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Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.

Philp AR, Riquelme TT, Millar-Büchner P, González R, Sepúlveda FV, Cid LP, Flores CA.

Sci Rep. 2018 Jun 18;8(1):9320. doi: 10.1038/s41598-018-27465-3.


Delivery Of Cascade Screening For Hereditary Conditions: A Scoping Review Of The Literature.

Roberts MC, Dotson WD, DeVore CS, Bednar EM, Bowen DJ, Ganiats TG, Green RF, Hurst GM, Philp AR, Ricker CN, Sturm AC, Trepanier AM, Williams JL, Zierhut HA, Wilemon KA, Hampel H.

Health Aff (Millwood). 2018 May;37(5):801-808. doi: 10.1377/hlthaff.2017.1630.


SIRT1 regulates nuclear number and domain size in skeletal muscle fibers.

Ross JA, Levy Y, Svensson K, Philp A, Schenk S, Ochala J.

J Cell Physiol. 2018 Sep;233(9):7157-7163. doi: 10.1002/jcp.26542. Epub 2018 Mar 25.


Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.

Pollock RD, O'Brien KA, Daniels LJ, Nielsen KB, Rowlerson A, Duggal NA, Lazarus NR, Lord JM, Philp A, Harridge SDR.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12735. Epub 2018 Mar 8.


Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise.

Abou Sawan S, van Vliet S, Parel JT, Beals JW, Mazzulla M, West DWD, Philp A, Li Z, Paluska SA, Burd NA, Moore DR.

Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13628.


Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.

Riquelme D, Silva I, Philp AM, Huidobro-Toro JP, Cerda O, Trimmer JS, Leiva-Salcedo E.

Front Cell Neurosci. 2018 Jan 30;12:12. doi: 10.3389/fncel.2018.00012. eCollection 2018.


Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.

Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer JS.

Front Mol Neurosci. 2018 Jan 19;11:1. doi: 10.3389/fnmol.2018.00001. eCollection 2018.


Characterisation of L-Type Amino Acid Transporter 1 (LAT1) Expression in Human Skeletal Muscle by Immunofluorescent Microscopy.

Hodson N, Brown T, Joanisse S, Aguirre N, West DWD, Moore DR, Baar K, Breen L, Philp A.

Nutrients. 2017 Dec 26;10(1). pii: E23. doi: 10.3390/nu10010023.


Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule.

Elhassan YS, Philp AA, Lavery GG.

J Endocr Soc. 2017 May 15;1(7):816-835. doi: 10.1210/js.2017-00092. eCollection 2017 Jul 1. Review.


Skeletal Muscle Fibre-Specific Knockout of p53 Does Not Reduce Mitochondrial Content or Enzyme Activity.

Stocks B, Dent JR, Joanisse S, McCurdy CE, Philp A.

Front Physiol. 2017 Dec 4;8:941. doi: 10.3389/fphys.2017.00941. eCollection 2017.


Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation.

Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A.

Mol Metab. 2017 Dec;6(12):1574-1584. doi: 10.1016/j.molmet.2017.10.004. Epub 2017 Oct 16.


Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism.

Wilkinson DJ, Hossain T, Limb MC, Phillips BE, Lund J, Williams JP, Brook MS, Cegielski J, Philp A, Ashcroft S, Rathmacher JA, Szewczyk NJ, Smith K, Atherton PJ.

Clin Nutr. 2017 Oct 6. pii: S0261-5614(17)31356-0. doi: 10.1016/j.clnu.2017.09.024. [Epub ahead of print]


Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle.

Pérez-Schindler J, Kanhere A, Edwards L, Allwood JW, Dunn WB, Schenk S, Philp A.

Sci Rep. 2017 Oct 18;7(1):13485. doi: 10.1038/s41598-017-14081-w.


Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise.

Hodson N, McGlory C, Oikawa SY, Jeromson S, Song Z, Rüegg MA, Hamilton DL, Phillips SM, Philp A.

Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C604-C611. doi: 10.1152/ajpcell.00176.2017. Epub 2017 Sep 27.


DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH.

Cell Metab. 2017 Aug 1;26(2):447. doi: 10.1016/j.cmet.2017.07.005. No abstract available.


Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G, Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery GG.

Mol Metab. 2017 May 29;6(8):819-832. doi: 10.1016/j.molmet.2017.05.011. eCollection 2017 Aug.


Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle.

