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Items: 1 to 50 of 64

1.

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.

Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC.

Nat Med. 2018 Nov;24(11):1701-1707. doi: 10.1038/s41591-018-0186-4. Epub 2018 Sep 26.

PMID:
30258217
2.

Combination therapy with anti-HIV-1 antibodies maintains viral suppression.

Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP Jr, Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M, Nussenzweig MC.

Nature. 2018 Sep;561(7724):479-484. doi: 10.1038/s41586-018-0531-2. Epub 2018 Sep 26.

PMID:
30258136
3.

An evaluation of a safety improvement intervention in care homes in England: a participatory qualitative study.

Marshall M, Pfeifer N, de Silva D, Wei L, Anderson J, Cruickshank L, Attreed-James K, Shand J.

J R Soc Med. 2018 Sep 20:141076818803457. doi: 10.1177/0141076818803457. [Epub ahead of print]

PMID:
30235053
4.

Automatic determination of 3D orientations of fossilized oyster shells from a densely packed Miocene shell bed.

Puttonen A, Harzhauser M, Puttonen E, Mandic O, Székely B, Molnár G, Pfeifer N.

Int J Earth Sci. 2018;107(6):2125-2142. doi: 10.1007/s00531-018-1591-0. Epub 2018 Feb 23.

5.

Editorial: Optical Approaches to Capture Plant Dynamics in Time, Space, and Across Scales.

Puttonen E, Bucksch A, Zlinszky A, Pfeifer N.

Front Plant Sci. 2018 Jun 11;9:791. doi: 10.3389/fpls.2018.00791. eCollection 2018. No abstract available.

6.

geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data.

Döring M, Büch J, Friedrich G, Pironti A, Kalaghatgi P, Knops E, Heger E, Obermeier M, Däumer M, Thielen A, Kaiser R, Lengauer T, Pfeifer N.

Nucleic Acids Res. 2018 Jul 2;46(W1):W271-W277. doi: 10.1093/nar/gky349.

7.

Performance Evaluation of a Genotypic Tropism Test Using HIV-1 CRF01_AE Isolates in Japan.

Matsuda M, Louvel S, Sugiura W, Haas A, Pfeifer N, Yokomaku Y, Iwatani Y, Kaiser R, Klimkait T.

Jpn J Infect Dis. 2018 Jul 24;71(4):264-266. doi: 10.7883/yoken.JJID.2017.482. Epub 2018 Apr 27.

8.

XplOit: An Ontology-Based Data Integration Platform Supporting the Development of Predictive Models for Personalized Medicine.

Weiler G, Schwarz U, Rauch J, Rohm K, Lehr T, Theobald S, Kiefer S, Götz K, Och K, Pfeifer N, Handl L, Smola S, Ihle M, Turki AT, Beelen DW, Rissland J, Bittenbring J, Graf N.

Stud Health Technol Inform. 2018;247:21-25.

PMID:
29677915
9.

Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.

10.

Integrated Change Detection and Classification in Urban Areas Based on Airborne Laser Scanning Point Clouds.

Tran THG, Ressl C, Pfeifer N.

Sensors (Basel). 2018 Feb 3;18(2). pii: E448. doi: 10.3390/s18020448.

11.

Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time.

Hake A, Pfeifer N.

PLoS Comput Biol. 2017 Oct 24;13(10):e1005789. doi: 10.1371/journal.pcbi.1005789. eCollection 2017 Oct.

12.

Towards Multiple Kernel Principal Component Analysis for Integrative Analysis of Tumor Samples.

Speicher NK, Pfeifer N.

J Integr Bioinform. 2017 Jul 8;14(2). pii: /j/jib.2017.14.issue-2/jib-2017-0019/jib-2017-0019.xml. doi: 10.1515/jib-2017-0019.

13.
14.

Using drug exposure for predicting drug resistance - A data-driven genotypic interpretation tool.

