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Items: 1 to 50 of 482

1.

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2).

Gregory JM, Smith TJ, Slaughter JC, Mason HR, Hughey CC, Smith MS, Kandasamy B, Greeley SAW, Philipson LH, Naylor RN, Letourneau LR, Abumrad NN, Cherrington AD, Moore DJ.

Diabetes. 2019 Aug;68(8):1565-1576. doi: 10.2337/db19-0324. Epub 2019 May 15.

PMID:
31092478
2.

GCK-MODY in the US Monogenic Diabetes Registry: Description of 27 unpublished variants.

Sanyoura M, Letourneau L, Knight Johnson AE, Del Gaudio D, Greeley SAW, Philipson LH, Naylor RN.

Diabetes Res Clin Pract. 2019 May;151:231-236. doi: 10.1016/j.diabres.2019.04.017. Epub 2019 May 4.

PMID:
31063852
3.

Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry.

Dickens LT, Letourneau LR, Sanyoura M, Greeley SAW, Philipson LH, Naylor RN.

Acta Diabetol. 2019 Apr;56(4):405-411. doi: 10.1007/s00592-018-1267-z. Epub 2018 Dec 11.

PMID:
30535721
4.

Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.

Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC.

J Clin Invest. 2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994. Epub 2018 Dec 3.

5.

Multi-level Supervision and Modification of Artificial Pancreas Control System.

Feng J, Hajizadeh I, Yu X, Rashid M, Turksoy K, Samadi S, Sevil M, Hobbs N, Brandt R, Lazaro C, Maloney Z, Littlejohn E, Philipson LH, Cinar A.

Comput Chem Eng. 2018 Apr 6;112:57-69. doi: 10.1016/j.compchemeng.2018.02.002. Epub 2018 Feb 10.

6.

Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options.

Sanyoura M, Philipson LH, Naylor R.

Curr Diab Rep. 2018 Jun 22;18(8):58. doi: 10.1007/s11892-018-1024-2. Review.

7.

Precision medicine in KCNJ11 permanent neonatal diabetes.

Greeley SAW, Letourneau LR, Philipson LH.

Lancet Diabetes Endocrinol. 2018 Aug;6(8):594-595. doi: 10.1016/S2213-8587(18)30138-4. Epub 2018 Jun 4. No abstract available.

8.

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC.

Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032.

9.

Early Intensive Insulin Use May Preserve β-Cell Function in Neonatal Diabetes Due to Mutations in the Proinsulin Gene.

Letourneau LR, Carmody D, Philipson LH, Greeley SAW.

J Endocr Soc. 2017 Nov 24;2(1):1-8. doi: 10.1210/js.2017-00356. eCollection 2018 Jan 1.

10.

Comparative evaluation of simple indices using a single fasting blood sample to estimate beta cell function after islet transplantation.

Gołębiewska JE, Solomina J, Thomas C, Kijek MR, Bachul PJ, Basto L, Gołąb K, Wang LJ, Fillman N, Tibudan M, Ciepły K, Philipson L, Dębska-Ślizień A, Millis JM, Fung J, Witkowski P.

Am J Transplant. 2018 Apr;18(4):990-997. doi: 10.1111/ajt.14620. Epub 2018 Jan 21.

11.

External Validation of the Newly Developed BETA-2 Scoring System for Pancreatic Islet Graft Function Assessment.

Gołębiewska J, Solomina J, Kijek MR, Kotukhov A, Basto L, Gołąb K, Bachul PJ, Konsur E, Ciepły K, Fillman N, Wang LJ, Thomas CC, Philipson LH, Tibudan M, Krenc A, Dębska-Ślizień A, Fung J, Witkowski P.

Transplant Proc. 2017 Dec;49(10):2340-2346. doi: 10.1016/j.transproceed.2017.10.011.

12.

