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5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

Jin S, Cojocari D, Purkal JJ, Popovic R, Talaty NN, Xiao Y, Solomon LR, Boghaert ER, Leverson JD, Phillips DC.

Clin Cancer Res. 2020 Feb 13. pii: clincanres.1900.2019. doi: 10.1158/1078-0432.CCR-19-1900. [Epub ahead of print]


A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.

Phillips DC, Jin S, Gregory GP, Zhang Q, Xue J, Zhao X, Chen J, Tong Y, Zhang H, Smith M, Tahir SK, Clark RF, Penning TD, Devlin JR, Shortt J, Hsi ED, Albert DH, Konopleva M, Johnstone RW, Leverson JD, Souers AJ.

Leukemia. 2019 Dec 11. doi: 10.1038/s41375-019-0652-0. [Epub ahead of print]


Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models.

Han L, Zhang Q, Dail M, Shi C, Cavazos A, Ruvolo VR, Zhao Y, Kim E, Rahmani M, Mak DH, Jin SS, Chen J, Phillips DC, Koller PB, Jacamo R, Burks JK, DiNardo C, Daver N, Jabbour E, Wang J, Kantarjian HM, Andreeff M, Grant S, Leverson JD, Sampath D, Konopleva M.

Haematologica. 2020 Mar;105(3):697-707. doi: 10.3324/haematol.2018.205534. Epub 2019 May 23.


Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells.

Bodo J, Zhao X, Durkin L, Souers AJ, Phillips DC, Smith MR, Hsi ED.

Oncotarget. 2016 Oct 25;7(43):70000-70010. doi: 10.18632/oncotarget.12132.


Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199).

Phillips DC, Xiao Y, Lam LT, Litvinovich E, Roberts-Rapp L, Souers AJ, Leverson JD.

Blood Cancer J. 2016 Mar 11;6:e403. doi: 10.1038/bcj.2016.12. No abstract available.


Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199).

Phillips DC, Xiao Y, Lam LT, Litvinovich E, Roberts-Rapp L, Souers AJ, Leverson JD.

Blood Cancer J. 2015 Nov 13;5:e368. doi: 10.1038/bcj.2015.88. Erratum in: Blood Cancer J. 2016;6:e403.


The Importance of Accurate Patient History and Imaging Correlation Prior to Ordering Additional Imaging: A Case Study.

Gammons M, Phillips DC.

Radiol Technol. 2015 Sep-Oct;87(1):100-2. No abstract available.


MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.

Xiao Y, Nimmer P, Sheppard GS, Bruncko M, Hessler P, Lu X, Roberts-Rapp L, Pappano WN, Elmore SW, Souers AJ, Leverson JD, Phillips DC.

Mol Cancer Ther. 2015 Aug;14(8):1837-47. doi: 10.1158/1535-7163.MCT-14-0928. Epub 2015 May 26.


Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.

Bruncko M, Wang L, Sheppard GS, Phillips DC, Tahir SK, Xue J, Erickson S, Fidanze S, Fry E, Hasvold L, Jenkins GJ, Jin S, Judge RA, Kovar PJ, Madar D, Nimmer P, Park C, Petros AM, Rosenberg SH, Smith ML, Song X, Sun C, Tao ZF, Wang X, Xiao Y, Zhang H, Tse C, Leverson JD, Elmore SW, Souers AJ.

J Med Chem. 2015 May 14;58(9):4089. doi: 10.1021/acs.jmedchem.5b00616. Epub 2015 May 1. No abstract available.


Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ.

Sci Transl Med. 2015 Mar 18;7(279):279ra40. doi: 10.1126/scitranslmed.aaa4642.


Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.

Bruncko M, Wang L, Sheppard GS, Phillips DC, Tahir SK, Xue J, Erickson S, Fidanze S, Fry E, Hasvold L, Jenkins GJ, Jin S, Judge RA, Kovar PJ, Madar D, Nimmer P, Park C, Petros AM, Rosenberg SH, Smith ML, Song X, Sun C, Tao ZF, Wang X, Xiao Y, Zhang H, Tse C, Leverson JD, Elmore SW, Souers AJ.

J Med Chem. 2015 Mar 12;58(5):2180-94. doi: 10.1021/jm501258m. Epub 2015 Feb 26. Erratum in: J Med Chem. 2015 May 14;58(9):4089.


Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

Leverson JD, Zhang H, Chen J, Tahir SK, Phillips DC, Xue J, Nimmer P, Jin S, Smith M, Xiao Y, Kovar P, Tanaka A, Bruncko M, Sheppard GS, Wang L, Gierke S, Kategaya L, Anderson DJ, Wong C, Eastham-Anderson J, Ludlam MJ, Sampath D, Fairbrother WJ, Wertz I, Rosenberg SH, Tse C, Elmore SW, Souers AJ.

