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Items: 11


Immune-Checkpoint Blockade Opposes CD8+ T-Cell Suppression in Human and Murine Cancer.

Pfannenstiel LW, Diaz-Montero M, Tian YF, Scharpf J, Ko J, Gastman B.

Cancer Immunol Res. 2019 Feb 6. pii: canimm.0054.2018. doi: 10.1158/2326-6066.CIR-18-0054. [Epub ahead of print]


Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.

Pfannenstiel LW, McNeilly C, Xiang C, Kang K, Diaz-Montero CM, Yu JS, Gastman BR.

Oncoimmunology. 2018 Oct 11;8(1):e1507669. doi: 10.1080/2162402X.2018.1507669. eCollection 2019.


Tumor-derived exosomes induce CD8+ T cell suppressors.

Maybruck BT, Pfannenstiel LW, Diaz-Montero M, Gastman BR.

J Immunother Cancer. 2017 Aug 15;5(1):65. doi: 10.1186/s40425-017-0269-7.


Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence.

Demelash A, Pfannenstiel LW, Liu L, Gastman BR.

Oncotarget. 2017 Apr 25;8(17):28154-28168. doi: 10.18632/oncotarget.15962.


Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.

Demelash A, Pfannenstiel LW, Tannenbaum CS, Li X, Kalady MF, DeVecchio J, Gastman BR.

J Biol Chem. 2015 Sep 4;290(36):21962-75. doi: 10.1074/jbc.M115.663898. Epub 2015 Jul 23.


Mcl-1 and tumor cell persistence.

Pfannenstiel LW, Gastman BR.

Oncotarget. 2015 Jan 1;6(1):5-6. No abstract available.


Raiding the pharmacy: genomic screening identifies known chemotherapies as negative regulators of MCL1.

Pfannenstiel LW, Demelash A, Gastman BR.

Genome Med. 2012 Jun 27;4(6):53. doi: 10.1186/gm352.


Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance.

Bolesta E, Pfannenstiel LW, Demelash A, Lesniewski ML, Tobin M, Schlanger SE, Nallar SC, Papadimitriou JC, Kalvakolanu DV, Gastman BR.

Mol Cell Biol. 2012 May;32(10):1879-92. doi: 10.1128/MCB.06214-11. Epub 2012 Mar 26.


Interleukin-7 inhibits tumor-induced CD27-CD28- suppressor T cells: implications for cancer immunotherapy.

Zhang Y, Pfannenstiel LW, Bolesta E, Montes CL, Zhang X, Chapoval AI, Gartenhaus RB, Strome SE, Gastman BR.

Clin Cancer Res. 2011 Aug 1;17(15):4975-86. doi: 10.1158/1078-0432.CCR-10-3328. Epub 2011 Jun 28.


Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice.

Pfannenstiel LW, Lam SS, Emens LA, Jaffee EM, Armstrong TD.

Cell Immunol. 2010;263(1):79-87. doi: 10.1016/j.cellimm.2010.03.001. Epub 2010 Mar 6.


Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response.

Ercolini AM, Ladle BH, Manning EA, Pfannenstiel LW, Armstrong TD, Machiels JP, Bieler JG, Emens LA, Reilly RT, Jaffee EM.

J Exp Med. 2005 May 16;201(10):1591-602. Epub 2005 May 9.

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