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Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo.

Yao C, Yu KP, Philbrick W, Sun BH, Simpson C, Zhang C, Insogna K.

Int J Mol Med. 2017 Oct;40(4):1067-1077. doi: 10.3892/ijmm.2017.3091. Epub 2017 Aug 4.


Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.

Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI.

J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct 17.


Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue.

Lester SG, Russo L, Ghanem SS, Khuder SS, DeAngelis AM, Esakov EL, Bowman TA, Heinrich G, Al-Share QY, McInerney MF, Philbrick WM, Najjar SM.

Front Endocrinol (Lausanne). 2015 Aug 3;6:116. doi: 10.3389/fendo.2015.00116. eCollection 2015.


Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance.

Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, Philbrick WM, Najjar SM.

Diabetes. 2015 Aug;64(8):2780-90. doi: 10.2337/db14-1772. Epub 2015 May 13.


MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism.

Shroff EH, Eberlin LS, Dang VM, Gouw AM, Gabay M, Adam SJ, Bellovin DI, Tran PT, Philbrick WM, Garcia-Ocana A, Casey SC, Li Y, Dang CV, Zare RN, Felsher DW.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6539-44. doi: 10.1073/pnas.1507228112. Epub 2015 May 11.


NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA.

Cell. 2014 Feb 27;156(5):1045-59. doi: 10.1016/j.cell.2014.01.026.


mHealth for HIV Treatment & Prevention: A Systematic Review of the Literature.

Catalani C, Philbrick W, Fraser H, Mechael P, Israelski DM.

Open AIDS J. 2013 Aug 13;7:17-41. doi: 10.2174/1874613620130812003. eCollection 2013.


Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle.

Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, Bogan JS.

J Biol Chem. 2013 Jul 12;288(28):20135-50. doi: 10.1074/jbc.M113.458075. Epub 2013 Jun 6.


Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23. doi: 10.1073/pnas.1109769108. Epub 2011 Jul 25.


Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

Hong EG, Ko HJ, Cho YR, Kim HJ, Ma Z, Yu TY, Friedline RH, Kurt-Jones E, Finberg R, Fischer MA, Granger EL, Norbury CC, Hauschka SD, Philbrick WM, Lee CG, Elias JA, Kim JK.

Diabetes. 2009 Nov;58(11):2525-35. doi: 10.2337/db08-1261. Epub 2009 Aug 18.


Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo.

Wu M, Hesse E, Morvan F, Zhang JP, Correa D, Rowe GC, Kiviranta R, Neff L, Philbrick WM, Horne WC, Baron R.

Bone. 2009 Apr;44(4):528-36. doi: 10.1016/j.bone.2008.11.011. Epub 2008 Nov 27.


The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic mice.

Boskey A, Frank A, Fujimoto Y, Spevak L, Verdelis K, Ellis B, Troiano N, Philbrick W, Carpenter T.

Calcif Tissue Int. 2009 Feb;84(2):126-37. doi: 10.1007/s00223-008-9201-y. Epub 2008 Dec 12.


Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.

Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.

Diabetes. 2008 Oct;57(10):2644-51. doi: 10.2337/db06-0454. Epub 2008 Jul 15.


Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.

Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R.

J Bone Miner Res. 2008 May;23(5):584-95. doi: 10.1359/jbmr.080110.


Parathyroid hormone hormone-related protein and the PTH receptor regulate angiogenesis of the skin.

Diamond AG, Gonterman RM, Anderson AL, Menon K, Offutt CD, Weaver CH, Philbrick WM, Foley J.

J Invest Dermatol. 2006 Sep;126(9):2127-34. Epub 2006 May 4.


Initial characterization of PTH-related protein gene-driven lacZ expression in the mouse.

Chen X, Macica CM, Dreyer BE, Hammond VE, Hens JR, Philbrick WM, Broadus AE.

J Bone Miner Res. 2006 Jan;21(1):113-23. Epub 2005 Oct 10.


Dexamethasone suppresses phospholipase C activation and insulin secretion from isolated rat islets.

Zawalich WS, Tesz GJ, Yamazaki H, Zawalich KC, Philbrick W.

Metabolism. 2006 Jan;55(1):35-42.


Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine.

Yamazaki H, Philbrick W, Zawalich KC, Zawalich WS.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E26-E33. Epub 2005 Aug 16.


Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors.

Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R.

J Clin Endocrinol Metab. 2005 Feb;90(2):1012-20. Epub 2004 Nov 23.


DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms.

Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick WM, Horne WC, Baron R.

Mol Cell Biol. 2004 Apr;24(7):2820-30.


Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses.

Zawalich WS, Zawalich KC, Tesz GJ, Taketo MM, Sterpka J, Philbrick W, Matsui M.

