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Items: 32


Expanding the Natural Products Heterologous Expression Repertoire in the Model Cyanobacterium Anabaena sp. Strain PCC 7120: Production of Pendolmycin and Teleocidin B-4.

Videau P, Wells KN, Singh AJ, Eiting J, Proteau PJ, Philmus B.

ACS Synth Biol. 2020 Jan 17;9(1):63-75. doi: 10.1021/acssynbio.9b00334. Epub 2020 Jan 8.


3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis.

Nofiani R, Philmus B, Nindita Y, Mahmud T.

Medchemcomm. 2019 Apr 29;10(9):1517-1530. doi: 10.1039/c9md00162j. eCollection 2019 Sep 1. Review.


Assessment and verification of commercially available pressure cookers for laboratory sterilization.

Swenson VA, Stacy AD, Gaylor MO, Ushijima B, Philmus B, Cozy LM, Videau NM, Videau P.

PLoS One. 2018 Dec 11;13(12):e0208769. doi: 10.1371/journal.pone.0208769. eCollection 2018.


The influence of sigma factors and ribosomal recognition elements on heterologous expression of cyanobacterial gene clusters in Escherichia coli.

Wells KN, Videau P, Nelson D, Eiting JE, Philmus B.

FEMS Microbiol Lett. 2018 Aug 1;365(15). doi: 10.1093/femsle/fny164.


Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea.

Gallegos DA, Saurí J, Cohen RD, Wan X, Videau P, Vallota-Eastman AO, Shaala LA, Youssef DTA, Williamson RT, Martin GE, Philmus B, Sikora AE, Ishmael JE, McPhail KL.

J Nat Prod. 2018 Jun 22;81(6):1417-1425. doi: 10.1021/acs.jnatprod.8b00117. Epub 2018 May 29.


Self-Resistance of Natural Product Producers: Past, Present, and Future Focusing on Self-Resistant Protein Variants.

Almabruk KH, Dinh LK, Philmus B.

ACS Chem Biol. 2018 Jun 15;13(6):1426-1437. doi: 10.1021/acschembio.8b00173. Epub 2018 May 30. Review.


The hetZ gene indirectly regulates heterocyst development at the level of pattern formation in Anabaena sp. strain PCC 7120.

Videau P, Rivers OS, Tom SK, Oshiro RT, Ushijima B, Swenson VA, Philmus B, Gaylor MO, Cozy LM.

Mol Microbiol. 2018 Apr 20. doi: 10.1111/mmi.13974. [Epub ahead of print]


Secondary Metabolism and Interspecific Competition Affect Accumulation of Spontaneous Mutants in the GacS-GacA Regulatory System in Pseudomonas protegens.

Yan Q, Lopes LD, Shaffer BT, Kidarsa TA, Vining O, Philmus B, Song C, Stockwell VO, Raaijmakers JM, McPhail KL, Andreote FD, Chang JH, Loper JE.

mBio. 2018 Jan 16;9(1). pii: e01845-17. doi: 10.1128/mBio.01845-17.


Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.

Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B.

Biochemistry. 2017 Aug 1;56(30):3934-3944. doi: 10.1021/acs.biochem.7b00476. Epub 2017 Jul 20.


The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery.

Alanjary M, Kronmiller B, Adamek M, Blin K, Weber T, Huson D, Philmus B, Ziemert N.

Nucleic Acids Res. 2017 Jul 3;45(W1):W42-W48. doi: 10.1093/nar/gkx360.


Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in Pseudomonas protegens.

Yan Q, Philmus B, Chang JH, Loper JE.

Elife. 2017 Mar 6;6. pii: e22835. doi: 10.7554/eLife.22835.


A Highly Promiscuous ß-Ketoacyl-ACP Synthase (KAS) III-like Protein Is Involved in Pactamycin Biosynthesis.

Abugrain ME, Brumsted CJ, Osborn AR, Philmus B, Mahmud T.

ACS Chem Biol. 2017 Feb 17;12(2):362-366. doi: 10.1021/acschembio.6b01043. Epub 2017 Jan 12.


Identification of the First Riboflavin Catabolic Gene Cluster Isolated from Microbacterium maritypicum G10.

Xu H, Chakrabarty Y, Philmus B, Mehta AP, Bhandari D, Hohmann HP, Begley TP.

J Biol Chem. 2016 Nov 4;291(45):23506-23515. Epub 2016 Sep 2.


Assessment of Anabaena sp. Strain PCC 7120 as a Heterologous Expression Host for Cyanobacterial Natural Products: Production of Lyngbyatoxin A.

Videau P, Wells KN, Singh AJ, Gerwick WH, Philmus B.

ACS Synth Biol. 2016 Sep 16;5(9):978-88. doi: 10.1021/acssynbio.6b00038. Epub 2016 Jun 1.


The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5.

Yan Q, Philmus B, Hesse C, Kohen M, Chang JH, Loper JE.

Front Microbiol. 2016 Apr 19;7:497. doi: 10.3389/fmicb.2016.00497. eCollection 2016.


Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis.