Pain Control, Glucose Control, and Quality of Life in Patients With Chronic Pancreatitis After Total Pancreatectomy With Islet Autotransplantation: A Preliminary Report.

Solomina J, Gołębiewska J, Kijek MR, Kotukhov A, Bachul PJ, Basto L, Gołąb K, Konsur E, Cieply K, Fillman N, Wang LJ, Thomas CC, Philipson LH, Tibudan M, Dębska-Ślizień A, Fung J, Gelrud A, Matthews JB, Witkowski P.

Transplant Proc. 2017 Dec;49(10):2333-2339. doi: 10.1016/j.transproceed.2017.10.010.

13.

FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

Hwang JL, Park SY, Ye H, Sanyoura M, Pastore AN, Carmody D, Del Gaudio D, Wilson JF, Hanis CL, Liu X, Atzmon G, Glaser B, Philipson LH, Greeley SAW; T2D-Genes Consortium.

Pediatr Diabetes. 2018 May;19(3):388-392. doi: 10.1111/pedi.12612. Epub 2017 Nov 29.

14.

Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on β-Cell Function.

Vierra NC, Dickerson MT, Philipson LH, Jacobson DA.

Methods Mol Biol. 2018;1684:73-84. doi: 10.1007/978-1-4939-7362-0_7.

15.

Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.

Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V.

Diabetes. 2018 Jan;67(1):71-77. doi: 10.2337/db17-0982. Epub 2017 Oct 16.

16.

Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.

Sanyoura M, Jacobsen L, Carmody D, Del Gaudio D, Alkorta-Aranburu G, Arndt K, Hu Y, Kobiernicki F, Kusmartseva I, Atkinson MA, Philipson LH, Schatz D, Campbell-Thompson M, Greeley SAW.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):35-45. doi: 10.1210/jc.2017-01159.

17.

Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis.

Letourneau LR, Carmody D, Wroblewski K, Denson AM, Sanyoura M, Naylor RN, Philipson LH, Greeley SAW.

Diabetes Care. 2017 Oct;40(10):e147-e148. doi: 10.2337/dc17-1145. Epub 2017 Aug 4. No abstract available.

18.

Correlative imaging across microscopy platforms using the fast and accurate relocation of microscopic experimental regions (FARMER) method.

Huynh T, Daddysman MK, Bao Y, Selewa A, Kuznetsov A, Philipson LH, Scherer NF.

Rev Sci Instrum. 2017 May;88(5):053702. doi: 10.1063/1.4982818.

PMID:
28571460
19.

Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes.

Greeley SA, Zielinski MC, Poudel A, Ye H, Berry S, Taxy JB, Carmody D, Steiner DF, Philipson LH, Wood JR, Hara M.

J Clin Endocrinol Metab. 2017 Jan 1;102(1):1-5. doi: 10.1210/jc.2016-2826.

20.

Outcomes of Pancreatic Islet Allotransplantation Using the Edmonton Protocol at the University of Chicago.

Tekin Z, Garfinkel MR, Chon WJ, Schenck L, Golab K, Savari O, Thistlethwaite JR, Philipson LH, Majewski C, Pannain S, Ramachandran S, Rezania K, Hariprasad SM, Millis JM, Witkowski P.

Transplant Direct. 2016 Sep 13;2(10):e105. eCollection 2016 Oct.

21.

Growth Hormone-Releasing Hormone in Diabetes.

Fridlyand LE, Tamarina NA, Schally AV, Philipson LH.

Front Endocrinol (Lausanne). 2016 Oct 10;7:129. eCollection 2016. Review.

22.

Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls.

Carmody D, Pastore AN, Landmeier KA, Letourneau LR, Martin R, Hwang JL, Naylor RN, Hunter SJ, Msall ME, Philipson LH, Scott MN, Greeley SA.

Diabet Med. 2016 Oct;33(10):1380-6. doi: 10.1111/dme.13159. Epub 2016 Jun 22.

23.

The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.

