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Items: 1 to 50 of 66

1.

Inulin, the gut microbiome and the deeper breath of asthma patients - Novel pathways in asthma treatment.

Brehm CU, Pfefferle PI.

EBioMedicine. 2019 Aug;46:15-16. doi: 10.1016/j.ebiom.2019.07.052. Epub 2019 Jul 25. No abstract available.

2.

Author Correction: Farm-like indoor microbiota in non-farm homes protects children from asthma development.

Kirjavainen PV, Karvonen AM, Adams RI, Täubel M, Roponen M, Tuoresmäki P, Loss G, Jayaprakash B, Depner M, Ege MJ, Renz H, Pfefferle PI, Schaub B, Lauener R, Hyvärinen A, Knight R, Heederik DJJ, von Mutius E, Pekkanen J.

Nat Med. 2019 Aug;25(8):1319. doi: 10.1038/s41591-019-0546-8.

PMID:
31316162
3.

Farm-like indoor microbiota in non-farm homes protects children from asthma development.

Kirjavainen PV, Karvonen AM, Adams RI, Täubel M, Roponen M, Tuoresmäki P, Loss G, Jayaprakash B, Depner M, Ege MJ, Renz H, Pfefferle PI, Schaub B, Lauener R, Hyvärinen A, Knight R, Heederik DJJ, von Mutius E, Pekkanen J.

Nat Med. 2019 Jul;25(7):1089-1095. doi: 10.1038/s41591-019-0469-4. Epub 2019 Jun 17. Erratum in: Nat Med. 2019 Aug;25(8):1319.

PMID:
31209334
4.

Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery.

Brock J, Schmid A, Karrasch T, Pfefferle P, Schlegel J, Busse I, Hauenschild A, Schmidt B, Koukou M, Arapogianni E, Schultz A, Thomalla M, Akinci S, Kruse J, Padberg W, Schäffler A, Albrecht J.

Clin Endocrinol (Oxf). 2019 Sep;91(3):400-410. doi: 10.1111/cen.14040. Epub 2019 Jun 7.

PMID:
31102282
5.

Evidence of an anti-inflammatory toll-like receptor 9 (TLR 9) pathway in adipocytes.

Thomalla M, Schmid A, Neumann E, Pfefferle PI, Müller-Ladner U, Schäffler A, Karrasch T.

J Endocrinol. 2019 Feb 1;240(2):325-343. doi: 10.1530/JOE-18-0326.

PMID:
30508414
6.

Neurobiology of the major psychoses: a translational perspective on brain structure and function-the FOR2107 consortium.

Kircher T, Wöhr M, Nenadic I, Schwarting R, Schratt G, Alferink J, Culmsee C, Garn H, Hahn T, Müller-Myhsok B, Dempfle A, Hahmann M, Jansen A, Pfefferle P, Renz H, Rietschel M, Witt SH, Nöthen M, Krug A, Dannlowski U.

Eur Arch Psychiatry Clin Neurosci. 2018 Sep 28. doi: 10.1007/s00406-018-0943-x. [Epub ahead of print]

PMID:
30267149
7.

A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes.

Schrimpf A, Brödje D, Pfefferle P, Geyer A.

PLoS One. 2018 Aug 3;13(8):e0201735. doi: 10.1371/journal.pone.0201735. eCollection 2018.

8.

Early age exposure to moisture damage and systemic inflammation at the age of 6 years.

Karvonen AM, Tischer C, Kirjavainen PV, Roponen M, Hyvärinen A, Illi S, Mustonen K, Pfefferle PI, Renz H, Remes S, Schaub B, von Mutius E, Pekkanen J.

Indoor Air. 2018 May;28(3):450-458. doi: 10.1111/ina.12454. Epub 2018 Mar 24.

PMID:
29450910
9.

Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children.

Twardziok M, Schröder PC, Krusche J, Casaca VI, Illi S, Böck A, Loss GJ, Kabesch M, Toncheva AA, Roduit C, Depner M, Genuneit J, Renz H, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Schaub B; PASTURE Study Group:, Hyvärinen A, Karvonen AM, Kirjavainen PV, Remes S, Kaulek V, Dalphin ML, Ege M, Pfefferle PI, Doekes G.

Clin Immunol. 2017 Oct;183:285-292. doi: 10.1016/j.clim.2017.09.009. Epub 2017 Sep 13. No abstract available.

PMID:
28917722
10.

Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.

Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, Schmausser-Hechfellner E, Pekkanen J, Riedler J, Dalphin JC, von Mutius E, Lauener RP; the PASTURE study group, Hyvärinen A, Kirjavainen P, Remes S, Roponen M, Dalphin ML, Kaulek V, Ege M, Genuneit J, Illi S, Kabesch M, Schaub B, Pfefferle PI, Doekes G.

