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TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation.

Jha KA, Pentecost M, Lenin R, Gentry J, Klaic L, Del Mar N, Reiner A, Yang CH, Pfeffer LM, Sohl N, Gangaraju R.

Stem Cell Res Ther. 2019 Nov 5;10(1):318. doi: 10.1186/s13287-019-1436-1.


Correction: Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression.

Wang W, Chapman NM, Zhang B, Li M, Fan M, Laribee RN, Zaidi MR, Pfeffer LM, Chi H, Wu ZH.

Cancer Res. 2019 Nov 1;79(21):5682. doi: 10.1158/0008-5472.CAN-19-2862. No abstract available.


Ovarian primary and metastatic tumors suppressed by survivin knockout or a novel survivin inhibitor.

Zhao G, Wang Q, Wu Z, Tian X, Yan H, Wang B, Dong P, Watari H, Pfeffer LM, Guo Y, Li W, Yue J.

Mol Cancer Ther. 2019 Sep 12. pii: molcanther.0118.2019. doi: 10.1158/1535-7163.MCT-19-0118. [Epub ahead of print]


MicroRNA-1 suppresses glioblastoma in preclinical models by targeting fibronectin.

Yang CH, Wang Y, Sims M, Cai C, Pfeffer LM.

Cancer Lett. 2019 Nov 28;465:59-67. doi: 10.1016/j.canlet.2019.08.021. Epub 2019 Sep 3.


Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer.

Ponnusamy S, He Y, Hwang DJ, Thiyagarajan T, Houtman R, Bocharova V, Sumpter BG, Fernandez E, Johnson D, Du Z, Pfeffer LM, Getzenberg RH, McEwan IJ, Miller DD, Narayanan R.

Clin Cancer Res. 2019 Nov 15;25(22):6764-6780. doi: 10.1158/1078-0432.CCR-19-1458. Epub 2019 Sep 3.


APELA Expression in Glioma, and Its Association with Patient Survival and Tumor Grade.

Ganguly D, Cai C, Sims MM, Yang CH, Thomas M, Cheng J, Saad AG, Pfeffer LM.

Pharmaceuticals (Basel). 2019 Mar 26;12(1). pii: E45. doi: 10.3390/ph12010045.


Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression.

Wang W, Chapman NM, Zhang B, Li M, Fan M, Laribee RN, Zaidi MR, Pfeffer LM, Chi H, Wu ZH.

Cancer Res. 2019 Jun 1;79(11):2909-2922. doi: 10.1158/0008-5472.CAN-18-3134. Epub 2019 Feb 8. Erratum in: Cancer Res. 2019 Nov 1;79(21):5682.


Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells.

Ji L, Zhao G, Zhang P, Huo W, Dong P, Watari H, Jia L, Pfeffer LM, Yue J, Zheng J.

J Cancer. 2018 Nov 11;9(24):4578-4585. doi: 10.7150/jca.28040. eCollection 2018.


The STAT3 and hypoxia pathways converge on Vasorin to promote stemness and glioblastoma tumorigenesis through Notch1 stabilization.

Fan M, Pfeffer LM.

Stem Cell Investig. 2018 Oct 22;5:35. doi: 10.21037/sci.2018.10.01. eCollection 2018. No abstract available.


BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.

Sethuraman A, Brown M, Krutilina R, Wu ZH, Seagroves TN, Pfeffer LM, Fan M.

Breast Cancer Res. 2018 Oct 1;20(1):117. doi: 10.1186/s13058-018-1046-3.


miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway.

Wang B, Li X, Zhao G, Yan H, Dong P, Watari H, Sims M, Li W, Pfeffer LM, Guo Y, Yue J.

J Exp Clin Cancer Res. 2018 Sep 21;37(1):235. doi: 10.1186/s13046-018-0906-0.


Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells.

Ganguly D, Sims M, Cai C, Fan M, Pfeffer LM.

Stem Cells. 2018 Dec;36(12):1804-1815. doi: 10.1002/stem.2909. Epub 2018 Nov 12.


The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.

Ganguly D, Fan M, Yang CH, Zbytek B, Finkelstein D, Roussel MF, Pfeffer LM.

Oncotarget. 2018 Apr 24;9(31):22095-22112. doi: 10.18632/oncotarget.25188. eCollection 2018 Apr 24.


Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.

Zhang T, Zhao G, Yang C, Dong P, Watari H, Zeng L, Pfeffer LM, Yue J.

Oncol Lett. 2018 Apr;15(4):4432-4438. doi: 10.3892/ol.2018.7834. Epub 2018 Jan 22.


MicroRNA203a suppresses glioma tumorigenesis through an ATM-dependent interferon response pathway.

Yang CH, Wang Y, Sims M, Cai C, He P, Häcker H, Yue J, Cheng J, Boop FA, Pfeffer LM.

Oncotarget. 2017 Dec 6;8(68):112980-112991. doi: 10.18632/oncotarget.22945. eCollection 2017 Dec 22.


The effects of type I interferon on glioblastoma cancer stem cells.

