Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 214


Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling.

Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI.

Cell Calcium. 2020 Jan 30;87:102167. doi: 10.1016/j.ceca.2020.102167. [Epub ahead of print]


Heterogeneity of transverse-axial tubule system in mouse atria: Remodeling in atrial-specific Na+-Ca2+ exchanger knockout mice.

Yue X, Zhang R, Kim B, Ma A, Philipson KD, Goldhaber JI.

J Mol Cell Cardiol. 2017 Jul;108:50-60. doi: 10.1016/j.yjmcc.2017.05.008. Epub 2017 May 19.


Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice.

Torrente AG, Zhang R, Wang H, Zaini A, Kim B, Yue X, Philipson KD, Goldhaber JI.

J Physiol. 2017 Jun 15;595(12):3847-3865. doi: 10.1113/JP274249. Epub 2017 May 13.


Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt.

Molinaro P, Sirabella R, Pignataro G, Petrozziello T, Secondo A, Boscia F, Vinciguerra A, Cuomo O, Philipson KD, De Felice M, Di Lauro R, Di Renzo G, Annunziato L.

J Cereb Blood Flow Metab. 2016 Oct;36(10):1790-1803. Epub 2015 Oct 23.


Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.

Torrente AG, Zhang R, Zaini A, Giani JF, Kang J, Lamp ST, Philipson KD, Goldhaber JI.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9769-74. doi: 10.1073/pnas.1505670112. Epub 2015 Jul 20.


Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.

Kapoor N, Tran A, Kang J, Zhang R, Philipson KD, Goldhaber JI.

J Physiol. 2015 Jun 15;593(12):2649-63. doi: 10.1113/JP270082. Epub 2015 May 26.


Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.

Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD.

Mol Cell Biol. 2014 Jun;34(11):1991-2002. doi: 10.1128/MCB.00339-14. Epub 2014 Mar 24.


Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.

Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI.

PLoS One. 2013 Nov 21;8(11):e81633. doi: 10.1371/journal.pone.0081633. eCollection 2013.


Na/Ca exchange and contraction of the heart.

Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI.

J Mol Cell Cardiol. 2013 Aug;61:28-33. doi: 10.1016/j.yjmcc.2013.06.001. Epub 2013 Jun 12. Review.


The topology of the cardiac Na⁺/Ca²⁺ exchanger, NCX1.

Ren X, Philipson KD.

J Mol Cell Cardiol. 2013 Apr;57:68-71. doi: 10.1016/j.yjmcc.2013.01.010. Epub 2013 Jan 31.


Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease.

Goldhaber JI, Philipson KD.

Adv Exp Med Biol. 2013;961:355-64. doi: 10.1007/978-1-4614-4756-6_30. Review.


NCX1: mechanism of transport.

Ottolia M, Philipson KD.

Adv Exp Med Biol. 2013;961:49-54. doi: 10.1007/978-1-4614-4756-6_5. Review.


20 years from NCX purification and cloning: milestones.

Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD.

Adv Exp Med Biol. 2013;961:17-23. doi: 10.1007/978-1-4614-4756-6_2. Review.


Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy.

Bai Y, Morgan EE, Giovannucci DR, Pierre SV, Philipson KD, Askari A, Liu L.

Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H427-35. doi: 10.1152/ajpheart.00462.2012. Epub 2012 Nov 30.


Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.

Gao Z, Rasmussen TP, Li Y, Kutschke W, Koval OM, Wu Y, Wu Y, Hall DD, Joiner ML, Wu XQ, Swaminathan PD, Purohit A, Zimmerman K, Weiss RM, Philipson KD, Song LS, Hund TJ, Anderson ME.

Circ Res. 2013 Jan 18;112(2):309-17. doi: 10.1161/CIRCRESAHA.111.300193. Epub 2012 Nov 27.


Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms.

Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, Schmitz W, Philipson KD, Eckardt L, Kirchhof P, Müller FU.

Basic Res Cardiol. 2012 Mar;107(2):247. doi: 10.1007/s00395-012-0247-7. Epub 2012 Feb 11.


Structural biology. It's all in the symmetry.

Abramson J, Paz A, Philipson KD.

Science. 2012 Feb 10;335(6069):669-70. doi: 10.1126/science.1218696. No abstract available.


Characterization and purification of a Na+/Ca2+ exchanger from an archaebacterium.

Besserer GM, Nicoll DA, Abramson J, Philipson KD.

J Biol Chem. 2012 Mar 9;287(11):8652-9. doi: 10.1074/jbc.M111.331280. Epub 2012 Jan 27.


Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers.

John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1699-704. doi: 10.1073/pnas.1016114108. Epub 2011 Jan 5.


The Na+/Ca2+ exchanger-1 mediates left ventricular dysfunction in mice with chronic intermittent hypoxia.

Chen L, Zhang J, Hu X, Philipson KD, Scharf SM.

J Appl Physiol (1985). 2010 Dec;109(6):1675-85. doi: 10.1152/japplphysiol.01372.2009. Epub 2010 Oct 14.


Myocardial function with reduced expression of the sodium-calcium exchanger.

Jordan MC, Henderson SA, Han T, Fishbein MC, Philipson KD, Roos KP.

J Card Fail. 2010 Sep;16(9):786-96. doi: 10.1016/j.cardfail.2010.03.012. Epub 2010 May 14.


Transmembrane segment packing of the Na(+)/Ca(2+) exchanger investigated with chemical cross-linkers.

Ren X, Nicoll DA, Xu L, Qu Z, Philipson KD.

Biochemistry. 2010 Oct 5;49(39):8585-91. doi: 10.1021/bi101173c. Epub 2010 Sep 9.


Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart.

Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI.

Biophys J. 2010 Aug 4;99(3):755-64. doi: 10.1016/j.bpj.2010.04.071.


Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice.

Larbig R, Torres N, Bridge JH, Goldhaber JI, Philipson KD.

J Physiol. 2010 Sep 1;588(Pt 17):3267-76. doi: 10.1113/jphysiol.2010.187708. Epub 2010 Jul 19.


Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation.

Ottolia M, Nicoll DA, John S, Philipson KD.

Channels (Austin). 2010 May-Jun;4(3):159-62.


Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure.

Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1472-83. doi: 10.1152/ajpheart.00964.2009. Epub 2010 Feb 19.


Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice.

Ren C, Zhang J, Philipson KD, Kotlikoff MI, Blaustein MP, Matteson DR.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1484-91. doi: 10.1152/ajpheart.00965.2009. Epub 2010 Jan 15.


Phospholemman and beta-adrenergic stimulation in the heart.

Wang J, Gao E, Song J, Zhang XQ, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H807-15. doi: 10.1152/ajpheart.00877.2009. Epub 2009 Dec 11.


Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger.

Ottolia M, Nicoll DA, Philipson KD.

J Biol Chem. 2009 Nov 20;284(47):32735-41. doi: 10.1074/jbc.M109.055434. Epub 2009 Oct 2.


Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger.

Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J.

J Biol Chem. 2009 May 29;284(22):14688-92. doi: 10.1074/jbc.C900037200. Epub 2009 Mar 30.


The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension.

Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM.

Hypertension. 2009 Feb;53(2):291-8. doi: 10.1161/HYPERTENSIONAHA.108.119974. Epub 2008 Dec 22. Review. No abstract available.


How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger?

Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J.

Channels (Austin). 2007 Nov-Dec;1(6):397-9. Epub 2008 Jan 24.


Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart.

Xie Y, Ottolia M, John SA, Chen JN, Philipson KD.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C388-93. doi: 10.1152/ajpcell.00178.2008. Epub 2008 Jun 11.


Intermolecular cross-linking of Na+-Ca2+ exchanger proteins: evidence for dimer formation.

Ren X, Nicoll DA, Galang G, Philipson KD.

Biochemistry. 2008 Jun 3;47(22):6081-7. doi: 10.1021/bi800177t. Epub 2008 May 9.


The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis.

Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18467-72. Epub 2007 Oct 25.


A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage.

Luo J, Wang Y, Chen H, Kintner DB, Cramer SW, Gerdts JK, Chen X, Shull GE, Philipson KD, Sun D.

J Cereb Blood Flow Metab. 2008 Apr;28(4):737-46. Epub 2007 Oct 3.


Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger.

Roos KP, Jordan MC, Fishbein MC, Ritter MR, Friedlander M, Chang HC, Rahgozar P, Han T, Garcia AJ, Maclellan WR, Ross RS, Philipson KD.

J Card Fail. 2007 May;13(4):318-29.


Homozygous overexpression of the Na+-Ca2+ exchanger in mice: evidence for increased transsarcolemmal Ca2+ fluxes.

Pott C, Goldhaber JI, Philipson KD.

Ann N Y Acad Sci. 2007 Mar;1099:310-4.


Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1.

Luo J, Wang Y, Chen X, Chen H, Kintner DB, Shull GE, Philipson KD, Sun D.

Ann N Y Acad Sci. 2007 Mar;1099:292-305.


Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling.

Pott C, Henderson SA, Goldhaber JI, Philipson KD.

Ann N Y Acad Sci. 2007 Mar;1099:270-5. Review.


Shedding light on the Na+/Ca2+ exchanger.

Ottolia M, John S, Xie Y, Ren X, Philipson KD.

Ann N Y Acad Sci. 2007 Mar;1099:78-85. Review.


Transmembrane segments I, II, and VI of the canine cardiac Na+/Ca2+ exchanger are in proximity.

Ren X, Nicoll DA, Philipson KD.

Ann N Y Acad Sci. 2007 Mar;1099:40-2. Epub 2007 Mar 1.


Localization of sarcolemmal proteins to lipid rafts in the myocardium.

Cavalli A, Eghbali M, Minosyan TY, Stefani E, Philipson KD.

Cell Calcium. 2007 Sep;42(3):313-22. Epub 2007 Feb 23.


What we know about the structure of NCX1 and how it relates to its function.

Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD.

Ann N Y Acad Sci. 2007 Mar;1099:1-6. Epub 2007 Feb 15. Review.


Xenopus oocyte plasma membrane sheets for FRET analysis.

Ottolia M, Philipson KD, John S.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1519-22. Epub 2006 Dec 13.


Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization.

Ottolia M, John S, Ren X, Philipson KD.

J Biol Chem. 2007 Feb 9;282(6):3695-701. Epub 2006 Dec 11.


Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice.

Pott C, Ren X, Tran DX, Yang MJ, Henderson S, Jordan MC, Roos KP, Garfinkel A, Philipson KD, Goldhaber JI.

Am J Physiol Cell Physiol. 2007 Feb;292(2):C968-73. Epub 2006 Aug 30.


Helix packing of the cardiac Na+-Ca2+ exchanger: proximity of transmembrane segments 1, 2, and 6.

Ren X, Nicoll DA, Philipson KD.

J Biol Chem. 2006 Aug 11;281(32):22808-14. Epub 2006 Jun 19.


The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif.

Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J.

J Biol Chem. 2006 Aug 4;281(31):21577-81. Epub 2006 Jun 14.

Supplemental Content

Loading ...
Support Center