JAMA Pediatr. 2017 Jul 1;171(7):655-662. doi: 10.1001/jamapediatrics.2017.0556.

11.

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts.

Hose AJ, Depner M, Illi S, Lau S, Keil T, Wahn U, Fuchs O, Pfefferle PI, Schmaußer-Hechfellner E, Genuneit J, Lauener R, Karvonen AM, Roduit C, Dalphin JC, Riedler J, Pekkanen J, von Mutius E, Ege MJ; MAS; PASTURE study groups.

J Allergy Clin Immunol. 2017 Jun;139(6):1935-1945.e12. doi: 10.1016/j.jaci.2016.08.046. Epub 2016 Oct 19.

PMID:
27771325
12.

Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy.

Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin JC, Kaulek V, Loss GJ, Lauener R, Hirvonen MR, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J; PASTURE Study Group.

Pediatr Allergy Immunol. 2017 Feb;28(1):53-59. doi: 10.1111/pai.12658. Epub 2016 Oct 24.

PMID:
27633913
13.

IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort.

Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Kabesch M, Schaub B; PASTURE Study group.

Pediatr Allergy Immunol. 2016 Nov;27(7):687-695. doi: 10.1111/pai.12597. Epub 2016 Jul 12.

PMID:
27171815
14.

A switch in regulatory T cells through farm exposure during immune maturation in childhood.

Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, Depner M, Frei R, Genuneit J, Pfefferle PI, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Dalphin JC, Pekkanen J, Lauener R, von Mutius E, Schaub B; PASTURE study group.

Allergy. 2017 Apr;72(4):604-615. doi: 10.1111/all.13069. Epub 2016 Nov 17.

PMID:
27732759
15.

Microbes and asthma: Opportunities for intervention.

Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C.

J Allergy Clin Immunol. 2016 Mar;137(3):690-7. doi: 10.1016/j.jaci.2016.01.004. Review.

PMID:
26947981
16.

ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk.

Brick T, Schober Y, Böcking C, Pekkanen J, Genuneit J, Loss G, Dalphin JC, Riedler J, Lauener R, Nockher WA, Renz H, Vaarala O, Braun-Fahrländer C, von Mutius E, Ege MJ, Pfefferle PI; PASTURE study group.

J Allergy Clin Immunol. 2016 Jun;137(6):1699-1706.e13. doi: 10.1016/j.jaci.2015.10.042. Epub 2016 Jan 12.

PMID:
26792208
17.

Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation.

Harb H, Amarasekera M, Ashley S, Tulic MK, Pfefferle PI, Potaczek DP, Martino D, Kesper DA, Prescott SL, Renz H.

Int Arch Allergy Immunol. 2015;168(3):173-81. doi: 10.1159/000442158. Epub 2016 Jan 21.

18.

The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21.

Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE (Protection against Allergy Study in Rural Environments) Study Group.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):889-97. doi: 10.1164/rccm.201507-1493OC. Erratum in: Am J Respir Crit Care Med. 2019 Oct 1;200(7):946.

19.

Circulating Dendritic Cells, Farm Exposure and Asthma at Early Age.

Kääriö H, Nieminen JK, Karvonen AM, Huttunen K, Schröder PC, Vaarala O, von Mutius E, Pfefferle PI, Schaub B, Pekkanen J, Hirvonen MR, Roponen M.

Scand J Immunol. 2016 Jan;83(1):18-25. doi: 10.1111/sji.12389.

20.

Moisture damage in home associates with systemic inflammation in children.

Mustonen K, Karvonen AM, Kirjavainen P, Roponen M, Schaub B, Hyvärinen A, Frey U, Renz H, Pfefferle PI, Genuneit J, Vaarala O, Pekkanen J.

Indoor Air. 2016 Jun;26(3):439-47. doi: 10.1111/ina.12216. Epub 2015 May 23.

PMID:
25924948
21.

Moisture damage and asthma: a birth cohort study.

Karvonen AM, Hyvärinen A, Korppi M, Haverinen-Shaughnessy U, Renz H, Pfefferle PI, Remes S, Genuneit J, Pekkanen J.

Pediatrics. 2015 Mar;135(3):e598-606. doi: 10.1542/peds.2014-1239. Epub 2015 Feb 16.

22.

Consumption of unprocessed cow's milk protects infants from common respiratory infections.

Loss G, Depner M, Ulfman LH, van Neerven RJ, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Kaulek V, Roduit C, Weber J, Lauener R, Pfefferle PI, Pekkanen J, Vaarala O, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE study group.

J Allergy Clin Immunol. 2015 Jan;135(1):56-62. doi: 10.1016/j.jaci.2014.08.044. Epub 2014 Oct 19.

PMID:
25441645
23.

Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.

Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, Joeris T, Pfefferle PI, Hofer MJ, Steinhoff U.