Pironti A, Pfeifer N, Walter H, Jensen BO, Zazzi M, Gomes P, Kaiser R, Lengauer T.

PLoS One. 2017 Apr 10;12(4):e0174992. doi: 10.1371/journal.pone.0174992. eCollection 2017.

15.

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.

Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F.

Nat Med. 2017 Feb;23(2):185-191. doi: 10.1038/nm.4268. Epub 2017 Jan 16.

16.

A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Döring M, Borrego P, Büch J, Martins A, Friedrich G, Camacho RJ, Eberle J, Kaiser R, Lengauer T, Taveira N, Pfeifer N.

Retrovirology. 2016 Dec 20;13(1):85. doi: 10.1186/s12977-016-0320-7.

17.

Determination of Phenotypic Resistance Cutoffs From Routine Clinical Data.

Pironti A, Walter H, Pfeifer N, Knops E, Lübke N, Büch J, Di Giambenedetto S, Kaiser R, Lengauer T; EuResist Network Study Group.

J Acquir Immune Defic Syndr. 2017 Apr 15;74(5):e129-e137. doi: 10.1097/QAI.0000000000001198.

18.

Family-Joining: A Fast Distance-Based Method for Constructing Generally Labeled Trees.

Kalaghatgi P, Pfeifer N, Lengauer T.

Mol Biol Evol. 2016 Oct;33(10):2720-34. doi: 10.1093/molbev/msw123. Epub 2016 Jul 19.

19.

Interpretable per case weighted ensemble method for cancer associations.

Jalali A, Pfeifer N.

BMC Genomics. 2016 Jul 19;17:501. doi: 10.1186/s12864-016-2647-9.

20.

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.

Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, Settler A, Witmer-Pack M, West AP Jr, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Bjorkman PJ, Klein F, Schlesinger SJ, Walker BD, Hahn BH, Nussenzweig MC, Caskey M.

Nature. 2016 Jul 28;535(7613):556-60. Epub 2016 Jun 22.

21.

Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis.

Burmester GR, Landewé R, Genovese MC, Friedman AW, Pfeifer ND, Varothai NA, Lacerda AP.

Ann Rheum Dis. 2017 Feb;76(2):414-417. doi: 10.1136/annrheumdis-2016-209322. Epub 2016 Jun 23.

22.

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC.

Science. 2016 May 20;352(6288):997-1001. doi: 10.1126/science.aaf0972. Epub 2016 May 5.

23.

Impact of pre-adapted HIV transmission.

Carlson JM, Du VY, Pfeifer N, Bansal A, Tan VY, Power K, Brumme CJ, Kreimer A, DeZiel CE, Fusi N, Schaefer M, Brockman MA, Gilmour J, Price MA, Kilembe W, Haubrich R, John M, Mallal S, Shapiro R, Frater J, Harrigan PR, Ndung'u T, Allen S, Heckerman D, Sidney J, Allen TM, Goulder PJ, Brumme ZL, Hunter E, Goepfert PA.

Nat Med. 2016 Jun;22(6):606-13. doi: 10.1038/nm.4100. Epub 2016 May 16.

24.

Quantification of Overnight Movement of Birch (Betula pendula) Branches and Foliage with Short Interval Terrestrial Laser Scanning.

Puttonen E, Briese C, Mandlburger G, Wieser M, Pfennigbauer M, Zlinszky A, Pfeifer N.

Front Plant Sci. 2016 Feb 29;7:222. doi: 10.3389/fpls.2016.00222. eCollection 2016.

25.

Sinusoidal Wave Estimation Using Photogrammetry and Short Video Sequences.

Rupnik E, Jansa J, Pfeifer N.

Sensors (Basel). 2015 Dec 5;15(12):30784-809. doi: 10.3390/s151229828.

26.

CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba.

