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Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology.

Mäki-Marttunen T, Devor A, Phillips WA, Dale AM, Andreassen OA, Einevoll GT.

Front Comput Neurosci. 2019 Sep 26;13:66. doi: 10.3389/fncom.2019.00066. eCollection 2019.


Tension Band Plate (TBP)-guided Hemiepiphysiodesis in Blount Disease: 10-Year Single-center Experience With a Systematic Review of Literature.

Jain MJ, Inneh IA, Zhu H, Phillips WA.

J Pediatr Orthop. 2019 Apr 23. doi: 10.1097/BPO.0000000000001393. [Epub ahead of print]


Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations.

Mitchell CB, Phillips WA.

Biomolecules. 2019 Apr 23;9(4). pii: E158. doi: 10.3390/biom9040158. Review.


MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer.

ElMokh O, Taelman V, Radojewski P, Roelli MA, Stoss A, Dumont RA, Dettmer MS, Phillips WA, Walter MA, Charles RP.

J Nucl Med. 2019 Jul;60(7):917-923. doi: 10.2967/jnumed.118.216721. Epub 2018 Nov 21.


TGF-beta signaling and its targeted therapy in gastrointestinal cancers.

Gotovac JR, Fujihara KM, Phillips WA, Clemons NJ.

Discov Med. 2018 Sep;26(142):103-112. Review.


TP53 is not a prognostic marker-clinical consequences of a generally disregarded fact.

Braunschmid T, Kührer I, Mittlböck M, Westerhoff M, Kappel-Latif S, Brammen L, Krishnadath KK, Phillips WA, Gnant M, Kandioler D.

Ann N Y Acad Sci. 2018 Dec;1434(1):46-53. doi: 10.1111/nyas.13947. Epub 2018 Aug 15. Review.


Evaluation of Serum Glycoprotein Biomarker Candidates for Detection of Esophageal Adenocarcinoma and Surveillance of Barrett's Esophagus.

Shah AK, Hartel G, Brown I, Winterford C, Na R, Cao KL, Spicer BA, Dunstone MA, Phillips WA, Lord RV, Barbour AP, Watson DI, Joshi V, Whiteman DC, Hill MM.

Mol Cell Proteomics. 2018 Dec;17(12):2324-2334. doi: 10.1074/mcp.RA118.000734. Epub 2018 Aug 10.


Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State.

Phillips WA, Bachmann T, Storm JF.

Front Neural Circuits. 2018 Jul 2;12:50. doi: 10.3389/fncir.2018.00050. eCollection 2018. Review.


Identification of microRNA Biomarkers of Response to Neoadjuvant Chemoradiotherapy in Esophageal Adenocarcinoma Using Next Generation Sequencing.

Chiam K, Mayne GC, Watson DI, Woodman RJ, Bright TF, Michael MZ, Karapetis CS, Irvine T, Phillips WA, Hummel R, Wang T, Pimlott LK, Marri S, Astill DS, Ruszkiewicz AR, Thompson SK, Hussey DJ.

Ann Surg Oncol. 2018 Sep;25(9):2731-2738. doi: 10.1245/s10434-018-6626-z. Epub 2018 Jul 9.


Preclinical models for the study of Barrett's carcinogenesis.

Read MD, Krishnadath KK, Clemons NJ, Phillips WA.

Ann N Y Acad Sci. 2018 Dec;1434(1):139-148. doi: 10.1111/nyas.13916. Epub 2018 Jul 5. Review.


PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein.

Daniel PM, Filiz G, Brown DV, Christie M, Waring PM, Zhang Y, Haynes JM, Pouton C, Flanagan D, Vincan E, Johns TG, Montgomery K, Phillips WA, Mantamadiotis T.

Neuro Oncol. 2018 Sep 3;20(10):1344-1355. doi: 10.1093/neuonc/noy068.


Feed efficiency of tropically adapted cattle when fed in winter or spring in a temperate location.

Coleman SW, Chase CC, Phillips WA, Riley DG.

J Anim Sci. 2018 Jun 4;96(6):2438-2452. doi: 10.1093/jas/sky138.


Implications of Information Theory for Computational Modeling of Schizophrenia.

Silverstein SM, Wibral M, Phillips WA.

Comput Psychiatr. 2017 Oct 1;1:82-101. doi: 10.1162/CPSY_a_00004. eCollection 2017 Oct.


Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.


Salvage Surgery for Locoregional Failure in Anal Squamous Cell Carcinoma.

Guerra GR, Kong JC, Bernardi MP, Ramsay RG, Phillips WA, Warrier SK, Lynch AC, Ngan SY, Heriot AG.

Dis Colon Rectum. 2018 Feb;61(2):179-186. doi: 10.1097/DCR.0000000000001010.


Evaluation of tropically adapted straightbred and crossbred beef cattle: Cortisol concentration and measures of temperament at weaning and transport.

Chase CC, Randel RD, Riley DG, Coleman SW, Phillips WA.