Mucosal Immunol. 2015 Mar;8(2):307-15. doi: 10.1038/mi.2014.68. Epub 2014 Aug 6.

PMID:
25100292
24.

Immunoglobulin A and immunoglobulin G antibodies against β-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6.

Orivuori L, Mustonen K, Roduit C, Braun-Fahrländer C, Dalphin JC, Genuneit J, Lauener R, Pfefferle P, Riedler J, Weber J, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.

Pediatr Allergy Immunol. 2014 Jun;25(4):329-37. doi: 10.1111/pai.12246.

PMID:
24953294
25.

Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study.

Karvonen AM, Hyvärinen A, Rintala H, Korppi M, Täubel M, Doekes G, Gehring U, Renz H, Pfefferle PI, Genuneit J, Keski-Nisula L, Remes S, Lampi J, von Mutius E, Pekkanen J.

Allergy. 2014 Aug;69(8):1092-101. doi: 10.1111/all.12439. Epub 2014 Jun 13.

26.

Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation.

Böcking C, Harb H, Ege MJ, Zehethofer N, Fischer K, Krauß J, Holst O, Nüsing RM, Lindner B, von Mutius E, Renz H, Garn H, Pfefferle PI.

Int Arch Allergy Immunol. 2014;163(3):234-42. doi: 10.1159/000358523. Epub 2014 Mar 1.

PMID:
24603060
27.

The mucosal microbiome in shaping health and disease.

Pfefferle PI, Renz H.

F1000Prime Rep. 2014 Feb 3;6:11. doi: 10.12703/P6-11. eCollection 2014. Review.

28.

Microbial exposure and onset of allergic diseases - potential prevention strategies?

Pfefferle PI, Renz H.

Allergol Int. 2014 Mar;63(1):3-10. doi: 10.2332/allergolint.13-RAI-0671. Review.

29.

Increased food diversity in the first year of life is inversely associated with allergic diseases.

Roduit C, Frei R, Depner M, Schaub B, Loss G, Genuneit J, Pfefferle P, Hyvärinen A, Karvonen AM, Riedler J, Dalphin JC, Pekkanen J, von Mutius E, Braun-Fahrländer C, Lauener R; PASTURE study group.

J Allergy Clin Immunol. 2014 Apr;133(4):1056-64. doi: 10.1016/j.jaci.2013.12.1044. Epub 2014 Feb 6.

PMID:
24508301
30.

Clinical and epidemiologic phenotypes of childhood asthma.

Depner M, Fuchs O, Genuneit J, Karvonen AM, Hyvärinen A, Kaulek V, Roduit C, Weber J, Schaub B, Lauener R, Kabesch M, Pfefferle PI, Frey U, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE Study Group.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):129-38. doi: 10.1164/rccm.201307-1198OC.

PMID:
24283801
31.

Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study.

Nwaru BI, Virtanen SM, Alfthan G, Karvonen AM, Genuneit J, Lauener RP, Dalphin JC, Hyvärinen A, Pfefferle P, Riedler J, Weber J, Roduit C, Kaulek V, Braun-Fahrländer C, von Mutius E, Pekkanen J; PASTURE study group.

Allergy. 2014 Jan;69(1):87-94. doi: 10.1111/all.12307. Epub 2013 Nov 11.

PMID:
24205866
32.

Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study.

Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O; PASTURE Study Group.

Clin Exp Allergy. 2014 Jan;44(1):102-12. doi: 10.1111/cea.12199.

PMID:
24102779
33.

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood.

Lluis A, Depner M, Gaugler B, Saas P, Casaca VI, Raedler D, Michel S, Tost J, Liu J, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Schaub B; Protection Against Allergy: Study in Rural Environments Study Group.

J Allergy Clin Immunol. 2014 Feb;133(2):551-9. doi: 10.1016/j.jaci.2013.06.034. Epub 2013 Aug 28.

PMID:
23993223
34.

The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.

Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26.

35.

Microbial influence on tolerance and opportunities for intervention with prebiotics/probiotics and bacterial lysates.

Pfefferle PI, Prescott SL, Kopp M.

J Allergy Clin Immunol. 2013 Jun;131(6):1453-63; quiz 1464. doi: 10.1016/j.jaci.2013.03.020. Epub 2013 May 2. Review.

PMID:
23643095
36.

Inflammatory response and IgE sensitization at early age.

Mustonen K, Orivuori L, Keski-Nisula L, Hyvärinen A, Pfefferle PI, Riedler J, Dalphin JC, Genuneit J, Lauener R, Roduit C, Braun-Fahrländer C, Weber J, Schaub B, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.

Pediatr Allergy Immunol. 2013 Jun;24(4):395-401. doi: 10.1111/pai.12072. Epub 2013 Apr 11.

