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Water-Soluble Silver(I) Complexes Featuring the Hemilabile 3,7-Dimethyl-1,3,5-triaza-7-phosphabicyclo[3.3.1]nonane Ligand: Synthesis, Characterization, and Antimicrobial Activity.

Armstrong D, Kirk SM, Murphy C, Guerriero A, Peruzzini M, Gonsalvi L, Phillips AD.

Inorg Chem. 2018 Jun 4;57(11):6309-6323. doi: 10.1021/acs.inorgchem.8b00227. Epub 2018 May 23.


The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies.

Stenson PD, Mort M, Ball EV, Evans K, Hayden M, Heywood S, Hussain M, Phillips AD, Cooper DN.

Hum Genet. 2017 Jun;136(6):665-677. doi: 10.1007/s00439-017-1779-6. Epub 2017 Mar 27. Review.


Matrix expansion and syncytial aggregation of syndecan-1+ cells underpin villous atrophy in coeliac disease.

Salvestrini C, Lucas M, Lionetti P, Torrente F, James S, Phillips AD, Murch SH.

PLoS One. 2014 Sep 8;9(9):e106005. doi: 10.1371/journal.pone.0106005. eCollection 2014.


Shiga toxin production and translocation during microaerobic human colonic infection with Shiga toxin-producing E. coli O157:H7 and O104:H4.

Tran SL, Billoud L, Lewis SB, Phillips AD, Schüller S.

Cell Microbiol. 2014 Aug;16(8):1255-66. doi: 10.1111/cmi.12281. Epub 2014 Mar 21.


Towards the design of novel boron- and nitrogen-substituted ammonia-borane and bifunctional arene ruthenium catalysts for hydrogen storage.

Bandaru S, English NJ, Phillips AD, MacElroy JM.

J Comput Chem. 2014 May 5;35(12):891-903. doi: 10.1002/jcc.23534. Epub 2014 Feb 5.


A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy.

Walker D, Knuchel-Takano A, McCutchan A, Chang YM, Downes C, Miller S, Stevens K, Verheyen K, Phillips AD, Miah S, Turmaine M, Hibbert A, Steiner JM, Suchodolski JS, Mohan K, Eastwood J, Allenspach K, Smith K, Garden OA.

J Vet Intern Med. 2013 Jul-Aug;27(4):862-74. doi: 10.1111/jvim.12093. Epub 2013 May 10.


Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing.

Xue Y, Chen Y, Ayub Q, Huang N, Ball EV, Mort M, Phillips AD, Shaw K, Stenson PD, Cooper DN, Tyler-Smith C; 1000 Genomes Project Consortium.

Am J Hum Genet. 2012 Dec 7;91(6):1022-32. doi: 10.1016/j.ajhg.2012.10.015.


The Human Gene Mutation Database (HGMD) and its exploitation in the fields of personalized genomics and molecular evolution.

Stenson PD, Ball EV, Mort M, Phillips AD, Shaw K, Cooper DN.

Curr Protoc Bioinformatics. 2012 Sep;Chapter 1:Unit1.13. doi: 10.1002/0471250953.bi0113s39.


Insights into hominid evolution from the gorilla genome sequence.

Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen T, Mailund T, Marques-Bonet T, McCarthy S, Montgomery SH, Schwalie PC, Tang YA, Ward MC, Xue Y, Yngvadottir B, Alkan C, Andersen LN, Ayub Q, Ball EV, Beal K, Bradley BJ, Chen Y, Clee CM, Fitzgerald S, Graves TA, Gu Y, Heath P, Heger A, Karakoc E, Kolb-Kokocinski A, Laird GK, Lunter G, Meader S, Mort M, Mullikin JC, Munch K, O'Connor TD, Phillips AD, Prado-Martinez J, Rogers AS, Sajjadian S, Schmidt D, Shaw K, Simpson JT, Stenson PD, Turner DJ, Vigilant L, Vilella AJ, Whitener W, Zhu B, Cooper DN, de Jong P, Dermitzakis ET, Eichler EE, Flicek P, Goldman N, Mundy NI, Ning Z, Odom DT, Ponting CP, Quail MA, Ryder OA, Searle SM, Warren WC, Wilson RK, Schierup MH, Rogers J, Tyler-Smith C, Durbin R.