Cell Death Dis. 2015 Jan 15;6:e1590. doi: 10.1038/cddis.2014.561.


Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Tao ZF, Hasvold L, Wang L, Wang X, Petros AM, Park CH, Boghaert ER, Catron ND, Chen J, Colman PM, Czabotar PE, Deshayes K, Fairbrother WJ, Flygare JA, Hymowitz SG, Jin S, Judge RA, Koehler MF, Kovar PJ, Lessene G, Mitten MJ, Ndubaku CO, Nimmer P, Purkey HE, Oleksijew A, Phillips DC, Sleebs BE, Smith BJ, Smith ML, Tahir SK, Watson KG, Xiao Y, Xue J, Zhang H, Zobel K, Rosenberg SH, Tse C, Leverson JD, Elmore SW, Souers AJ.

ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93. doi: 10.1021/ml5001867. eCollection 2014 Oct 9.


ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.

Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ, Huang DC, Hymowitz SG, Jin S, Khaw SL, Kovar PJ, Lam LT, Lee J, Maecker HL, Marsh KC, Mason KD, Mitten MJ, Nimmer PM, Oleksijew A, Park CH, Park CM, Phillips DC, Roberts AW, Sampath D, Seymour JF, Smith ML, Sullivan GM, Tahir SK, Tse C, Wendt MD, Xiao Y, Xue JC, Zhang H, Humerickhouse RA, Rosenberg SH, Elmore SW.

Nat Med. 2013 Feb;19(2):202-8. doi: 10.1038/nm.3048. Epub 2013 Jan 6.


Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo.

Ackler S, Mitten MJ, Chen J, Clarin J, Foster K, Jin S, Phillips DC, Schlessinger S, Wang B, Leverson JD, Boghaert ER.

Br J Pharmacol. 2012 Oct;167(4):881-91. doi: 10.1111/j.1476-5381.2012.02048.x.


Genetically defining the mechanism of Puma- and Bim-induced apoptosis.

Garrison SP, Phillips DC, Jeffers JR, Chipuk JE, Parsons MJ, Rehg JE, Opferman JT, Green DR, Zambetti GP.

Cell Death Differ. 2012 Apr;19(4):642-9. doi: 10.1038/cdd.2011.136. Epub 2011 Oct 21.


Free radicals and redox signalling in T-cells during chronic inflammation and ageing.

Griffiths HR, Dunston CR, Bennett SJ, Grant MM, Phillips DC, Kitas GD.

Biochem Soc Trans. 2011 Oct;39(5):1273-8. doi: 10.1042/BST0391273.


Rotavirus vaccines: the role of researchers in moving evidence to action.

Wecker JR, Phillips DC, Hayes J.

Vaccine. 2009 Nov 20;27 Suppl 5:F4-6. doi: 10.1016/j.vaccine.2009.08.066.


Past, present, and future of Japanese encephalitis.

Hills SL, Phillips DC.

Emerg Infect Dis. 2009 Aug;15(8):1333. doi: 10.3201/eid1508.090149. No abstract available.


Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention.

Phillips DC, Dias HK, Kitas GD, Griffiths HR.

Antioxid Redox Signal. 2010 Mar 15;12(6):743-85. doi: 10.1089/ars.2009.2607. Review.


Assays to measure p53-dependent and -independent apoptosis.

Phillips DC, Garrison SP, Jeffers JR, Zambetti GP.

Methods Mol Biol. 2009;559:143-59. doi: 10.1007/978-1-60327-017-5_11.


Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L).

Rossi M, Bang JK, Mazur S, Iera JA, Phillips DC, Zambetti GP, Appella DH.

Bioorg Med Chem Lett. 2009 May 1;19(9):2429-34. doi: 10.1016/j.bmcl.2009.03.067. Epub 2009 Mar 21.


Environmental nanotechnology: a near-term opportunity assessment.

Huang CP, Phillips DC.

Water Environ Res. 2007 Sep;79(9):939. No abstract available.


Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression.

Phillips DC, Hunt JT, Moneypenny CG, Maclean KH, McKenzie PP, Harris LC, Houghton JA.

Cell Death Differ. 2007 Oct;14(10):1780-91. Epub 2007 Jul 13.


Directions in peptide interfacial science.

Mermut O, York RL, Phillips DC, McCrea KR, Ward RS, Somorjai GA.

