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Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.

Gomez RC, Wawro P, Lis P, Alessi DR, Pfeffer SR.

J Cell Biol. 2019 Oct 17. pii: jcb.201902184. doi: 10.1083/jcb.201902184. [Epub ahead of print]


NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes.

Pfeffer SR.

J Biol Chem. 2019 Feb 1;294(5):1706-1709. doi: 10.1074/jbc.TM118.004165. Review.


Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR.

EMBO J. 2019 Jan 15;38(2). pii: e101237. doi: 10.15252/embj.2018101237. No abstract available.


Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs.

Lu A, Wawro P, Morgens DW, Portela F, Bassik MC, Pfeffer SR.

Elife. 2018 Dec 17;7. pii: e41460. doi: 10.7554/eLife.41460.


LRRK2 and Rab GTPases.

Pfeffer SR.

Biochem Soc Trans. 2018 Dec 17;46(6):1707-1712. doi: 10.1042/BST20180470. Epub 2018 Nov 22. Review.


A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR.

Elife. 2018 Nov 6;7. pii: e40202. doi: 10.7554/eLife.40202.


Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR.

EMBO J. 2018 Jan 4;37(1):1-18. doi: 10.15252/embj.201798099. Epub 2017 Dec 6. Erratum in: EMBO J. 2019 Jan 15;38(2):.


Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M.

Elife. 2017 Nov 10;6. pii: e31012. doi: 10.7554/eLife.31012.


Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons.

Pfeffer SR, Fan M, Du Z, Yang CH, Pfeffer LM.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):739-745. doi: 10.1016/j.bbrc.2017.06.111. Epub 2017 Jun 20.


Rab GTPases: master regulators that establish the secretory and endocytic pathways.

Pfeffer SR.

Mol Biol Cell. 2017 Mar 15;28(6):712-715. doi: 10.1091/mbc.E16-10-0737. Review.


Quantitative Measurement of Cholesterol in Cell Populations Using Flow Cytometry and Fluorescent Perfringolysin O.

Li J, Lee PL, Pfeffer SR.

Methods Mol Biol. 2017;1583:85-95. doi: 10.1007/978-1-4939-6875-6_8.


Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export.

Li J, Pfeffer SR.

Elife. 2016 Sep 24;5. pii: e21635. doi: 10.7554/eLife.21635.


MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis.

Yang CH, Wang Y, Sims M, Cai C, He P, Yue J, Cheng J, Boop FA, Pfeffer SR, Pfeffer LM.

Oncotarget. 2016 Dec 20;7(51):84017-84029. doi: 10.18632/oncotarget.12401.


Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.

Li X, Saha P, Li J, Blobel G, Pfeffer SR.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10079-84. doi: 10.1073/pnas.1611956113. Epub 2016 Aug 22.


Clues to NPC1-mediated cholesterol export from lysosomes.

Pfeffer SR.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):7941-3. doi: 10.1073/pnas.1608530113. Epub 2016 Jul 7. No abstract available.


Lipoprotein secretion: It takes two to TANGO.

Pfeffer SR.

J Cell Biol. 2016 May 9;213(3):297-9. doi: 10.1083/jcb.201604084. Epub 2016 May 2.


Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis.

Johnson TA, Pfeffer SR.

Mol Biol Cell. 2016 Jun 1;27(11):1845-52. doi: 10.1091/mbc.E16-03-0154. Epub 2016 Apr 13.


Transport Vesicle Tethering at the Trans Golgi Network: Coiled Coil Proteins in Action.

Cheung PY, Pfeffer SR.

Front Cell Dev Biol. 2016 Mar 15;4:18. doi: 10.3389/fcell.2016.00018. eCollection 2016. Review.


Detection of Exosomal miRNAs in the Plasma of Melanoma Patients.

Pfeffer SR, Grossmann KF, Cassidy PB, Yang CH, Fan M, Kopelovich L, Leachman SA, Pfeffer LM.

J Clin Med. 2015 Dec 17;4(12):2012-27. doi: 10.3390/jcm4121957.


Protein flexibility is required for vesicle tethering at the Golgi.

Cheung PY, Limouse C, Mabuchi H, Pfeffer SR.

Elife. 2015 Dec 14;4. pii: e12790. doi: 10.7554/eLife.12790.


The Type I IFN-Induced miRNA, miR-21.

Yang CH, Li K, Pfeffer SR, Pfeffer LM.

Pharmaceuticals (Basel). 2015 Nov 25;8(4):836-47. doi: 10.3390/ph8040836. Review.


Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells.

Li J, Deffieu MS, Lee PL, Saha P, Pfeffer SR.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14876-81. doi: 10.1073/pnas.1520490112. Epub 2015 Nov 17.


The Role of miR-21 in Cancer.

Pfeffer SR, Yang CH, Pfeffer LM.

Drug Dev Res. 2015 Sep;76(6):270-7. doi: 10.1002/ddr.21257. Epub 2015 Jun 16. Review.


Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering.

Lee PL, Ohlson MB, Pfeffer SR.

Elife. 2015 Mar 30;4. doi: 10.7554/eLife.06029.


Measuring Rab GTPase-activating protein (GAP) activity in live cells and extracts.

Nottingham RM, Pfeffer SR.

Methods Mol Biol. 2015;1298:61-71. doi: 10.1007/978-1-4939-2569-8_5.


Molecular and cellular characterization of GCC185: a tethering protein of the trans-Golgi network.

Cheung PY, Pfeffer SR.

Methods Mol Biol. 2015;1270:179-90. doi: 10.1007/978-1-4939-2309-0_14.


