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Items: 33


Ca2+-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels.

Przibilla J, Dembla S, Rizun O, Lis A, Jung M, Oberwinkler J, Beck A, Philipp SE.

Cell Calcium. 2018 Jul;73:40-52. doi: 10.1016/j.ceca.2018.03.005. Epub 2018 Mar 31.


Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels.

Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider FM, Schmidt M, Stab J, Enzeroth R, Leitner MG, Nuñez-Badinez P, Schwenk J, Nürnberg B, Cohen A, Philipp SE, Greffrath W, Bünemann M, Oliver D, Zakharian E, Schmidt M, Oberwinkler J.

Elife. 2017 Aug 15;6. pii: e26280. doi: 10.7554/eLife.26280.


TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.

Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A.

Glia. 2017 Sep;65(9):1535-1549. doi: 10.1002/glia.23180. Epub 2017 Jun 21.


The S4---S5 linker - gearbox of TRP channel gating.

Hofmann L, Wang H, Zheng W, Philipp SE, Hidalgo P, Cavalié A, Chen XZ, Beck A, Flockerzi V.

Cell Calcium. 2017 Nov;67:156-165. doi: 10.1016/j.ceca.2017.04.002. Epub 2017 Apr 4. Review.


Identification of Sidt2 as a lysosomal cation-conducting protein.

Beck A, Fecher-Trost C, Wolske K, Philipp SE, Flockerzi V, Wissenbach U.

FEBS Lett. 2017 Jan;591(1):76-87. doi: 10.1002/1873-3468.12528. Epub 2017 Jan 2.


Transient receptor potential A1 channels regulate epithelial cell barriers formed by MDCK cells.

Dembla S, Hasan N, Becker A, Beck A, Philipp SE.

FEBS Lett. 2016 May;590(10):1509-20. doi: 10.1002/1873-3468.12183. Epub 2016 May 3.


A reliable method for quantification of splice variants using RT-qPCR.

Camacho Londoño J, Philipp SE.

BMC Mol Biol. 2016 Mar 15;17:8. doi: 10.1186/s12867-016-0060-1.


A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.

Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M, Lipp P.

Eur Heart J. 2015 Sep 1;36(33):2257-66. doi: 10.1093/eurheartj/ehv250. Epub 2015 Jun 11.



Oberwinkler J, Philipp SE.

Handb Exp Pharmacol. 2014;222:427-59. doi: 10.1007/978-3-642-54215-2_17. Review.


Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels.

Drews A, Mohr F, Rizun O, Wagner TF, Dembla S, Rudolph S, Lambert S, Konrad M, Philipp SE, Behrendt M, Marchais-Oberwinkler S, Covey DF, Oberwinkler J.

Br J Pharmacol. 2014 Feb;171(4):1019-32. doi: 10.1111/bph.12521.


Morphologically homogeneous red blood cells present a heterogeneous response to hormonal stimulation.

Wang J, Wagner-Britz L, Bogdanova A, Ruppenthal S, Wiesen K, Kaiser E, Tian Q, Krause E, Bernhardt I, Lipp P, Philipp SE, Kaestner L.

PLoS One. 2013 Jun 28;8(6):e67697. doi: 10.1371/journal.pone.0067697. Print 2013.


Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure.

Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW.

Sci Signal. 2013 Jun 25;6(281):ra50. doi: 10.1126/scisignal.2003701.


Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.

Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, Vogt T, Herlyn M.

Cancer Cell. 2013 Jun 10;23(6):811-25. doi: 10.1016/j.ccr.2013.05.003.


Conserved gating elements in TRPC4 and TRPC5 channels.

Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh SA, Abdulmughni A, Cavalié A, Philipp SE, Zhu MX, Helms V, Wissenbach U, Flockerzi V.

J Biol Chem. 2013 Jul 5;288(27):19471-83. doi: 10.1074/jbc.M113.478305. Epub 2013 May 15.


Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.

Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M.

Br J Pharmacol. 2013 Apr;168(8):1835-50. doi: 10.1111/bph.12076.


Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels.

Frühwald J, Camacho Londoño J, Dembla S, Mannebach S, Lis A, Drews A, Wissenbach U, Oberwinkler J, Philipp SE.

J Biol Chem. 2012 Oct 26;287(44):36663-72. doi: 10.1074/jbc.M112.396663. Epub 2012 Sep 7.


