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Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial.

Lai ZW, Kelly R, Winans T, Marchena I, Shadakshari A, Yu J, Dawood M, Garcia R, Tily H, Francis L, Faraone SV, Phillips PE, Perl A.

Lancet. 2018 Mar 24;391(10126):1186-1196. doi: 10.1016/S0140-6736(18)30485-9. Epub 2018 Mar 15.


The Protective Action Encoding of Serotonin Transients in the Human Brain.

Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR, Tatter SB, Ellis TL, Phillips PE, Dayan P, Montague PR.

Neuropsychopharmacology. 2018 May;43(6):1425-1435. doi: 10.1038/npp.2017.304. Epub 2018 Jan 3.


Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.

Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE, Chavkin C.

Nat Commun. 2017 Sep 29;8(1):743. doi: 10.1038/s41467-017-00791-2.


Dopamine Encodes Retrospective Temporal Information in a Context-Independent Manner.

Fonzi KM, Lefner MJ, Phillips PEM, Wanat MJ.

Cell Rep. 2017 Aug 22;20(8):1765-1774. doi: 10.1016/j.celrep.2017.07.076.


Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.

Rodeberg NT, Sandberg SG, Johnson JA, Phillips PE, Wightman RM.

ACS Chem Neurosci. 2017 Feb 15;8(2):221-234. doi: 10.1021/acschemneuro.6b00393. Epub 2017 Feb 9. Review.


Temperature gradient scale length measurement: A high accuracy application of electron cyclotron emission without calibration.

Houshmandyar S, Yang ZJ, Phillips PE, Rowan WL, Hubbard AE, Rice JE, Hughes JW, Wolfe SM.

Rev Sci Instrum. 2016 Nov;87(11):11E101.


Physics design of the in-vessel collection optics for the ITER electron cyclotron emission diagnostic.

Rowan WL, Houshmandyar S, Phillips PE, Austin ME, Beno JH, Hubbard AE, Khodak A, Ouroua A, Taylor G.

Rev Sci Instrum. 2016 Nov;87(11):11E132.


Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.

Pes R, Godar SC, Fox AT, Burgeno LM, Strathman HJ, Jarmolowicz DP, Devoto P, Levant B, Phillips PE, Fowler SC, Bortolato M.

Neuropharmacology. 2017 Mar 1;114:77-87. doi: 10.1016/j.neuropharm.2016.11.014. Epub 2016 Nov 23.


Validation of a gauze sponge sampling methodology to detect Tritrichomonas foetus by real-time PCR.

Dewell GA, Phillips PE, Dohlman TM, Harmon KM, Gauger PC.

J Vet Diagn Invest. 2016 Sep;28(5):595-8. doi: 10.1177/1040638716653637. Epub 2016 Jul 7.


Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior.

Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS, Zweifel LS.

Cell Rep. 2016 Jul 12;16(2):304-313. doi: 10.1016/j.celrep.2016.05.067. Epub 2016 Jun 23.


Embryo Transfer (Techniques, Donors, and Recipients).

Phillips PE, Jahnke MM.

Vet Clin North Am Food Anim Pract. 2016 Jul;32(2):365-85. doi: 10.1016/j.cvfa.2016.01.008. Epub 2016 Apr 30. Review.


Effects of label-dose permethrin administration in yearling beef cattle: I. Reproductive function and embryo quality of superovulated heifers.

Dohlman TM, Jahnke MM, West JK, Phillips PE, Gunn PJ.

Theriogenology. 2016 Jun;85(9):1528-1533. doi: 10.1016/j.theriogenology.2015.10.015. Epub 2016 Feb 21.


Effects of label-dose permethrin administration in yearling beef cattle: I. Bull reproductive function and testicular histopathology.

Dohlman TM, Phillips PE, Madson DM, Clark CA, Gunn PJ.

Theriogenology. 2016 Jun;85(9):1534-1539. doi: 10.1016/j.theriogenology.2016.02.014. Epub 2016 Feb 24.


Neuroscience: Making risk-takers settle.

Hollon NG, Phillips PE.

Nature. 2016 Mar 31;531(7596):588-9. doi: 10.1038/nature17314. Epub 2016 Mar 23. No abstract available.


Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward.

Kishida KT, Saez I, Lohrenz T, Witcher MR, Laxton AW, Tatter SB, White JP, Ellis TL, Phillips PE, Montague PR.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):200-5. doi: 10.1073/pnas.1513619112. Epub 2015 Nov 23.


