Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 662

1.

S1P d20:1, an endogenous modulator of S1P d18:1/S1P2 -dependent signaling.

Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R.

FASEB J. 2020 Jan 15. doi: 10.1096/fj.201902391R. [Epub ahead of print]

PMID:
31944406
2.

Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.

Nasrullah U, Haeussler K, Biyanee A, Wittig I, Pfeilschifter J, Eberhardt W.

Cells. 2019 Dec 12;8(12). pii: E1622. doi: 10.3390/cells8121622.

3.

Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs.

Dreis C, Ottenlinger FM, Putyrski M, Ernst A, Huhn M, Schmidt KG, Pfeilschifter JM, Radeke HH.

Front Immunol. 2019 Jul 24;10:1698. doi: 10.3389/fimmu.2019.01698. eCollection 2019.

4.

Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus.

Patyna S, Büttner S, Eckes T, Obermüller N, Bartel C, Braner A, Trautmann S, Thomas D, Geiger H, Pfeilschifter J, Koch A.

Prostaglandins Other Lipid Mediat. 2019 Oct;144:106348. doi: 10.1016/j.prostaglandins.2019.106348. Epub 2019 Jul 10.

PMID:
31301404
5.

Effects of adenovirus-induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model.

Fuchs S, Bayer M, Taubert R, Manns MP, Pfeilschifter JM, Christen U, Hintermann E.

Liver Int. 2019 Dec;39(12):2330-2340. doi: 10.1111/liv.14183. Epub 2019 Jul 10.

PMID:
31225929
6.

Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response.

Mücke VT, Thomas D, Mücke MM, Waidmann O, Zeuzem S, Sarrazin C, Pfeilschifter J, Vermehren J, Finkelmeier F, Grammatikos G.

Liver Int. 2019 Nov;39(11):2174-2183. doi: 10.1111/liv.14178. Epub 2019 Jul 3.

PMID:
31207039
7.

National survey of evaluation practices and performance-guided resource allocation at German medical schools.

Schiekirka-Schwake S, Barth J, Pfeilschifter J, Hickel R, Raupach T, Herrmann-Lingen C.

Ger Med Sci. 2019 Apr 18;17:Doc04. doi: 10.3205/000270. eCollection 2019.

8.

[Diuretic Therapy].

Büttner S, Koch A, Pfeilschifter J.

Dtsch Med Wochenschr. 2019 Mar;144(6):387-392. doi: 10.1055/a-0661-4426. Epub 2019 Mar 14. German.

PMID:
30870869
9.

Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.

Goren I, Köhler Y, Aglan A, Pfeilschifter J, Beck KF, Frank S.

Nitric Oxide. 2019 Jun 1;87:31-42. doi: 10.1016/j.niox.2019.03.004. Epub 2019 Mar 9.

PMID:
30862476
10.

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.

Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28.

PMID:
30816345
11.

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L.

Kidney Int. 2019 Mar;95(3):540-562. doi: 10.1016/j.kint.2018.10.037. Epub 2019 Jan 31.

PMID:
30712922
12.

Diurnal regulation of sphingolipids in blood.

Brunkhorst R, Pfeilschifter W, Rajkovic N, Pfeffer M, Fischer C, Korf HW, Christoffersen C, Trautmann S, Thomas D, Pfeilschifter J, Koch A.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):304-311. doi: 10.1016/j.bbalip.2018.12.001. Epub 2018 Dec 15.

PMID:
30557628
13.

Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection.

Mücke VT, Jakobi K, Knop V, Thomas D, Mücke MM, Peiffer KH, Zeuzem S, Sarrazin C, Pfeilschifter J, Grammatikos G.

PLoS One. 2018 Nov 15;13(11):e0207293. doi: 10.1371/journal.pone.0207293. eCollection 2018.

14.

Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls.

Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M.

J Steroid Biochem Mol Biol. 2019 Feb;186:130-135. doi: 10.1016/j.jsbmb.2018.10.005. Epub 2018 Oct 15.

PMID:
30336275
15.

Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors.

Eberhardt W, Nasrullah U, Pfeilschifter J.

Cell Signal. 2018 Dec;52:1-11. doi: 10.1016/j.cellsig.2018.08.013. Epub 2018 Aug 23. Review.

PMID:
30145216
16.

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis.

Beyer S, Schwalm S, Pfeilschifter J, Huwiler A.

Cell Physiol Biochem. 2018;47(6):2522-2533. doi: 10.1159/000491625. Epub 2018 Jul 10.

