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Items: 1 to 50 of 87

1.

Prognostic Significance of Tumor-Associated Macrophage Content in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.

Kumar AT, Knops A, Swendseid B, Martinez-Outschoom U, Harshyne L, Philp N, Rodeck U, Luginbuhl A, Cognetti D, Johnson J, Curry J.

Front Oncol. 2019 Jul 23;9:656. doi: 10.3389/fonc.2019.00656. eCollection 2019.

2.

Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma.

Domingo-Vidal M, Whitaker-Menezes D, Martos-Rus C, Tassone P, Snyder CM, Tuluc M, Philp N, Curry J, Martinez-Outschoorn U.

Mol Cancer Res. 2019 Sep;17(9):1893-1909. doi: 10.1158/1541-7786.MCR-18-1191. Epub 2019 Jun 25.

PMID:
31239287
3.

Loss of MPC1 reprograms retinal metabolism to impair visual function.

Grenell A, Wang Y, Yam M, Swarup A, Dilan TL, Hauer A, Linton JD, Philp NJ, Gregor E, Zhu S, Shi Q, Murphy J, Guan T, Lohner D, Kolandaivelu S, Ramamurthy V, Goldberg AFX, Hurley JB, Du J.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3530-3535. doi: 10.1073/pnas.1812941116. Epub 2019 Feb 11.

4.

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

Léveillard T, Philp NJ, Sennlaub F.

Int J Mol Sci. 2019 Feb 11;20(3). pii: E762. doi: 10.3390/ijms20030762. Review.

5.

Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells.

Swarup A, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ.

Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C121-C133. doi: 10.1152/ajpcell.00410.2018. Epub 2018 Nov 21.

PMID:
30462537
6.

Metformin Clinical Trial in HPV+ and HPV- Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate.

Curry JM, Johnson J, Mollaee M, Tassone P, Amin D, Knops A, Whitaker-Menezes D, Mahoney MG, South A, Rodeck U, Zhan T, Harshyne L, Philp N, Luginbuhl A, Cognetti D, Tuluc M, Martinez-Outschoorn U.

Front Oncol. 2018 Oct 11;8:436. doi: 10.3389/fonc.2018.00436. eCollection 2018.

7.

Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium.

Dhingra A, Bell BA, Peachey NS, Daniele LL, Reyes-Reveles J, Sharp RC, Jun B, Bazan NG, Sparrow JR, Kim HJ, Philp NJ, Boesze-Battaglia K.

Front Cell Neurosci. 2018 Oct 8;12:351. doi: 10.3389/fncel.2018.00351. eCollection 2018.

8.

Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer.

Bisetto S, Whitaker-Menezes D, Wilski NA, Tuluc M, Curry J, Zhan T, Snyder CM, Martinez-Outschoorn UE, Philp NJ.

Front Oncol. 2018 Aug 28;8:324. doi: 10.3389/fonc.2018.00324. eCollection 2018.

9.

Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.

Zhang K, Hast MW, Izumi S, Usami Y, Shetye S, Akabudike N, Philp NJ, Iwamoto M, Nissim I, Soslowsky LJ, Enomoto-Iwamoto M.

Am J Sports Med. 2018 Jul;46(9):2222-2231. doi: 10.1177/0363546518778789. Epub 2018 Jun 21.

10.

Impact of MCT1 Haploinsufficiency on the Mouse Retina.

Peachey NS, Yu M, Han JYS, Lengacher S, Magistretti PJ, Pellerin L, Philp NJ.

Adv Exp Med Biol. 2018;1074:375-380. doi: 10.1007/978-3-319-75402-4_46.

11.

Deletion of GLUT1 in mouse lens epithelium leads to cataract formation.

Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ.

Exp Eye Res. 2018 Jul;172:45-53. doi: 10.1016/j.exer.2018.03.021. Epub 2018 Mar 28.

12.

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development.

Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U.

Semin Oncol. 2017 Jun;44(3):198-203. doi: 10.1053/j.seminoncol.2017.10.004. Epub 2017 Oct 10. Review.

13.

Phagocytosis-dependent ketogenesis in retinal pigment epithelium.

