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Items: 1 to 50 of 97

1.

GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.

Kuchay S, Wang H, Marzio A, Jain K, Homer H, Fehrenbacher N, Philips MR, Zheng N, Pagano M.

Nat Struct Mol Biol. 2019 Jun 17. doi: 10.1038/s41594-019-0249-3. [Epub ahead of print]

PMID:
31209342
2.

A potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor improves survival in Ras-driven acute myeloid leukemia.

Marin-Ramos NI, Balabasquer M, Ortega-Nogales FJ, Torrecillas IR, Gil-Ordoñez A, Marcos-Ramiro B, Aguilar-Garrido P, Cushman I, Romero A, Medrano FJ, Gajate C, Mollinedo F, Philips MR, Campillo M, Gallardo M, Martín-Fontecha M, López-Rodríguez ML, Ortega-Gutierrez S.

J Med Chem. 2019 Jun 10. doi: 10.1021/acs.jmedchem.9b00145. [Epub ahead of print]

PMID:
31181882
3.

Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.

Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3524-3529. doi: 10.1073/pnas.1818880116. Epub 2019 Feb 7.

PMID:
30733287
4.

K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion.

Choi BH, Philips MR, Chen Y, Lu L, Dai W.

J Biol Chem. 2018 Nov 9;293(45):17574-17581. doi: 10.1074/jbc.RA118.003723. Epub 2018 Sep 18.

PMID:
30228186
5.

Posttranslational Modifications of RAS Proteins.

Ahearn I, Zhou M, Philips MR.

Cold Spring Harb Perspect Med. 2018 Nov 1;8(11). pii: a031484. doi: 10.1101/cshperspect.a031484. Review.

6.

Targeting RAS - will GPR31 deliver us a new path forward?

Fehrenbacher N, Philips MR.

Mol Cell Oncol. 2017 Jul 31;4(6):e1359228. doi: 10.1080/23723556.2017.1359228. eCollection 2017.

7.

Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.

Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR.

J Cell Biol. 2017 Dec 4;216(12):4165-4182. doi: 10.1083/jcb.201701053. Epub 2017 Oct 19.

8.

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ.

Sci Signal. 2017 Sep 26;10(498). pii: eaao3332. doi: 10.1126/scisignal.aao3332.

10.

The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

Fehrenbacher N, Tojal da Silva I, Ramirez C, Zhou Y, Cho KJ, Kuchay S, Shi J, Thomas S, Pagano M, Hancock JF, Bar-Sagi D, Philips MR.

J Cell Biol. 2017 Aug 7;216(8):2329-2338. doi: 10.1083/jcb.201609096. Epub 2017 Jun 15.

11.

TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1.

Genova T, Grolez GP, Camillo C, Bernardini M, Bokhobza A, Richard E, Scianna M, Lemonnier L, Valdembri D, Munaron L, Philips MR, Mattot V, Serini G, Prevarskaya N, Gkika D, Pla AF.

J Cell Biol. 2017 Jul 3;216(7):2107-2130. doi: 10.1083/jcb.201506024. Epub 2017 May 26.

12.

Where no Ras has gone before: VPS35 steers N-Ras through the cytosol.

Zhou M, Philips MR.

Small GTPases. 2019 Jan;10(1):20-25. doi: 10.1080/21541248.2016.1263380. Epub 2017 Jan 27.

13.

ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.

Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S.

Oncogene. 2016 Oct 27;35(43):5692-5698. doi: 10.1038/onc.2016.122. Epub 2016 Apr 18.

PMID:
27086924
14.

VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking.

Zhou M, Wiener H, Su W, Zhou Y, Liot C, Ahearn I, Hancock JF, Philips MR.

J Cell Biol. 2016 Aug 15;214(4):445-58. doi: 10.1083/jcb.201604061. Epub 2016 Aug 8.

15.

p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability.

