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Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification.

Song H, Rogers NJ, Allison SJ, Brabec V, Bridgewater H, Kostrhunova H, Markova L, Phillips RM, Pinder EC, Shepherd SL, Young LS, Zajac J, Scott P.

Chem Sci. 2019 Jul 18;10(37):8547-8557. doi: 10.1039/c9sc02651g. eCollection 2019 Oct 7.


Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy.

Johansson H, Hussain O, Allison SJ, Robinson TV, Phillips RM, Sejer Pedersen D.

ChemMedChem. 2019 Nov 26. doi: 10.1002/cmdc.201900578. [Epub ahead of print]


Metastasis-Directed Therapy in Prostate Cancer. Why, When, and How?

Phillips RM, Deek MP, Deweese TL, Tran PT.

Oncology (Williston Park). 2019 Oct 28;33(10). pii: 686509.


Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models.

Jove M, Spencer JA, Hubbard ME, Holden EC, O'Dea RD, Brook BS, Phillips RM, Smye SW, Loadman PM, Twelves CJ.

J Pharmacol Exp Ther. 2019 Aug;370(2):242-251. doi: 10.1124/jpet.119.256693. Epub 2019 Jun 12.


Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations.

Phillips RM, Lam C, Wang H, Tran PT.

Adv Cancer Res. 2019;142:23-62. doi: 10.1016/bs.acr.2019.01.002. Epub 2019 Feb 27.


Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer.

Phillips RM, Loadman PM, Reddy G.

Cancer Chemother Pharmacol. 2019 Jun;83(6):1183-1189. doi: 10.1007/s00280-019-03812-7. Epub 2019 Mar 13.


Is Androgen Deprivation Therapy "Another Deficient Therapy" for Gleason Score 9-10 Prostate Cancer?

Deek MP, Phillips RM, Haffner M, Tran PT.

Eur Urol. 2019 Jan;75(1):42-43. doi: 10.1016/j.eururo.2018.09.027. Epub 2018 Sep 26. No abstract available.


Corrigendum to "Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands" [Canc. Lett. 403 (2017) 98-107].

Allison SJ, Sadiq M, Baronou E, Cooper PA, Dunnill C, Georgopoulos NT, Latif A, Shepherd S, Shnyder SD, Stratford IJ, Wheelhouse RT, Willans CE, Phillips RM.

Cancer Lett. 2018 Sep 1;431:247. doi: 10.1016/j.canlet.2018.06.022. Epub 2018 Jun 19. No abstract available.


Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells.

Allison SJ, Cooke D, Davidson FS, Elliott PIP, Faulkner RA, Griffiths HBS, Harper OJ, Hussain O, Owen-Lynch PJ, Phillips RM, Rice CR, Shepherd SL, Wheelhouse RT.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9799-9804. doi: 10.1002/anie.201805510. Epub 2018 Jul 3.


Reply to J.-E. Bibault et al, B. Tombal, and C. Cattrini et al.

Tran PT, Hayman J, Phillips RM.

J Clin Oncol. 2018 Aug 1;36(22):2352-2353. doi: 10.1200/JCO.2018.78.2151. Epub 2018 Jun 1. No abstract available.


Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Perego P, Hempel G, Linder S, Bradshaw TD, Larsen AK, Peters GJ, Phillips RM; EORTC PAMM Group.

Cancer Chemother Pharmacol. 2018 Mar;81(3):427-441. doi: 10.1007/s00280-017-3502-7. Epub 2017 Dec 28. Review.


STOMPing Out Hormone-Sensitive Metastases With Local Therapies in Prostate Cancer.

Phillips RM, Hayman J, Tran PT.

J Clin Oncol. 2018 Feb 10;36(5):435-437. doi: 10.1200/JCO.2017.76.5495. Epub 2017 Dec 14. No abstract available.


