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Items: 1 to 50 of 118

1.

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

Gilmour J, O'Connor L, Middleton CP, Keane P, Gillemans N, Cazier JB, Philipsen S, Bonifer C.

Epigenetics Chromatin. 2019 Jun 4;12(1):33. doi: 10.1186/s13072-019-0282-9.

2.

Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles.

Visser S, Hou J, Bezemer K, de Vogel LL, Hegmans JPJJ, Stricker BH, Philipsen S, Aerts JGJV.

BMC Cancer. 2019 May 14;19(1):440. doi: 10.1186/s12885-019-5645-x.

3.

The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.

Cantú I, van de Werken HJG, Gillemans N, Stadhouders R, Heshusius S, Maas A, Esteghamat F, Ozgur Z, van IJcken WFJ, Grosveld F, von Lindern M, Philipsen S, van Dijk TB.

PLoS One. 2019 Mar 28;14(3):e0208659. doi: 10.1371/journal.pone.0208659. eCollection 2019.

4.

Transcription factor Sp4 is required for hyperalgesic state persistence.

Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M.

PLoS One. 2019 Feb 27;14(2):e0211349. doi: 10.1371/journal.pone.0211349. eCollection 2019.

5.

Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes.

Bouchard C, Sahu P, Meixner M, Nötzold RR, Rust MB, Kremmer E, Feederle R, Hart-Smith G, Finkernagel F, Bartkuhn M, Savai Pullamsetti S, Nist A, Stiewe T, Philipsen S, Bauer UM.

Cell Rep. 2018 Sep 18;24(12):3339-3352. doi: 10.1016/j.celrep.2018.08.052.

6.

Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.

Loucari CC, Patsali P, van Dijk TB, Stephanou C, Papasavva P, Zanti M, Kurita R, Nakamura Y, Christou S, Sitarou M, Philipsen S, Lederer CW, Kleanthous M.

Hum Gene Ther Methods. 2018 Feb;29(1):60-74. doi: 10.1089/hgtb.2017.190.

7.

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.

Norton LJ, Funnell APW, Burdach J, Wienert B, Kurita R, Nakamura Y, Philipsen S, Pearson RCM, Quinlan KGR, Crossley M.

Blood Adv. 2017 Apr 25;1(11):685-692. doi: 10.1182/bloodadvances.2016002303. eCollection 2017 Apr 25.

8.

Identification and in silico structural analysis of Gallus gallus protein arginine methyltransferase 4 (PRMT4).

Berberich H, Terwesten F, Rakow S, Sahu P, Bouchard C, Meixner M, Philipsen S, Kolb P, Bauer UM.

FEBS Open Bio. 2017 Oct 10;7(12):1909-1923. doi: 10.1002/2211-5463.12323. eCollection 2017 Dec.

9.

Evolution of hemoglobin loci and their regulatory elements.

Philipsen S, Hardison RC.

Blood Cells Mol Dis. 2018 May;70:2-12. doi: 10.1016/j.bcmd.2017.08.001. Epub 2017 Aug 9. Review.

10.

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.

Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M.

J Neurochem. 2017 Jan;140(2):245-256. doi: 10.1111/jnc.13908. Epub 2016 Dec 20.

11.

GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid.

Scheenstra MR, De Cuyper IM, Branco-Madeira F, de Bleser P, Kool M, Meinders M, Hoogenboezem M, Mul E, Wolkers MC, Salerno F, Nota B, Saeys Y, Klarenbeek S, van IJcken WF, Hammad H, Philipsen S, van den Berg TK, Kuijpers TW, Lambrecht BN, Gutiérrez L.

J Immunol. 2016 Dec 1;197(11):4312-4324. Epub 2016 Nov 4.

12.

ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus.

Breton A, Theodorou A, Aktuna S, Sonzogni L, Darling D, Chan L, Menzel S, van der Spek PJ, Swagemakers SM, Grosveld F, Philipsen S, Thein SL.

Br J Haematol. 2016 Nov;175(3):525-530. doi: 10.1111/bjh.14256. Epub 2016 Jul 19.

PMID:
27434206
13.

Hereditary persistence of fetal hemoglobin in two patients with KLF1 haploinsufficiency due to 19p13.2-p13.12/13 deletion.

Natiq A, Lysy PA, Gillemans N, Schaap R, Sefiani A, Amzazi S, Chafai El-Alaoui S, Cantú I, Banjanin B, van Lom K, Harteveld CL, Philipsen S.

Am J Hematol. 2017 Jan;92(1):E2-E3. doi: 10.1002/ajh.24574. Epub 2016 Nov 12. No abstract available.

