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Target identification reveals lanosterol synthase as a vulnerability in glioma.

Phillips RE, Yang Y, Smith RC, Thompson BM, Yamasaki T, Soto-Feliciano YM, Funato K, Liang Y, Garcia-Bermudez J, Wang X, Garcia BA, Yamasaki K, McDonald JG, Birsoy K, Tabar V, Allis CD.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7957-7962. doi: 10.1073/pnas.1820989116. Epub 2019 Mar 28.


Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis-Specific T-Cell Responses.

Murray LW, Satti I, Meyerowitz J, Jones M, Willberg CB, Ussher JE, Goedhals D, Hurst J, Phillips RE, McShane H, Vuuren CV, Frater J.

J Infect Dis. 2018 May 5;217(11):1782-1792. doi: 10.1093/infdis/jiy052.


Religious Coping with Sexual Stigma in Young Adults with Same-Sex Attractions.

Lauricella SK, Phillips RE 3rd, Dubow EF.

J Relig Health. 2017 Aug;56(4):1436-1449. doi: 10.1007/s10943-017-0374-4.


TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells.

Ussher JE, van Wilgenburg B, Hannaway RF, Ruustal K, Phalora P, Kurioka A, Hansen TH, Willberg CB, Phillips RE, Klenerman P.

Eur J Immunol. 2016 Jul;46(7):1600-14. doi: 10.1002/eji.201545969. Epub 2016 May 30.


LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Llibre A, López-Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD, Walker LJ, Milne P, Phillips RE, Kelly DF, Freeman GJ, El Shikh ME, Klenerman P, Willberg CB.

J Immunol. 2016 Mar 1;196(5):2085-94. doi: 10.4049/jimmunol.1502462. Epub 2016 Feb 1.


Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.

Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C, Koelsch KK, Robinson N, Brown H, Fisher M, Kinloch S, Cooper DA, Schechter M, Tambussi G, Fidler S, Babiker A, Weber J, Kelleher AD, Phillips RE, Frater J.

Nat Commun. 2015 Oct 9;6:8495. doi: 10.1038/ncomms9495.


Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study.

Ussher JE, Phalora P, Cosgrove C, Hannaway RF, Rauch A, Günthard HF, Goulder P, Phillips RE, Willberg CB, Klenerman P.

Medicine (Baltimore). 2015 Jul;94(29):e1134. doi: 10.1097/MD.0000000000001134.


Management of late extraneural recurrence of medulloblastoma without high-dose chemotherapy.

Phillips RE, Curran KJ, Khakoo Y.

J Neurooncol. 2015 Sep;124(3):523-4. doi: 10.1007/s11060-015-1850-x. Epub 2015 Jun 27. No abstract available.


Structured observations reveal slow HIV-1 CTL escape.

Roberts HE, Hurst J, Robinson N, Brown H, Flanagan P, Vass L, Fidler S, Weber J, Babiker A, Phillips RE, McLean AR, Frater J; SPARTAC trial investigators.

PLoS Genet. 2015 Feb 2;11(2):e1004914. doi: 10.1371/journal.pgen.1004914. eCollection 2015 Feb.


HIV-1 DNA predicts disease progression and post-treatment virological control.

Williams JP, Hurst J, Stöhr W, Robinson N, Brown H, Fisher M, Kinloch S, Cooper D, Schechter M, Tambussi G, Fidler S, Carrington M, Babiker A, Weber J, Koelsch KK, Kelleher AD, Phillips RE, Frater J; SPARTACTrial Investigators.

Elife. 2014 Sep 12;3:e03821. doi: 10.7554/eLife.03821.


HIV-1-specific CD4(+) responses in primary HIV-1 infection predict disease progression.

Frater J, Ewings F, Hurst J, Brown H, Robinson N, Fidler S, Babiker A, Weber J, Porter K, Phillips RE; SPARTAC Trial Investigators.

AIDS. 2014 Mar 13;28(5):699-708. doi: 10.1097/QAD.0000000000000130.


Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy.

Stöhr W, Fidler S, McClure M, Weber J, Cooper D, Ramjee G, Kaleebu P, Tambussi G, Schechter M, Babiker A, Phillips RE, Porter K, Frater J.

PLoS One. 2013 Oct 25;8(10):e78287. doi: 10.1371/journal.pone.0078287. eCollection 2013.


Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell transplant recipient.

Awosika OO, Lyons JL, Ciarlini P, Phillips RE, Alfson ED, Johnson EL, Koo S, Marty F, Drew C, Zaki S, Folkerth RD, Klein JP.

Neurology. 2013 Apr 30;80(18):1715-7. doi: 10.1212/WNL.0b013e3182904f96. Epub 2013 Apr 17. No abstract available.


Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.

Cosgrove C, Ussher JE, Rauch A, Gärtner K, Kurioka A, Hühn MH, Adelmann K, Kang YH, Fergusson JR, Simmonds P, Goulder P, Hansen TH, Fox J, Günthard HF, Khanna N, Powrie F, Steel A, Gazzard B, Phillips RE, Frater J, Uhlig H, Klenerman P.

Blood. 2013 Feb 7;121(6):951-61. doi: 10.1182/blood-2012-06-436436. Epub 2012 Dec 18.


HIV-2 encephalitis: case report and literature review.

Wood BR, Klein JP, Lyons JL, Milner DA, Phillips RE, Schutten M, Folkerth RD, Ciarlini P, Henrich TJ, Johnson JA.

AIDS Patient Care STDS. 2012 Jul;26(7):383-7. doi: 10.1089/apc.2012.0048. Epub 2012 Jun 13. Review.


Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.

Fryer HR, Frater J, Duda A, Palmer D, Phillips RE, McLean AR.

J Virol. 2012 Aug;86(16):8568-80. doi: 10.1128/JVI.07020-11. Epub 2012 Jun 6.


Beating atomic swords into immunological ploughshares.

Frater J, Hurst J, Phillips RE.

Immunity. 2011 Jul 22;35(1):10-2. doi: 10.1016/j.immuni.2011.07.005.


Modelling the evolution and spread of HIV immune escape mutants.

Fryer HR, Frater J, Duda A, Roberts MG; SPARTAC Trial Investigators, Phillips RE, McLean AR.

PLoS Pathog. 2010 Nov 18;6(11):e1001196. doi: 10.1371/journal.ppat.1001196.


B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection.

Huang KH, Bonsall D, Katzourakis A, Thomson EC, Fidler SJ, Main J, Muir D, Weber JN, Frater AJ, Phillips RE, Pybus OG, Goulder PJ, McClure MO, Cooke GS, Klenerman P.

Nat Commun. 2010 Oct 19;1:102. doi: 10.1038/ncomms1100.


What have we learnt from experimental renal transplantation?

Brown K, Phillips RE, Wong W.

Nephron Exp Nephrol. 2010;115(1):e9-e14. doi: 10.1159/000309420. Epub 2010 Apr 14. Review.


HLA-associated clinical progression correlates with epitope reversion rates in early human immunodeficiency virus infection.

Duda A, Lee-Turner L, Fox J, Robinson N, Dustan S, Kaye S, Fryer H, Carrington M, McClure M, McLean AR, Fidler S, Weber J, Phillips RE, Frater AJ; SPARTAC Trial Investigators.

J Virol. 2009 Feb;83(3):1228-39. doi: 10.1128/JVI.01545-08. Epub 2008 Nov 19.


Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.

Varela-Rohena A, Molloy PE, Dunn SM, Li Y, Suhoski MM, Carroll RG, Milicic A, Mahon T, Sutton DH, Laugel B, Moysey R, Cameron BJ, Vuidepot A, Purbhoo MA, Cole DK, Phillips RE, June CH, Jakobsen BK, Sewell AK, Riley JL.