17.

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I.

Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.

PMID:
29970364
18.

Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke.

Luger S, Schwebler A, Vutukuri R, Bouzas NF, Labocha S, Schreiber Y, Brunkhorst R, Steinmetz H, Pfeilschifter J, Pfeilschifter W.

Ther Adv Neurol Disord. 2018 Apr 19;11:1756286418769830. doi: 10.1177/1756286418769830. eCollection 2018.

19.

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells.

Blanchard O, Stepanovska B, Starck M, Erhardt M, Römer I, Meyer Zu Heringdorf D, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A.

Int J Mol Sci. 2018 May 17;19(5). pii: E1498. doi: 10.3390/ijms19051498.

20.

Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice.

Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, Christen U.

J Autoimmun. 2018 Jul;91:83-96. doi: 10.1016/j.jaut.2018.05.001. Epub 2018 May 9.

PMID:
29753567
21.

Preanalytical Biases in the Measurement of Human Blood Sphingolipids.

Brunkhorst R, Pfeilschifter W, Patyna S, Büttner S, Eckes T, Trautmann S, Thomas D, Pfeilschifter J, Koch A.

Int J Mol Sci. 2018 May 7;19(5). pii: E1390. doi: 10.3390/ijms19051390.

22.

Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.

Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, Eberhardt W.

Oncotarget. 2018 Apr 6;9(26):18367-18385. doi: 10.18632/oncotarget.24840. eCollection 2018 Apr 6.

23.

Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation.

Mücke VT, Gerharz J, Jakobi K, Thomas D, Ferreirós Bouzas N, Mücke MM, Trötschler S, Weiler N, Welker MW, Zeuzem S, Pfeilschifter J, Grammatikos G.

Int J Mol Sci. 2018 Mar 26;19(4). pii: E991. doi: 10.3390/ijms19040991.

24.

A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation.

Bachmann M, Pfeilschifter J, Mühl H.

Front Immunol. 2018 Feb 8;9:161. doi: 10.3389/fimmu.2018.00161. eCollection 2018.

25.

Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells.

Bachmann M, Pfeilschifter J, Mühl H.

Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):191-199. doi: 10.1016/j.bbagrm.2018.01.020. Epub 2018 Jan 31.

PMID:
29409936
26.

Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreirós N, Schreiber Y, Schröder K, Devraj K, Popp R, Huwiler A, Hattenbach LO, Pfeilschifter J, Pfeilschifter W.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):653-661. doi: 10.1167/iovs.17-22544. Erratum in: Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2503.

27.

Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells.

Schwiebs A, Thomas D, Kleuser B, Pfeilschifter JM, Radeke HH.

Mediators Inflamm. 2017;2017:5187368. doi: 10.1155/2017/5187368. Epub 2017 Dec 11.

28.

A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds.

Goren I, Christen U, Pfeilschifter J, Frank S.

Nitric Oxide. 2018 Apr 1;74:23-31. doi: 10.1016/j.niox.2018.01.004. Epub 2018 Feb 2.

PMID:
29355774
29.

Sphingolipid signaling in renal fibrosis.

Huwiler A, Pfeilschifter J.

Matrix Biol. 2018 Aug;68-69:230-247. doi: 10.1016/j.matbio.2018.01.006. Epub 2018 Jan 16. Review.

PMID:
29343457
30.

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study.

Schmidt KG, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger FM, Thomas D, Zaucke F, Pfeilschifter JM, Radeke HH.

Front Immunol. 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242. eCollection 2017.

31.

Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption.

Vutukuri R, Brunkhorst R, Kestner RI, Hansen L, Bouzas NF, Pfeilschifter J, Devraj K, Pfeilschifter W.

J Neurochem. 2018 Jan;144(2):172-185. doi: 10.1111/jnc.14236. Epub 2017 Dec 28.

32.

Self-perception of fracture risk: what can it tell us?

Litwic AE, Compston JE, Wyman A, Siris ES, Gehlbach SH, Adachi JD, Chapurlat R, Díez-Pérez A, LaCroix AZ, Nieves JW, Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Saag KG, Silverman S, Watts NB, Greenspan SL, March L, Gregson CL, Cooper C, Dennison EM; Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators.

Osteoporos Int. 2017 Dec;28(12):3495-3500. doi: 10.1007/s00198-017-4200-3. Epub 2017 Aug 31.

33.

Type I Interferon Supports Inducible Nitric Oxide Synthase in Murine Hepatoma Cells and Hepatocytes and during Experimental Acetaminophen-Induced Liver Damage.