Fenwick MK, Philmus B, Begley TP, Ealick SE.

Biochemistry. 2016 May 17;55(19):2748-59. doi: 10.1021/acs.biochem.6b00167. Epub 2016 May 3.


The response regulator Npun_F1278 is essential for scytonemin biosynthesis in the cyanobacterium Nostoc punctiforme ATCC 29133.

Naurin S, Bennett J, Videau P, Philmus B, Soule T.

J Phycol. 2016 Aug;52(4):564-71. doi: 10.1111/jpy.12414. Epub 2016 May 11.


Mutation of the murC and murB Genes Impairs Heterocyst Differentiation in Anabaena sp. Strain PCC 7120.

Videau P, Rivers OS, Ushijima B, Oshiro RT, Kim MJ, Philmus B, Cozy LM.

J Bacteriol. 2016 Mar 31;198(8):1196-206. doi: 10.1128/JB.01027-15. Print 2016 Apr.


Investigations into the Biosynthesis, Regulation, and Self-Resistance of Toxoflavin in Pseudomonas protegens Pf-5.

Philmus B, Shaffer BT, Kidarsa TA, Yan Q, Raaijmakers JM, Begley TP, Loper JE.

Chembiochem. 2015 Aug 17;16(12):1782-90. doi: 10.1002/cbic.201500247. Epub 2015 Jul 3.


Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis.

Philmus B, Decamps L, Berteau O, Begley TP.

J Am Chem Soc. 2015 Apr 29;137(16):5406-13. doi: 10.1021/ja513287k. Epub 2015 Apr 20.


Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions.

Mehta AP, Abdelwahed SH, Mahanta N, Fedoseyenko D, Philmus B, Cooper LE, Liu Y, Jhulki I, Ealick SE, Begley TP.

J Biol Chem. 2015 Feb 13;290(7):3980-6. doi: 10.1074/jbc.R114.623793. Epub 2014 Dec 4. Review.


Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate.

Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O.

J Am Chem Soc. 2012 Nov 7;134(44):18173-6. doi: 10.1021/ja307762b. Epub 2012 Oct 24.


Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate.

Lai RY, Huang S, Fenwick MK, Hazra A, Zhang Y, Rajashankar K, Philmus B, Kinsland C, Sanders JM, Ealick SE, Begley TP.

J Am Chem Soc. 2012 Jun 6;134(22):9157-9. doi: 10.1021/ja302474a. Epub 2012 May 24.


RNA-seq analysis reveals that an ECF σ factor, AcsS, regulates achromobactin biosynthesis in Pseudomonas syringae pv. syringae B728a.

Greenwald JW, Greenwald CJ, Philmus BJ, Begley TP, Gross DC.

PLoS One. 2012;7(4):e34804. doi: 10.1371/journal.pone.0034804. Epub 2012 Apr 18.


Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.

Philmus B, Abdelwahed S, Williams HJ, Fenwick MK, Ealick SE, Begley TP.

J Am Chem Soc. 2012 Mar 21;134(11):5326-30. doi: 10.1021/ja211759n. Epub 2012 Mar 9.


Genetic variation of adenylation domains of the anabaenopeptin synthesis operon and evolution of substrate promiscuity.

Christiansen G, Philmus B, Hemscheidt T, Kurmayer R.

J Bacteriol. 2011 Aug;193(15):3822-31. doi: 10.1128/JB.00360-11. Epub 2011 May 27.


A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism.

Pribat A, Blaby IK, Lara-Núñez A, Jeanguenin L, Fouquet R, Frelin O, Gregory JF 3rd, Philmus B, Begley TP, de Crécy-Lagard V, Hanson AD.

Funct Integr Genomics. 2011 Sep;11(3):467-78. doi: 10.1007/s10142-011-0224-5. Epub 2011 May 3.


Toxoflavin lyase requires a novel 1-His-2-carboxylate facial triad.

Fenwick MK, Philmus B, Begley TP, Ealick SE.

Biochemistry. 2011 Feb 15;50(6):1091-100. doi: 10.1021/bi101741v. Epub 2011 Jan 20.


Substrate specificity and scope of MvdD, a GRASP-like ligase from the microviridin biosynthetic gene cluster.

Philmus B, Guerrette JP, Hemscheidt TK.

ACS Chem Biol. 2009 Jun 19;4(6):429-34. doi: 10.1021/cb900088r.


Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8.

Okumura HS, Philmus B, Portmann C, Hemscheidt TK.

J Nat Prod. 2009 Jan;72(1):172-6. doi: 10.1021/np800557m.


Post-translational modification in microviridin biosynthesis.

Philmus B, Christiansen G, Yoshida WY, Hemscheidt TK.

Chembiochem. 2008 Dec 15;9(18):3066-73. doi: 10.1002/cbic.200800560.


Nontoxic strains of cyanobacteria are the result of major gene deletion events induced by a transposable element.

Christiansen G, Molitor C, Philmus B, Kurmayer R.

Mol Biol Evol. 2008 Aug;25(8):1695-704. doi: 10.1093/molbev/msn120. Epub 2008 May 22.

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