PMID:
23578387
37.

Hygiene and the cytokine jungle in Brazil.

Pfefferle PI, von Mutius E.

J Allergy Clin Immunol. 2013 May;131(5):1417-8. doi: 10.1016/j.jaci.2013.02.033. Epub 2013 Mar 29. No abstract available.

PMID:
23545273
38.

Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice.

Hagner S, Harb H, Zhao M, Stein K, Holst O, Ege MJ, Mayer M, Matthes J, Bauer J, von Mutius E, Renz H, Heine H, Pfefferle PI, Garn H.

Allergy. 2013 Mar;68(3):322-9. doi: 10.1111/all.12094. Epub 2013 Feb 1.

PMID:
23369007
39.

Atopic sensitization in the first year of life.

Depner M, Ege MJ, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Kaulek V, Krauss-Etschmann S, Riedler J, Braun-Fahrländer C, Roduit C, Lauener R, Pfefferle PI, Weber J, von Mutius E; PASTURE Study Group.

J Allergy Clin Immunol. 2013 Mar;131(3):781-8. doi: 10.1016/j.jaci.2012.11.048. Epub 2013 Jan 16.

PMID:
23333112
40.

Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas.

Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin JC, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J; PASTURE Study Group.

Clin Exp Allergy. 2012 Aug;42(8):1246-56. doi: 10.1111/j.1365-2222.2012.04002.x.

PMID:
22805472
41.

High indoor microbial levels are associated with reduced Th1 cytokine secretion capacity in infancy.

Lappalainen MH, Hyvärinen A, Hirvonen MR, Rintala H, Roivainen J, Renz H, Pfefferle PI, Nevalainen A, Roponen M, Pekkanen J.

Int Arch Allergy Immunol. 2012;159(2):194-203. doi: 10.1159/000335596. Epub 2012 Jun 1.

42.

Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children.

Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin JC, Buechele G, Lauener R, Braun-Fahrländer C, von Mutius E, Pekkanen J; PASTURE Study Group.

Pediatr Allergy Immunol. 2012 Sep;23(6):522-8. doi: 10.1111/j.1399-3038.2012.01306.x. Epub 2012 May 3.

PMID:
22554299
43.

[Prevalence and socio-economic relevance of allergies in Germany].

Böcking C, Renz H, Pfefferle PI.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Mar;55(3):303-7. doi: 10.1007/s00103-011-1427-6. Review. German.

PMID:
22373842
44.

DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma.

Brand S, Kesper DA, Teich R, Kilic-Niebergall E, Pinkenburg O, Bothur E, Lohoff M, Garn H, Pfefferle PI, Renz H.

J Allergy Clin Immunol. 2012 Jun;129(6):1602-10.e6. doi: 10.1016/j.jaci.2011.12.963. Epub 2012 Jan 24.

PMID:
22277202
45.

Maternal cytokine profiles during pregnancy - predictors for later allergy or just reading the tea leaves?

Pfefferle P, Böcking C, Renz H.

Allergy. 2011 Aug;66(8):987-8. doi: 10.1111/j.1398-9995.2011.02665.x. No abstract available.

PMID:
21726234
46.

Allergic diseases, gene-environment interactions.

Renz H, Conrad M, Brand S, Teich R, Garn H, Pfefferle PI.

Allergy. 2011 Jul;66 Suppl 95:10-2. doi: 10.1111/j.1398-9995.2011.02622.x.

PMID:
21668842
47.

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes.

Brand S, Teich R, Dicke T, Harb H, Yildirim AÖ, Tost J, Schneider-Stock R, Waterland RA, Bauer UM, von Mutius E, Garn H, Pfefferle PI, Renz H.

J Allergy Clin Immunol. 2011 Sep;128(3):618-25.e1-7. doi: 10.1016/j.jaci.2011.04.035. Epub 2011 Jun 15.

PMID:
21680015
48.

Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples.

Bomert M, Köllisch G, Roponen M, Lauener R, Renz H, Pfefferle PI, Al-Fakhri N.

Clin Chem Lab Med. 2011 Oct;49(10):1691-3. doi: 10.1515/CCLM.2011.631. Epub 2011 Jun 10.

PMID:
21663461
49.

Maternal signals for progeny prevention against allergy and asthma.

Marsh LM, Pfefferle PI, Pinkenburg O, Renz H.

Cell Mol Life Sci. 2011 Jun;68(11):1851-62. doi: 10.1007/s00018-011-0644-3. Epub 2011 Mar 3. Review.

PMID:
21369709
50.

Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources.

Böcking C, Nockher WA, Schreiner M, Renz H, Pfefferle PI.

Clin Chem Lab Med. 2010 Dec;48(12):1757-63. doi: 10.1515/CCLM.2010.350. Epub 2010 Oct 25.

PMID:
20969511

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