Rosario W, Singh I, Wautlet A, Patterson C, Flak J, Becker TC, Ali A, Tamarina N, Philipson LH, Enquist LW, Myers MG Jr, Rhodes CJ.

Diabetes. 2016 Sep;65(9):2711-23. doi: 10.2337/db15-0629. Epub 2016 Apr 12.

24.

Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis.

Fridlyand LE, Philipson LH.

PLoS One. 2016 May 3;11(5):e0152869. doi: 10.1371/journal.pone.0152869. eCollection 2016.

25.

GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated.

Carmody D, Naylor RN, Bell CD, Berry S, Montgomery JT, Tadie EC, Hwang JL, Greeley SA, Philipson LH.

Acta Diabetol. 2016 Oct;53(5):703-8. doi: 10.1007/s00592-016-0859-8. Epub 2016 Apr 22.

26.

A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling.

Yi Y, Sun X, Gibson-Corley K, Xie W, Liang B, He N, Tyler SR, Uc A, Philipson LH, Wang K, Hara M, Ode KL, Norris AW, Engelhardt JF.

Endocrinology. 2016 May;157(5):1852-65. doi: 10.1210/en.2015-1935. Epub 2016 Feb 10.

27.

Resting beta-cells - A functional reserve?

Hara M, Fowler JL, Bell GI, Philipson LH.

Diabetes Metab. 2016 Jun;42(3):157-61. doi: 10.1016/j.diabet.2016.01.001. Epub 2016 Jan 27. Review.

PMID:
26827115
28.

TCF1 links GIPR signaling to the control of beta cell function and survival.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ.

Nat Med. 2016 Jan;22(1):84-90. doi: 10.1038/nm.3997. Epub 2015 Dec 7.

PMID:
26642437
29.

PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids.

Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette LJ, Philipson LH, Kiss RS, Poitout V, Alquier T, Estall JL.

Mol Metab. 2015 Aug 14;4(11):811-22. doi: 10.1016/j.molmet.2015.08.001. eCollection 2015 Nov.

30.

Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis.

Fan F, Ji C, Wu Y, Ferguson SM, Tamarina N, Philipson LH, Lou X.

J Clin Invest. 2015 Nov 2;125(11):4026-41. doi: 10.1172/JCI80652. Epub 2015 Sep 28.

31.

An online monogenic diabetes discussion group: supporting families and fueling new research.

Perrone ME, Carmody D, Philipson LH, Greeley SA.

Transl Res. 2015 Nov;166(5):425-31. doi: 10.1016/j.trsl.2015.06.013. Epub 2015 Jun 28.

32.

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.

Swisa A, Granot Z, Tamarina N, Sayers S, Bardeesy N, Philipson L, Hodson DJ, Wikstrom JD, Rutter GA, Leibowitz G, Glaser B, Dor Y.

J Biol Chem. 2015 Aug 21;290(34):20934-46. doi: 10.1074/jbc.M115.639237. Epub 2015 Jul 2.

33.

Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism.

Carmody D, Park SY, Ye H, Perrone ME, Alkorta-Aranburu G, Highland HM, Hanis CL, Philipson LH, Bell GI, Greeley SA.

J Med Genet. 2015 Sep;52(9):612-6. doi: 10.1136/jmedgenet-2015-103220. Epub 2015 Jun 22.

34.

Insulin dosing in pediatric diabetic ketoacidosis: where to start?

Carmody D, Naylor RN, Philipson LH.

JAMA. 2015 Jun 9;313(22):2274-5. doi: 10.1001/jama.2015.135. No abstract available.

PMID:
26057288
35.

Role of noninsulin therapies alone or in combination in chromosome 6q24-related transient neonatal diabetes: sulfonylurea improves but does not always normalize insulin secretion.

Carmody D, Beca FA, Bell CD, Hwang JL, Dickens JT, Devine NA, Mackay DJ, Temple IK, Hays LR, Naylor RN, Philipson LH, Greeley SA.

