

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI.

Infect Immun. 2015 Nov 2;84(1):275-85. doi: 10.1128/IAI.01187-15. Print 2016 Jan.


Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.

Sibony M, Abdullah M, Greenfield L, Raju D, Wu T, Rodrigues DM, Galindo-Mata E, Mascarenhas H, Philpott DJ, Silverberg MS, Jones NL.

Inflamm Bowel Dis. 2015 Dec;21(12):2778-86. doi: 10.1097/MIB.0000000000000553.


Cadence-dependent changes in corticospinal excitability of the biceps brachii during arm cycling.

Forman DA, Philpott DT, Button DC, Power KE.

J Neurophysiol. 2015 Oct;114(4):2285-94. doi: 10.1152/jn.00418.2015. Epub 2015 Aug 19.


LRRK2 and Nod2 promote lysozyme sorting in Paneth cells.

Rocha JD, Schlossmacher MG, Philpott DJ.

Nat Immunol. 2015 Sep;16(9):898-900. doi: 10.1038/ni.3255. No abstract available.


Intracellular Bacterial Pathogens Trigger the Formation of U Small Nuclear RNA Bodies (U Bodies) through Metabolic Stress Induction.

Tsalikis J, Tattoli I, Ling A, Sorbara MT, Croitoru DO, Philpott DJ, Girardin SE.

J Biol Chem. 2015 Aug 21;290(34):20904-18. doi: 10.1074/jbc.M115.659466. Epub 2015 Jul 1.


NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers.

Claes AK, Zhou JY, Philpott DJ.

Physiology (Bethesda). 2015 May;30(3):241-50. doi: 10.1152/physiol.00025.2014. Review.


Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.

Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.

Cell Metab. 2015 Apr 7;21(4):527-42. doi: 10.1016/j.cmet.2015.03.001.

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