J Anim Sci. 2017 Dec;95(12):5253-5262. doi: 10.2527/jas2017.1924.


PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors.

Roelli MA, Ruffieux-Daidié D, Stooss A, ElMokh O, Phillips WA, Dettmer MS, Charles RP.

Oncotarget. 2017 Oct 11;8(61):103207-103222. doi: 10.18632/oncotarget.21732. eCollection 2017 Nov 28.


Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B.

Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4.


Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers.

Clemons NJ, Liu DS, Duong CP, Phillips WA.

Mol Cell Oncol. 2017 Jul 5;4(5):e1344757. doi: 10.1080/23723556.2017.1344757. eCollection 2017.


Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer.

Teo ZL, Versaci S, Dushyanthen S, Caramia F, Savas P, Mintoff CP, Zethoven M, Virassamy B, Luen SJ, McArthur GA, Phillips WA, Darcy PK, Loi S.

Cancer Res. 2017 Nov 15;77(22):6340-6352. doi: 10.1158/0008-5472.CAN-17-2210. Epub 2017 Sep 25.


Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

ElMokh O, Ruffieux-Daidié D, Roelli MA, Stooss A, Phillips WA, Gertsch J, Dettmer MS, Charles RP.

Oncotarget. 2017 Apr 11;8(15):24604-24620. doi: 10.18632/oncotarget.15599.


Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation.

Liu DS, Duong CP, Haupt S, Montgomery KG, House CM, Azar WJ, Pearson HB, Fisher OM, Read M, Guerra GR, Haupt Y, Cullinane C, Wiman KG, Abrahmsen L, Phillips WA, Clemons NJ.

Nat Commun. 2017 Mar 28;8:14844. doi: 10.1038/ncomms14844.


Preclinical models of esophageal adenocarcinoma for drug development.

Liu DS, Duong CP, Phillips WA, Clemons NJ.

Discov Med. 2016 Dec;22(123):371-379. Review.


Editorial to the special issue on perspectives on human probabilistic inference and the 'Bayesian brain'.

Kwisthout J, Phillips WA, Seth AK, van Rooij I, Clark A.

Brain Cogn. 2017 Mar;112:1-2. doi: 10.1016/j.bandc.2016.12.002. Epub 2016 Dec 24. No abstract available.


Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis.

Liu DS, Hoefnagel SJ, Fisher OM, Krishnadath KK, Montgomery KG, Busuttil RA, Colebatch AJ, Read M, Duong CP, Phillips WA, Clemons NJ.

Oncotarget. 2016 Dec 13;7(50):83342-83358. doi: 10.18632/oncotarget.13391.


The effects of arousal on apical amplification and conscious state.

Phillips WA, Larkum ME, Harley CW, Silverstein SM.

Neurosci Conscious. 2016 Sep 11;2016(1):niw015. doi: 10.1093/nc/niw015. eCollection 2016. Review.


Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.

Denoyer D, Pearson HB, Clatworthy SA, Smith ZM, Francis PS, Llanos RM, Volitakis I, Phillips WA, Meggyesy PM, Masaldan S, Cater MA.

Oncotarget. 2016 Jun 14;7(24):37064-37080. doi: 10.18632/oncotarget.9245.


Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B.

Sci Transl Med. 2016 Mar 30;8(332):332ra43. doi: 10.1126/scitranslmed.aad9982.


The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

To H, Clemons NJ, Duong CP, Trainer AH, Phillips WA.

Dig Dis Sci. 2016 Jul;61(7):1826-34. doi: 10.1007/s10620-016-4109-2. Epub 2016 Mar 12. Review.


Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma.

Krause L, Nones K, Loffler KA, Nancarrow D, Oey H, Tang YH, Wayte NJ, Patch AM, Patel K, Brosda S, Manning S, Lampe G, Clouston A, Thomas J, Stoye J, Hussey DJ, Watson DI, Lord RV, Phillips WA, Gotley D, Smithers BM, Whiteman DC, Hayward NK, Grimmond SM, Waddell N, Barbour AP.

Carcinogenesis. 2016 Apr;37(4):356-65. doi: 10.1093/carcin/bgw018. Epub 2016 Feb 10.


Does arousal enhance apical amplification and disamplification?

Larkum ME, Phillips WA.

Behav Brain Sci. 2016 Jan;39:e215. doi: 10.1017/S0140525X15001867.


Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.

Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA.

Lancet Oncol. 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. Review.


Predicting pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review.

Ryan JE, Warrier SK, Lynch AC, Ramsay RG, Phillips WA, Heriot AG.

Colorectal Dis. 2016 Mar;18(3):234-46. doi: 10.1111/codi.13207. Review.


Partial information decomposition as a unified approach to the specification of neural goal functions.

Wibral M, Priesemann V, Kay JW, Lizier JT, Phillips WA.

Brain Cogn. 2017 Mar;112:25-38. doi: 10.1016/j.bandc.2015.09.004. Epub 2015 Oct 21.