Lessons of Studying TRP Channels with Antibodies.

Meissner M, Obmann VC, Hoschke M, Link S, Jung M, Held G, Philipp SE, Zimmermann R, Flockerzi V.

In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 6.


TRPM3 is a nociceptor channel involved in the detection of noxious heat.

Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, Benoit M, Xue F, Janssens A, Kerselaers S, Oberwinkler J, Vennekens R, Gudermann T, Nilius B, Voets T.

Neuron. 2011 May 12;70(3):482-94. doi: 10.1016/j.neuron.2011.02.051.


Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.

Lambert S, Drews A, Rizun O, Wagner TF, Lis A, Mannebach S, Plant S, Portz M, Meissner M, Philipp SE, Oberwinkler J.

J Biol Chem. 2011 Apr 8;286(14):12221-33. doi: 10.1074/jbc.M110.202945. Epub 2011 Jan 28.


Thapsigargin induces expression of activating transcription factor 3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase.

Spohn D, Rössler OG, Philipp SE, Raubuch M, Kitajima S, Griesemer D, Hoth M, Thiel G.

Mol Pharmacol. 2010 Nov;78(5):865-76. doi: 10.1124/mol.110.067637. Epub 2010 Aug 16.


TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells.

Wagner TF, Drews A, Loch S, Mohr F, Philipp SE, Lambert S, Oberwinkler J.

Pflugers Arch. 2010 Sep;460(4):755-65. doi: 10.1007/s00424-010-0838-9. Epub 2010 Apr 18.


TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels.

Gross SA, Guzmán GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalié A.

J Biol Chem. 2009 Dec 4;284(49):34423-32. doi: 10.1074/jbc.M109.018192. Epub 2009 Oct 8.


Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.

Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L, Freichel M, Flockerzi V.

Gastroenterology. 2009 Oct;137(4):1415-24. doi: 10.1053/j.gastro.2009.06.046. Epub 2009 Jun 21.


Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.

Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J.

Nat Cell Biol. 2008 Dec;10(12):1421-30. doi: 10.1038/ncb1801. Epub 2008 Nov 2.


ONO-54918-07, a stable prostacyclin analogue, mimics the effect of prostaglandin PGE1 on NG108-15 cells.

Cavalié A, Philipp SE, Meves H.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov;376(3):165-73. Epub 2007 Oct 19.


Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes.

Wissenbach U, Philipp SE, Gross SA, Cavalié A, Flockerzi V.

Cell Calcium. 2007 Oct-Nov;42(4-5):439-46. Epub 2007 Jul 19.


Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels.

Gross SA, Wissenbach U, Philipp SE, Freichel M, Cavalié A, Flockerzi V.

J Biol Chem. 2007 Jul 6;282(27):19375-84. Epub 2007 Apr 26.


Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.

Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M.

Nat Immunol. 2007 Mar;8(3):312-20. Epub 2007 Feb 11.


TRPV6 potentiates calcium-dependent cell proliferation.

Schwarz EC, Wissenbach U, Niemeyer BA, Strauss B, Philipp SE, Flockerzi V, Hoth M.

Cell Calcium. 2006 Feb;39(2):163-73. Epub 2005 Dec 13.


Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies.

Freichel M, Vennekens R, Olausson J, Stolz S, Philipp SE, Weissgerber P, Flockerzi V.

J Physiol. 2005 Aug 15;567(Pt 1):59-66. Epub 2005 Jun 23. Review.


Specific detection and semi-quantitative analysis of TRPC4 protein expression by antibodies.

Flockerzi V, Jung C, Aberle T, Meissner M, Freichel M, Philipp SE, Nastainczyk W, Maurer P, Zimmermann R.

Pflugers Arch. 2005 Oct;451(1):81-6. Epub 2005 Jun 18. Review.


Transcriptional regulation and processing increase the functional variability of TRPM channels.

Lis A, Wissenbach U, Philipp SE.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):315-24. Epub 2005 Apr 27. Review.


Alternative splicing switches the divalent cation selectivity of TRPM3 channels.

Oberwinkler J, Lis A, Giehl KM, Flockerzi V, Philipp SE.

J Biol Chem. 2005 Jun 10;280(23):22540-8. Epub 2005 Apr 11.

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