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Correction to: Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.

Goehring I, Sauter NS, Catchpole G, Assmann A, Shu L, Zien KS, Moehlig M, Pfeiffer AFH, Oberholzer J, Willmitzer L, Spranger J, Maedler K.

Diabetologia. 2019 Mar;62(3):553-554. doi: 10.1007/s00125-018-4717-9.


An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial.

Karusheva Y, Kunstein L, Bierwagen A, Nowotny B, Kabisch S, Groener JB, Fleitmann AK, Herder C, Pacini G, Strassburger K, Häring HU, Nawroth PP, Pfeiffer AFH, Burkart V, Müssig K, Roden M, Szendroedi J.

Nutr Metab (Lond). 2018 Dec 29;15:90. doi: 10.1186/s12986-018-0324-5. eCollection 2018.


Diurnal distribution of carbohydrates and fat affects substrate oxidation and adipokine secretion in humans.

Kessler K, Hornemann S, Petzke KJ, Kemper M, Markova M, Rudovich N, Grune T, Kramer A, Pfeiffer AFH, Pivovarova-Ramich O.

Am J Clin Nutr. 2018 Dec 1;108(6):1209-1219. doi: 10.1093/ajcn/nqy224.


Acute Endothelial Benefits of Fat Restriction over Carbohydrate Restriction in Type 2 Diabetes Mellitus: Beyond Carbs and Fats.

Barbosa-Yañez RL, Dambeck U, Li L, Machann J, Kabisch S, Pfeiffer AFH.

Nutrients. 2018 Dec 1;10(12). pii: E1859. doi: 10.3390/nu10121859.


Diverse Excretion Pathways of Benzyl Glucosinolate in Humans after Consumption of Nasturtium (Tropaeolum majus L.)-A Pilot Study.

Kühn C, Kupke F, Baldermann S, Klopsch R, Lamy E, Hornemann S, Pfeiffer AFH, Schreiner M, Hanschen FS, Rohn S.

Mol Nutr Food Res. 2018 Oct;62(20):e1800588. doi: 10.1002/mnfr.201800588. Epub 2018 Aug 28.


Rate of appearance of amino acids after a meal regulates insulin and glucagon secretion in patients with type 2 diabetes: a randomized clinical trial.

Markova M, Hornemann S, Sucher S, Wegner K, Pivovarova O, Rudovich N, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AFH.

Am J Clin Nutr. 2018 Aug 1;108(2):279-291. doi: 10.1093/ajcn/nqy100.


Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum.

Meyer S, Markova M, Pohl G, Marschall TA, Pivovarova O, Pfeiffer AFH, Schwerdtle T.

J Trace Elem Med Biol. 2018 Sep;49:157-163. doi: 10.1016/j.jtemb.2018.05.012. Epub 2018 May 19.


The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.

Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM.

Diabetologia. 2018 May 12. doi: 10.1007/s00125-018-4636-9. [Epub ahead of print]


High Glycemic Index Metabolic Damage - a Pivotal Role of GIP and GLP-1.

Pfeiffer AFH, Keyhani-Nejad F.

Trends Endocrinol Metab. 2018 May;29(5):289-299. doi: 10.1016/j.tem.2018.03.003. Epub 2018 Mar 27. Review.


Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance.

Weickert MO, Hattersley JG, Kyrou I, Arafat AM, Rudovich N, Roden M, Nowotny P, von Loeffelholz C, Matysik S, Schmitz G, Pfeiffer AFH.

Nutr Diabetes. 2018 Mar 7;8(1):11. doi: 10.1038/s41387-018-0020-6.


VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans.

Schüler R, Seebeck N, Osterhoff MA, Witte V, Flöel A, Busjahn A, Jais A, Brüning JC, Frahnow T, Kabisch S, Pivovarova O, Hornemann S, Kruse M, Pfeiffer AFH.

Mol Metab. 2018 May;11:129-136. doi: 10.1016/j.molmet.2018.02.004. Epub 2018 Feb 12.


Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT).

Honsek C, Kabisch S, Kemper M, Gerbracht C, Arafat AM, Birkenfeld AL, Dambeck U, Osterhoff MA, Weickert MO, Pfeiffer AFH.

Diabetologia. 2018 Jun;61(6):1295-1305. doi: 10.1007/s00125-018-4582-6. Epub 2018 Feb 28.


Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes.

Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM.

Oxid Med Cell Longev. 2017;2017:3035184. doi: 10.1155/2017/3035184. Epub 2017 Dec 20.


Liver Fat Scores Moderately Reflect Interventional Changes in Liver Fat Content by a Low-Fat Diet but Not by a Low-Carb Diet.

