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Items: 39


Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing.

Wilson SC, White KI, Zhou Q, Pfuetzner RA, Choi UB, Südhof TC, Brunger AT.

EMBO J. 2019 Nov 15;38(22):e101603. doi: 10.15252/embj.2019101603. Epub 2019 Sep 30.


Structural principles of SNARE complex recognition by the AAA+ protein NSF.

White KI, Zhao M, Choi UB, Pfuetzner RA, Brunger AT.

Elife. 2018 Sep 10;7. pii: e38888. doi: 10.7554/eLife.38888.


NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin.

Choi UB, Zhao M, White KI, Pfuetzner RA, Esquivies L, Zhou Q, Brunger AT.

Elife. 2018 Jul 9;7. pii: e36497. doi: 10.7554/eLife.36497.


Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT.

Neuron. 2017 Aug 2;95(3):591-607.e10. doi: 10.1016/j.neuron.2017.07.004.


C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.

Gong J, Lai Y, Li X, Wang M, Leitz J, Hu Y, Zhang Y, Choi UB, Cipriano D, Pfuetzner RA, Südhof TC, Yang X, Brunger AT, Diao J.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7590-E7599. Epub 2016 Nov 7.


N-terminal domain of complexin independently activates calcium-triggered fusion.

Lai Y, Choi UB, Zhang Y, Zhao M, Pfuetzner RA, Wang AL, Diao J, Brunger AT.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4698-707. doi: 10.1073/pnas.1604348113. Epub 2016 Jul 21.


Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.

Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T.

EMBO J. 2016 Aug 15;35(16):1810-21. doi: 10.15252/embj.201694071. Epub 2016 Jul 11.


Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Südhof TC, Brunger AT.

Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.


Delivery of cardiolipins to the Salmonella outer membrane is necessary for survival within host tissues and virulence.

Dalebroux ZD, Edrozo MB, Pfuetzner RA, Ressl S, Kulasekara BR, Blanc MP, Miller SI.

Cell Host Microbe. 2015 Apr 8;17(4):441-51. doi: 10.1016/j.chom.2015.03.003.


Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT.

J Biol Chem. 2015 Apr 17;290(16):10518-34. doi: 10.1074/jbc.M114.630772. Epub 2015 Feb 25.


ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz LM, Li J, Vivona S, Pfuetzner RA, Brunger AT, Zhong Q.

Nature. 2015 Apr 23;520(7548):563-6. doi: 10.1038/nature14147. Epub 2015 Feb 9.


Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.

Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT.

Elife. 2014 Aug 13;3:e03756. doi: 10.7554/eLife.03756.


Complexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions.

Diao J, Cipriano DJ, Zhao M, Zhang Y, Shah S, Padolina MS, Pfuetzner RA, Brunger AT.

J Am Chem Soc. 2013 Oct 16;135(41):15274-7. doi: 10.1021/ja407392n. Epub 2013 Oct 4.


A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly.

Bergeron JR, Worrall LJ, Sgourakis NG, DiMaio F, Pfuetzner RA, Felise HB, Vuckovic M, Yu AC, Miller SI, Baker D, Strynadka NC.

PLoS Pathog. 2013;9(4):e1003307. doi: 10.1371/journal.ppat.1003307. Epub 2013 Apr 25.


Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.

Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2343-52. doi: 10.1073/pnas.1206701109. Epub 2012 Jul 25.


Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system.

Sanowar S, Singh P, Pfuetzner RA, André I, Zheng H, Spreter T, Strynadka NC, Gonen T, Baker D, Goodlett DR, Miller SI.

MBio. 2010 Aug 3;1(3). pii: e00158-10. doi: 10.1128/mBio.00158-10.


Activation of a bacterial virulence protein by the GTPase RhoA.

Christen M, Coye LH, Hontz JS, LaRock DL, Pfuetzner RA, Megha, Miller SI.

Sci Signal. 2009 Nov 3;2(95):ra71. doi: 10.1126/scisignal.2000430.


A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.

Spreter T, Yip CK, Sanowar S, André I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC.

Nat Struct Mol Biol. 2009 May;16(5):468-76. doi: 10.1038/nsmb.1603. Epub 2009 Apr 26.


Characterization of protein cross-links via mass spectrometry and an open-modification search strategy.

Singh P, Shaffer SA, Scherl A, Holman C, Pfuetzner RA, Larson Freeman TJ, Miller SI, Hernandez P, Appel RD, Goodlett DR.