Song Z, Moore DR, Hodson N, Ward C, Dent JR, O'Leary MF, Shaw AM, Hamilton DL, Sarkar S, Gangloff YG, Hornberger TA, Spriet LL, Heigenhauser GJ, Philp A.

Sci Rep. 2017 Jul 10;7(1):5028. doi: 10.1038/s41598-017-05483-x.


Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3.

Pérez-Schindler J, Esparza MC, McKendry J, Breen L, Philp A, Schenk S.

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C257-C261. doi: 10.1152/ajpcell.00100.2017. Epub 2017 Jun 28.


Lipid remodeling and an altered membrane-associated proteome may drive the differential effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion.

Jeromson S, Mackenzie I, Doherty MK, Whitfield PD, Bell G, Dick J, Shaw A, Rao FV, Ashcroft SP, Philp A, Galloway SDR, Gallagher I, Hamilton DL.

Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E605-E619. doi: 10.1152/ajpendo.00438.2015. Epub 2017 Jun 27.


Resistin promotes the abnormal Type I collagen phenotype of subchondral bone in obese patients with end stage hip osteoarthritis.

Philp AM, Collier RL, Grover LM, Davis ET, Jones SW.

Sci Rep. 2017 Jun 22;7(1):4042. doi: 10.1038/s41598-017-04119-4.


Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans.

Jackman SR, Witard OC, Philp A, Wallis GA, Baar K, Tipton KD.

Front Physiol. 2017 Jun 7;8:390. doi: 10.3389/fphys.2017.00390. eCollection 2017.


IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity.

Pearson MJ, Herndler-Brandstetter D, Tariq MA, Nicholson TA, Philp AM, Smith HL, Davis ET, Jones SW, Lord JM.

Sci Rep. 2017 Jun 14;7(1):3451. doi: 10.1038/s41598-017-03759-w.


DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH.

Cell Metab. 2017 May 2;25(5):1135-1146.e7. doi: 10.1016/j.cmet.2017.04.008. Erratum in: Cell Metab. 2017 Aug 1;26(2):447.


Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.

Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH.

EBioMedicine. 2017 Apr;18:128-138. doi: 10.1016/j.ebiom.2017.03.019. Epub 2017 Mar 14.


11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice.

Doig CL, Fletcher RS, Morgan SA, McCabe EL, Larner DP, Tomlinson JW, Stewart PM, Philp A, Lavery GG.

Endocrinology. 2017 Jun 1;158(6):1964-1976. doi: 10.1210/en.2016-1722.


The Effect of Vancomycin and Gentamicin Antibiotics on Human Osteoblast Proliferation, Metabolic Function, and Bone Mineralization.

Philp AM, Raja S, Philp A, Newton Ede MP, Jones SW.

Spine (Phila Pa 1976). 2017 Feb;42(3):202-207. doi: 10.1097/BRS.0000000000001712.


Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome.

Millar-Büchner P, Philp AR, Gutierrez N, Villanueva S, Kerr B, Flores CA.

Mol Cell Pediatr. 2016 Dec;3(1):37. Epub 2016 Nov 21.


Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.

McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE.

JCI Insight. 2016 Oct 6;1(16):e86612.


Developing anti-inflammatory therapeutics for patients with osteoarthritis.

Philp AM, Davis ET, Jones SW.

Rheumatology (Oxford). 2017 Jun 1;56(6):869-881. doi: 10.1093/rheumatology/kew278. Review.


Fuel for the work required: a practical approach to amalgamating train-low paradigms for endurance athletes.

Impey SG, Hammond KM, Shepherd SO, Sharples AP, Stewart C, Limb M, Smith K, Philp A, Jeromson S, Hamilton DL, Close GL, Morton JP.

Physiol Rep. 2016 May;4(10). pii: e12803. doi: 10.14814/phy2.12803.


Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis and intracellular signalling in young males.

McKendry J, Pérez-López A, McLeod M, Luo D, Dent JR, Smeuninx B, Yu J, Taylor AE, Philp A, Breen L.

Exp Physiol. 2016 Jul 1;101(7):866-82. doi: 10.1113/EP085647. Epub 2016 Jun 2.


Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways.

Gianotti A, Ferrera L, Philp AR, Caci E, Zegarra-Moran O, Galietta LJ, Flores CA.

Eur J Pharmacol. 2016 Jun 15;781:100-8. doi: 10.1016/j.ejphar.2016.04.007. Epub 2016 Apr 7.


Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage.

Pearson MJ, Philp AM, Heward JA, Roux BT, Walsh DA, Davis ET, Lindsay MA, Jones SW.