Reyes-Reveles J, Dhingra A, Alexander D, Bragin A, Philp NJ, Boesze-Battaglia K.

J Biol Chem. 2017 May 12;292(19):8038-8047. doi: 10.1074/jbc.M116.770784. Epub 2017 Mar 16.

14.

Plasma membrane protein polarity and trafficking in RPE cells: past, present and future.

Lehmann GL, Benedicto I, Philp NJ, Rodriguez-Boulan E.

Exp Eye Res. 2014 Sep;126:5-15. doi: 10.1016/j.exer.2014.04.021. Review.

15.

Cell culture of retinal pigment epithelium: Special Issue.

Pfeffer BA, Philp NJ.

Exp Eye Res. 2014 Sep;126:1-4. doi: 10.1016/j.exer.2014.07.010.

PMID:
25152358
16.

The retinal pigment epithelium utilizes fatty acids for ketogenesis.

Adijanto J, Du J, Moffat C, Seifert EL, Hurle JB, Philp NJ.

J Biol Chem. 2014 Jul 25;289(30):20570-82.

17.

Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability.

Londin ER, Adijanto J, Philp N, Novelli A, Vitale E, Perria C, Serra G, Alesi V, Surrey S, Fortina P.

Am J Med Genet A. 2014 Sep;164A(9):2294-9. doi: 10.1002/ajmg.a.36629. Epub 2014 Jun 4.

18.

Cultured primary human fetal retinal pigment epithelium (hfRPE) as a model for evaluating RPE metabolism.

Adijanto J, Philp NJ.

Exp Eye Res. 2014 Sep;126:77-84. doi: 10.1016/j.exer.2014.01.015. Epub 2014 Jan 28. Review.

19.

The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter.

Abplanalp J, Laczko E, Philp NJ, Neidhardt J, Zuercher J, Braun P, Schorderet DF, Munier FL, Verrey F, Berger W, Camargo SM, Kloeckener-Gruissem B.

Hum Mol Genet. 2013 Aug 15;22(16):3218-26. doi: 10.1093/hmg/ddt175. Epub 2013 Apr 10.

20.

The SLC16A family of monocarboxylate transporters (MCTs)--physiology and function in cellular metabolism, pH homeostasis, and fluid transport.

Adijanto J, Philp NJ.

Curr Top Membr. 2012;70:275-311. doi: 10.1016/B978-0-12-394316-3.00009-0. Review.

PMID:
23177990
21.

Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.

Adijanto J, Castorino JJ, Wang ZX, Maminishkis A, Grunwald GB, Philp NJ.

J Biol Chem. 2012 Jun 8;287(24):20491-503. doi: 10.1074/jbc.M112.354761. Epub 2012 Apr 20.

22.

Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue.

Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Philp NJ, Pestell RG, Lisanti MP.

Cell Cycle. 2012 Apr 1;11(7):1445-54. doi: 10.4161/cc.19841. Epub 2012 Apr 1.

23.

Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.

Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, Philp NJ, Lin Z, Gandara R, Sneddon S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Mar 15;11(6):1108-17. doi: 10.4161/cc.11.6.19530. Epub 2012 Mar 15.

24.

Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.

Castorino JJ, Gallagher-Colombo SM, Levin AV, Fitzgerald PG, Polishook J, Kloeckener-Gruissem B, Ostertag E, Philp NJ.

Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6774-84. doi: 10.1167/iovs.10-6579.

25.

Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy.

Vogt SD, Curcio CA, Wang L, Li CM, McGwin G Jr, Medeiros NE, Philp NJ, Kimble JA, Read RW.

Exp Eye Res. 2011 Oct;93(4):413-23. doi: 10.1016/j.exer.2011.06.002. Epub 2011 Jun 12.

26.

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.

Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP.

Cell Cycle. 2011 Jun 1;10(11):1772-83. Epub 2011 Jun 1.

27.

Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia.

Castorino JJ, Deborde S, Deora A, Schreiner R, Gallagher-Colombo SM, Rodriguez-Boulan E, Philp NJ.

