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Items: 1 to 50 of 107

1.

Multi-platform Approach for Microbial Biomarker Identification Using Borrelia burgdorferi as a Model.

Pflughoeft KJ, Mash M, Hasenkampf NR, Jacobs MB, Tardo AC, Magee DM, Song L, LaBaer J, Philipp MT, Embers ME, AuCoin DP.

Front Cell Infect Microbiol. 2019 Jun 11;9:179. doi: 10.3389/fcimb.2019.00179. eCollection 2019.

2.

Intracellular TLR7 is activated in human oligodendrocytes in response to Borrelia burgdorferi exposure.

Parthasarathy G, Philipp MT.

Neurosci Lett. 2018 Apr 3;671:38-42. doi: 10.1016/j.neulet.2018.01.058. Epub 2018 Feb 3.

3.

Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P.

Burmeister AR, Johnson MB, Chauhan VS, Moerdyk-Schauwecker MJ, Young AD, Cooley ID, Martinez AN, Ramesh G, Philipp MT, Marriott I.

J Neuroinflammation. 2017 Dec 13;14(1):245. doi: 10.1186/s12974-017-1012-5.

4.

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.

Embers ME, Hasenkampf NR, Jacobs MB, Tardo AC, Doyle-Meyers LA, Philipp MT, Hodzic E.

PLoS One. 2017 Dec 13;12(12):e0189071. doi: 10.1371/journal.pone.0189071. eCollection 2017.

5.
6.

Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis.

Martinez AN, Burmeister AR, Ramesh G, Doyle-Meyers L, Marriott I, Philipp MT.

J Neuroinflammation. 2017 Feb 15;14(1):37. doi: 10.1186/s12974-017-0813-x.

7.

Effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in glial and neuronal cells of the central nervous system.

Ramesh G, Martinez AN, Martin DS, Philipp MT.

J Neuroinflammation. 2017 Feb 2;14(1):28. doi: 10.1186/s12974-017-0806-9.

9.

Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease.

Scholl DC, Embers ME, Caskey JR, Kaushal D, Mather TN, Buck WR, Morici LA, Philipp MT.

Parasit Vectors. 2016 Jul 8;9(1):394. doi: 10.1186/s13071-016-1638-7.

10.

Five-Antigen Fluorescent Bead-Based Assay for Diagnosis of Lyme Disease.

Embers ME, Hasenkampf NR, Barnes MB, Didier ES, Philipp MT, Tardo AC.

Clin Vaccine Immunol. 2016 Apr 4;23(4):294-303. doi: 10.1128/CVI.00685-15. Print 2016 Apr.

11.

Antagonist of the neurokinin-1 receptor curbs neuroinflammation in ex vivo and in vitro models of Lyme neuroborreliosis.

Martinez AN, Ramesh G, Jacobs MB, Philipp MT.

J Neuroinflammation. 2015 Dec 30;12:243. doi: 10.1186/s12974-015-0453-y.

12.

Phosphoenolpyruvate Phosphotransferase System Components Modulate Gene Transcription and Virulence of Borrelia burgdorferi.

Khajanchi BK, Odeh E, Gao L, Jacobs MB, Philipp MT, Lin T, Norris SJ.

Infect Immun. 2015 Dec 28;84(3):754-64. doi: 10.1128/IAI.00917-15.

14.

Inflammation in the pathogenesis of lyme neuroborreliosis.

Ramesh G, Didier PJ, England JD, Santana-Gould L, Doyle-Meyers LA, Martin DS, Jacobs MB, Philipp MT.

Am J Pathol. 2015 May;185(5):1344-60. doi: 10.1016/j.ajpath.2015.01.024. Epub 2015 Apr 16.

15.
16.

Mediators of neuroinflammation.

Ramesh G, Philipp MT, Vallières L, MacLean AG, Ahmad M.

Mediators Inflamm. 2013;2013:314261. doi: 10.1155/2013/314261. Epub 2013 Oct 3. No abstract available.

17.

Non-viable Borrelia burgdorferi induce inflammatory mediators and apoptosis in human oligodendrocytes.

Parthasarathy G, Fevrier HB, Philipp MT.

Neurosci Lett. 2013 Nov 27;556:200-3. doi: 10.1016/j.neulet.2013.10.032. Epub 2013 Oct 22.

18.

Correction: Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection.

