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The plastidial metabolite 2-C-methyl-D-erythritol-2,4-cyclodiphosphate modulates defense responses against aphids.

Onkokesung N, Reichelt M, Wright LP, Phillips MA, Gershenzon J, Dicke M.

Plant Cell Environ. 2019 Feb 20. doi: 10.1111/pce.13538. [Epub ahead of print]


Evaluation of the clinical impact of concomitant acid suppression therapy in colorectal cancer patients treated with capecitabine monotherapy.

Rhinehart HE, Phillips MA, Wade N, Baran A.

J Oncol Pharm Pract. 2018 Dec 14:1078155218818237. doi: 10.1177/1078155218818237. [Epub ahead of print]


Toward a chemical vaccine for malaria.

Phillips MA, Goldberg DE.

Science. 2018 Dec 7;362(6419):1112-1113. doi: 10.1126/science.aav7479. No abstract available.


Effect of a Palliative Screening Tool on Referrals: An Approach to Increase Access to Palliative Care Services.

Kichler CM, Cothran FA, Phillips MA.

J Hosp Palliat Nurs. 2018 Dec;20(6):548-553. doi: 10.1097/NJH.0000000000000475.


Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

White J, Dhingra SK, Deng X, El Mazouni F, Lee MCS, Afanador GA, Lawong A, Tomchick DR, Ng CL, Bath J, Rathod PK, Fidock DA, Phillips MA.

ACS Infect Dis. 2018 Nov 13. doi: 10.1021/acsinfecdis.8b00211. [Epub ahead of print]


A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.

Patel MM, Volkov OA, Leija C, Lemoff A, Phillips MA.

PLoS Pathog. 2018 Oct 26;14(10):e1007404. doi: 10.1371/journal.ppat.1007404. eCollection 2018 Oct.


Polyamines in protozoan pathogens.

Phillips MA.

J Biol Chem. 2018 Nov 30;293(48):18746-18756. doi: 10.1074/jbc.TM118.003342. Epub 2018 Oct 17. Review.


Effects of evolutionary history on genome wide and phenotypic convergence in Drosophila populations.

Phillips MA, Rutledge GA, Kezos JN, Greenspan ZS, Talbott A, Matty S, Arain H, Mueller LD, Rose MR, Shahrestani P.

BMC Genomics. 2018 Oct 11;19(1):743. doi: 10.1186/s12864-018-5118-7.


Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.

Kokkonda S, El Mazouni F, White KL, White J, Shackleford DM, Lafuente-Monasterio MJ, Rowland P, Manjalanagara K, Joseph JT, Garcia-Pérez A, Fernandez J, Gamo FJ, Waterson D, Burrows JN, Palmer MJ, Charman SA, Rathod PK, Phillips MA.

ACS Omega. 2018 Aug 31;3(8):9227-9240. doi: 10.1021/acsomega.8b01573. Epub 2018 Aug 15.


Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.

Afanador GA, Tomchick DR, Phillips MA.

Structure. 2018 Nov 6;26(11):1499-1512.e5. doi: 10.1016/j.str.2018.07.012. Epub 2018 Sep 6.


SPEKcheck - fluorescence microscopy spectral visualisation and optimisation: a web application, javascript library, and data resource.

Phillips MA, Susano Pinto DM, Dobbie IM.

Wellcome Open Res. 2018 Jul 30;3:92. doi: 10.12688/wellcomeopenres.14703.1. eCollection 2018.


Male sexual assault: Physical injury and vulnerability in 103 presentations.

Zilkens RR, Smith DA, Mukhtar SA, Semmens JB, Phillips MA, Kelly MC.

J Forensic Leg Med. 2018 Aug;58:145-151. doi: 10.1016/j.jflm.2018.05.009. Epub 2018 Jun 27.


Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.