Nat Med. 2008 Dec;14(12):1390-5. doi: 10.1038/nm.1779. Epub 2008 Nov 9.


Evaluation of a generic brief acculturation scale in a sample of male enlisted naval personnel.

Norris AE, Phillips RE, Kang HP.

Clin Nurse Spec. 2008 Jul-Aug;22(4):172-8. doi: 10.1097/01.NUR.0000311705.38404.14.


Human immunodeficiency virus (HIV)-specific T helper responses fail to predict CD4+ T cell decline following short-course treatment at primary HIV-1 infection.

Fox J, Scriba TJ, Robinson N, Weber JN, Phillips RE, Fidler S.

Clin Exp Immunol. 2008 Jun;152(3):532-7. doi: 10.1111/j.1365-2249.2008.03653.x. Epub 2008 Apr 16.


The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines.

Scriba TJ, Sierro S, Brown EL, Phillips RE, Sewell AK, Massey RC.

Infect Immun. 2008 May;76(5):2164-8. doi: 10.1128/IAI.01699-07. Epub 2008 Mar 10.


Functional impairment of cytomegalovirus specific CD8 T cells predicts high-level replication after renal transplantation.

Mattes FM, Vargas A, Kopycinski J, Hainsworth EG, Sweny P, Nebbia G, Bazeos A, Lowdell M, Klenerman P, Phillips RE, Griffiths PD, Emery VC.

Am J Transplant. 2008 May;8(5):990-9. doi: 10.1111/j.1600-6143.2008.02191.x. Epub 2008 Mar 4. Erratum in: Am J Transplant. 2011 May;11(5):1107.


Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection.

Moxham VF, Karegli J, Phillips RE, Brown KL, Tapmeier TT, Hangartner R, Sacks SH, Wong W.

J Immunol. 2008 Mar 15;180(6):3910-8.


CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation.

Northfield JW, Kasprowicz V, Lucas M, Kersting N, Bengsch B, Kim A, Phillips RE, Walker BD, Thimme R, Lauer G, Klenerman P.

Hepatology. 2008 Feb;47(2):396-406. doi: 10.1002/hep.22040. Erratum in: Hepatology. 2008 Mar;47(3):1102. Bengsh, Bertram [corrected to Bengsch, Bertram].


Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells.

Massey RC, Scriba TJ, Brown EL, Phillips RE, Sewell AK.

Infect Immun. 2007 Dec;75(12):5711-5. Epub 2007 Oct 15.


Measuring the condom use self-efficacy of deployed, enlisted male U.S. Naval personnel.

Norris AE, Phillips RE, Grady K.

J Nurs Meas. 2007;15(1):46-61.


Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

Frater AJ, Brown H, Oxenius A, Günthard HF, Hirschel B, Robinson N, Leslie AJ, Payne R, Crawford H, Prendergast A, Brander C, Kiepiela P, Walker BD, Goulder PJ, McLean A, Phillips RE.

J Virol. 2007 Jun;81(12):6742-51. Epub 2007 Apr 4.


Precise identification of a human immunodeficiency virus type 1 antigen processing mutant.

Zimbwa P, Milicic A, Frater J, Scriba TJ, Willis A, Goulder PJ, Pillay T, Gunthard H, Weber JN, Zhang HT, Phillips RE.

J Virol. 2007 Feb;81(4):2031-8. Epub 2006 Nov 15.


Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection.

Edwards CT, Holmes EC, Pybus OG, Wilson DJ, Viscidi RP, Abrams EJ, Phillips RE, Drummond AJ.

Genetics. 2006 Nov;174(3):1441-53. Epub 2006 Sep 1.


Passive sexual transmission of human immunodeficiency virus type 1 variants and adaptation in new hosts.

Frater AJ, Edwards CT, McCarthy N, Fox J, Brown H, Milicic A, Mackie N, Pillay T, Drijfhout JW, Dustan S, Clarke JR, Holmes EC, Zhang HT, Pfafferott K, Goulder PJ, McClure MO, Weber J, Phillips RE, Fidler S.