14.

Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA.

Izumikawa K, Yoshikawa H, Ishikawa H, Nobe Y, Yamauchi Y, Philipsen S, Simpson RJ, Isobe T, Takahashi N.

Nucleic Acids Res. 2016 Nov 16;44(20):9847-9859. Epub 2016 Sep 28.

15.

Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach.

Tam KT, Chan PK, Zhang W, Law PP, Tian Z, Fung Chan GC, Philipsen S, Festenstein R, Tan-Un KC.

Nucleic Acids Res. 2017 Jan 9;45(1):115-126. doi: 10.1093/nar/gkw820. Epub 2016 Sep 19.

16.

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.

Perkins A, Xu X, Higgs DR, Patrinos GP, Arnaud L, Bieker JJ, Philipsen S; KLF1 Consensus Workgroup.

Blood. 2016 Apr 14;127(15):1856-62. doi: 10.1182/blood-2016-01-694331. Epub 2016 Feb 22. Review.

17.

TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.

Papadopoulos P, Gutiérrez L, Demmers J, Scheer E, Pourfarzad F, Papageorgiou DN, Karkoulia E, Strouboulis J, van de Werken HJ, van der Linden R, Vandenberghe P, Dekkers DH, Philipsen S, Grosveld F, Tora L.

Mol Cell Biol. 2015 Jun;35(12):2103-18. doi: 10.1128/MCB.01370-14. Epub 2015 Apr 13.

18.

Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells.

Kurek D, Neagu A, Tastemel M, Tüysüz N, Lehmann J, van de Werken HJG, Philipsen S, van der Linden R, Maas A, van IJcken WFJ, Drukker M, Ten Berge D.

Stem Cell Reports. 2015 Jan 13;4(1):114-128. doi: 10.1016/j.stemcr.2014.11.007. Epub 2014 Dec 24.

19.

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.

Meinders M, Kulu DI, van de Werken HJ, Hoogenboezem M, Janssen H, Brouwer RW, van Ijcken WF, Rijkers EJ, Demmers JA, Krüger I, van den Berg TK, Suske G, Gutiérrez L, Philipsen S.

Blood. 2015 Mar 19;125(12):1957-67. doi: 10.1182/blood-2014-08-593343. Epub 2014 Dec 23.

20.

Flicking the switch: adult hemoglobin expression in erythroid cells derived from cord blood and human induced pluripotent stem cells.

Cantú I, Philipsen S.

Haematologica. 2014 Nov;99(11):1647-9. doi: 10.3324/haematol.2014.116483. No abstract available.

21.

Transfusion-independent β(0)-thalassemia after bone marrow transplantation failure: proposed involvement of high parental HbF and an epigenetic mechanism.

Paciaroni K, Lucarelli G, Martelli F, Migliaccio AR, von Lindern M, Borg J, Gillemans N, van Dijk TB, Philipsen S.

Am J Blood Res. 2014 Sep 5;4(1):27-32. eCollection 2014.

22.

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Gilmour J, Assi SA, Jaegle U, Kulu D, van de Werken H, Clarke D, Westhead DR, Philipsen S, Bonifer C.

Development. 2014 Jun;141(12):2391-401. doi: 10.1242/dev.106054. Epub 2014 May 21.

23.

Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.

Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.

Mol Cell Biol. 2014 May;34(10):1812-26. doi: 10.1128/MCB.01524-13. Epub 2014 Mar 10.

24.

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells.

Leithner K, Wohlkoenig C, Stacher E, Lindenmann J, Hofmann NA, Gallé B, Guelly C, Quehenberger F, Stiegler P, Smolle-Jüttner FM, Philipsen S, Popper HH, Hrzenjak A, Olschewski A, Olschewski H.

BMC Cancer. 2014 Jan 25;14:40. doi: 10.1186/1471-2407-14-40.

25.

Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression.

Viprakasit V, Ekwattanakit S, Riolueang S, Chalaow N, Fisher C, Lower K, Kanno H, Tachavanich K, Bejrachandra S, Saipin J, Juntharaniyom M, Sanpakit K, Tanphaichitr VS, Songdej D, Babbs C, Gibbons RJ, Philipsen S, Higgs DR.

Blood. 2014 Mar 6;123(10):1586-95. doi: 10.1182/blood-2013-09-526087. Epub 2014 Jan 17.

26.

A new twist to the GATA switch.

Philipsen S.

Blood. 2013 Nov 14;122(20):3391-2. doi: 10.1182/blood-2013-09-527606.

27.

Locus-specific proteomics by TChP: targeted chromatin purification.