Kabisch S, Bäther S, Dambeck U, Kemper M, Gerbracht C, Honsek C, Sachno A, Pfeiffer AFH.

Nutrients. 2018 Jan 31;10(2). pii: E157. doi: 10.3390/nu10020157.


Impact of Dietary Fiber Consumption on Insulin Resistance and the Prevention of Type 2 Diabetes.

Weickert MO, Pfeiffer AFH.

J Nutr. 2018 Jan 1;148(1):7-12. doi: 10.1093/jn/nxx008. Review.


Dietary Intake of Protein from Different Sources and Weight Regain, Changes in Body Composition and Cardiometabolic Risk Factors after Weight Loss: The DIOGenes Study.

van Baak MA, Larsen TM, Jebb SA, Martinez A, Saris WHM, Handjieva-Darlenska T, Kafatos A, Pfeiffer AFH, Kunešová M, Astrup A.

Nutrients. 2017 Dec 6;9(12). pii: E1326. doi: 10.3390/nu9121326.


Assessment of circulating Wnt1 inducible signalling pathway protein 1 (WISP-1)/CCN4 as a novel biomarker of obesity.

Tacke C, Aleksandrova K, Rehfeldt M, Murahovschi V, Markova M, Kemper M, Hornemann S, Kaiser U, Honig C, Gerbracht C, Kabisch S, Hörbelt T, Ouwens DM, Weickert MO, Boeing H, Pfeiffer AFH, Pivovarova O, Rudovich N.

J Cell Commun Signal. 2018 Sep;12(3):539-548. doi: 10.1007/s12079-017-0427-1. Epub 2017 Nov 11.


Glycaemic response after intake of a high energy, high protein, diabetes-specific formula in older malnourished or at risk of malnutrition type 2 diabetes patients.

Laksir H, Lansink M, Regueme SC, de Vogel-van den Bosch J, Pfeiffer AFH, Bourdel-Marchasson I.

Clin Nutr. 2018 Dec;37(6 Pt A):2084-2090. doi: 10.1016/j.clnu.2017.09.027. Epub 2017 Oct 6.


Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins.

Sarem Z, Bumke-Vogt C, Mahmoud AM, Assefa B, Weickert MO, Adamidou A, Bähr V, Frystyk J, Möhlig M, Spranger J, Lieske S, Birkenfeld AL, Pfeiffer AFH, Arafat AM.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3480-3490. doi: 10.1210/jc.2017-00558.


Metformin extended-release versus immediate-release: An international, randomized, double-blind, head-to-head trial in pharmacotherapy-naïve patients with type 2 diabetes.

Aggarwal N, Singla A, Mathieu C, Montanya E, Pfeiffer AFH, Johnsson E, Zhao J, Iqbal N, Bailey C.

Diabetes Obes Metab. 2018 Feb;20(2):463-467. doi: 10.1111/dom.13104. Epub 2017 Oct 2.


Retinol saturase coordinates liver metabolism by regulating ChREBP activity.

Heidenreich S, Witte N, Weber P, Goehring I, Tolkachov A, von Loeffelholz C, Döcke S, Bauer M, Stockmann M, Pfeiffer AFH, Birkenfeld AL, Pietzke M, Kempa S, Muenzner M, Schupp M.

Nat Commun. 2017 Aug 30;8(1):384. doi: 10.1038/s41467-017-00430-w.


Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes.

Schüler R, Osterhoff MA, Frahnow T, Möhlig M, Spranger J, Stefanovski D, Bergman RN, Xu L, Seltmann AC, Kabisch S, Hornemann S, Kruse M, Pfeiffer AFH.

Sci Rep. 2017 Aug 23;7(1):9234. doi: 10.1038/s41598-017-08300-7.


Plasminogen Activator Inhibitor-1 is Regulated Through Dietary Fat Intake and Heritability: Studies in Twins.

Engstler AJ, Frahnow T, Kruse M, Pfeiffer AFH, Bergheim I.

Twin Res Hum Genet. 2017 Aug;20(4):338-348. doi: 10.1017/thg.2017.36. Epub 2017 Jun 21.


Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop.

Peters HPF, Schrauwen P, Verhoef P, Byrne CD, Mela DJ, Pfeiffer AFH, Risérus U, Rosendaal FR, Schrauwen-Hinderling V.

J Nutr Sci. 2017 May 8;6:e15. doi: 10.1017/jns.2017.13. eCollection 2017. Review.


Heritability and responses to high fat diet of plasma lipidomics in a twin study.

Frahnow T, Osterhoff MA, Hornemann S, Kruse M, Surma MA, Klose C, Simons K, Pfeiffer AFH.