Complete biochemical response after stereotactic ablative radiotherapy of an isolated prostate cancer pelvic soft tissue recurrence detected by 18F-DCFPyL PET/CT.

Phillips RM, Gorin MA, Rowe SP, Pomper MG, Pienta KJ, Ross AE, Tran PT.

Urol Case Rep. 2017 Nov 22;16:86-88. doi: 10.1016/j.eucr.2017.11.021. eCollection 2018 Jan. No abstract available.


Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer.

Phillips RM, Hendriks HR, Sweeney JB, Reddy G, Peters GJ.

Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):783-791. doi: 10.1080/17425255.2017.1341490. Epub 2017 Jul 3. Review.


Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands.

Allison SJ, Sadiq M, Baronou E, Cooper PA, Dunnill C, Georgopoulos NT, Latif A, Shepherd S, Shnyder SD, Stratford IJ, Wheelhouse RT, Willans CE, Phillips RM.

Cancer Lett. 2017 Sep 10;403:98-107. doi: 10.1016/j.canlet.2017.04.041. Epub 2017 Jun 15. Erratum in: Cancer Lett. 2018 Sep 1;431:247.


Drug delivery in a tumour cord model: a computational simulation.

Hubbard ME, Jove M, Loadman PM, Phillips RM, Twelves CJ, Smye SW.

R Soc Open Sci. 2017 May 24;4(5):170014. doi: 10.1098/rsos.170014. eCollection 2017 May.


Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity.

Basri AM, Lord RM, Allison SJ, Rodríguez-Bárzano A, Lucas SJ, Janeway FD, Shepherd HJ, Pask CM, Phillips RM, McGowan PC.

Chemistry. 2017 May 5;23(26):6341-6356. doi: 10.1002/chem.201605960. Epub 2017 Apr 7.


Development and characterization of a microfluidic model of the tumour microenvironment.

Ayuso JM, Virumbrales-Muñoz M, Lacueva A, Lanuza PM, Checa-Chavarria E, Botella P, Fernández E, Doblare M, Allison SJ, Phillips RM, Pardo J, Fernandez LJ, Ochoa I.

Sci Rep. 2016 Oct 31;6:36086. doi: 10.1038/srep36086.


Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes.

Lucas SJ, Lord RM, Basri AM, Allison SJ, Phillips RM, Blacker AJ, McGowan PC.

Dalton Trans. 2016 Apr 28;45(16):6812-5. doi: 10.1039/c6dt00186f.


Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Javid FA, Phillips RM, Afshinjavid S, Verde R, Ligresti A.

Eur J Pharmacol. 2016 Mar 15;775:1-14. doi: 10.1016/j.ejphar.2016.02.010. Epub 2016 Feb 5. Review.


Anticancer metallohelices: nanomolar potency and high selectivity.

Kaner RA, Allison SJ, Faulkner AD, Phillips RM, Roper DI, Shepherd SL, Simpson DH, Waterfield NR, Scott P.

Chem Sci. 2016 Feb 1;7(2):951-958. doi: 10.1039/c5sc03677a. Epub 2015 Oct 26.


Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs.

Phillips RM.

Cancer Chemother Pharmacol. 2016 Mar;77(3):441-57. doi: 10.1007/s00280-015-2920-7. Epub 2016 Jan 25. Review.


Soap is not enough: handwashing practices and knowledge in refugee camps, Maban County, South Sudan.

Phillips RM, Vujcic J, Boscoe A, Handzel T, Aninyasi M, Cookson ST, Blanton C, S Blum L, Ram PK.

Confl Health. 2015 Dec 20;9:39. doi: 10.1186/s13031-015-0065-2. eCollection 2015.


Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis.

Lord RM, Hebden AJ, Pask CM, Henderson IR, Allison SJ, Shepherd SL, Phillips RM, McGowan PC.

J Med Chem. 2015 Jun 25;58(12):4940-53. doi: 10.1021/acs.jmedchem.5b00455. Epub 2015 Jun 8.


Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine.

Mohamed HA, Lake BR, Laing T, Phillips RM, Willans CE.

Dalton Trans. 2015 Apr 28;44(16):7563-9. doi: 10.1039/c4dt03679d.


Synthesis and anticancer activity evaluation of η(5)-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands.

Rodríguez-Bárzano A, Lord RM, Basri AM, Phillips RM, Blacker AJ, McGowan PC.

Dalton Trans. 2015 Feb 21;44(7):3265-70. doi: 10.1039/c4dt02748e.


Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

Ramirez YP, Mladek AC, Phillips RM, Gynther M, Rautio J, Ross AH, Wheelhouse RT, Sakaria JN.

Mol Cancer Ther. 2015 Jan;14(1):111-9. doi: 10.1158/1535-7163.MCT-14-0113. Epub 2014 Oct 28.


Asymmetric triplex metallohelices with high and selective activity against cancer cells.

Faulkner AD, Kaner RA, Abdallah QM, Clarkson G, Fox DJ, Gurnani P, Howson SE, Phillips RM, Roper DI, Simpson DH, Scott P.

Nat Chem. 2014 Sep;6(9):797-803. doi: 10.1038/nchem.2024. Epub 2014 Aug 3.


Creative classroom strategies for teaching nursing research.

Phillips RM.

Nurse Educ. 2014 Jul-Aug;39(4):199-201. doi: 10.1097/NNE.0000000000000052.


Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways.

Allison SJ, Knight JR, Granchi C, Rani R, Minutolo F, Milner J, Phillips RM.

Oncogenesis. 2014 May 12;3:e102. doi: 10.1038/oncsis.2014.16.


Mechanistic and cytotoxicity studies of group IV β-diketonate complexes.

Lord RM, Mannion JJ, Hebden AJ, Nako AE, Crossley BD, McMullon MW, Janeway FD, Phillips RM, McGowan PC.

ChemMedChem. 2014 Jun;9(6):1136-9. doi: 10.1002/cmdc.201402019. Epub 2014 Apr 29.


Mathematical and computational models of drug transport in tumours.

Groh CM, Hubbard ME, Jones PF, Loadman PM, Periasamy N, Sleeman BD, Smye SW, Twelves CJ, Phillips RM.

J R Soc Interface. 2014 Mar 12;11(94):20131173. doi: 10.1098/rsif.2013.1173. Print 2014 May 6.


Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.

Viney JM, Andrew DP, Phillips RM, Meiser A, Patel P, Lennartz-Walker M, Cousins DJ, Barton NP, Hall DA, Pease JE.

J Immunol. 2014 Apr 1;192(7):3419-27. doi: 10.4049/jimmunol.1300232. Epub 2014 Feb 21.


Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents.

Almodares Z, Lucas SJ, Crossley BD, Basri AM, Pask CM, Hebden AJ, Phillips RM, McGowan PC.

Inorg Chem. 2014 Jan 21;53(2):727-36. doi: 10.1021/ic401529u. Epub 2014 Jan 7.


Ex vivo chemical cytometric analysis of protein tyrosine phosphatase activity in single human airway epithelial cells.

Phillips RM, Dailey LA, Bair E, Samet JM, Allbritton NL.

Anal Chem. 2014 Jan 21;86(2):1291-7. doi: 10.1021/ac403705c. Epub 2013 Dec 31.


Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors.

Ahmadi M, Ahmadihosseini Z, Allison SJ, Begum S, Rockley K, Sadiq M, Chintamaneni S, Lokwani R, Hughes N, Phillips RM.

Br J Pharmacol. 2014 Jan;171(1):224-36. doi: 10.1111/bph.12438.


Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.

Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W, Cravatt BF, Parise LV.

Chem Biol. 2013 Sep 19;20(9):1125-34. doi: 10.1016/j.chembiol.2013.07.011. Epub 2013 Aug 29.


Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

Pletsas D, Garelnabi EA, Li L, Phillips RM, Wheelhouse RT.

J Med Chem. 2013 Sep 12;56(17):7120-32. doi: 10.1021/jm401121k. Epub 2013 Aug 16.


Multidisciplinary guidelines for the care of late preterm infants.

Phillips RM, Goldstein M, Hougland K, Nandyal R, Pizzica A, Santa-Donato A, Staebler S, Stark AR, Treiger TM, Yost E; National Perinatal Association.

J Perinatol. 2013 Jul;33 Suppl 2:S5-22. doi: 10.1038/jp.2013.53. No abstract available.


Multidisciplinary guidelines for the care of late preterm infants. Introduction.

Phillips RM.

J Perinatol. 2013 Jul;33 Suppl 2:S3-4. doi: 10.1038/jp.2013.52. No abstract available.


Measurement of protein tyrosine phosphatase activity in single cells by capillary electrophoresis.

Phillips RM, Bair E, Lawrence DS, Sims CE, Allbritton NL.

Anal Chem. 2013 Jun 18;85(12):6136-42. doi: 10.1021/ac401106e. Epub 2013 May 30.


Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Qiao B, Kerr M, Groselj B, Teo MT, Knowles MA, Bristow RG, Phillips RM, Kiltie AE.

Cancer Res. 2013 Mar 1;73(5):1611-20. doi: 10.1158/0008-5472.CAN-12-1170. Epub 2013 Jan 9.


Carbophilic 3-component cascades: access to complex bioactive cyclopropyl diindolylmethanes.

Groome NM, Elboray EE, Inman MW, Dondas HA, Phillips RM, Kilner C, Grigg R.

Chemistry. 2013 Feb 4;19(6):2180-4. doi: 10.1002/chem.201202647. Epub 2012 Dec 20.


Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

Garelnabi EA, Pletsas D, Li L, Kiakos K, Karodia N, Hartley JA, Phillips RM, Wheelhouse RT.

ACS Med Chem Lett. 2012 Sep 18;3(12):965-8. doi: 10.1021/ml300132t. eCollection 2012 Dec 13.


A hybrid cellular automaton model of solid tumor growth and bioreductive drug transport.

Kazmi N, Hossain MA, Phillips RM.

IEEE/ACM Trans Comput Biol Bioinform. 2012 Nov-Dec;9(6):1595-606. doi: 10.1109/TCBB.2012.118.


Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents.

Lucas SJ, Lord RM, Wilson RL, Phillips RM, Sridharan V, McGowan PC.

Dalton Trans. 2012 Dec 7;41(45):13800-2. doi: 10.1039/c2dt32104a. Epub 2012 Sep 27.


Avascular tumour growth dynamics and the constraints of protein binding for drug transportation.

Kazmi N, Hossain MA, Phillips RM, Al-Mamun MA, Bass R.

J Theor Biol. 2012 Nov 21;313:142-52. doi: 10.1016/j.jtbi.2012.07.026. Epub 2012 Aug 15.


Nutrition and depression in the community-based oldest-old.

Phillips RM.

Home Healthc Nurse. 2012 Sep;30(8):462-71; quiz 472-3. doi: 10.1097/NHH.0b013e31826517ad. Review.


EO9 (Apaziquone): from the clinic to the laboratory and back again.

Phillips RM, Hendriks HR, Peters GJ; EORTC-Pharmacology and Molecular Mechanism Group.

Br J Pharmacol. 2013 Jan;168(1):11-8. doi: 10.1111/j.1476-5381.2012.01996.x. Review.


Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids.

McMahon KM, Volpato M, Chi HY, Musiwaro P, Poterlowicz K, Peng Y, Scally AJ, Patterson LH, Phillips RM, Sutton CW.

J Proteome Res. 2012 May 4;11(5):2863-75. doi: 10.1021/pr2012472. Epub 2012 Mar 30.


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