Pourfarzad F, Aghajanirefah A, de Boer E, Ten Have S, Bryn van Dijk T, Kheradmandkia S, Stadhouders R, Thongjuea S, Soler E, Gillemans N, von Lindern M, Demmers J, Philipsen S, Grosveld F.

Cell Rep. 2013 Aug 15;4(3):589-600. doi: 10.1016/j.celrep.2013.07.004. Epub 2013 Aug 1.

28.

Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b.

Bergink S, Theil AF, Toussaint W, De Cuyper IM, Kulu DI, Clapes T, van der Linden R, Demmers JA, Mul EP, van Alphen FP, Marteijn JA, van Gent T, Maas A, Robin C, Philipsen S, Vermeulen W, Mitchell JR, Gutiérrez L.

Mol Cell Biol. 2013 Oct;33(19):3879-92. doi: 10.1128/MCB.05772-11. Epub 2013 Jul 29.

29.

Genomic variation in the MAP3K5 gene is associated with β-thalassemia disease severity and hydroxyurea treatment efficacy.

Tafrali C, Paizi A, Borg J, Radmilovic M, Bartsakoulia M, Giannopoulou E, Giannakopoulou O, Stojiljkovic-Petrovic M, Zukic B, Poulas K, Stavrou EF, Lambropoulou P, Kourakli A, Felice AE, Papachatzopoulou A, Philipsen S, Pavlovic S, Georgitsi M, Patrinos GP.

Pharmacogenomics. 2013 Apr;14(5):469-83. doi: 10.2217/pgs.13.31.

PMID:
23556445
30.

Erythropoiesis: development and differentiation.

Dzierzak E, Philipsen S.

Cold Spring Harb Perspect Med. 2013 Apr 1;3(4):a011601. doi: 10.1101/cshperspect.a011601. Review.

31.

Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas.

Carvalho RH, Hou J, Haberle V, Aerts J, Grosveld F, Lenhard B, Philipsen S.

J Thorac Oncol. 2013 May;8(5):562-73. doi: 10.1097/JTO.0b013e3182863ed2.

32.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantù I, van Gent T, Klingmüller U, van Lom K, von Lindern M, Grosveld F, Bryn van Dijk T, Busslinger M, Philipsen S.

Blood. 2013 Mar 28;121(13):2553-62. doi: 10.1182/blood-2012-06-434530. Epub 2013 Jan 29.

33.

Chtop is a component of the dynamic TREX mRNA export complex.

Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA.

EMBO J. 2013 Feb 6;32(3):473-86. doi: 10.1038/emboj.2012.342. Epub 2013 Jan 8.

34.

A dual reporter mouse model of the human β-globin locus: applications and limitations.

Papadopoulos P, Gutiérrez L, van der Linden R, Kong-A-San J, Maas A, Drabek D, Patrinos GP, Philipsen S, Grosveld F.

PLoS One. 2012;7(12):e51272. doi: 10.1371/journal.pone.0051272. Epub 2012 Dec 14.

35.

Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.

Pourfarzad F, von Lindern M, Azarkeivan A, Hou J, Kia SK, Esteghamat F, van Ijcken W, Philipsen S, Najmabadi H, Grosveld F.

Haematologica. 2013 May;98(5):696-704. doi: 10.3324/haematol.2012.074492. Epub 2012 Oct 25.

36.

The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.

Drabek K, Gutiérrez L, Vermeij M, Clapes T, Patel SR, Boisset JC, van Haren J, Pereira AL, Liu Z, Akinci U, Nikolic T, van Ijcken W, van den Hout M, Meinders M, Melo C, Sambade C, Drabek D, Hendriks RW, Philipsen S, Mommaas M, Grosveld F, Maiato H, Italiano JE Jr, Robin C, Galjart N.

Cell Rep. 2012 Oct 25;2(4):781-8. doi: 10.1016/j.celrep.2012.08.040. Epub 2012 Oct 19.

37.

KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.

Borg J, Phylactides M, Bartsakoulia M, Tafrali C, Lederer C, Felice AE, Papachatzopoulou A, Kourakli A, Stavrou EF, Christou S, Hou J, Karkabouna S, Lappa-Manakou C, Ozgur Z, van Ijcken W, von Lindern M, Grosveld FG, Georgitsi M, Kleanthous M, Philipsen S, Patrinos GP.

Pharmacogenomics. 2012 Oct;13(13):1487-500. doi: 10.2217/pgs.12.125.

PMID:
23057549
38.

Regulation of GATA factor expression is distinct between erythroid and mast cell lineages.

Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, Yamamoto M, Ohneda K.