Bachmann M, Waibler Z, Pleli T, Pfeilschifter J, Mühl H.

Front Immunol. 2017 Jul 31;8:890. doi: 10.3389/fimmu.2017.00890. eCollection 2017.

34.

Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.

Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, Pfeilschifter J.

Am J Pathol. 2017 Nov;187(11):2413-2429. doi: 10.1016/j.ajpath.2017.06.017. Epub 2017 Aug 12.

35.

Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients.

Koch A, Grammatikos G, Trautmann S, Schreiber Y, Thomas D, Bruns F, Pfeilschifter J, Badenhoop K, Penna-Martinez M.

Int J Mol Sci. 2017 Jul 15;18(7). pii: E1532. doi: 10.3390/ijms18071532.

36.

Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity.

Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, Mühl H.

Front Immunol. 2017 Jun 29;8:742. doi: 10.3389/fimmu.2017.00742. eCollection 2017.

37.

Correction for Doller et al., "Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR".

Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, Eberhardt W.

Mol Cell Biol. 2017 Jun 15;37(13). pii: e00151-17. doi: 10.1128/MCB.00151-17. Print 2017 Jul 1. No abstract available.

38.

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.

Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L.

Int J Mol Sci. 2017 Mar 9;18(3). pii: E595. doi: 10.3390/ijms18030595.

39.

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.

Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, Meyer Zu Heringdorf D.

Sci Rep. 2017 Mar 6;7:43575. doi: 10.1038/srep43575.

40.

Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.

Badawi A, Hehlgans S, Pfeilschifter J, Rödel F, Eberhardt W.

Cancer Lett. 2017 May 1;393:103-112. doi: 10.1016/j.canlet.2017.02.010. Epub 2017 Feb 20.

PMID:
28219770
41.

Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer.

Richter C, Herrero San Juan M, Weigmann B, Bergis D, Dauber K, Muders MH, Baretton GB, Pfeilschifter JM, Bonig H, Brenner S, Radeke HH.

Front Immunol. 2017 Jan 27;8:44. doi: 10.3389/fimmu.2017.00044. eCollection 2017.

42.

Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis.

Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, Pfeilschifter J.

J Mol Med (Berl). 2017 Mar;95(3):257-271. doi: 10.1007/s00109-016-1503-3. Epub 2017 Jan 4.

PMID:
28054119
43.

Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation.

Siebert A, Goren I, Pfeilschifter J, Frank S.

PLoS One. 2016 Dec 19;11(12):e0168562. doi: 10.1371/journal.pone.0168562. eCollection 2016.

44.

Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab.

Ottenlinger FM, Mayer CA, Ferreirós N, Schreiber Y, Schwiebs A, Schmidt KG, Ackermann H, Pfeilschifter JM, Radeke HH.

Front Pharmacol. 2016 Nov 3;7:412. eCollection 2016.

45.

Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells.

Bachmann M, Meissner C, Pfeilschifter J, Mühl H.

Biofactors. 2017 Mar;43(2):283-292. doi: 10.1002/biof.1341. Epub 2016 Nov 1.

PMID:
27801948
46.

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes.

Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, Christen U.

Diabetes. 2017 Jan;66(1):113-126. doi: 10.2337/db16-0547. Epub 2016 Oct 26.

47.

Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation.

Filipenko I, Schwalm S, Reali L, Pfeilschifter J, Fabbro D, Huwiler A, Zangemeister-Wittke U.

Biochim Biophys Acta. 2016 Nov;1861(11):1840-1851. doi: 10.1016/j.bbalip.2016.09.005. Epub 2016 Sep 9.

PMID:
27616330
48.

Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons.

Eberhardt W, Badawi A, Biyanee A, Pfeilschifter J.

Front Pharmacol. 2016 Aug 17;7:251. doi: 10.3389/fphar.2016.00251. eCollection 2016. Review.

49.

H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases.

Longen S, Beck KF, Pfeilschifter J.

Pharmacol Res. 2016 Sep;111:642-651. doi: 10.1016/j.phrs.2016.07.026. Epub 2016 Jul 25. Review.

PMID:
27468648
50.

Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks.

Blankenbach KV, Schwalm S, Pfeilschifter J, Meyer Zu Heringdorf D.

Front Pharmacol. 2016 Jun 21;7:167. doi: 10.3389/fphar.2016.00167. eCollection 2016. Review.

Supplemental Content

Loading ...
Support Center