Du Z, Cai C, Sims M, Boop FA, Davidoff AM, Pfeffer LM.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):343-348. doi: 10.1016/j.bbrc.2017.07.098. Epub 2017 Jul 18.


Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons.

Pfeffer SR, Fan M, Du Z, Yang CH, Pfeffer LM.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):739-745. doi: 10.1016/j.bbrc.2017.06.111. Epub 2017 Jun 20.


Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.

Ponnusamy S, Sullivan RD, You D, Zafar N, He Yang C, Thiyagarajan T, Johnson DL, Barrett ML, Koehler NJ, Star M, Stephenson EJ, Bridges D, Cormier SA, Pfeffer LM, Narayanan R.

Hum Mol Genet. 2017 Jul 1;26(13):2526-2540. doi: 10.1093/hmg/ddx150.


Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.

Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum E, Pfeffer LM, Yue J.

J Cancer. 2017 Jan 1;8(1):57-64. doi: 10.7150/jca.16723. eCollection 2017.


KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells.

Wang B, Shen A, Ouyang X, Zhao G, Du Z, Huo W, Zhang T, Wang Y, Yang C, Dong P, Watari H, Pfeffer LM, Yue J.

Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492. doi: 10.1016/j.bbrc.2017.01.062. Epub 2017 Jan 18.


Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models.

Skobowiat C, Oak AS, Kim TK, Yang CH, Pfeffer LM, Tuckey RC, Slominski AT.

Oncotarget. 2017 Feb 7;8(6):9823-9834. doi: 10.18632/oncotarget.14193.


MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis.

Yang CH, Wang Y, Sims M, Cai C, He P, Yue J, Cheng J, Boop FA, Pfeffer SR, Pfeffer LM.

Oncotarget. 2016 Dec 20;7(51):84017-84029. doi: 10.18632/oncotarget.12401.


SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway.

Sethuraman A, Brown M, Seagroves TN, Wu ZH, Pfeffer LM, Fan M.

Breast Cancer Res. 2016 Aug 5;18(1):81. doi: 10.1186/s13058-016-0738-9.


Bortezomib sensitizes human glioblastoma cells to induction of apoptosis by type I interferons through NOXA expression and Mcl-1 cleavage.

Wang R, Davidoff AM, Pfeffer LM.

Biochem Biophys Res Commun. 2016 Sep 9;478(1):128-134. doi: 10.1016/j.bbrc.2016.07.080. Epub 2016 Jul 20.


miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer.

Zhao G, Guo Y, Chen Z, Wang Y, Yang C, Dudas A, Du Z, Liu W, Zou Y, Szabo E, Lee SC, Sims M, Gu W, Tillmanns T, Pfeffer LM, Tigyi G, Yue J.

J Cancer Sci Ther. 2015;7(2):34-43.


Detection of Exosomal miRNAs in the Plasma of Melanoma Patients.

Pfeffer SR, Grossmann KF, Cassidy PB, Yang CH, Fan M, Kopelovich L, Leachman SA, Pfeffer LM.

J Clin Med. 2015 Dec 17;4(12):2012-27. doi: 10.3390/jcm4121957.


Correction: Molecular Heterogeneity in a Patient-Derived Glioblastoma Xenoline is Regulated by Different Cancer Stem Cell Populations.

Garner JM, Ellison DW, Finkelstein D, Ganguly D, Du Z, Sims M, Yang CH, Interiano RB, Davidoff AM, Pfeffer LM.

PLoS One. 2015 Dec 10;10(12):e0145052. doi: 10.1371/journal.pone.0145052. eCollection 2015.


The Type I IFN-Induced miRNA, miR-21.

Yang CH, Li K, Pfeffer SR, Pfeffer LM.

Pharmaceuticals (Basel). 2015 Nov 25;8(4):836-47. doi: 10.3390/ph8040836. Review.


MicroRNA regulation of F-box proteins and its role in cancer.

Wu ZH, Pfeffer LM.

Semin Cancer Biol. 2016 Feb;36:80-7. doi: 10.1016/j.semcancer.2015.09.016. Epub 2015 Oct 1. Review.


Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents.

Banerjee S, Wang J, Pfeffer S, Ma D, Pfeffer LM, Patil SA, Li W, Miller DD.

Molecules. 2015 Sep 17;20(9):17152-65. doi: 10.3390/molecules200917152.


The Role of miR-21 in Cancer.

Pfeffer SR, Yang CH, Pfeffer LM.

Drug Dev Res. 2015 Sep;76(6):270-7. doi: 10.1002/ddr.21257. Epub 2015 Jun 16. Review.


KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells.

Wang Y, Yang C, Gu Q, Sims M, Gu W, Pfeffer LM, Yue J.

PLoS One. 2015 Jun 15;10(6):e0130341. doi: 10.1371/journal.pone.0130341. eCollection 2015.


Lentiviral Vector Mediated Claudin1 Silencing Inhibits Epithelial to Mesenchymal Transition in Breast Cancer Cells.

Zhao X, Zou Y, Gu Q, Zhao G, Gray H, Pfeffer LM, Yue J.