Nature. 2012 Mar 7;483(7388):169-75. doi: 10.1038/nature10842.


Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease.

Casola C, Zekonyte U, Phillips AD, Cooper DN, Hahn MW.

Genome Res. 2012 Mar;22(3):429-35. doi: 10.1101/gr.127738.111. Epub 2011 Nov 16.


Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative Escherichia coli.

Edwards LA, Bajaj-Elliott M, Klein NJ, Murch SH, Phillips AD.

PLoS One. 2011;6(10):e27030. doi: 10.1371/journal.pone.0027030. Epub 2011 Oct 28.


Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics.

Hartinger CG, Phillips AD, Nazarov AA.

Curr Top Med Chem. 2011;11(21):2688-702. Review.


Intestinal alpha-defensin expression in pediatric inflammatory bowel disease.

Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips AD, Lucas M, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S.

Inflamm Bowel Dis. 2011 Oct;17(10):2076-86. doi: 10.1002/ibd.21577. Epub 2010 Dec 16.


Enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation.

Edwards LA, O'Neill C, Furman MA, Hicks S, Torrente F, Pérez-Machado M, Wellington EM, Phillips AD, Murch SH.

Inflamm Bowel Dis. 2012 Apr;18(4):624-40. doi: 10.1002/ibd.21852. Epub 2011 Sep 1.


Significance of molecular testing for congenital chloride diarrhea.

Lechner S, Ruemmele FM, Zankl A, Lausch E, Huber WD, Mihatsch W, Phillips AD, Lewindon P, Querfeld U, Heinz-Erian P, Müller T, Janecke AR.

J Pediatr Gastroenterol Nutr. 2011 Jul;53(1):48-54. doi: 10.1097/MPG.0b013e31820bc856.


Aberrant response to commensal Bacteroides thetaiotaomicron in Crohn's disease: an ex vivo human organ culture study.

Edwards LA, Lucas M, Edwards EA, Torrente F, Heuschkel RB, Klein NJ, Murch SH, Bajaj-Elliott M, Phillips AD.

Inflamm Bowel Dis. 2011 May;17(5):1201-8. doi: 10.1002/ibd.21501. Epub 2010 Nov 4.


Comparative analysis of germline and somatic microlesion mutational spectra in 17 human tumor suppressor genes.

Ivanov D, Hamby SE, Stenson PD, Phillips AD, Kehrer-Sawatzki H, Cooper DN, Chuzhanova N.

Hum Mutat. 2011 Jun;32(6):620-32. doi: 10.1002/humu.21483. Epub 2011 Mar 22.


Expression of human beta-defensins in children with chronic inflammatory bowel disease.

Zilbauer M, Jenke A, Wenzel G, Postberg J, Heusch A, Phillips AD, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S.

PLoS One. 2010 Oct 22;5(10):e15389. doi: 10.1371/journal.pone.0015389.


Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics.

Cooper DN, Chen JM, Ball EV, Howells K, Mort M, Phillips AD, Chuzhanova N, Krawczak M, Kehrer-Sawatzki H, Stenson PD.

Hum Mutat. 2010 Jun;31(6):631-55. doi: 10.1002/humu.21260. Review.


The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Newton HJ, Pearson JS, Badea L, Kelly M, Lucas M, Holloway G, Wagstaff KM, Dunstone MA, Sloan J, Whisstock JC, Kaper JB, Robins-Browne RM, Jans DA, Frankel G, Phillips AD, Coulson BS, Hartland EL.

PLoS Pathog. 2010 May 13;6(5):e1000898. doi: 10.1371/journal.ppat.1000898.


Microaerobic conditions enhance type III secretion and adherence of enterohaemorrhagic Escherichia coli to polarized human intestinal epithelial cells.

Schüller S, Phillips AD.

Environ Microbiol. 2010 Sep;12(9):2426-35. doi: 10.1111/j.1462-2920.2010.02216.x. Epub 2010 Apr 7.


The Human Gene Mutation Database: providing a comprehensive central mutation database for molecular diagnostics and personalized genomics.

Stenson PD, Ball EV, Howells K, Phillips AD, Mort M, Cooper DN.

Hum Genomics. 2009 Dec;4(2):69-72. No abstract available.


Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo.

Crepin VF, Girard F, Schüller S, Phillips AD, Mousnier A, Frankel G.

Mol Microbiol. 2010 Jan;75(2):308-23. doi: 10.1111/j.1365-2958.2009.06938.x. Epub 2009 Nov 2.


The Human Gene Mutation Database: 2008 update.

Stenson PD, Mort M, Ball EV, Howells K, Phillips AD, Thomas NS, Cooper DN.

Genome Med. 2009 Jan 22;1(1):13. doi: 10.1186/gm13.


The Escherichia coli common pilus and the bundle-forming pilus act in concert during the formation of localized adherence by enteropathogenic E. coli.

Saldaña Z, Erdem AL, Schüller S, Okeke IN, Lucas M, Sivananthan A, Phillips AD, Kaper JB, Puente JL, Girón JA.

J Bacteriol. 2009 Jun;191(11):3451-61. doi: 10.1128/JB.01539-08. Epub 2009 Feb 13.


Synergistic role of curli and cellulose in cell adherence and biofilm formation of attaching and effacing Escherichia coli and identification of Fis as a negative regulator of curli.

Saldaña Z, Xicohtencatl-Cortes J, Avelino F, Phillips AD, Kaper JB, Puente JL, Girón JA.

Environ Microbiol. 2009 Apr;11(4):992-1006. doi: 10.1111/j.1462-2920.2008.01824.x. Epub 2009 Nov 14.


The ex vivo response of human intestinal mucosa to enteropathogenic Escherichia coli infection.

Schüller S, Lucas M, Kaper JB, Girón JA, Phillips AD.

Cell Microbiol. 2009 Mar;11(3):521-30. doi: 10.1111/j.1462-5822.2008.01275.x. Epub 2008 Dec 30.


Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.

Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD, Berger CN, Mousnier A, Crepin VF, Kruidenier L, Woodward MJ, Stevens MP, La Ragione RM, MacDonald TT, Frankel G.

Infect Immun. 2008 Nov;76(11):4804-13. doi: 10.1128/IAI.00742-08. Epub 2008 Aug 25.


Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo.

Mousnier A, Whale AD, Schüller S, Leong JM, Phillips AD, Frankel G.

Infect Immun. 2008 Oct;76(10):4669-76. doi: 10.1128/IAI.00140-08. Epub 2008 Aug 4.


Synthesis and characterization of a quasi-one-coordinate lead cation.

Hino S, Brynda M, Phillips AD, Power PP.

Angew Chem Int Ed Engl. 2004 May 10;43(20):2655-8. No abstract available.


Interaction of enterohemorrhagic Escherichia coli O157:H7 with mouse intestinal mucosa.

Girard F, Frankel G, Phillips AD, Cooley W, Weyer U, Dugdale AH, Woodward MJ, La Ragione RM.

FEMS Microbiol Lett. 2008 Jun;283(2):196-202. doi: 10.1111/j.1574-6968.2008.01166.x. Epub 2008 Apr 16.


Attaching effacing Escherichia coli and paradigms of Tir-triggered actin polymerization: getting off the pedestal.

Frankel G, Phillips AD.

Cell Microbiol. 2008 Mar;10(3):549-56. Epub 2007 Dec 4. Review.


Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2.

Bai L, Schüller S, Whale A, Mousnier A, Marches O, Wang L, Ooka T, Heuschkel R, Torrente F, Kaper JB, Gomes TA, Xu J, Phillips AD, Frankel G.

Infect Immun. 2008 Jan;76(1):361-8. Epub 2007 Nov 5.


TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli.

Whale AD, Hernandes RT, Ooka T, Beutin L, Schüller S, Garmendia J, Crowther L, Vieira MAM, Ogura Y, Krause G, Phillips AD, Gomes TAT, Hayashi T, Frankel G.

Microbiology. 2007 Jun;153(Pt 6):1743-1755. doi: 10.1099/mic.0.2006/004325-0.


Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms.

Vock CA, Ang WH, Scolaro C, Phillips AD, Lagopoulos L, Juillerat-Jeanneret L, Sava G, Scopelliti R, Dyson PJ.

J Med Chem. 2007 May 3;50(9):2166-75. Epub 2007 Apr 10.


Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism.