Embers ME, Barthold SW, Borda JT, Bowers L, Doyle L, Hodzic E, Jacobs MB, Hasenkampf NR, Martin DS, Narasimhan S, Phillippi-Falkenstein KM, Purcell JE, Ratterree MS, Philipp MT.

PLoS One. 2013 Sep 24;8(9). doi: 10.1371/annotation/f84663e3-0a2c-4243-8f97-3a58133c1b0f. eCollection 2013.

19.
20.

Feeding of ticks on animals for transmission and xenodiagnosis in Lyme disease research.

Embers ME, Grasperge BJ, Jacobs MB, Philipp MT.

J Vis Exp. 2013 Aug 31;(78). doi: 10.3791/50617.

21.

Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain.

Ramesh G, MacLean AG, Philipp MT.

Mediators Inflamm. 2013;2013:480739. doi: 10.1155/2013/480739. Epub 2013 Aug 12. Review.

22.

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia.

Ramesh G, Santana-Gould L, Inglis FM, England JD, Philipp MT.

J Neuroinflammation. 2013 Jul 18;10:88. doi: 10.1186/1742-2094-10-88.

23.

Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity.

Lin T, Gao L, Zhang C, Odeh E, Jacobs MB, Coutte L, Chaconas G, Philipp MT, Norris SJ.

PLoS One. 2012;7(10):e47532. doi: 10.1371/journal.pone.0047532. Epub 2012 Oct 25.

24.

Review: apoptotic mechanisms in bacterial infections of the central nervous system.

Parthasarathy G, Philipp MT.

Front Immunol. 2012 Oct 4;3:306. doi: 10.3389/fimmu.2012.00306. eCollection 2012.

25.

Different patterns of expression and of IL-10 modulation of inflammatory mediators from macrophages of Lyme disease-resistant and -susceptible mice.

Gautam A, Dixit S, Embers M, Gautam R, Philipp MT, Singh SR, Morici L, Dennis VA.

PLoS One. 2012;7(9):e43860. Epub 2012 Sep 14.

26.

Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques.

Embers ME, Hasenkampf NR, Jacobs MB, Philipp MT.

Clin Vaccine Immunol. 2012 Aug;19(8):1218-26. doi: 10.1128/CVI.00228-12. Epub 2012 Jun 20.

27.

A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi.

Ramesh G, Benge S, Pahar B, Philipp MT.

J Neuroinflammation. 2012 Apr 23;9:72. doi: 10.1186/1742-2094-9-72.

28.

Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection.

Embers ME, Barthold SW, Borda JT, Bowers L, Doyle L, Hodzic E, Jacobs MB, Hasenkampf NR, Martin DS, Narasimhan S, Phillippi-Falkenstein KM, Purcell JE, Ratterree MS, Philipp MT.

PLoS One. 2012;7(1):e29914. doi: 10.1371/journal.pone.0029914. Epub 2012 Jan 11. Erratum in: PLoS One. 2012;7(4):10.1371/annotation/4cafed66-fb84-4589-a001-131d9c50aea6. PLoS One. 2013;8(9). doi:10.1371/annotation/f84663e3-0a2c-4243-8f97-3a58133c1b0f.

29.

A rhesus macaque model of Streptococcus pneumoniae carriage.

Philipp MT, Doyle LA, Martin DS, Plauché GB, Phillippi-Falkenstein KM, Bohm RP Jr.

J Med Primatol. 2012 Feb;41(1):60-6. doi: 10.1111/j.1600-0684.2011.00512.x. Epub 2011 Oct 4.

30.

Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.

Gautam A, Dixit S, Philipp MT, Singh SR, Morici LA, Kaushal D, Dennis VA.

Infect Immun. 2011 Dec;79(12):4876-92. doi: 10.1128/IAI.05451-11. Epub 2011 Sep 26.

31.

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae.

Denoël P, Philipp MT, Doyle L, Martin D, Carletti G, Poolman JT.

Vaccine. 2011 Jul 26;29(33):5495-501. doi: 10.1016/j.vaccine.2011.05.051. Epub 2011 May 30.

32.

Characterization of a Moraxella species that causes epistaxis in macaques.

Embers ME, Doyle LA, Whitehouse CA, Selby EB, Chappell M, Philipp MT.

Vet Microbiol. 2011 Jan 27;147(3-4):367-75. doi: 10.1016/j.vetmic.2010.06.029. Epub 2010 Jul 7.

33.

Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.

Lin T, Gao L, Edmondson DG, Jacobs MB, Philipp MT, Norris SJ.