Biointerphases. 2006 Jun;1(2):P5-11. doi: 10.1116/1.2194033. No abstract available.


Ceramide induces a loss in cytosolic peroxide levels in mononuclear cells.

Phillips DC, Griffiths HR.

Biochem J. 2003 Nov 1;375(Pt 3):567-79.


A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells.

Petak I, Vernes R, Szucs KS, Anozie M, Izeradjene K, Douglas L, Tillman DM, Phillips DC, Houghton JA.

Cell Death Differ. 2003 Jun;10(6):729-39.


Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status.

Phillips DC, Allen K, Griffiths HR.

Arch Biochem Biophys. 2002 Nov 1;407(1):15-24.


Direct modulatory effect of C-reactive protein on primary human monocyte adhesion to human endothelial cells.

Woollard KJ, Phillips DC, Griffiths HR.

Clin Exp Immunol. 2002 Nov;130(2):256-62.


Crystal structure of human alpha-lactalbumin at 1.7 A resolution.

Acharya KR, Ren JS, Stuart DI, Phillips DC, Fenna RE.

J Mol Biol. 1991 Sep 20;221(2):571-81.


A critical evaluation of the predicted and X-ray structures of alpha-lactalbumin.

Acharya KR, Stuart DI, Phillips DC, Scheraga HA.

J Protein Chem. 1990 Oct;9(5):549-63.


The effect of donor source on the outcome of living related renal transplantation.

Gaber AO, Jordan IL, Winsett RP, Ammons JA, Phillips DC, Vera SR, Roy S 3rd, Britt LG.

Transplant Proc. 1990 Apr;22(2):340-1. No abstract available.


Survey of attitudes of health care professionals toward organ donation.

Gaber AO, Hall G, Phillips DC, Tolley EA, Britt LG.

Transplant Proc. 1990 Apr;22(2):313-5. No abstract available.


Refined structure of baboon alpha-lactalbumin at 1.7 A resolution. Comparison with C-type lysozyme.

Acharya KR, Stuart DI, Walker NP, Lewis M, Phillips DC.

J Mol Biol. 1989 Jul 5;208(1):99-127.


Protein-oligosaccharide interactions: lysozyme, phosphorylase, amylases.

Johnson LN, Cheetham J, McLaughlin PJ, Acharya KR, Barford D, Phillips DC.

Curr Top Microbiol Immunol. 1988;139:81-134. Review. No abstract available.


An X-ray-crystallographic study of beta-lactamase II from Bacillus cereus at 0.35 nm resolution.

Sutton BJ, Artymiuk PJ, Cordero-Borboa AE, Little C, Phillips DC, Waley SG.

Biochem J. 1987 Nov 15;248(1):181-8.


From lysozyme to alpha-lactalbumin: protein engineering and evolution.

Phillips DC, Acharya KR, Handoll HH, Stuart DI.

Biochem Soc Trans. 1987 Aug;15(4):737-44. No abstract available.


Epidural catheter migration during labour.

Phillips DC, Macdonald R.

Anaesthesia. 1987 Jun;42(6):661-3.


Crystallographic analysis of the three-dimensional structure of baboon alpha-lactalbumin at low resolution. Homology with lysozyme.

Smith SG, Lewis M, Aschaffenburg R, Fenna RE, Wilson IA, Sundaralingam M, Stuart DI, Phillips DC.

Biochem J. 1987 Mar 1;242(2):353-60.


Alpha-lactalbumin possesses a novel calcium binding loop.

Stuart DI, Acharya KR, Walker NP, Smith SG, Lewis M, Phillips DC.

Nature. 1986 Nov 6-12;324(6092):84-7.


Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme.

Daar IO, Artymiuk PJ, Phillips DC, Maquat LE.

Proc Natl Acad Sci U S A. 1986 Oct;83(20):7903-7.


Molecular dynamics simulations of native and substrate-bound lysozyme. A study of the average structures and atomic fluctuations.

Post CB, Brooks BR, Karplus M, Dobson CM, Artymiuk PJ, Cheetham JC, Phillips DC.

J Mol Biol. 1986 Aug 5;190(3):455-79.


Possible subarachnoid migration of an epidural catheter.

Phillips DC, MacDonald R, Lyons G.

Anaesthesia. 1986 Jun;41(6):653-4. No abstract available.


Tertiary structural similarity between a class A beta-lactamase and a penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase.

Samraoui B, Sutton BJ, Todd RJ, Artymiuk PJ, Waley SG, Phillips DC.

Nature. 1986 Mar 27-Apr 2;320(6060):378-80.


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