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Items: 1 to 50 of 266

1.

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.

Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, Tainer JA, Phillips GN Jr, Kurie JM.

Nat Commun. 2018 Jul 10;9(1):2719. doi: 10.1038/s41467-018-05295-1.

2.

Resistance to Enediyne Antitumor Antibiotics by Sequestration.

Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Cell Chem Biol. 2018 May 29. pii: S2451-9456(18)30183-1. doi: 10.1016/j.chembiol.2018.05.012. [Epub ahead of print]

PMID:
29937405
3.

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.

Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Nat Chem Biol. 2018 Jul;14(7):730-737. doi: 10.1038/s41589-018-0061-0. Epub 2018 Jun 4.

PMID:
29867143
4.

Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.

Olmos JL Jr, Pandey S, Martin-Garcia JM, Calvey G, Katz A, Knoska J, Kupitz C, Hunter MS, Liang M, Oberthuer D, Yefanov O, Wiedorn M, Heyman M, Holl M, Pande K, Barty A, Miller MD, Stern S, Roy-Chowdhury S, Coe J, Nagaratnam N, Zook J, Verburgt J, Norwood T, Poudyal I, Xu D, Koglin J, Seaberg MH, Zhao Y, Bajt S, Grant T, Mariani V, Nelson G, Subramanian G, Bae E, Fromme R, Fung R, Schwander P, Frank M, White TA, Weierstall U, Zatsepin N, Spence J, Fromme P, Chapman HN, Pollack L, Tremblay L, Ourmazd A, Phillips GN Jr, Schmidt M.

BMC Biol. 2018 May 31;16(1):59. doi: 10.1186/s12915-018-0524-5.

5.

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2018 Jun 12;57(23):3278-3288. doi: 10.1021/acs.biochem.8b00174. Epub 2018 Mar 21.

PMID:
29533601
6.

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.

Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, Tainer JA, Phillips GN Jr, Kurie JM.

Nat Commun. 2018 Feb 6;9(1):512. doi: 10.1038/s41467-018-02859-z. Erratum in: Nat Commun. 2018 Jul 10;9(1):2719.

7.

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.

Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

ACS Omega. 2017 Aug 31;2(8):5159-5169. doi: 10.1021/acsomega.7b00933. Epub 2017 Aug 30.

8.

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers.

Fuller FD, Gul S, Chatterjee R, Burgie ES, Young ID, Lebrette H, Srinivas V, Brewster AS, Michels-Clark T, Clinger JA, Andi B, Ibrahim M, Pastor E, de Lichtenberg C, Hussein R, Pollock CJ, Zhang M, Stan CA, Kroll T, Fransson T, Weninger C, Kubin M, Aller P, Lassalle L, Bräuer P, Miller MD, Amin M, Koroidov S, Roessler CG, Allaire M, Sierra RG, Docker PT, Glownia JM, Nelson S, Koglin JE, Zhu D, Chollet M, Song S, Lemke H, Liang M, Sokaras D, Alonso-Mori R, Zouni A, Messinger J, Bergmann U, Boal AK, Bollinger JM Jr, Krebs C, Högbom M, Phillips GN Jr, Vierstra RD, Sauter NK, Orville AM, Kern J, Yachandra VK, Yano J.

Nat Methods. 2017 Apr;14(4):443-449. doi: 10.1038/nmeth.4195. Epub 2017 Feb 27.

9.

Mechanism of Human Apohemoglobin Unfolding.

Samuel PP, Ou WC, Phillips GN Jr, Olson JS.

Biochemistry. 2017 Mar 14;56(10):1444-1459. doi: 10.1021/acs.biochem.6b01235. Epub 2017 Mar 2.

PMID:
28218841
10.

A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay.

Guo HF, Cho EJ, Devkota AK, Chen Y, Russell W, Phillips GN Jr, Yamauchi M, Dalby KN, Kurie JM.

Arch Biochem Biophys. 2017 Mar 15;618:45-51. doi: 10.1016/j.abb.2017.02.003. Epub 2017 Feb 20.

11.

Structure and specificity of a permissive bacterial C-prenyltransferase.

Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S.

Nat Chem Biol. 2017 Apr;13(4):366-368. doi: 10.1038/nchembio.2285. Epub 2017 Feb 6.

12.

Structural enzymology using X-ray free electron lasers.