Kouri V, Khouri R, Alemán Y, Abrahantes Y, Vercauteren J, Pineda-Peña AC, Theys K, Megens S, Moutschen M, Pfeifer N, Van Weyenbergh J, Pérez AB, Pérez J, Pérez L, Van Laethem K, Vandamme AM.

EBioMedicine. 2015 Jan 28;2(3):244-54. doi: 10.1016/j.ebiom.2015.01.015. eCollection 2015 Mar.

27.

Integrating different data types by regularized unsupervised multiple kernel learning with application to cancer subtype discovery.

Speicher NK, Pfeifer N.

Bioinformatics. 2015 Jun 15;31(12):i268-75. doi: 10.1093/bioinformatics/btv244.

28.

Effects of sequence alterations on results from genotypic tropism testing.

Pironti A, Sierra S, Kaiser R, Lengauer T, Pfeifer N.

J Clin Virol. 2015 Apr;65:68-73. doi: 10.1016/j.jcv.2015.02.006. Epub 2015 Feb 10.

29.

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.

Yang K, Pfeifer ND, Köck K, Brouwer KL.

J Pharmacol Exp Ther. 2015 May;353(2):415-23. doi: 10.1124/jpet.114.221564. Epub 2015 Feb 23.

30.

Improved therapy-success prediction with GSS estimated from clinical HIV-1 sequences.

Pironti A, Pfeifer N, Kaiser R, Walter H, Lengauer T.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19743. doi: 10.7448/IAS.17.4.19743. eCollection 2014.

31.

Association between HIV-1 coreceptor usage and resistance to broadly neutralizing antibodies.

Pfeifer N, Walter H, Lengauer T.

J Acquir Immune Defic Syndr. 2014 Oct 1;67(2):107-12. doi: 10.1097/QAI.0000000000000283.

32.

Primarily oseltamivir-resistant influenza A (H1N1pdm09) virus evolving into a multidrug-resistant virus carrying H275Y and I223R neuraminidase substitutions.

Grund S, Gkioule C, Termos T, Pfeifer N, Kobbe G, Verheyen J, Adams O.

Antivir Ther. 2015;20(1):97-100. doi: 10.3851/IMP2811. Epub 2014 Jun 18.

PMID:
24941247
33.

Personalized HIV therapy to control drug resistance.

Lengauer T, Pfeifer N, Kaiser R.

Drug Discov Today Technol. 2014 Mar;11:57-64. doi: 10.1016/j.ddtec.2014.02.004. Review.

34.
35.
36.

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.

Bartha I, Carlson JM, Brumme CJ, McLaren PJ, Brumme ZL, John M, Haas DW, Martinez-Picado J, Dalmau J, López-Galíndez C, Casado C, Rauch A, Günthard HF, Bernasconi E, Vernazza P, Klimkait T, Yerly S, O'Brien SJ, Listgarten J, Pfeifer N, Lippert C, Fusi N, Kutalik Z, Allen TM, Müller V, Harrigan PR, Heckerman D, Telenti A, Fellay J.

Elife. 2013 Oct 29;2:e01123. doi: 10.7554/eLife.01123.

37.

Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics.

Pfeifer ND, Hardwick RN, Brouwer KL.

Annu Rev Pharmacol Toxicol. 2014;54:509-35. doi: 10.1146/annurev-pharmtox-011613-140021. Epub 2013 Oct 23. Review.

PMID:
24160696
38.

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.

Pfeifer ND, Bridges AS, Ferslew BC, Hardwick RN, Brouwer KL.

J Pharmacol Exp Ther. 2013 Dec;347(3):737-45. doi: 10.1124/jpet.113.208314. Epub 2013 Sep 30.

39.
40.

Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

Pfeifer ND, Harris KB, Yan GZ, Brouwer KL.

Drug Metab Dispos. 2013 Nov;41(11):1949-56. doi: 10.1124/dmd.113.052134. Epub 2013 Aug 29.

41.

Effect of Ritonavir on (99m)Technetium-Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs.