Biochem Biophys Res Commun. 2004 Mar 19;315(4):872-6.


Perspective. Osteoclastogenesis and growth plate chondrocyte differentiation: emergence of convergence.

Odgren PR, Philbrick WM, Gartland A.

Crit Rev Eukaryot Gene Expr. 2003;13(2-4):181-93. Review.


Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: the efficacy of parathyroid hormone-related protein and hepatocyte growth factor.

Fiaschi-Taesch NM, Santos S, Reddy V, Van Why SK, Philbrick WF, Ortega A, Esbrit P, Orloff JJ, Garcia-Ocaña A.

J Am Soc Nephrol. 2004 Jan;15(1):112-25.


Endogenous parathyroid hormone-related protein functions as a neuroprotective agent.

Chatterjee O, Nakchbandi IA, Philbrick WM, Dreyer BE, Zhang JP, Kaczmarek LK, Brines ML, Broadus AE.

Brain Res. 2002 Mar 15;930(1-2):58-66.


Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes.

Dunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ.

J Endocrinol. 2001 Dec;171(3):403-16.


Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction.

Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, Roume J, Delezoide AL, Silve C.

J Clin Endocrinol Metab. 2001 Apr;86(4):1788-94.


Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets.

Zawalich WS, Zawalich KC, Tesz GJ, Sterpka JA, Philbrick WM.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E720-8.


Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development.

Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J.

Development. 2001 Feb;128(4):513-25.


Activation of PTHrP gene expression in squamous carcinoma cell lines by mutant isoforms of the tumor suppressor p53.

Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM.

Oncol Res. 2000;12(2):71-81.


betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.

Berghs S, Aggujaro D, Dirkx R Jr, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M.

J Cell Biol. 2000 Nov 27;151(5):985-1002.


Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade.

Nakchbandi IA, Weir EE, Insogna KL, Philbrick WM, Broadus AE.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7296-300.


Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

J Biol Chem. 2000 Jan 14;275(2):1226-32.


Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site.

Foley J, Wysolmerski JJ, Missero C, King CS, Philbrick WM.

Mol Cell Endocrinol. 1999 Oct 25;156(1-2):13-23.


PTHrP regulates epidermal differentiation in adult mice.

Foley J, Longely BJ, Wysolmerski JJ, Dreyer BE, Broadus AE, Philbrick WM.

J Invest Dermatol. 1998 Dec;111(6):1122-8.


Parathyroid hormone-related protein is required for tooth eruption.

Philbrick WM, Dreyer BE, Nakchbandi IA, Karaplis AC.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11846-51.


Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE.

Development. 1998 Apr;125(7):1285-94.


Parathyroid hormone-related protein is a developmental regulatory molecule.

Philbrick WM.

Eur J Oral Sci. 1998 Jan;106 Suppl 1:32-7. Review.


Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development.

Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, Philbrick WM, Broadus AE, Baron R.

J Cell Biol. 1997 Jan 13;136(1):205-13.


Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE.

Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10240-5.


Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.

Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM.

Cancer Res. 1996 Sep 1;56(17):4056-62.


Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice.

Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM.

Cancer Res. 1996 Mar 1;56(5):1043-9.


Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia.

Vasavada RC, Cavaliere C, D'Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick W, Stewart AF.

J Biol Chem. 1996 Jan 12;271(2):1200-8.


Clonal variation of p53 expression and proliferative phenotype in A253 squamous carcinoma cells.

Galbraith SC, Foley J, Kats Y, Moy A, Dann P, Burtis WJ, Philbrick WM, Orloff JJ.

Oncol Res. 1996;8(9):353-61.


Defining the roles of parathyroid hormone-related protein in normal physiology.

Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF.

Physiol Rev. 1996 Jan;76(1):127-73. Review.


Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development.

Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM.

Development. 1995 Nov;121(11):3539-47.


Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines.

Orloff JJ, Kats Y, Urena P, Schipani E, Vasavada RC, Philbrick WM, Behal A, Abou-Samra AB, Segre GV, Jüppner H.

Endocrinology. 1995 Jul;136(7):3016-23.


Cell type-specific secretion of parathyroid hormone-related protein via the regulated versus the constitutive secretory pathway.

Plawner LL, Philbrick WM, Burtis WJ, Broadus AE, Stewart AF.

J Biol Chem. 1995 Jun 9;270(23):14078-84.


Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM.

Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1133-7.


Region-specific methylation of the parathyroid hormone-related peptide gene determines its expression in human renal carcinoma cell lines.

Holt EH, Vasavada RC, Bander NH, Broadus AE, Philbrick WM.

J Biol Chem. 1993 Sep 25;268(27):20639-45.

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