Kupitz C, Olmos JL Jr, Holl M, Tremblay L, Pande K, Pandey S, Oberthür D, Hunter M, Liang M, Aquila A, Tenboer J, Calvey G, Katz A, Chen Y, Wiedorn MO, Knoska J, Meents A, Majriani V, Norwood T, Poudyal I, Grant T, Miller MD, Xu W, Tolstikova A, Morgan A, Metz M, Martin-Garcia JM, Zook JD, Roy-Chowdhury S, Coe J, Nagaratnam N, Meza D, Fromme R, Basu S, Frank M, White T, Barty A, Bajt S, Yefanov O, Chapman HN, Zatsepin N, Nelson G, Weierstall U, Spence J, Schwander P, Pollack L, Fromme P, Ourmazd A, Phillips GN Jr, Schmidt M.

Struct Dyn. 2016 Dec 15;4(4):044003. doi: 10.1063/1.4972069. eCollection 2017 Jul.

13.

OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.

Hughes RR, Shaaban KA, Zhang J, Cao H, Phillips GN Jr, Thorson JS.

Chembiochem. 2017 Feb 16;18(4):363-367. doi: 10.1002/cbic.201600676. Epub 2017 Jan 9.

14.

Reader domain specificity and lysine demethylase-4 family function.

Su Z, Wang F, Lee JH, Stephens KE, Papazyan R, Voronina E, Krautkramer KA, Raman A, Thorpe JJ, Boersma MD, Kuznetsov VI, Miller MD, Taverna SD, Phillips GN Jr, Denu JM.

Nat Commun. 2016 Nov 14;7:13387. doi: 10.1038/ncomms13387.

15.

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.

Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B.

J Antibiot (Tokyo). 2016 Oct;69(10):731-740. doi: 10.1038/ja.2016.88. Epub 2016 Jul 13.

16.

Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm.

He H, Fang H, Miller MD, Phillips GN Jr, Su WP.

Acta Crystallogr A Found Adv. 2016 Sep 1;72(Pt 5):539-47. doi: 10.1107/S2053273316010731. Epub 2016 Jul 15.

17.

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.

Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2016 Sep 13;55(36):5142-54. doi: 10.1021/acs.biochem.6b00713. Epub 2016 Sep 1.

18.

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.

Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

J Am Chem Soc. 2016 Aug 31;138(34):10905-15. doi: 10.1021/jacs.6b04317. Epub 2016 Aug 18.

19.

Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.

Huber TD, Wang F, Singh S, Johnson BR, Zhang J, Sunkara M, Van Lanen SG, Morris AJ, Phillips GN Jr, Thorson JS.

ACS Chem Biol. 2016 Sep 16;11(9):2484-91. doi: 10.1021/acschembio.6b00348. Epub 2016 Jul 14.

20.

Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.

Cao H, Tan K, Wang F, Bigelow L, Yennamalli RM, Jedrzejczak R, Babnigg G, Bingman CA, Joachimiak A, Kharel MK, Singh S, Thorson JS, Phillips GN Jr.

Struct Dyn. 2016 Apr 29;3(3):034702. doi: 10.1063/1.4948539. eCollection 2016 May.

21.

Preface to Special Topic on Protein Dynamics: Beyond Static Snapshots in Structural Biology.

Phillips GN Jr, Onuchic JN.

Struct Dyn. 2016 Feb 26;3(1):011901. doi: 10.1063/1.4942424. eCollection 2016 Jan. No abstract available.

22.

Loop dynamics of thymidine diphosphate-rhamnose 3'-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis.

Han L, Singh S, Thorson JS, Phillips GN Jr.

Struct Dyn. 2016 Feb 18;3(1):012004. doi: 10.1063/1.4941368. eCollection 2016 Jan.

23.

Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin.

Helmich KE, Pereira JH, Gall DL, Heins RA, McAndrew RP, Bingman C, Deng K, Holland KC, Noguera DR, Simmons BA, Sale KL, Ralph J, Donohue TJ, Adams PD, Phillips GN Jr.

J Biol Chem. 2016 Mar 4;291(10):5234-46. doi: 10.1074/jbc.M115.694307. Epub 2015 Dec 4.

24.

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.

Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2015 Nov 17;54(45):6842-51. doi: 10.1021/acs.biochem.5b01008. Epub 2015 Nov 5.

25.

Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.

Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12693-8. doi: 10.1073/pnas.1515460112. Epub 2015 Sep 29.

26.

Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.

Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr.

J Biol Chem. 2015 Oct 23;290(43):26249-58. doi: 10.1074/jbc.M115.673459. Epub 2015 Aug 3.

27.

Apoglobin Stability Is the Major Factor Governing both Cell-free and in Vivo Expression of Holomyoglobin.

Samuel PP, Smith LP, Phillips GN Jr, Olson JS.

J Biol Chem. 2015 Sep 25;290(39):23479-95. doi: 10.1074/jbc.M115.672204. Epub 2015 Jul 23.

28.

Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.

Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr.

Proteins. 2015 Aug;83(8):1547-54. doi: 10.1002/prot.24844. Epub 2015 Jul 1.

29.

Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases.

Wang F, Singh S, Xu W, Helmich KE, Miller MD, Cao H, Bingman CA, Thorson JS, Phillips GN Jr.

ACS Chem Biol. 2015 Sep 18;10(9):2048-56. doi: 10.1021/acschembio.5b00244. Epub 2015 Jun 23.

30.

Crystal structure of the protein At3g01520, a eukaryotic universal stress protein-like protein from Arabidopsis thaliana in complex with AMP.

Kim DJ, Bitto E, Bingman CA, Kim HJ, Han BW, Phillips GN Jr.

Proteins. 2015 Jul;83(7):1368-73. doi: 10.1002/prot.24821. Epub 2015 May 14.

31.

LucY: A Versatile New Fluorescent Reporter Protein.

Auldridge ME, Cao H, Sen S, Franz LP, Bingman CA, Yennamalli RM, Phillips GN Jr, Mead D, Steinmetz EJ.

PLoS One. 2015 Apr 23;10(4):e0124272. doi: 10.1371/journal.pone.0124272. eCollection 2015.

32.

Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus).

Traeger LL, Volkening JD, Moffett H, Gallant JR, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Güth R, Unguez GA, Albert JS, Zakon H, Sussman MR, Samanta MP.

BMC Genomics. 2015 Mar 26;16:243. doi: 10.1186/s12864-015-1288-8.

33.

Expression platforms for producing eukaryotic proteins: a comparison of E. coli cell-based and wheat germ cell-free synthesis, affinity and solubility tags, and cloning strategies.

Aceti DJ, Bingman CA, Wrobel RL, Frederick RO, Makino S, Nichols KW, Sahu SC, Bergeman LF, Blommel PG, Cornilescu CC, Gromek KA, Seder KD, Hwang S, Primm JG, Sabat G, Vojtik FC, Volkman BF, Zolnai Z, Phillips GN Jr, Markley JL, Fox BG.

J Struct Funct Genomics. 2015 Jun;16(2):67-80. doi: 10.1007/s10969-015-9198-1. Epub 2015 Apr 9.

34.

Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.

Park MS, Bitto E, Kim KR, Bingman CA, Miller MD, Kim HJ, Han BW, Phillips GN Jr.

PLoS One. 2014 Oct 30;9(10):e111142. doi: 10.1371/journal.pone.0111142. eCollection 2014.

35.

Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 Å resolution.

Weerth RS, Michalska K, Bingman CA, Yennamalli RM, Li H, Jedrzejczak R, Wang F, Babnigg G, Joachimiak A, Thomas MG, Phillips GN Jr.

Proteins. 2015 Feb;83(2):383-8. doi: 10.1002/prot.24705. Epub 2014 Dec 18.

36.

Biochemical characterization and crystal structures of a fungal family 3 β-glucosidase, Cel3A from Hypocrea jecorina.

Karkehabadi S, Helmich KE, Kaper T, Hansson H, Mikkelsen NE, Gudmundsson M, Piens K, Fujdala M, Banerjee G, Scott-Craig JS, Walton JD, Phillips GN Jr, Sandgren M.

J Biol Chem. 2014 Nov 7;289(45):31624-37. doi: 10.1074/jbc.M114.587766. Epub 2014 Aug 27.

37.

Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases.

Book AJ, Yennamalli RM, Takasuka TE, Currie CR, Phillips GN Jr, Fox BG.

Biotechnol Biofuels. 2014 Aug 6;7:109. doi: 10.1186/1754-6834-7-109. eCollection 2014.

38.

Structure of RNA 3'-phosphate cyclase bound to substrate RNA.