Sci Rep. 2017 Jun 16;7(1):3750. doi: 10.1038/s41598-017-03965-6.


Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K.

Aging Cell. 2017 Aug;16(4):761-772. doi: 10.1111/acel.12610. Epub 2017 May 22.


Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate.

Weitkunat K, Schumann S, Nickel D, Hornemann S, Petzke KJ, Schulze MB, Pfeiffer AF, Klaus S.

Am J Clin Nutr. 2017 Jun;105(6):1544-1551. doi: 10.3945/ajcn.117.152702. Epub 2017 Apr 19.


Oral administration of nasturtium affects peptide YY secretion in male subjects.

Schiess S, Platz S, Kemper M, Schreiner M, Mewis I, Rohn S, Bumke-Vogt C, Pivovarova O, Pfeiffer AFH.

Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600886. Epub 2017 Apr 6.


ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives.

von Loeffelholz C, Pfeiffer AFH, Lock JF, Lieske S, Döcke S, Murahovschi V, Kriebel J, de Las Heras Gala T, Grallert H, Rudovich N, Stockmann M, Spranger J, Jahreis G, Bornstein SR, Lau G, Xu A, Schulz-Menger J, Exner L, Haufe S, Jordan J, Engeli S, Birkenfeld AL.

Horm Metab Res. 2017 May;49(5):343-349. doi: 10.1055/s-0043-102950. Epub 2017 Mar 28.


Novel adipokines: methodological utility in human obesity research.

Eichelmann F, Rudovich N, Pfeiffer AF, Schulze MB, Giuseppe RD, Boeing H, Aleksandrova K.

Int J Obes (Lond). 2017 Jun;41(6):976-981. doi: 10.1038/ijo.2017.68. Epub 2017 Mar 15.


The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial.

Kessler K, Hornemann S, Petzke KJ, Kemper M, Kramer A, Pfeiffer AF, Pivovarova O, Rudovich N.

Sci Rep. 2017 Mar 8;7:44170. doi: 10.1038/srep44170.


A phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency.

Höybye C, Pfeiffer AF, Ferone D, Christiansen JS, Gilfoyle D, Christoffersen ED, Mortensen E, Leff JA, Beckert M.

Endocr Connect. 2017 Apr;6(3):129-138. doi: 10.1530/EC-17-0007. Epub 2017 Feb 14.


Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial.

Sucher S, Markova M, Hornemann S, Pivovarova O, Rudovich N, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AFH.

Diabetes Obes Metab. 2017 Jul;19(7):944-952. doi: 10.1111/dom.12901. Epub 2017 Mar 8.


The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.


High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure.

Schüler R, Osterhoff MA, Frahnow T, Seltmann AC, Busjahn A, Kabisch S, Xu L, Mosig AS, Spranger J, Möhlig M, Hornemann S, Kruse M, Pfeiffer AF.

J Am Heart Assoc. 2017 Jan 17;6(1). pii: e004465. doi: 10.1161/JAHA.116.004465.


Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes.

Markova M, Pivovarova O, Hornemann S, Sucher S, Frahnow T, Wegner K, Machann J, Petzke KJ, Hierholzer J, Lichtinghagen R, Herder C, Carstensen-Kirberg M, Roden M, Rudovich N, Klaus S, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AF.

Gastroenterology. 2017 Feb;152(3):571-585.e8. doi: 10.1053/j.gastro.2016.10.007. Epub 2016 Oct 17.


Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver.

von Loeffelholz C, Döcke S, Lock JF, Lieske S, Horn P, Kriebel J, Wahl S, Singmann P, de Las Heras Gala T, Grallert H, Raschzok N, Sauer IM, Heller R, Jahreis G, Claus RA, Bauer M, Stockmann M, Birkenfeld AL, Pfeiffer AFH.

Hepatol Res. 2017 Aug;47(9):890-901. doi: 10.1111/hepr.12825. Epub 2016 Nov 18.


Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells.

Guzmán-Pérez V, Bumke-Vogt C, Schreiner M, Mewis I, Borchert A, Pfeiffer AF.

PLoS One. 2016 Sep 13;11(9):e0162397. doi: 10.1371/journal.pone.0162397. eCollection 2016.


Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?

Pivovarova O, Höhn A, Grune T, Pfeiffer AF, Rudovich N.

Ann Med. 2016 Dec;48(8):614-624. Epub 2016 Jun 19. Review.


Modulation of circulating vasoactive peptides and extracellular matrix proteins are two novel mechanisms in the cardioprotective action of acarbose.

Rudovich N, Pivovarova O, Bernigau W, Sparwasser A, Tacke C, Murahovshi V, Mertes G, Birkenfeld AL, Bergmann A, Weickert MO, Pfeiffer AF.