Viruses. 2015 Jun 10;7(6):2965-79. doi: 10.3390/v7062755.


Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer.

Niu J, Xue A, Chi Y, Xue J, Wang W, Zhao Z, Fan M, Yang CH, Shao ZM, Pfeffer LM, Wu J, Wu ZH.

Oncogene. 2016 Mar 10;35(10):1302-1313. doi: 10.1038/onc.2015.189. Epub 2015 Jun 1.


Molecular heterogeneity in a patient-derived glioblastoma xenoline is regulated by different cancer stem cell populations.

Garner JM, Ellison DW, Finkelstein D, Ganguly D, Du Z, Sims M, Yang CH, Interiano RB, Davidoff AM, Pfeffer LM.

PLoS One. 2015 May 8;10(5):e0125838. doi: 10.1371/journal.pone.0125838. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0145052.


MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity.

Xue J, Chi Y, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer LM, Shao ZM, Wu ZH, Wu J.

Oncogene. 2016 Jan 28;35(4):448-58. doi: 10.1038/onc.2015.96. Epub 2015 Apr 13.


Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion.

Guo Y, Tian P, Yang C, Liang Z, Li M, Sims M, Lu L, Zhang Z, Li H, Pfeffer LM, Yue J.

Pharm Res. 2015 Mar;32(3):769-78.


The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis.

Yang CH, Pfeffer SR, Sims M, Yue J, Wang Y, Linga VG, Paulus E, Davidoff AM, Pfeffer LM.

J Biol Chem. 2015 Mar 6;290(10):6037-46. doi: 10.1074/jbc.M114.632125. Epub 2015 Jan 14.


EDL-360: A Potential Novel Antiglioma Agent.

Hosni-Ahmed A, Sims M, Jones TS, Patil R, Patil S, Abdelsamed H, Yates CR, Miller DD, Pfeffer LM.

J Cancer Sci Ther. 2014 Sep 25;6(9):370-377.


Identification of imidazoquinoline derivatives as potent antiglioma agents.

Patil SA, Pfeffer SR, Seibel WL, Pfeffer LM, Miller DD.

Med Chem. 2015;11(4):400-6.


An interferon response gene signature is associated with the therapeutic response of hepatitis C patients.

Pfeffer LM, Li K, Fleckenstein JF, Marion TN, Diament J, Yang CH, Pfeffer SR, Fan M, Handorf E, Handorf CR.

PLoS One. 2014 Aug 11;9(8):e104202. doi: 10.1371/journal.pone.0104202. eCollection 2014.


MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers.

Krutilina R, Sun W, Sethuraman A, Brown M, Seagroves TN, Pfeffer LM, Ignatova T, Fan M.

Breast Cancer Res. 2014 Jul 28;16(4):R78. doi: 10.1186/bcr3693.


MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3).

Yang CH, Yue J, Pfeffer SR, Fan M, Paulus E, Hosni-Ahmed A, Sims M, Qayyum S, Davidoff AM, Handorf CR, Pfeffer LM.

J Biol Chem. 2014 Sep 5;289(36):25079-87. doi: 10.1074/jbc.M114.593863. Epub 2014 Jul 24.


Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer.

Fan M, Sethuraman A, Brown M, Sun W, Pfeffer LM.

Breast Cancer Res Treat. 2014 Aug;146(3):487-502. doi: 10.1007/s10549-014-3040-5. Epub 2014 Jul 8.


Isolation of circulating microRNAs from microvesicles found in human plasma.

Quackenbush JF, Cassidy PB, Pfeffer LM, Boucher KM, Hawkes JE, Pfeffer SR, Kopelovich L, Leachman SA.

Methods Mol Biol. 2014;1102:641-53. doi: 10.1007/978-1-62703-727-3_34.


Chromenes: potential new chemotherapeutic agents for cancer.

Patil SA, Patil R, Pfeffer LM, Miller DD.

Future Med Chem. 2013 Sep;5(14):1647-60. doi: 10.4155/fmc.13.126. Review.


The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo.

Yang CH, Yue J, Sims M, Pfeffer LM.

PLoS One. 2013 Aug 7;8(8):e71130. doi: 10.1371/journal.pone.0071130. Print 2013.


Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells.

Fan M, Krutilina R, Sun J, Sethuraman A, Yang CH, Wu ZH, Yue J, Pfeffer LM.

J Biol Chem. 2013 Sep 20;288(38):27480-93. doi: 10.1074/jbc.M113.491803. Epub 2013 Aug 6.


Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway.

Garner JM, Fan M, Yang CH, Du Z, Sims M, Davidoff AM, Pfeffer LM.

J Biol Chem. 2013 Sep 6;288(36):26167-76. doi: 10.1074/jbc.M113.477950. Epub 2013 Jul 31.


Novel approaches to glioma drug design and drug screening.

Patil SA, Hosni-Ahmed A, Jones TS, Patil R, Pfeffer LM, Miller DD.

Expert Opin Drug Discov. 2013 Sep;8(9):1135-51. doi: 10.1517/17460441.2013.807248. Epub 2013 Jun 6. Review.


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