Desai KK, Bingman CA, Cheng CL, Phillips GN Jr, Raines RT.

RNA. 2014 Oct;20(10):1560-6. doi: 10.1261/rna.045823.114. Epub 2014 Aug 26.

39.

Structure and substrate specificity of a eukaryotic fucosidase from Fusarium graminearum.

Cao H, Walton JD, Brumm P, Phillips GN Jr.

J Biol Chem. 2014 Sep 12;289(37):25624-38. doi: 10.1074/jbc.M114.583286. Epub 2014 Aug 1.

40.

Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19.

Elshahawi SI, Ramelot TA, Seetharaman J, Chen J, Singh S, Yang Y, Pederson K, Kharel MK, Xiao R, Lew S, Yennamalli RM, Miller MD, Wang F, Tong L, Montelione GT, Kennedy MA, Bingman CA, Zhu H, Phillips GN Jr, Thorson JS.

ACS Chem Biol. 2014 Oct 17;9(10):2347-58. doi: 10.1021/cb500327m. Epub 2014 Aug 13.

41.

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.

Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Proteins. 2014 Jul;82(7):1210-8.

42.

Nonhuman genetics. Genomic basis for the convergent evolution of electric organs.

Gallant JR, Traeger LL, Volkening JD, Moffett H, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Güth R, Unguez GA, Albert JS, Zakon HH, Samanta MP, Sussman MR.

Science. 2014 Jun 27;344(6191):1522-5. doi: 10.1126/science.1254432.

43.

Functional evolution of ribonuclease inhibitor: insights from birds and reptiles.

Lomax JE, Bianchetti CM, Chang A, Phillips GN Jr, Fox BG, Raines RT.

J Mol Biol. 2014 Aug 26;426(17):3041-56. doi: 10.1016/j.jmb.2014.06.007. Epub 2014 Jun 15.

44.

Effectiveness and limitations of local structural entropy optimization in the thermal stabilization of mesophilic and thermophilic adenylate kinases.

Moon S, Bannen RM, Rutkoski TJ, Phillips GN Jr, Bae E.

Proteins. 2014 Oct;82(10):2631-42. doi: 10.1002/prot.24627. Epub 2014 Jun 28.

PMID:
24931334
45.

Using a commodity high-definition television for collaborative structural biology.

Yennamalli R, Arangarasan R, Bryden A, Gleicher M, Phillips GN Jr.

J Appl Crystallogr. 2014 May 29;47(Pt 3):1153-1157. eCollection 2014 Jun 1.

46.

Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus.

Wang F, Singh S, Zhang J, Huber TD, Helmich KE, Sunkara M, Hurley KA, Goff RD, Bingman CA, Morris AJ, Thorson JS, Phillips GN Jr.

FEBS J. 2014 Sep;281(18):4224-39. doi: 10.1111/febs.12784. Epub 2014 Apr 7.

47.

An integrated approach for thermal stabilization of a mesophilic adenylate kinase.

Moon S, Jung DK, Phillips GN Jr, Bae E.

Proteins. 2014 Sep;82(9):1947-59. doi: 10.1002/prot.24549. Epub 2014 Mar 24.

PMID:
24615904
48.

A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation.

Desai KK, Cheng CL, Bingman CA, Phillips GN Jr, Raines RT.

Nucleic Acids Res. 2014 Apr;42(6):3931-42. doi: 10.1093/nar/gkt1375. Epub 2014 Jan 16.

49.

Structure, dynamics, and specificity of endoglucanase D from Clostridium cellulovorans.

Bianchetti CM, Brumm P, Smith RW, Dyer K, Hura GL, Rutkoski TJ, Phillips GN Jr.

J Mol Biol. 2013 Nov 15;425(22):4267-85. doi: 10.1016/j.jmb.2013.05.030. Epub 2013 Jun 8.

50.

Structural and functional characterization of CalS11, a TDP-rhamnose 3'-O-methyltransferase involved in calicheamicin biosynthesis.

Singh S, Chang A, Helmich KE, Bingman CA, Wrobel RL, Beebe ET, Makino S, Aceti DJ, Dyer K, Hura GL, Sunkara M, Morris AJ, Phillips GN Jr, Thorson JS.

ACS Chem Biol. 2013 Jul 19;8(7):1632-9. doi: 10.1021/cb400068k. Epub 2013 May 23.

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