PLoS Pathog. 2009 Dec;5(12):e1000679. doi: 10.1371/journal.ppat.1000679. Epub 2009 Dec 4.

34.

Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells.

Myers TA, Kaushal D, Philipp MT.

PLoS Pathog. 2009 Nov;5(11):e1000659. doi: 10.1371/journal.ppat.1000659. Epub 2009 Nov 13.

35.

Possible role of glial cells in the onset and progression of Lyme neuroborreliosis.

Ramesh G, Borda JT, Gill A, Ribka EP, Morici LA, Mottram P, Martin DS, Jacobs MB, Didier PJ, Philipp MT.

J Neuroinflammation. 2009 Aug 25;6:23. doi: 10.1186/1742-2094-6-23.

36.

The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi.

Bernardino AL, Kaushal D, Philipp MT.

J Infect Dis. 2009 May 1;199(9):1379-88. doi: 10.1086/597807.

37.

Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway.

Dennis VA, Dixit S, O'Brien SM, Alvarez X, Pahar B, Philipp MT.

Infect Immun. 2009 Mar;77(3):1238-45. doi: 10.1128/IAI.01078-08. Epub 2009 Jan 12.

38.

Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis.

Ramesh G, Borda JT, Dufour J, Kaushal D, Ramamoorthy R, Lackner AA, Philipp MT.

Am J Pathol. 2008 Nov;173(5):1415-27. doi: 10.2353/ajpath.2008.080483. Epub 2008 Oct 2.

39.

Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease.

Wormser GP, Liveris D, Hanincová K, Brisson D, Ludin S, Stracuzzi VJ, Embers ME, Philipp MT, Levin A, Aguero-Rosenfeld M, Schwartz I.

Clin Infect Dis. 2008 Oct 1;47(7):910-4. doi: 10.1086/591529.

40.

Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.

Bernardino AL, Myers TA, Alvarez X, Hasegawa A, Philipp MT.

Infect Immun. 2008 Oct;76(10):4385-95. doi: 10.1128/IAI.00394-08. Epub 2008 Aug 11.

41.

Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons.

Myers TA, Nickerson CA, Kaushal D, Ott CM, Höner zu Bentrup K, Ramamurthy R, Nelman-Gonzalez M, Pierson DL, Philipp MT.

J Neurosci Methods. 2008 Sep 15;174(1):31-41. doi: 10.1016/j.jneumeth.2008.06.031. Epub 2008 Jul 10.

42.

The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein.

Embers ME, Alvarez X, Ooms T, Philipp MT.

Infect Immun. 2008 Sep;76(9):3984-91. doi: 10.1128/IAI.00387-08. Epub 2008 Jul 14.

43.

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete.

Embers ME, Liang FT, Howell JK, Jacobs MB, Purcell JE, Norris SJ, Johnson BJ, Philipp MT.

FEMS Immunol Med Microbiol. 2007 Aug;50(3):421-9. Epub 2007 Jun 26.

44.

Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE molecule.

Embers ME, Jacobs MB, Johnson BJ, Philipp MT.

Clin Vaccine Immunol. 2007 Aug;14(8):931-6. Epub 2007 Jun 13.

45.

Borrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme disease.

Embers ME, Wormser GP, Schwartz I, Martin DS, Philipp MT.

Clin Vaccine Immunol. 2007 Jan;14(1):90-3. Epub 2006 Nov 15.

46.

Serologic evaluation of patients from Missouri with erythema migrans-like skin lesions with the C6 Lyme test.

Philipp MT, Masters E, Wormser GP, Hogrefe W, Martin D.

Clin Vaccine Immunol. 2006 Oct;13(10):1170-1.

47.
48.

Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment.

Philipp MT, Purcell JE, Martin DS, Buck WR, Plauché GB, Ribka EP, DeNoel P, Hermand P, Leiva LE, Bagby GJ, Nelson S.

J Med Primatol. 2006 Jun;35(3):113-22.

PMID:
16764668
49.

Infectivity of the highly transformable BBE02- lp56- mutant of Borrelia burgdorferi, the Lyme disease spirochete, via ticks.

Jacobs MB, Norris SJ, Phillippi-Falkenstein KM, Philipp MT.

Infect Immun. 2006 Jun;74(6):3678-81.

50.

A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis.

Philipp MT, Wormser GP, Marques AR, Bittker S, Martin DS, Nowakowski J, Dally LG.

Clin Diagn Lab Immunol. 2005 Sep;12(9):1069-74.

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