Fabris L, Berton S, Pellizzari I, Segatto I, D'Andrea S, Armenia J, Bomben R, Schiappacassi M, Gattei V, Philips MR, Vecchione A, Belletti B, Baldassarre G.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13916-21. doi: 10.1073/pnas.1508514112. Epub 2015 Oct 28.

16.

Rap1 and its effector RIAM are required for lymphocyte trafficking.

Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR.

Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31.

17.

Seeing is believing: Ras dimers observed in live cells.

Philips MR, Der CJ.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9793-4. doi: 10.1073/pnas.1511805112. Epub 2015 Jul 30. No abstract available.

18.

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Cox AD, Der CJ, Philips MR.

Clin Cancer Res. 2015 Apr 15;21(8):1819-27. doi: 10.1158/1078-0432.CCR-14-3214. Review.

19.

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):779-84. doi: 10.1073/pnas.1412811112. Epub 2015 Jan 5.

20.

The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations.

Lynch SJ, Snitkin H, Gumper I, Philips MR, Sabatini D, Pellicer A.

J Cell Physiol. 2015 Mar;230(3):610-9. doi: 10.1002/jcp.24779.

21.

Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation.

Tsai FD, Wynne JP, Ahearn IM, Philips MR.

Methods Mol Biol. 2014;1120:33-41. doi: 10.1007/978-1-62703-791-4_3.

22.

Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors.

Sung PJ, Tsai FD, Vais H, Court H, Yang J, Fehrenbacher N, Foskett JK, Philips MR.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20593-8. doi: 10.1073/pnas.1306431110. Epub 2013 Dec 2.

23.

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR.

J Clin Invest. 2013 Nov;123(11):4681-94.

24.

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.

Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR.

J Cell Biol. 2012 Oct 15;199(2):317-30. doi: 10.1083/jcb.201201157. Epub 2012 Oct 8.

25.

Regulation of RAS oncogenicity by acetylation.

Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8. doi: 10.1073/pnas.1201487109. Epub 2012 Jun 18.

26.

Ras hitchhikes on PDE6δ.

Philips MR.

Nat Cell Biol. 2012 Feb 2;14(2):128-9. doi: 10.1038/ncb2429. No abstract available.

27.

Rac1 gets fattier.

Tsai FD, Philips MR.

EMBO J. 2012 Feb 1;31(3):517-8. doi: 10.1038/emboj.2011.481. Epub 2012 Feb 1. No abstract available.

28.

Regulating the regulator: post-translational modification of RAS.

Ahearn IM, Haigis K, Bar-Sagi D, Philips MR.

Nat Rev Mol Cell Biol. 2011 Dec 22;13(1):39-51. doi: 10.1038/nrm3255. Review.

29.

Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens.

Villa CH, Dao T, Ahearn I, Fehrenbacher N, Casey E, Rey DA, Korontsvit T, Zakhaleva V, Batt CA, Philips MR, Scheinberg DA.

ACS Nano. 2011 Jul 26;5(7):5300-11. doi: 10.1021/nn200182x. Epub 2011 Jun 23.

30.

The perplexing case of the geranylgeranyl transferase-deficient mouse.

Philips MR.

J Clin Invest. 2011 Feb;121(2):510-3. doi: 10.1172/JCI45952. Epub 2011 Jan 25.

31.

FKBP12 binds to acylated H-ras and promotes depalmitoylation.

Ahearn IM, Tsai FD, Court H, Zhou M, Jennings BC, Ahmed M, Fehrenbacher N, Linder ME, Philips MR.

Mol Cell. 2011 Jan 21;41(2):173-85. doi: 10.1016/j.molcel.2011.01.001.

32.

Cytosolic Ras supports eye development in Drosophila.

Sung PJ, Rodrigues AB, Kleinberger A, Quatela S, Bach EA, Philips MR.

Mol Cell Biol. 2010 Dec;30(24):5649-57. doi: 10.1128/MCB.00635-10. Epub 2010 Oct 11.

33.

[Suicide ideation among college students in Chongqing.].