Anal Chem. 2008 Nov 15;80(22):8799-806. doi: 10.1021/ac801646f. Epub 2008 Oct 24.


An inhibitor of gram-negative bacterial virulence protein secretion.

Felise HB, Nguyen HV, Pfuetzner RA, Barry KC, Jackson SR, Blanc MP, Bronstein PA, Kline T, Miller SI.

Cell Host Microbe. 2008 Oct 16;4(4):325-36. doi: 10.1016/j.chom.2008.08.001.


Structural characterization of the molecular platform for type III secretion system assembly.

Yip CK, Kimbrough TG, Felise HB, Vuckovic M, Thomas NA, Pfuetzner RA, Frey EA, Finlay BB, Miller SI, Strynadka NC.

Nature. 2005 Jun 2;435(7042):702-7.


Backbone chemical shift assignments of the LexA catalytic domain in its active conformation.

Okon M, Pfuetzner RA, Vuckovic M, Little JW, Strynadka NC, McIntosh LP.

J Biomol NMR. 2005 Apr;31(4):371-2. No abstract available.


Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens.

Deng W, Li Y, Hardwidge PR, Frey EA, Pfuetzner RA, Lee S, Gruenheid S, Strynakda NC, Puente JL, Finlay BB.

Infect Immun. 2005 Apr;73(4):2135-46.


Structure and biochemical analysis of a secretin pilot protein.

Lario PI, Pfuetzner RA, Frey EA, Creagh L, Haynes C, Maurelli AT, Strynadka NC.

EMBO J. 2005 Mar 23;24(6):1111-21. Epub 2005 Mar 10.


Structural and biochemical characterization of the type III secretion chaperones CesT and SigE.

Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, Strynadka NC.

Nat Struct Biol. 2001 Dec;8(12):1031-6.


Crystal structure of LexA: a conformational switch for regulation of self-cleavage.

Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC.

Cell. 2001 Sep 7;106(5):585-94.


Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex.

Luo Y, Frey EA, Pfuetzner RA, Creagh AL, Knoechel DG, Haynes CA, Finlay BB, Strynadka NC.

Nature. 2000 Jun 29;405(6790):1073-7.


Enteropathogenic E. coli translocated intimin receptor, Tir, interacts directly with alpha-actinin.

Goosney DL, DeVinney R, Pfuetzner RA, Frey EA, Strynadka NC, Finlay BB.

Curr Biol. 2000 Jun 15;10(12):735-8.


Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.

Abe A, de Grado M, Pfuetzner RA, Sánchez-Sanmartín C, Devinney R, Puente JL, Strynadka NC, Finlay BB.

Mol Microbiol. 1999 Sep;33(6):1162-75.


The structure of the potassium channel: molecular basis of K+ conduction and selectivity.

Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R.

Science. 1998 Apr 3;280(5360):69-77.


Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA.

Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L.

Nature. 1997 Jan 9;385(6612):176-81.


Replication protein A. Characterization and crystallization of the DNA binding domain.

Pfuetzner RA, Bochkarev A, Frappier L, Edwards AM.

J Biol Chem. 1997 Jan 3;272(1):430-4.


Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA.

Bochkarev A, Barwell JA, Pfuetzner RA, Bochkareva E, Frappier L, Edwards AM.

Cell. 1996 Mar 8;84(5):791-800.


Cooperative assembly of EBNA1 on the Epstein-Barr virus latent origin of replication.

Summers H, Barwell JA, Pfuetzner RA, Edwards AM, Frappier L.

J Virol. 1996 Feb;70(2):1228-31.


Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1.

Bochkarev A, Barwell JA, Pfuetzner RA, Furey W Jr, Edwards AM, Frappier L.

Cell. 1995 Oct 6;83(1):39-46.


Overexpression, purification, and crystallization of the DNA binding and dimerization domains of the Epstein-Barr virus nuclear antigen 1.

Barwell JA, Bochkarev A, Pfuetzner RA, Tong H, Yang DS, Frappier L, Edwards AM.

J Biol Chem. 1995 Sep 1;270(35):20556-9.


Synergistic binding of hydrophobic probes and zinc ligands to thermolysin.

Pfuetzner RA, Chan WW.

Eur J Biochem. 1993 Dec 1;218(2):523-8.


Synergistic binding of ligands to angiotensin-converting enzyme.

Pfuetzner RA, Chan WW.

J Biol Chem. 1988 Mar 25;263(9):4056-8.

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