Diabetes Care. 2015 Jun;38(6):e86-7. doi: 10.2337/dc14-3056. No abstract available.

36.

Insulin Biosynthesis, Secretion, Structure, and Structure-Activity Relationships.

Weiss M, Steiner DF, Philipson LH.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
2014 Feb 1.

37.

Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes.

Thurber BW, Carmody D, Tadie EC, Pastore AN, Dickens JT, Wroblewski KE, Naylor RN, Philipson LH, Greeley SA; United States Neonatal Diabetes Working Group.

Diabetologia. 2015 Jul;58(7):1430-5. doi: 10.1007/s00125-015-3593-9. Epub 2015 Apr 17.

38.

Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A.

Rajan S, Dickson LM, Mathew E, Orr CM, Ellenbroek JH, Philipson LH, Wicksteed B.

Mol Metab. 2015 Feb 3;4(4):265-76. doi: 10.1016/j.molmet.2015.01.010. eCollection 2015 Apr.

39.

A review of the mental health issues of diabetes conference.

Ducat L, Rubenstein A, Philipson LH, Anderson BJ.

Diabetes Care. 2015 Feb;38(2):333-8. doi: 10.2337/dc14-1383. Review.

40.

Donald F. Steiner MD, 1930-2014: discoverer of proinsulin.

Philipson LH, Bell G, Polonsky KS.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):940-1. doi: 10.1073/pnas.1423774112. Epub 2015 Jan 5. No abstract available.

41.

Routine depression screening for patients with diabetes--reply.

Ducat LJ, Philipson LH, Anderson BJ.

JAMA. 2014 Dec 10;312(22):2413. doi: 10.1001/jama.2014.14778. No abstract available.

42.
43.

Update on diabetes classification.

Thomas CC, Philipson LH.

Med Clin North Am. 2015 Jan;99(1):1-16. doi: 10.1016/j.mcna.2014.08.015. Epub 2014 Nov 22. Review.

PMID:
25456640
44.

Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

Kim K, Oh CM, Ohara-Imaizumi M, Park S, Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty G, Nagamatsu S, German MS, Kim H.

Endocrinology. 2015 Feb;156(2):444-52. doi: 10.1210/en.2014-1687. Epub 2014 Nov 26.

45.

Sulfonylurea treatment before genetic testing in neonatal diabetes: pros and cons.

Carmody D, Bell CD, Hwang JL, Dickens JT, Sima DI, Felipe DL, Zimmer CA, Davis AO, Kotlyarevska K, Naylor RN, Philipson LH, Greeley SA.

J Clin Endocrinol Metab. 2014 Dec;99(12):E2709-14. doi: 10.1210/jc.2014-2494.

46.

The mental health comorbidities of diabetes.

Ducat L, Philipson LH, Anderson BJ.

JAMA. 2014 Aug 20;312(7):691-2. doi: 10.1001/jama.2014.8040. No abstract available.

47.

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.

Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2319-28. doi: 10.1073/pnas.1323066111. Epub 2014 May 19.

48.

The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.

Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA.

Cell Metab. 2014 Jun 3;19(6):1050-7. doi: 10.1016/j.cmet.2014.04.005. Epub 2014 May 15.

49.

Neonatal diabetes: the brain comes into focus.

Carmody D, Philipson L.

Lancet Diabetes Endocrinol. 2013 Nov;1(3):167-8. doi: 10.1016/S2213-8587(13)70094-9. Epub 2013 Sep 6. No abstract available.

PMID:
24622356
50.

Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets.

Sui H, Yi Y, Yao J, Liang B, Sun X, Hu S, Uc A, Nelson DJ, Ode KL, Philipson LH, Engelhardt JF, Norris AW.

PLoS One. 2014 Mar 3;9(3):e90519. doi: 10.1371/journal.pone.0090519. eCollection 2014.

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