Pfeifer ND, Goss SL, Swift B, Ghibellini G, Ivanovic M, Heizer WD, Gangarosa LM, Brouwer KL.

CPT Pharmacometrics Syst Pharmacol. 2013 Jan 2;2:e20. doi: 10.1038/psp.2012.21.

42.

Distinct HIV-1 escape patterns selected by cytotoxic T cells with identical epitope specificity.

Yagita Y, Kuse N, Kuroki K, Gatanaga H, Carlson JM, Chikata T, Brumme ZL, Murakoshi H, Akahoshi T, Pfeifer N, Mallal S, John M, Ose T, Matsubara H, Kanda R, Fukunaga Y, Honda K, Kawashima Y, Ariumi Y, Oka S, Maenaka K, Takiguchi M.

J Virol. 2013 Feb;87(4):2253-63. doi: 10.1128/JVI.02572-12. Epub 2012 Dec 12.

43.

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.

Carlson JM, Brumme CJ, Martin E, Listgarten J, Brockman MA, Le AQ, Chui CK, Cotton LA, Knapp DJ, Riddler SA, Haubrich R, Nelson G, Pfeifer N, Deziel CE, Heckerman D, Apps R, Carrington M, Mallal S, Harrigan PR, John M, Brumme ZL; International HIV Adaptation Collaborative.

J Virol. 2012 Dec;86(24):13202-16. doi: 10.1128/JVI.01998-12. Epub 2012 Oct 10.

44.

Improving HIV coreceptor usage prediction in the clinic using hints from next-generation sequencing data.

Pfeifer N, Lengauer T.

Bioinformatics. 2012 Sep 15;28(18):i589-i595. doi: 10.1093/bioinformatics/bts373.

45.

Selection of the in vitro culture media influences mRNA expression of Hedgehog genes, Il-6, and important genes regarding reactive oxygen species in single murine preimplantation embryos.

Pfeifer N, Baston-Büst DM, Hirchenhain J, Friebe-Hoffmann U, Rein DT, Krüssel JS, Hess AP.

ScientificWorldJournal. 2012;2012:479315. doi: 10.1100/2012/479315. Epub 2012 Jul 31.

46.

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.

Carlson JM, Listgarten J, Pfeifer N, Tan V, Kadie C, Walker BD, Ndung'u T, Shapiro R, Frater J, Brumme ZL, Goulder PJ, Heckerman D.

J Virol. 2012 May;86(9):5230-43. doi: 10.1128/JVI.06728-11. Epub 2012 Feb 29.

47.

Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues.

Ji C, Tschantz WR, Pfeifer ND, Ullah M, Sadagopan N.

Anal Chim Acta. 2012 Mar 2;717:67-76. doi: 10.1016/j.aca.2011.12.005. Epub 2011 Dec 24.

PMID:
22304817
48.

How people interpret conditionals: shifts toward the conditional event.

Fugard AJ, Pfeifer N, Mayerhofer B, Kleiter GD.

J Exp Psychol Learn Mem Cogn. 2011 May;37(3):635-48. doi: 10.1037/a0022329.

PMID:
21534706
49.

Cortical control of thermoregulatory sympathetic activation.

Fechir M, Klega A, Buchholz HG, Pfeifer N, Balon S, Schlereth T, Geber C, Breimhorst M, Maihöfner C, Birklein F, Schreckenberger M.

Eur J Neurosci. 2010 Jun;31(11):2101-11. doi: 10.1111/j.1460-9568.2010.07243.x. Epub 2010 Jun 1.

PMID:
20529117
50.

Optimal de novo design of MRM experiments for rapid assay development in targeted proteomics.

Bertsch A, Jung S, Zerck A, Pfeifer N, Nahnsen S, Henneges C, Nordheim A, Kohlbacher O.

J Proteome Res. 2010 May 7;9(5):2696-704. doi: 10.1021/pr1001803.

PMID:
20201589

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