Llanos-Cuentas A, Casapia M, Chuquiyauri R, Hinojosa JC, Kerr N, Rosario M, Toovey S, Arch RH, Phillips MA, Rozenberg FD, Bath J, Ng CL, Cowell AN, Winzeler EA, Fidock DA, Baker M, Möhrle JJ, Hooft van Huijsduijnen R, Gobeau N, Araeipour N, Andenmatten N, Rückle T, Duparc S.

Lancet Infect Dis. 2018 Aug;18(8):874-883. doi: 10.1016/S1473-3099(18)30309-8. Epub 2018 Jun 13. Erratum in: Lancet Infect Dis. 2018 Aug;18(8):829.


Genome-Wide Mapping of Gene-Phenotype Relationships in Experimentally Evolved Populations.

Mueller LD, Phillips MA, Barter TT, Greenspan ZS, Rose MR.

Mol Biol Evol. 2018 Aug 1;35(8):2085-2095. doi: 10.1093/molbev/msy113.


Thalamocortical function in developing sensory circuits.

Colonnese MT, Phillips MA.

Curr Opin Neurobiol. 2018 Oct;52:72-79. doi: 10.1016/j.conb.2018.04.019. Epub 2018 Apr 30. Review.


Nerolidol production in agroinfiltrated tobacco: Impact of protein stability and membrane targeting of strawberry (Fragraria ananassa) NEROLIDOL SYNTHASE1.

Andrade P, Manzano D, Ramirez-Estrada K, Caudepon D, Arro M, Ferrer A, Phillips MA.

Plant Sci. 2018 Feb;267:112-123. doi: 10.1016/j.plantsci.2017.11.013. Epub 2017 Dec 2.


New Treatments for Hereditary Angioedema.

Johnson NM, Phillips MA.

Skin Therapy Lett. 2018 Jan;23(1):6-8. Review.


Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.

Flannery EL, Foquet L, Chuenchob V, Fishbaugher M, Billman Z, Navarro MJ, Betz W, Olsen TM, Lee J, Camargo N, Nguyen T, Schafer C, Sack BK, Wilson EM, Saunders J, Bial J, Campo B, Charman SA, Murphy SC, Phillips MA, Kappe SH, Mikolajczak SA.

JCI Insight. 2018 Jan 11;3(1). pii: 92587. doi: 10.1172/jci.insight.92587. eCollection 2018 Jan 11.


Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

Volkov OA, Brockway AJ, Wring SA, Peel M, Chen Z, Phillips MA, De Brabander JK.

J Med Chem. 2018 Feb 8;61(3):1182-1203. doi: 10.1021/acs.jmedchem.7b01654. Epub 2018 Jan 5.


Systems Thinking and Simulation Modeling to Inform Childhood Obesity Policy and Practice.

Powell KE, Kibbe DL, Ferencik R, Soderquist C, Phillips MA, Vall EA, Minyard KJ.

Public Health Rep. 2017 Nov/Dec;132(2_suppl):33S-38S. doi: 10.1177/0033354917723601.


Sexual assault and general body injuries: A detailed cross-sectional Australian study of 1163 women.

Zilkens RR, Smith DA, Kelly MC, Mukhtar SA, Semmens JB, Phillips MA.

Forensic Sci Int. 2017 Oct;279:112-120. doi: 10.1016/j.forsciint.2017.08.001. Epub 2017 Aug 9.


Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.

Brockway AJ, Volkov OA, Cosner CC, MacMillan KS, Wring SA, Richardson TE, Peel M, Phillips MA, De Brabander JK.

Bioorg Med Chem. 2017 Oct 15;25(20):5433-5440. doi: 10.1016/j.bmc.2017.07.063. Epub 2017 Aug 3.



Phillips MA, Burrows JN, Manyando C, van Huijsduijnen RH, Van Voorhis WC, Wells TNC.

Nat Rev Dis Primers. 2017 Aug 3;3:17050. doi: 10.1038/nrdp.2017.50. Review.


Capturing sexual assault data: An information system designed by forensic clinicians and healthcare researchers.

Mukhtar SA, Smith DA, Phillips MA, Kelly MC, Zilkens RR, Semmens JB.

