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Items: 25

1.

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.

Elkholi R, Abraham-Enachescu I, Trotta AP, Rubio-PatiƱo C, Mohammed JN, Luna-Vargas MPA, Gelles JD, Kaminetsky JR, Serasinghe MN, Zou C, Ali S, McStay GP, Pfleger CM, Chipuk JE.

Mol Cell. 2019 May 2;74(3):452-465.e7. doi: 10.1016/j.molcel.2019.02.012. Epub 2019 Mar 14.

PMID:
30879903
2.

The Power of Drosophila Genetics: The Discovery of the Hippo Pathway.

Gokhale R, Pfleger CM.

Methods Mol Biol. 2019;1893:3-26. doi: 10.1007/978-1-4939-8910-2_1. Review.

PMID:
30565121
3.

The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease.

Pfleger CM.

Curr Top Dev Biol. 2017;123:181-228. doi: 10.1016/bs.ctdb.2016.12.001. Epub 2017 Jan 19. Review.

PMID:
28236967
4.

Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae.

Reimels TA, Pfleger CM.

J Vis Exp. 2016 Nov 28;(117). doi: 10.3791/54544.

5.

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.

Jahanshahi M, Hsiao K, Jenny A, Pfleger CM.

PLoS Genet. 2016 Aug 5;12(8):e1006198. doi: 10.1371/journal.pgen.1006198. eCollection 2016 Aug.

6.

Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis.

Reimels TA, Pfleger CM.

J Cell Sci. 2015 Dec 15;128(24):4512-25. doi: 10.1242/jcs.174433. Epub 2015 Nov 13.

7.

Alcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophila.

Ilanges A, Jahanshahi M, Balobin DM, Pfleger CM.

PLoS One. 2013 Oct 21;8(10):e78880. doi: 10.1371/journal.pone.0078880. eCollection 2013.

8.

Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.

Liu HY, Pfleger CM.

PLoS One. 2013;8(1):e32835. doi: 10.1371/journal.pone.0032835. Epub 2013 Jan 29.

9.

Ubiquitin on ras: warden or partner in crime?

Pfleger CM.

Sci Signal. 2011 Mar 8;4(163):pe12. doi: 10.1126/scisignal.2001874. Review.

10.

POTENTIAL APPLICATION OF GRAPE DERIVED POLYPHENOLS IN HUNTINGTON'S DISEASE.

Wang J, Pfleger CM, Friedman L, Vittorino R, Zhao W, Qian X, Conley L, Ho L, Pasinetti GM.

Transl Neurosci. 2010 Jun 1;1(2):95-100.

11.

Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.

Pfleger CM, Wang J, Friedman L, Vittorino R, Conley LM, Ho L, Fivecoat HC, Pasinetti GM.

Int J Alzheimers Dis. 2010 Aug 24;2010. pii: 576357. doi: 10.4061/2010/576357.

12.

Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

Yan H, Jahanshahi M, Horvath EA, Liu HY, Pfleger CM.

Curr Biol. 2010 Aug 10;20(15):1378-82. doi: 10.1016/j.cub.2010.06.058. Epub 2010 Jul 22.

13.

Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo.

Yan H, Chin ML, Horvath EA, Kane EA, Pfleger CM.

J Cell Sci. 2009 May 1;122(Pt 9):1461-70. doi: 10.1242/jcs.042267. Epub 2009 Apr 14.

14.

Recent efforts to model human diseases in vivo in Drosophila.

Pfleger CM, Reiter LT.

Fly (Austin). 2008 May-Jun;2(3):129-32. Epub 2008 May 23.

PMID:
18820469
15.

Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.

Pfleger CM, Harvey KF, Yan H, Hariharan IK.

Fly (Austin). 2007 Mar-Apr;1(2):95-105.

PMID:
18820468
16.

The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death.

Mills K, Daish T, Harvey KF, Pfleger CM, Hariharan IK, Kumar S.

J Cell Biol. 2006 Mar 13;172(6):809-15.

17.
18.

The C-terminal domain of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1, is both necessary and sufficient for phosphorylation-independent proteolysis.

Chuang LC, Zhu XN, Herrera CR, Tseng HM, Pfleger CM, Block K, Yew PR.

J Biol Chem. 2005 Oct 21;280(42):35290-8. Epub 2005 Aug 23.

19.
20.

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis.

Chabes AL, Pfleger CM, Kirschner MW, Thelander L.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3925-9. Epub 2003 Mar 24.

21.

Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.

Pfleger CM, Lee E, Kirschner MW.

Genes Dev. 2001 Sep 15;15(18):2396-407.

22.

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.

Pfleger CM, Salic A, Lee E, Kirschner MW.

Genes Dev. 2001 Jul 15;15(14):1759-64.

23.

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.

Pfleger CM, Kirschner MW.

Genes Dev. 2000 Mar 15;14(6):655-65.

24.

Surface tensions of embryonic tissues predict their mutual envelopment behavior.

Foty RA, Pfleger CM, Forgacs G, Steinberg MS.

Development. 1996 May;122(5):1611-20.

25.

Liquid properties of embryonic tissues: Measurement of interfacial tensions.

Foty RA, Forgacs G, Pfleger CM, Steinberg MS.

Phys Rev Lett. 1994 Apr 4;72(14):2298-2301. No abstract available.

PMID:
10055839

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