Mundy R, Schüller S, Girard F, Fairbrother JM, Phillips AD, Frankel G.

Microbiology. 2007 Apr;153(Pt 4):959-967. doi: 10.1099/mic.0.2006/003467-0.


Adherence of enterohemorrhagic Escherichia coli O157, O26, and O111 strains to bovine intestinal explants ex vivo.

Girard F, Dziva F, van Diemen P, Phillips AD, Stevens MP, Frankel G.

Appl Environ Microbiol. 2007 May;73(9):3084-90. Epub 2007 Mar 9.


Human intestinal tissue tropism in Escherichia coli O157 : H7--initial colonization of terminal ileum and Peyer's patches and minimal colonic adhesion ex vivo.

Chong Y, Fitzhenry R, Heuschkel R, Torrente F, Frankel G, Phillips AD.

Microbiology. 2007 Mar;153(Pt 3):794-802. doi: 10.1099/mic.0.2006/003178-0.


Shiga toxin binding in normal and inflamed human intestinal mucosa.

Schüller S, Heuschkel R, Torrente F, Kaper JB, Phillips AD.

Microbes Infect. 2007 Jan;9(1):35-9. Epub 2006 Dec 15.


Detection of enteroaggregative Escherichia coli in faecal samples from patients in the community with diarrhoea.

Jenkins C, Tembo M, Chart H, Cheasty T, Willshaw GA, Phillips AD, Tompkins D, Smith H.

J Med Microbiol. 2006 Nov;55(Pt 11):1493-7.


Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexes.

Vock CA, Scolaro C, Phillips AD, Scopelliti R, Sava G, Dyson PJ.

J Med Chem. 2006 Sep 7;49(18):5552-61.


Letter to the editor for the article "Celiac disease with mild to moderate histological changes is a common cause of chronic diarrhea in Indian children" published in August 2005 issue.

Bhatnagar S, Phillips AD, Bhan MK.

J Pediatr Gastroenterol Nutr. 2006 Aug;43(2):263. No abstract available. Erratum in: J Pediatr Gastroenterol Nutr. 2007 Nov;45(5):618. Bhatnagar, Shinjini [added]; Phillips, Alan D [added]; Bhan, Maharaj K [added]; Poddar, Ujjal [removed]; Yaccha, Surender Kumar [removed].


Celiac disease in India.

Poddar U, Yachha SK.

J Pediatr Gastroenterol Nutr. 2006 Aug;43(2):263-4. No abstract available. Erratum in: J Pediatr Gastroenterol Nutr. 2007 Nov;45(5):618. Poddar, Ujjal [added]; Yaccha, Surender Kumar [added]; Bhatnagar, Shinjini [removed]; Phillips, Alan D [removed]; Bhan, Maharaj K [removed].


Long polar fimbriae and tissue tropism in Escherichia coli O157:H7.

Fitzhenry R, Dahan S, Torres AG, Chong Y, Heuschkel R, Murch SH, Thomson M, Kaper JB, Frankel G, Phillips AD.

Microbes Infect. 2006 Jun;8(7):1741-9. Epub 2006 May 2.


A counterintuitive structural effect of metal-metal bond protonation and its electronic underpinnings.

Phillips AD, Ienco A, Reinhold J, Böttcher HC, Mealli C.

Chemistry. 2006 Jun 2;12(17):4691-701.


Experimental and computational studies on the solvent-controlled cluster isomerism of Ru3(H)(CO)9(NPPh3) and related dynamics.

Pattacini R, Predieri G, Tiripicchio A, Mealli C, Phillips AD.

Chem Commun (Camb). 2006 Apr 14;(14):1527-9. Epub 2006 Feb 27.


Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins.

Dean P, Maresca M, Schüller S, Phillips AD, Kenny B.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1876-81. Epub 2006 Jan 30.


The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium.

Tatsuno I, Mundy R, Frankel G, Chong Y, Phillips AD, Torres AG, Kaper JB.

Infect Immun. 2006 Jan;74(1):265-72.


Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens.

Marchés O, Wiles S, Dziva F, La Ragione RM, Schüller S, Best A, Phillips AD, Hartland EL, Woodward MJ, Stevens MP, Frankel G.

Infect Immun. 2005 Dec;73(12):8411-7.

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