Health Inf Manag. 2018 Jan;47(1):46-55. doi: 10.1177/1833358316687575. Epub 2017 Jan 12.


Tgm1-like transglutaminases in tilapia (Oreochromis mossambicus).

Rodriguez Cruz SI, Phillips MA, Kültz D, Rice RH.

PLoS One. 2017 May 4;12(5):e0177016. doi: 10.1371/journal.pone.0177016. eCollection 2017.


Metastatic basal cell carcinoma with loss of p63 and mismatch repair proteins.

Johnson NM, Holliday AC, Luyimbazi DT, Phillips MA, Collins GR, Grider DJ.

JAAD Case Rep. 2017 Apr 14;3(3):222-224. doi: 10.1016/j.jdcr.2017.02.018. eCollection 2017 May. No abstract available.


Genital and anal injuries: A cross-sectional Australian study of 1266 women alleging recent sexual assault.

Zilkens RR, Smith DA, Phillips MA, Mukhtar SA, Semmens JB, Kelly MC.

Forensic Sci Int. 2017 Jun;275:195-202. doi: 10.1016/j.forsciint.2017.03.013. Epub 2017 Mar 29.


Non-invasive quantification of ethylene in attached fruit headspace at 1 p.p.b. by gas chromatography-mass spectrometry.

Pereira L, Pujol M, Garcia-Mas J, Phillips MA.

Plant J. 2017 Jul;91(1):172-183. doi: 10.1111/tpj.13545. Epub 2017 May 5.


Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.

McCarthy JS, Lotharius J, Rückle T, Chalon S, Phillips MA, Elliott S, Sekuloski S, Griffin P, Ng CL, Fidock DA, Marquart L, Williams NS, Gobeau N, Bebrevska L, Rosario M, Marsh K, Möhrle JJ.

Lancet Infect Dis. 2017 Jun;17(6):626-635. doi: 10.1016/S1473-3099(17)30171-8. Epub 2017 Mar 28.


Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

Volkov OA, Cosner CC, Brockway AJ, Kramer M, Booker M, Zhong S, Ketcherside A, Wei S, Longgood J, McCoy M, Richardson TE, Wring SA, Peel M, Klinger JD, Posner BA, De Brabander JK, Phillips MA.

ACS Infect Dis. 2017 Jul 14;3(7):512-526. doi: 10.1021/acsinfecdis.7b00022. Epub 2017 Apr 7.


Erratum: Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome.

Berzhanskaya J, Phillips MA, Shen J, Colonnese MT.

Sci Rep. 2017 Mar 15;7:44515. doi: 10.1038/srep44515. No abstract available.


Genomics of Parallel Experimental Evolution in Drosophila.

Graves JL Jr, Hertweck KL, Phillips MA, Han MV, Cabral LG, Barter TT, Greer LF, Burke MK, Mueller LD, Rose MR.

Mol Biol Evol. 2017 Apr 1;34(4):831-842. doi: 10.1093/molbev/msw282.


Genome-wide analysis of long-term evolutionary domestication in Drosophila melanogaster.

Phillips MA, Long AD, Greenspan ZS, Greer LF, Burke MK, Villeponteau B, Matsagas KC, Rizza CL, Mueller LD, Rose MR.

Sci Rep. 2016 Dec 22;6:39281. doi: 10.1038/srep39281.


Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.

Volkov OA, Kinch L, Ariagno C, Deng X, Zhong S, Grishin N, Tomchick DR, Chen Z, Phillips MA.

Elife. 2016 Dec 15;5. pii: e20198. doi: 10.7554/eLife.20198.


Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.

Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM.

PLoS One. 2016 Dec 9;11(12):e0168074. doi: 10.1371/journal.pone.0168074. eCollection 2016.


Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei.

Leija C, Rijo-Ferreira F, Kinch LN, Grishin NV, Nischan N, Kohler JJ, Hu Z, Phillips MA.

PLoS Pathog. 2016 Nov 7;12(11):e1006010. doi: 10.1371/journal.ppat.1006010. eCollection 2016 Nov.


