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Items: 15


Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response.

Allen NC, Philip NH, Hui L, Zhou X, Franklin RA, Kong Y, Medzhitov R.

Sci Signal. 2019 Mar 5;12(571). pii: eaau1851. doi: 10.1126/scisignal.aau1851.


RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense.

Peterson LW, Philip NH, DeLaney A, Wynosky-Dolfi MA, Asklof K, Gray F, Choa R, Bjanes E, Buza EL, Hu B, Dillon CP, Green DR, Berger SB, Gough PJ, Bertin J, Brodsky IE.

J Exp Med. 2017 Nov 6;214(11):3171-3182. doi: 10.1084/jem.20170347. Epub 2017 Aug 30.


NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE.

Immunity. 2017 Apr 18;46(4):649-659. doi: 10.1016/j.immuni.2017.03.016. Epub 2017 Apr 11.


Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.

Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE.

PLoS Pathog. 2016 Oct 13;12(10):e1005910. doi: 10.1371/journal.ppat.1005910. eCollection 2016 Oct.


Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis.

Peterson LW, Philip NH, Dillon CP, Bertin J, Gough PJ, Green DR, Brodsky IE.

J Immunol. 2016 Nov 15;197(10):4110-4117. Epub 2016 Oct 12.


Activation and Evasion of Inflammasomes by Yersinia.

Philip NH, Zwack EE, Brodsky IE.

Curr Top Microbiol Immunol. 2016;397:69-90. doi: 10.1007/978-3-319-41171-2_4. Review.


A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC.

Cell Host Microbe. 2015 Dec 9;18(6):682-93. doi: 10.1016/j.chom.2015.11.006.


Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD.

Zwack EE, Snyder AG, Wynosky-Dolfi MA, Ruthel G, Philip NH, Marketon MM, Francis MS, Bliska JB, Brodsky IE.

MBio. 2015 Feb 17;6(1):e02095-14. doi: 10.1128/mBio.02095-14.


IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.

Chung LK, Philip NH, Schmidt VA, Koller A, Strowig T, Flavell RA, Brodsky IE, Bliska JB.

MBio. 2014 Jul 1;5(4):e01402-14. doi: 10.1128/mBio.01402-14.


Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling.

Philip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90. doi: 10.1073/pnas.1403252111. Epub 2014 May 5.


Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.

Wynosky-Dolfi MA, Snyder AG, Philip NH, Doonan PJ, Poffenberger MC, Avizonis D, Zwack EE, Riblett AM, Hu B, Strowig T, Flavell RA, Jones RG, Freedman BD, Brodsky IE.

J Exp Med. 2014 Apr 7;211(4):653-68. doi: 10.1084/jem.20130627. Epub 2014 Mar 17.


Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

May RM, Okumura M, Hsu CJ, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T.

Blood. 2013 Apr 18;121(16):3135-46. doi: 10.1182/blood-2012-12-474361. Epub 2013 Feb 13.


New friendships and old feuds: relationships between innate lymphoid cells and microbial communities.

Philip NH, Artis D.

Immunol Cell Biol. 2013 Mar;91(3):225-31. doi: 10.1038/icb.2013.2. Epub 2013 Jan 22. Review.


Cell death programs in Yersinia immunity and pathogenesis.

Philip NH, Brodsky IE.

Front Cell Infect Microbiol. 2012 Nov 30;2:149. doi: 10.3389/fcimb.2012.00149. eCollection 2012. Review.


A comparison of intramuscular ketorolac and pethidine in the alleviation of renal colic.

Sandhu DP, Iacovou JW, Fletcher MS, Kaisary AV, Philip NH, Arkell DG.

Br J Urol. 1994 Dec;74(6):690-3.


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