Stress effects on the neural substrates of motivated behavior.

Hollon NG, Burgeno LM, Phillips PE.

Nat Neurosci. 2015 Oct;18(10):1405-12. doi: 10.1038/nn.4114. Epub 2015 Sep 25. Review.


Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons.

Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C.

J Neurosci. 2015 Sep 16;35(37):12917-31. doi: 10.1523/JNEUROSCI.2444-15.2015.


Probing the neurochemical correlates of motivation and decision making.

Wassum KM, Phillips PE.

ACS Chem Neurosci. 2015 Jan 21;6(1):11-3. doi: 10.1021/cn500322y. Epub 2014 Dec 19. Review.


Dopamine-associated cached values are not sufficient as the basis for action selection.

Hollon NG, Arnold MM, Gan JO, Walton ME, Phillips PE.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18357-62. doi: 10.1073/pnas.1419770111. Epub 2014 Dec 8.


Cocaine increases dopaminergic neuron and motor activity via midbrain α1 adrenergic signaling.

Goertz RB, Wanat MJ, Gomez JA, Brown ZJ, Phillips PE, Paladini CA.

Neuropsychopharmacology. 2015 Mar 13;40(5):1151-62. doi: 10.1038/npp.2014.296.


Dynamic shaping of dopamine signals during probabilistic Pavlovian conditioning.

Hart AS, Clark JJ, Phillips PEM.

Neurobiol Learn Mem. 2015 Jan;117:84-92. doi: 10.1016/j.nlm.2014.07.010. Epub 2014 Aug 27.


Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats.

Willuhn I, Tose A, Wanat MJ, Hart AS, Hollon NG, Phillips PE, Schwarting RK, Wöhr M.

J Neurosci. 2014 Aug 6;34(32):10616-23. doi: 10.1523/JNEUROSCI.1060-14.2014.


Kappa opioid receptor activation potentiates the cocaine-induced increase in evoked dopamine release recorded in vivo in the mouse nucleus accumbens.

Ehrich JM, Phillips PE, Chavkin C.

Neuropsychopharmacology. 2014 Dec;39(13):3036-48. doi: 10.1038/npp.2014.157. Epub 2014 Jun 27.


Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats.

Groblewski PA, Zietz C, Willuhn I, Phillips PE, Chavkin C.

Addict Biol. 2015 Mar;20(2):297-301. doi: 10.1111/adb.12123. Epub 2014 Feb 15.


Excessive cocaine use results from decreased phasic dopamine signaling in the striatum.

Willuhn I, Burgeno LM, Groblewski PA, Phillips PE.

Nat Neurosci. 2014 May;17(5):704-9. doi: 10.1038/nn.3694. Epub 2014 Apr 6.


Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum.

Simpson EH, Morud J, Winiger V, Biezonski D, Zhu JP, Bach ME, Malleret G, Polan HJ, Ng-Evans S, Phillips PE, Kellendonk C, Kandel ER.

Learn Mem. 2014 Mar 17;21(4):205-14. doi: 10.1101/lm.032094.113.


Phasic dopamine release in the rat nucleus accumbens symmetrically encodes a reward prediction error term.

Hart AS, Rutledge RB, Glimcher PW, Phillips PE.

J Neurosci. 2014 Jan 15;34(3):698-704. doi: 10.1523/JNEUROSCI.2489-13.2014.


Prolonged dopamine signalling in striatum signals proximity and value of distant rewards.

Howe MW, Tierney PL, Sandberg SG, Phillips PE, Graybiel AM.

Nature. 2013 Aug 29;500(7464):575-9. doi: 10.1038/nature12475. Epub 2013 Aug 4.


Direct-pathway striatal neurons regulate the retention of decision-making strategies.

Ferguson SM, Phillips PE, Roth BL, Wess J, Neumaier JF.

J Neurosci. 2013 Jul 10;33(28):11668-76. doi: 10.1523/JNEUROSCI.4783-12.2013.


Dopamine encoding of Pavlovian incentive stimuli diminishes with extended training.

Clark JJ, Collins AL, Sanford CA, Phillips PE.

J Neurosci. 2013 Feb 20;33(8):3526-32. doi: 10.1523/JNEUROSCI.5119-12.2013.


CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors.

Wanat MJ, Bonci A, Phillips PE.

Nat Neurosci. 2013 Apr;16(4):383-5. doi: 10.1038/nn.3335. Epub 2013 Feb 17.


Overinhibition of corticostriatal activity following prenatal cocaine exposure.

Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS.

Ann Neurol. 2013 Mar;73(3):355-69. doi: 10.1002/ana.23805. Epub 2012 Dec 7.


Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use.

Willuhn I, Burgeno LM, Everitt BJ, Phillips PE.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20703-8. doi: 10.1073/pnas.1213460109. Epub 2012 Nov 26.


A 16-channel heterodyne electron cyclotron emission radiometer on J-TEXT.

Yang ZJ, Phillips PE, Zhuang G, Xiao JS, Huang H, Rowan WL, Wang ZJ.

Rev Sci Instrum. 2012 Oct;83(10):10E313. doi: 10.1063/1.4732069.


Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive.

Lemos JC, Wanat MJ, Smith JS, Reyes BA, Hollon NG, Van Bockstaele EJ, Chavkin C, Phillips PE.

Nature. 2012 Oct 18;490(7420):402-6. doi: 10.1038/nature11436. Epub 2012 Sep 19.


Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.

Lemos JC, Roth CA, Messinger DI, Gill HK, Phillips PE, Chavkin C.

J Neurosci. 2012 Sep 5;32(36):12325-36. doi: 10.1523/JNEUROSCI.2053-12.2012.


Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates.

Ariansen JL, Heien ML, Hermans A, Phillips PE, Hernadi I, Bermudez MA, Schultz W, Wightman RM.

Front Behav Neurosci. 2012 Jul 5;6:36. doi: 10.3389/fnbeh.2012.00036. eCollection 2012.


Pavlovian valuation systems in learning and decision making.

Clark JJ, Hollon NG, Phillips PE.

Curr Opin Neurobiol. 2012 Dec;22(6):1054-61. doi: 10.1016/j.conb.2012.06.004. Epub 2012 Jun 28. Review.


Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats.

Clark JJ, Nasrallah NA, Hart AS, Collins AL, Bernstein IL, Phillips PE.

PLoS One. 2012;7(5):e37357. doi: 10.1371/journal.pone.0037357. Epub 2012 May 16.


N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial.

Lai ZW, Hanczko R, Bonilla E, Caza TN, Clair B, Bartos A, Miklossy G, Jimah J, Doherty E, Tily H, Francis L, Garcia R, Dawood M, Yu J, Ramos I, Coman I, Faraone SV, Phillips PE, Perl A.

Arthritis Rheum. 2012 Sep;64(9):2937-46. doi: 10.1002/art.34502.



Phillips PE, Kim JJ, Lee D.

Front Behav Neurosci. 2012 Mar 30;6:15. doi: 10.3389/fnbeh.2012.00015. eCollection 2012. No abstract available.


Sub-second dopamine detection in human striatum.

Kishida KT, Sandberg SG, Lohrenz T, Comair YG, Sáez I, Phillips PE, Montague PR.

PLoS One. 2011;6(8):e23291. doi: 10.1371/journal.pone.0023291. Epub 2011 Aug 4.


Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine.

Nasrallah NA, Clark JJ, Collins AL, Akers CA, Phillips PE, Bernstein IL.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5466-71. doi: 10.1073/pnas.1017732108. Epub 2011 Mar 14.


Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse.

Willuhn I, Wanat MJ, Clark JJ, Phillips PE.

Curr Top Behav Neurosci. 2010;3:29-71. doi: 10.1007/7854_2009_27. Review.


A selective role for dopamine in stimulus-reward learning.

Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H.

Nature. 2011 Jan 6;469(7328):53-7. doi: 10.1038/nature09588. Epub 2010 Dec 8.


Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization.

Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF.

Nat Neurosci. 2011 Jan;14(1):22-4. doi: 10.1038/nn.2703. Epub 2010 Dec 5.


Delays conferred by escalating costs modulate dopamine release to rewards but not their predictors.

Wanat MJ, Kuhnen CM, Phillips PE.

J Neurosci. 2010 Sep 8;30(36):12020-7. doi: 10.1523/JNEUROSCI.2691-10.2010.


Endogenous retroviral pathogenesis in lupus.

Perl A, Fernandez D, Telarico T, Phillips PE.

Curr Opin Rheumatol. 2010 Sep;22(5):483-92. doi: 10.1097/BOR.0b013e32833c6297. Review.


Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning.

Parker JG, Zweifel LS, Clark JJ, Evans SB, Phillips PE, Palmiter RD.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13491-6. doi: 10.1073/pnas.1007827107. Epub 2010 Jul 7.

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