Chen JM, Ai M, Kuang L, Wang MJ, Shen Y, Li DQ, Gao XX, Li XM, Philips MR, Niu YJ.

Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Mar;31(3):290-3. Chinese.

PMID:
20510055
34.

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD.

Biochem J. 2009 Oct 23;424(1):153-61. doi: 10.1042/BJ20082377.

35.

Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.

Botelho RJ, Harrison RE, Stone JC, Hancock JF, Philips MR, Jongstra-Bilen J, Mason D, Plumb J, Gold MR, Grinstein S.

J Biol Chem. 2009 Oct 16;284(42):28522-32. doi: 10.1074/jbc.M109.009514. Epub 2009 Aug 21.

36.

Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

Mor A, Wynne JP, Ahearn IM, Dustin ML, Du G, Philips MR.

Mol Cell Biol. 2009 Jun;29(12):3297-306. doi: 10.1128/MCB.00366-09. Epub 2009 Mar 30.

37.

Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.

Wright LP, Court H, Mor A, Ahearn IM, Casey PJ, Philips MR.

Mol Cell Biol. 2009 Apr;29(7):1826-33. doi: 10.1128/MCB.01719-08. Epub 2009 Jan 21.

38.

Activation of the MAPK module from different spatial locations generates distinct system outputs.

Inder K, Harding A, Plowman SJ, Philips MR, Parton RG, Hancock JF.

Mol Biol Cell. 2008 Nov;19(11):4776-84. doi: 10.1091/mbc.E08-04-0407. Epub 2008 Sep 10.

39.

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans.

Yun C, Stanhill A, Yang Y, Zhang Y, Haynes CM, Xu CF, Neubert TA, Mor A, Philips MR, Ron D.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7094-9. doi: 10.1073/pnas.0707025105. Epub 2008 May 8.

40.

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.

Michaelson D, Abidi W, Guardavaccaro D, Zhou M, Ahearn I, Pagano M, Philips MR.

J Cell Biol. 2008 May 5;181(3):485-96. doi: 10.1083/jcb.200801047. Epub 2008 Apr 28.

41.

Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis.

Quatela SE, Sung PJ, Ahearn IM, Bivona TG, Philips MR.

Methods Enzymol. 2008;439:87-102. doi: 10.1016/S0076-6879(07)00407-7.

PMID:
18374158
42.

Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.

Quinlan MP, Quatela SE, Philips MR, Settleman J.

Mol Cell Biol. 2008 Apr;28(8):2659-74. doi: 10.1128/MCB.01661-07. Epub 2008 Feb 11.

43.

The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis.

Mor A, Philips MR, Pillinger MH.

Clin Immunol. 2007 Dec;125(3):215-23. Epub 2007 Oct 3. Review.

PMID:
17913587
44.

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.

Mor A, Dustin ML, Philips MR.

Immunol Rev. 2007 Aug;218:114-25. Review.

PMID:
17624948
45.

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, Philips MR.

Nat Cell Biol. 2007 Jun;9(6):713-9. Epub 2007 May 7.

PMID:
17486117
46.

Geranylgeranyltransferase I as a target for anti-cancer drugs.

Philips MR, Cox AD.

J Clin Invest. 2007 May;117(5):1223-5. Review.

47.

Spatial segregation of Ras signaling: new evidence from fission yeast.

Chang EC, Philips MR.

Cell Cycle. 2006 Sep;5(17):1936-9. Epub 2006 Sep 1. Review.

48.

Analysis of Ras activation in living cells with GFP-RBD.

Bivona TG, Quatela S, Philips MR.

Methods Enzymol. 2006;407:128-43.

PMID:
16757320
49.

Compartmentalized signaling of Ras in fission yeast.

Onken B, Wiener H, Philips MR, Chang EC.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9045-50. Epub 2006 Jun 5.

50.

Compartmentalized Ras/MAPK signaling.

Mor A, Philips MR.

Annu Rev Immunol. 2006;24:771-800. Review.

PMID:
16551266

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