J Virol. 2006 Jul;80(14):7226-34.


Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers.

Wooldridge L, Scriba TJ, Milicic A, Laugel B, Gostick E, Price DA, Phillips RE, Sewell AK.

Eur J Immunol. 2006 Jul;36(7):1847-55.


Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1.

Edwards CT, Holmes EC, Wilson DJ, Viscidi RP, Abrams EJ, Phillips RE, Drummond AJ.

BMC Evol Biol. 2006 Mar 23;6:28.


Condom use by male, enlisted, deployed navy personnel with multiple partners.

Norris AE, Phillips RE, Statton MA, Pearson TA.

Mil Med. 2005 Oct;170(10):898-904.


Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining.

Scriba TJ, Purbhoo M, Day CL, Robinson N, Fidler S, Fox J, Weber JN, Klenerman P, Sewell AK, Phillips RE.

J Immunol. 2005 Nov 15;175(10):6334-43.


Sexual transmission of single human immunodeficiency virus type 1 virions encoding highly polymorphic multisite cytotoxic T-lymphocyte escape variants.

Milicic A, Edwards CT, Hué S, Fox J, Brown H, Pillay T, Drijfhout JW, Weber JN, Holmes EC, Fidler SJ, Zhang HT, Phillips RE.

J Virol. 2005 Nov;79(22):13953-62.


CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

Milicic A, Price DA, Zimbwa P, Booth BL, Brown HL, Easterbrook PJ, Olsen K, Robinson N, Gileadi U, Sewell AK, Cerundolo V, Phillips RE.

J Immunol. 2005 Oct 1;175(7):4618-26.


Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.

Pillay T, Zhang HT, Drijfhout JW, Robinson N, Brown H, Khan M, Moodley J, Adhikari M, Pfafferott K, Feeney ME, St John A, Holmes EC, Coovadia HM, Klenerman P, Goulder PJ, Phillips RE.

J Virol. 2005 Sep;79(18):12100-5.


Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.

Joos B, Trkola A, Fischer M, Kuster H, Rusert P, Leemann C, Böni J, Oxenius A, Price DA, Phillips RE, Wong JK, Hirschel B, Weber R, Günthard HF; Swiss HIV Cohort Study.

J Virol. 2005 Jul;79(14):9026-37.


Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacs.

Harcourt GC, Donfield S, Gomperts E, Daar ES, Goulder P Jr, Phillips RE, Klenerman P; Hemophilia Growth and Development Study (HGDS).

AIDS. 2005 Jul 22;19(11):1135-43.


Measuring personal loss among adults coping with serious mental illness.

Stein CH, Dworsky DO, Phillips RE 3rd, Hunt MG.

Community Ment Health J. 2005 Apr;41(2):129-39.


Adaptive evolution in perinatal HIV-1.

Pillay T, Phillips RE.

Best Pract Res Clin Obstet Gynaecol. 2005 Apr;19(2):211-29. Epub 2005 Jan 5. Review.


HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound.

Scriba TJ, Zhang HT, Brown HL, Oxenius A, Tamm N, Fidler S, Fox J, Weber JN, Klenerman P, Day CL, Lucas M, Phillips RE.

J Clin Invest. 2005 Feb;115(2):443-50.


Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS.

Scherer A, Frater J, Oxenius A, Agudelo J, Price DA, Günthard HF, Barnardo M, Perrin L, Hirschel B, Phillips RE, McLean AR; Swiss HIV Cohort Study.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12266-70. Epub 2004 Aug 9.


Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies.

Oxenius A, Price DA, Trkola A, Edwards C, Gostick E, Zhang HT, Easterbrook PJ, Tun T, Johnson A, Waters A, Holmes EC, Phillips RE.

J Infect Dis. 2004 Aug 15;190(4):713-21. Epub 2004 Jul 20.


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