Cognitive functions of intracellular mechanisms for contextual amplification.

Phillips WA.

Brain Cogn. 2017 Mar;112:39-53. doi: 10.1016/j.bandc.2015.09.005. Epub 2015 Oct 1.


The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.

Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P, Humbert P.

Mol Cancer. 2015 Sep 17;14:169. doi: 10.1186/s12943-015-0440-z.


Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.

Van Keymeulen A, Lee MY, Ousset M, Brohée S, Rorive S, Giraddi RR, Wuidart A, Bouvencourt G, Dubois C, Salmon I, Sotiriou C, Phillips WA, Blanpain C.

Nature. 2015 Sep 3;525(7567):119-23. doi: 10.1038/nature14665. Epub 2015 Aug 12.


APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.

Liu DS, Read M, Cullinane C, Azar WJ, Fennell CM, Montgomery KG, Haupt S, Haupt Y, Wiman KG, Duong CP, Clemons NJ, Phillips WA.

Gut. 2015 Oct;64(10):1506-16. doi: 10.1136/gutjnl-2015-309770. Epub 2015 Jul 17.


Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.

Hare LM, Schwarz Q, Wiszniak S, Gurung R, Montgomery KG, Mitchell CA, Phillips WA.

Dev Biol. 2015 Aug 1;404(1):14-26. doi: 10.1016/j.ydbio.2015.04.022. Epub 2015 May 7.


On the functions, mechanisms, and malfunctions of intracortical contextual modulation.

Phillips WA, Clark A, Silverstein SM.

Neurosci Biobehav Rev. 2015 May;52:1-20. doi: 10.1016/j.neubiorev.2015.02.010. Epub 2015 Feb 23. Review.


Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts.

Read M, Liu D, Duong CP, Cullinane C, Murray WK, Fennell CM, Shortt J, Westerman D, Burton P, Clemons NJ, Phillips WA.

Ann Surg Oncol. 2016 Jan;23(1):305-11. doi: 10.1245/s10434-015-4425-3. Epub 2015 Feb 18.


Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

Kinross KM, Montgomery KG, Mangiafico SP, Hare LM, Kleinschmidt M, Bywater MJ, Poulton IJ, Vrahnas C, Henneicke H, Malaterre J, Waring PM, Cullinane C, Sims NA, McArthur GA, Andrikopoulos S, Phillips WA.

FASEB J. 2015 Apr;29(4):1426-34. doi: 10.1096/fj.14-262782. Epub 2014 Dec 30.


PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma.

Deuker MM, Marsh Durban V, Phillips WA, McMahon M.

Cancer Discov. 2015 Feb;5(2):143-53. doi: 10.1158/2159-8290.CD-14-0856. Epub 2014 Dec 3.


Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

Nones K, Waddell N, Wayte N, Patch AM, Bailey P, Newell F, Holmes O, Fink JL, Quinn MCJ, Tang YH, Lampe G, Quek K, Loffler KA, Manning S, Idrisoglu S, Miller D, Xu Q, Waddell N, Wilson PJ, Bruxner TJC, Christ AN, Harliwong I, Nourse C, Nourbakhsh E, Anderson M, Kazakoff S, Leonard C, Wood S, Simpson PT, Reid LE, Krause L, Hussey DJ, Watson DI, Lord RV, Nancarrow D, Phillips WA, Gotley D, Smithers BM, Whiteman DC, Hayward NK, Campbell PJ, Pearson JV, Grimmond SM, Barbour AP.

Nat Commun. 2014 Oct 29;5:5224. doi: 10.1038/ncomms6224.


Translational research on Barrett's esophagus.

Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X.

Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531.


Molecular epidemiology of and genetic susceptibility to esophageal cancer.

Bajpai M, Das KM, Lefferts J, Lisovsky M, Mashimo H, Phillips WA, Srivastava A, To H.

Ann N Y Acad Sci. 2014 Sep;1325:40-8. doi: 10.1111/nyas.12517.


Esophageal stem cells and genetics/epigenetics in esophageal cancer.

Croagh D, Frede J, Jones PH, Kaur P, Partensky C, Phillips WA.

Ann N Y Acad Sci. 2014 Sep;1325:8-14. doi: 10.1111/nyas.12521.


PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data.

Zardavas D, Phillips WA, Loi S.

Breast Cancer Res. 2014 Jan 23;16(1):201. doi: 10.1186/bcr3605. Review.


Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation.

Daniel P, Filiz G, Brown DV, Hollande F, Gonzales M, D'Abaco G, Papalexis N, Phillips WA, Malaterre J, Ramsay RG, Mantamadiotis T.

Oncogenesis. 2014 Jun 30;3:e108. doi: 10.1038/oncsis.2014.21.


Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.

Charles RP, Silva J, Iezza G, Phillips WA, McMahon M.

Mol Cancer Res. 2014 Jul;12(7):979-86. doi: 10.1158/1541-7786.MCR-14-0158-T. Epub 2014 Apr 25.

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