Mol Cell Biol. 2012 Dec;32(23):4742-55. doi: 10.1128/MCB.00718-12. Epub 2012 Sep 17.

39.

Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Fanis P, Gillemans N, Aghajanirefah A, Pourfarzad F, Demmers J, Esteghamat F, Vadlamudi RK, Grosveld F, Philipsen S, van Dijk TB.

Mol Cell Proteomics. 2012 Nov;11(11):1263-73. doi: 10.1074/mcp.M112.017194. Epub 2012 Aug 7.

40.

Genome-wide DNA methylation profiling of non-small cell lung carcinomas.

Carvalho RH, Haberle V, Hou J, van Gent T, Thongjuea S, van Ijcken W, Kockx C, Brouwer R, Rijkers E, Sieuwerts A, Foekens J, van Vroonhoven M, Aerts J, Grosveld F, Lenhard B, Philipsen S.

Epigenetics Chromatin. 2012 Jun 22;5(1):9. doi: 10.1186/1756-8935-5-9.

41.

cAMP response element-binding protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells.

Banan M, Esmaeilzadeh-Gharehdaghi E, Nezami M, Deilami Z, Farashi S, Philipsen S, Esteghamat F, Pourfarzad F, Ali Imam AM, Najmabadi H.

Clin Exp Pharmacol Physiol. 2012 Jun;39(6):510-7. doi: 10.1111/j.1440-1681.2012.05702.x.

PMID:
22469229
42.

Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy.

Hou J, Lambers M, den Hamer B, den Bakker MA, Hoogsteden HC, Grosveld F, Hegmans J, Aerts J, Philipsen S.

J Thorac Oncol. 2012 Jan;7(1):105-14. doi: 10.1097/JTO.0b013e3182352a45.

43.

Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.

Libregts SF, Gutiérrez L, de Bruin AM, Wensveen FM, Papadopoulos P, van Ijcken W, Ozgür Z, Philipsen S, Nolte MA.

Blood. 2011 Sep 1;118(9):2578-88. doi: 10.1182/blood-2010-10-315218. Epub 2011 Jul 1.

44.

The DNA binding factor Hmg20b is a repressor of erythroid differentiation.

Esteghamat F, van Dijk TB, Braun H, Dekker S, van der Linden R, Hou J, Fanis P, Demmers J, van IJcken W, Ozgür Z, Horos R, Pourfarzad F, von Lindern M, Philipsen S.

Haematologica. 2011 Sep;96(9):1252-60. doi: 10.3324/haematol.2011.045211. Epub 2011 May 23.

45.

Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.

Ingram RM, Valeaux S, Wilson N, Bouhlel MA, Clarke D, Krüger I, Kulu D, Suske G, Philipsen S, Tagoh H, Bonifer C.

Exp Hematol. 2011 Jul;39(7):730-40.e1-2. doi: 10.1016/j.exphem.2011.04.004. Epub 2011 Apr 23.

PMID:
21549805
46.

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.

Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van Ijcken W, Dekkers DH, Demmers J, Rijkers EJ, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA.

Nat Genet. 2011 Jun;43(6):607-11. doi: 10.1038/ng.825. Epub 2011 May 1.

PMID:
21532573
47.

Erythroid phenotypes associated with KLF1 mutations.

Borg J, Patrinos GP, Felice AE, Philipsen S.

Haematologica. 2011 May;96(5):635-8. doi: 10.3324/haematol.2011.043265. No abstract available.

48.

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.

Giardine B, Borg J, Higgs DR, Peterson KR, Philipsen S, Maglott D, Singleton BK, Anstee DJ, Basak AN, Clark B, Costa FC, Faustino P, Fedosyuk H, Felice AE, Francina A, Galanello R, Gallivan MV, Georgitsi M, Gibbons RJ, Giordano PC, Harteveld CL, Hoyer JD, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis MN, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye JS, Wiemann C, Zukic B, Chui DH, Wajcman H, Hardison RC, Patrinos GP.

Nat Genet. 2011 Mar 20;43(4):295-301. doi: 10.1038/ng.785.

49.

Functional and sequence analysis of human neuroglobin gene promoter region.

Zhang W, Tian Z, Sha S, Cheng LY, Philipsen S, Tan-Un KC.

Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):236-44. doi: 10.1016/j.bbagrm.2011.02.003. Epub 2011 Mar 9.

PMID:
21362510
50.

Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.

Stielow B, Krüger I, Diezko R, Finkernagel F, Gillemans N, Kong-a-San J, Philipsen S, Suske G.

PLoS Genet. 2010 Nov 11;6(11):e1001203. doi: 10.1371/journal.pgen.1001203.

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