A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh K, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, Chiu FC, Campbell M, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Martinez MS, Lafuente-Monasterio M, Kaminsky W, Silue K, Zeeman AM, Kocken C, Leroy D, Blasco B, Rossignol E, Rueckle T, Matthews D, Burrows JN, Waterson D, Palmer MJ, Rathod PK, Charman SA.

ACS Infect Dis. 2016 Dec 9;2(12):945-957. Epub 2016 Oct 4.


Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound.

Brockway AJ, Cosner CC, Volkov OA, Phillips MA, De Brabander JK.

Synthesis (Stuttg). 2016 Jul;48(13):2065-2068.


Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome.

Berzhanskaya J, Phillips MA, Shen J, Colonnese MT.

Sci Rep. 2016 Jul 28;6:30769. doi: 10.1038/srep30769. Erratum in: Sci Rep. 2017 Mar 15;7:44515.


Rapid divergence and convergence of life-history in experimentally evolved Drosophila melanogaster.

Burke MK, Barter TT, Cabral LG, Kezos JN, Phillips MA, Rutledge GA, Phung KH, Chen RH, Nguyen HD, Mueller LD, Rose MR.

Evolution. 2016 Sep;70(9):2085-98. doi: 10.1111/evo.13006. Epub 2016 Aug 8.


Non-fatal strangulation in sexual assault: A study of clinical and assault characteristics highlighting the role of intimate partner violence.

Zilkens RR, Phillips MA, Kelly MC, Mukhtar SA, Semmens JB, Smith DA.

J Forensic Leg Med. 2016 Oct;43:1-7. doi: 10.1016/j.jflm.2016.06.005. Epub 2016 Jun 24.


Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.

Kokkonda S, Deng X, White KL, Coteron JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, Leroy D, Martínez-Martínez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Waterson D, Burrows JN, Matthews D, Charman SA, Phillips MA, Rathod PK.

J Med Chem. 2016 Jun 9;59(11):5416-31. doi: 10.1021/acs.jmedchem.6b00275. Epub 2016 May 21.


Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts.

Perello C, Llamas E, Burlat V, Ortiz-Alcaide M, Phillips MA, Pulido P, Rodriguez-Concepcion M.

PLoS One. 2016 Feb 26;11(2):e0150539. doi: 10.1371/journal.pone.0150539. eCollection 2016.


Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.

Pavadai E, El Mazouni F, Wittlin S, de Kock C, Phillips MA, Chibale K.

J Chem Inf Model. 2016 Mar 28;56(3):548-62. doi: 10.1021/acs.jcim.5b00680. Epub 2016 Mar 8.


Disrupted Cortical State Regulation in a Rat Model of Fragile X Syndrome.

Berzhanskaya J, Phillips MA, Gorin A, Lai C, Shen J, Colonnese MT.

Cereb Cortex. 2017 Feb 1;27(2):1386-1400. doi: 10.1093/cercor/bhv331.


Parallel responses of human epidermal keratinocytes to inorganic SbIII and AsIII.

Phillips MA, Cánovas A, Wu PW, Islas-Trejo A, Medrano JF, Rice RH.

Environ Chem. 2016;13(6):963-970. doi: 10.1071/EN16019. Epub 2016 Apr 26.


A Teach-Discover-Treat Application of ZincPharmer: An Online Interactive Pharmacophore Modeling and Virtual Screening Tool.

Koes DR, Pabon NA, Deng X, Phillips MA, Camacho CJ.

PLoS One. 2015 Aug 10;10(8):e0134697. doi: 10.1371/journal.pone.0134697. eCollection 2015.


A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.


Four steps toward the control of aging: following the example of infectious disease.

Rose MR, Cabral LG, Kezos JN, Barter TT, Phillips MA, Smith BL, Burnham TC.

Biogerontology. 2016 Feb;17(1):21-31. doi: 10.1007/s10522-015-9588-6. Epub 2015 Jun 26. Review.


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