Traffic. 2011 Apr;12(4):483-98. doi: 10.1111/j.1600-0854.2010.01155.x. Epub 2011 Feb 1.

28.

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.

Di Cosmo C, Liao XH, Dumitrescu AM, Philp NJ, Weiss RE, Refetoff S.

J Clin Invest. 2010 Sep;120(9):3377-88. doi: 10.1172/JCI42113. Epub 2010 Aug 2.

29.

The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.

Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E.

Kidney Int. 2010 Aug;78(4):382-8. doi: 10.1038/ki.2010.166. Epub 2010 Jun 9.

30.

Modulation of MCT3 expression during wound healing of the retinal pigment epithelium.

Gallagher-Colombo S, Maminishkis A, Tate S, Grunwald GB, Philp NJ.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5343-50. doi: 10.1167/iovs.09-5028. Epub 2010 May 26.

31.

Evidence for a homodimeric structure of human monocarboxylate transporter 8.

Visser WE, Philp NJ, van Dijk TB, Klootwijk W, Friesema EC, Jansen J, Beesley PW, Ianculescu AG, Visser TJ.

Endocrinology. 2009 Nov;150(11):5163-70. doi: 10.1210/en.2009-0699. Epub 2009 Sep 24.

32.

Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration.

Gallagher SM, Castorino JJ, Philp NJ.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C414-21. doi: 10.1152/ajpcell.00430.2008. Epub 2008 Dec 10.

33.

Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping.

Lu W, Seeholzer SH, Han M, Arnold AS, Serrano M, Garita B, Philp NJ, Farthing C, Steele P, Chen J, Linask KK.

Dev Dyn. 2008 Dec;237(12):3577-90. doi: 10.1002/dvdy.21645.

34.

Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium.

Pratt CH, Vadigepalli R, Chakravarthula P, Gonye GE, Philp NJ, Grunwald GB.

Mol Vis. 2008 Aug 4;14:1414-28.

35.

Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice.

Daniele LL, Sauer B, Gallagher SM, Pugh EN Jr, Philp NJ.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C451-7. doi: 10.1152/ajpcell.00124.2008. Epub 2008 Jun 4.

36.

Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium.

Daniele LL, Adams RH, Durante DE, Pugh EN Jr, Philp NJ.

J Comp Neurol. 2007 Nov 10;505(2):166-76.

37.
38.

Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia.

Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16245-50. Epub 2005 Oct 31.

39.
40.

Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse.

Daniele LL, Lillo C, Lyubarsky AL, Nikonov SS, Philp N, Mears AJ, Swaroop A, Williams DS, Pugh EN Jr.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2156-67.

41.

Monocarboxylate transporter expression in the spontaneous hypertensive rat: effect of stroke.

Zhang F, Vannucci SJ, Philp NJ, Simpson IA.

J Neurosci Res. 2005 Jan 1-15;79(1-2):139-45.

PMID:
15578721
42.

MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells.

Fanelli A, Grollman EF, Wang D, Philp NJ.

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1223-9.

43.

Recurrent spontaneous bladder perforation: a complication of laparoscopic colposuspension?

Lynn NN, Yahya MY, Philp NH.

J Urol. 2003 May;169(5):1789. No abstract available.

PMID:
12686836
44.

Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.

Philp NJ, Wang D, Yoon H, Hjelmeland LM.

Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1716-21.

PMID:
12657613
45.

Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse.

Philp NJ, Ochrietor JD, Rudoy C, Muramatsu T, Linser PJ.

Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1305-11.

PMID:
12601063
46.

Mouse MCT3 gene is expressed preferentially in retinal pigment and choroid plexus epithelia.

Philp NJ, Yoon H, Lombardi L.

Am J Physiol Cell Physiol. 2001 May;280(5):C1319-26.

47.
48.

Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2.

Yoon H, Donoso LA, Philp NJ.

Genomics. 1999 Sep 15;60(3):366-70.

PMID:
10493836
49.
50.

Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE.

Philp NJ, Yoon H, Grollman EF.

Am J Physiol. 1998 Jun;274(6):R1824-8. doi: 10.1152/ajpregu.1998.274.6.R1824.

PMID:
9841555

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