Minerva Endocrinol. 2016 Dec;41(4):456-68. Epub 2016 Mar 23.


Fetuin A is a Predictor of Liver Fat in Preoperative Patients with Nonalcoholic Fatty Liver Disease.

von Loeffelholz C, Horn P, Birkenfeld AL, Claus RA, Metzing BU, Döcke S, Jahreis G, Heller R, Hoppe S, Stockmann M, Lock JF, Rieger A, Weickert MO, Settmacher U, Rauchfuß F, Pfeiffer AF, Bauer M, Sponholz C.

J Invest Surg. 2016 Oct;29(5):266-74. doi: 10.3109/08941939.2016.1149640. Epub 2016 Mar 16.


Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial.

Nowotny B, Zahiragic L, Bierwagen A, Kabisch S, Groener JB, Nowotny PJ, Fleitmann AK, Firouzi P, Herder C, Pacini G, Erlund I, Landberg R, Haering HU, Pfeiffer AF, Nawroth PP, Roden M.

Diabetologia. 2016 Jun;59(6):1329. No abstract available.


Regulation of the clock gene expression in human adipose tissue by weight loss.

Pivovarova O, Gögebakan Ö, Sucher S, Groth J, Murahovschi V, Kessler K, Osterhoff M, Rudovich N, Kramer A, Pfeiffer AF.

Int J Obes (Lond). 2016 Jun;40(6):899-906. doi: 10.1038/ijo.2016.34. Epub 2016 Feb 23.


Effects of Palatinose and Sucrose Intake on Glucose Metabolism and Incretin Secretion in Subjects With Type 2 Diabetes.

Keyhani-Nejad F, Kemper M, Schueler R, Pivovarova O, Rudovich N, Pfeiffer AF.

Diabetes Care. 2016 Mar;39(3):e38-9. doi: 10.2337/dc15-1891. Epub 2015 Dec 30. No abstract available.


High-Fat Diet During Mouse Pregnancy and Lactation Targets GIP-Regulated Metabolic Pathways in Adult Male Offspring.

Kruse M, Keyhani-Nejad F, Isken F, Nitz B, Kretschmer A, Reischl E, de las Heras Gala T, Osterhoff MA, Grallert H, Pfeiffer AF.

Diabetes. 2016 Mar;65(3):574-84. doi: 10.2337/db15-0478. Epub 2015 Dec 2.


Bioavailability and metabolism of benzyl glucosinolate in humans consuming Indian cress (Tropaeolum majus L.).

Platz S, Kühn C, Schiess S, Schreiner M, Kemper M, Pivovarova O, Pfeiffer AF, Rohn S.

Mol Nutr Food Res. 2016 Mar;60(3):652-60. doi: 10.1002/mnfr.201500633. Epub 2015 Dec 28.


GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial.

Gögebakan Ö, Osterhoff MA, Schüler R, Pivovarova O, Kruse M, Seltmann AC, Mosig AS, Rudovich N, Nauck M, Pfeiffer AF.

Diabetologia. 2015 Aug;58(8):1759-68. doi: 10.1007/s00125-015-3618-4. Epub 2015 May 21.


Modulation of insulin degrading enzyme activity and liver cell proliferation.

Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V, Lukowski S, Döcke S, Kriebel J, de las Heras Gala T, Malashicheva A, Kostareva A, Lock JF, Stockmann M, Grallert H, Gretz N, Dooley S, Pfeiffer AF, Rudovich N.

Cell Cycle. 2015;14(14):2293-300. doi: 10.1080/15384101.2015.1046647. Epub 2015 May 6.


The Impact of Gender and Protein Intake on the Success of Weight Maintenance and Associated Cardiovascular Risk Benefits, Independent of the Mode of Food Provision: The DiOGenes Randomized Trial.

Navas-Carretero S, Holst C, Saris WH, van Baak MA, Jebb SA, Kafatos A, Papadaki A, Pfeiffer AF, Handjieva-Darlenska T, Hlavaty P, Stender S, Larsen TM, Astrup A, Martinez JA.

J Am Coll Nutr. 2016;35(1):20-30. doi: 10.1080/07315724.2014.948642. Epub 2015 Mar 31.


Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans.

Pivovarova O, Jürchott K, Rudovich N, Hornemann S, Ye L, Möckel S, Murahovschi V, Kessler K, Seltmann AC, Maser-Gluth C, Mazuch J, Kruse M, Busjahn A, Kramer A, Pfeiffer AF.

J Clin Endocrinol Metab. 2015 Jun;100(6):2291-302. doi: 10.1210/jc.2014-3868. Epub 2015 Mar 30.


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