The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis.

Yang CH, Pfeffer SR, Sims M, Yue J, Wang Y, Linga VG, Paulus E, Davidoff AM, Pfeffer LM.

J Biol Chem. 2015 Mar 6;290(10):6037-46. doi: 10.1074/jbc.M114.632125. Epub 2015 Jan 14.


Identification of imidazoquinoline derivatives as potent antiglioma agents.

Patil SA, Pfeffer SR, Seibel WL, Pfeffer LM, Miller DD.

Med Chem. 2015;11(4):400-6.


An interferon response gene signature is associated with the therapeutic response of hepatitis C patients.

Pfeffer LM, Li K, Fleckenstein JF, Marion TN, Diament J, Yang CH, Pfeffer SR, Fan M, Handorf E, Handorf CR.

PLoS One. 2014 Aug 11;9(8):e104202. doi: 10.1371/journal.pone.0104202. eCollection 2014.


MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3).

Yang CH, Yue J, Pfeffer SR, Fan M, Paulus E, Hosni-Ahmed A, Sims M, Qayyum S, Davidoff AM, Handorf CR, Pfeffer LM.

J Biol Chem. 2014 Sep 5;289(36):25079-87. doi: 10.1074/jbc.M114.593863. Epub 2014 Jul 24.


A CULLINary ride across the secretory pathway: more than just secretion.

Lu A, Pfeffer SR.

Trends Cell Biol. 2014 Jul;24(7):389-99. doi: 10.1016/j.tcb.2014.02.001. Epub 2014 Mar 11. Review.


Mutant enzymes challenge all assumptions.

Nottingham RM, Pfeffer SR.

Elife. 2014 Feb 11;3:e02171. doi: 10.7554/eLife.02171.


A prize for membrane magic.

Pfeffer SR.

Cell. 2013 Dec 5;155(6):1203-6. doi: 10.1016/j.cell.2013.11.014.


Isolation of circulating microRNAs from microvesicles found in human plasma.

Quackenbush JF, Cassidy PB, Pfeffer LM, Boucher KM, Hawkes JE, Pfeffer SR, Kopelovich L, Leachman SA.

Methods Mol Biol. 2014;1102:641-53. doi: 10.1007/978-1-62703-727-3_34.


Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression.

Lu A, Pfeffer SR.

J Cell Biol. 2013 Oct 28;203(2):233-50. doi: 10.1083/jcb.201305158. Epub 2013 Oct 21.


Hopping rim to rim through the Golgi.

Pfeffer SR.

Elife. 2013 Jun 11;2:e00903. doi: 10.7554/eLife.00903.


Rab GTPase regulation of membrane identity.

Pfeffer SR.

Curr Opin Cell Biol. 2013 Aug;25(4):414-9. doi: 10.1016/ Epub 2013 Apr 29. Review.


A nexus for receptor recycling.

Pfeffer SR.

Nat Cell Biol. 2013 May;15(5):446-8. doi: 10.1038/ncb2751.


Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention.

Fan M, Pfeffer SR, Lynch HT, Cassidy P, Leachman S, Pfeffer LM, Kopelovich L.

Oncotarget. 2013 Jan;4(1):128-41.


Rab GTPase localization and Rab cascades in Golgi transport.

Pfeffer SR.

Biochem Soc Trans. 2012 Dec 1;40(6):1373-7. doi: 10.1042/BST20120168. Review.


Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.

Pusapati GV, Luchetti G, Pfeffer SR.

J Biol Chem. 2012 Dec 7;287(50):42129-37. doi: 10.1074/jbc.M112.414565. Epub 2012 Oct 22.


TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling.

Goueli BS, Powell MB, Finger EC, Pfeffer SR.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15787-92. Epub 2012 Sep 10.


Cargo carriers from the Golgi to the cell surface.

Pfeffer SR.

EMBO J. 2012 Oct 17;31(20):3954-5. doi: 10.1038/emboj.2012.249. Epub 2012 Aug 31.


The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.

van Rahden VA, Brand K, Najm J, Heeren J, Pfeffer SR, Braulke T, Kutsche K.

Hum Mol Genet. 2012 Dec 1;21(23):5019-38. doi: 10.1093/hmg/dds343. Epub 2012 Aug 19.


RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.

Nottingham RM, Pusapati GV, Ganley IG, Barr FA, Lambright DG, Pfeffer SR.

J Biol Chem. 2012 Jun 29;287(27):22740-8. doi: 10.1074/jbc.M112.362558. Epub 2012 May 25.


Ebola virus entry requires the host-programmed recognition of an intracellular receptor.

Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K.

EMBO J. 2012 Apr 18;31(8):1947-60. doi: 10.1038/emboj.2012.53. Epub 2012 Mar 6.


High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

Janjetovic Z, Brozyna AA, Tuckey RC, Kim TK, Nguyen MN, Jozwicki W, Pfeffer SR, Pfeffer LM, Slominski AT.

Br J Cancer. 2011 Dec 6;105(12):1874-84. doi: 10.1038/bjc.2011.458. Epub 2011 Nov 17.


Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding.

Deffieu MS, Pfeffer SR.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18932-6. doi: 10.1073/pnas.1110439108. Epub 2011 Nov 7.


MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells.

Yang CH, Yue J, Pfeffer SR, Handorf CR, Pfeffer LM.

J Biol Chem. 2011 Nov 11;286(45):39172-8. doi: 10.1074/jbc.M111.285098. Epub 2011 Sep 22.

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