Arthritis Rheumatol. 2016 Apr;68(4):845-56. doi: 10.1002/art.39520.


New strategies in sport nutrition to increase exercise performance.

Close GL, Hamilton DL, Philp A, Burke LM, Morton JP.

Free Radic Biol Med. 2016 Sep;98:144-158. doi: 10.1016/j.freeradbiomed.2016.01.016. Epub 2016 Feb 5. Review.


Live strong and prosper: the importance of skeletal muscle strength for healthy ageing.

McLeod M, Breen L, Hamilton DL, Philp A.

Biogerontology. 2016 Jun;17(3):497-510. doi: 10.1007/s10522-015-9631-7. Epub 2016 Jan 20. Review.


p300 is not required for metabolic adaptation to endurance exercise training.

LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S.

FASEB J. 2016 Apr;30(4):1623-33. doi: 10.1096/fj.15-281741. Epub 2015 Dec 28.


Povidone-Iodine Has a Profound Effect on In Vitro Osteoblast Proliferation and Metabolic Function and Inhibits Their Ability to Mineralize and Form Bone.

Newton Ede MP, Philp AM, Philp A, Richardson SM, Mohammad S, Jones SW.

Spine (Phila Pa 1976). 2016 May;41(9):729-34. doi: 10.1097/BRS.0000000000001332.


Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis.

Craig DM, Ashcroft SP, Belew MY, Stocks B, Currell K, Baar K, Philp A.

Front Physiol. 2015 Oct 27;6:296. doi: 10.3389/fphys.2015.00296. eCollection 2015. Review.


Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.

Philp A, Schenk S, Perez-Schindler J, Hamilton DL, Breen L, Laverone E, Jeromson S, Phillips SM, Baar K.

J Physiol. 2015 Sep 15;593(18):4275-84. doi: 10.1113/JP271219.


Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease.

Perez-Schindler J, Philp A.

Clin Sci (Lond). 2015 Oct;129(7):589-99. doi: 10.1042/CS20150246. Review.


Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise.

Brook MS, Wilkinson DJ, Phillips BE, Perez-Schindler J, Philp A, Smith K, Atherton PJ.

Acta Physiol (Oxf). 2016 Jan;216(1):15-41. doi: 10.1111/apha.12532. Epub 2015 Jun 21. Review.


Understanding the acetylome: translating targeted proteomics into meaningful physiology.

Philp A, Rowland T, Perez-Schindler J, Schenk S.

Am J Physiol Cell Physiol. 2014 Nov 1;307(9):C763-73. doi: 10.1152/ajpcell.00399.2013. Epub 2014 Sep 3. Review.


Nutritional strategies to support concurrent training.

Perez-Schindler J, Hamilton DL, Moore DR, Baar K, Philp A.

Eur J Sport Sci. 2015;15(1):41-52. doi: 10.1080/17461391.2014.950345. Epub 2014 Aug 27. Review.


High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.

White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E764-72. doi: 10.1152/ajpendo.00001.2014. Epub 2014 Aug 26.


Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation.

Hamilton DL, Philp A, MacKenzie MG, Patton A, Towler MC, Gallagher IJ, Bodine SC, Baar K.

Am J Physiol Endocrinol Metab. 2014 Aug 15;307(4):E365-73. doi: 10.1152/ajpendo.00674.2013. Epub 2014 Jun 24.


Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle.

McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL.

J Appl Physiol (1985). 2014 Mar 1;116(5):504-13. doi: 10.1152/japplphysiol.01072.2013. Epub 2014 Jan 16.


Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle.

Philp A, MacKenzie MG, Belew MY, Towler MC, Corstorphine A, Papalamprou A, Hardie DG, Baar K.

PLoS One. 2013 Oct 17;8(10):e77200. doi: 10.1371/journal.pone.0077200. eCollection 2013.


Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age.

Hwee DT, Baehr LM, Philp A, Baar K, Bodine SC.

Aging Cell. 2014 Feb;13(1):92-101. doi: 10.1111/acel.12150. Epub 2013 Sep 12.


Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle.

Philp A, Schenk S.

Exerc Sport Sci Rev. 2013 Jul;41(3):174-81. doi: 10.1097/JES.0b013e3182956803. Review.


Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice.

White AT, McCurdy CE, Philp A, Hamilton DL, Johnson CD, Schenk S.

Diabetologia. 2013 Jul;56(7):1629-37. doi: 10.1007/s00125-013-2912-2. Epub 2013 Apr 19.

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