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Items: 1 to 50 of 97

1.

Treatment of cervical intraepithelial neoplasia levels 2 and 3 with adapalene, a retinoid-related molecule.

DiSilvestro PA, DiSilvestro JM, Lernhardt W, Pfahl M, Mannel RS.

J Low Genit Tract Dis. 2001 Jan;5(1):33-7.

PMID:
17043560
2.

Retinoid related molecules: new promises against lung and breast cancer.

Pfahl M.

Expert Opin Investig Drugs. 1998 Apr;7(4):601-6.

PMID:
15991996
4.

Retinoid targets for apoptosis induction.

Pfahl M, Piedrafita FJ.

Oncogene. 2003 Dec 8;22(56):9058-62. Review.

PMID:
14663484
5.

Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.

Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ.

Mol Cell Biol. 2003 Feb;23(3):1061-74.

6.
7.

A selective retinoid with high activity against an androgen-resistant prostate cancer cell type.

Lu XP, Fanjul A, Picard N, Shroot B, Pfahl M.

Int J Cancer. 1999 Jan 18;80(2):272-8.

8.
9.

Apoptosis induction and potent antiestrogen receptor-negative breast cancer activity in vivo by a retinoid antagonist.

Fanjul AN, Piedrafita FJ, Al-Shamma H, Pfahl M.

Cancer Res. 1998 Oct 15;58(20):4607-10.

11.

Selective activation of an apoptotic retinoid precursor in macrophage cell lines.

Yarovoi SV, Lu XP, Picard N, Rungta D, Rideout D, Pfahl M.

J Biol Chem. 1998 Aug 14;273(33):20852-9.

12.
13.

Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo.

Lu XP, Fanjul A, Picard N, Pfahl M, Rungta D, Nared-Hood K, Carter B, Piedrafita J, Tang S, Fabbrizio E, Pfahl M.

Nat Med. 1997 Jun;3(6):686-90.

PMID:
9176499
14.

4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptors.

Fanjul AN, Delia D, Pierotti MA, Rideout D, Yu JQ, Pfahl M.

J Biol Chem. 1996 Sep 13;271(37):22441-6. Erratum in: J Biol Chem 1996 Dec 27;271(52):33705. Qiu J [corrected to Yu JQ].

15.

The receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal.

La Vista-Picard N, Hobbs PD, Pfahl M, Dawson MI, Pfahl M.

Mol Cell Biol. 1996 Aug;16(8):4137-46.

16.

An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element.

Piedrafita FJ, Molander RB, Vansant G, Orlova EA, Pfahl M, Reynolds WF.

J Biol Chem. 1996 Jun 14;271(24):14412-20.

17.

A novel class of retinoid antagonists and their mechanism of action.

Lee MO, Dawson MI, Picard N, Hobbs PD, Pfahl M.

J Biol Chem. 1996 May 17;271(20):11897-903.

18.
19.

Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.

Kizaki M, Dawson MI, Heyman R, Elster E, Morosetti R, Pakkala S, Chen DL, Ueno H, Chao W, Morikawa M, Ikeda Y, Heber D, Pfahl M, Koeffler HP.

Blood. 1996 Mar 1;87(5):1977-84.

PMID:
8634447
20.

Retinoid actions and implications for prevention and therapy of oral cancer.

Girod SC, Pfahl M.

Int J Oral Maxillofac Surg. 1996 Feb;25(1):69-73. Review.

PMID:
8833305
21.

Regulation of metabolism by retinoic acid and its nuclear receptors.

Pfahl M, Chytil F.

Annu Rev Nutr. 1996;16:257-83. Review.

PMID:
8839928
22.

TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals.

Ortiz MA, Piedrafita FJ, Pfahl M, Maki R.

Mol Endocrinol. 1995 Dec;9(12):1679-91.

PMID:
8614404
24.
25.

Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.

Dawson MI, Jong L, Hobbs PD, Cameron JF, Chao WR, Pfahl M, Lee MO, Shroot B, Pfahl M.

J Med Chem. 1995 Aug 18;38(17):3368-83.

PMID:
7650690
26.

The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways.

Hirose T, Apfel R, Pfahl M, Jetten AM.

Biochem Biophys Res Commun. 1995 Jun 6;211(1):83-91.

PMID:
7779113
27.

Thyroid hormone receptor homodimers can function as ligand-sensitive repressors.

Piedrafita FJ, Bendik I, Ortiz MA, Pfahl M.

Mol Endocrinol. 1995 May;9(5):563-78.

PMID:
7565804
30.

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.

Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Lu XP, Pfahl M.

Nature. 1994 Nov 3;372(6501):107-11.

PMID:
7969403
31.

A specific defect in the retinoic acid response associated with human lung cancer cell lines.

Zhang XK, Liu Y, Lee MO, Pfahl M.

Cancer Res. 1994 Nov 1;54(21):5663-9.

32.
33.

A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter.

Lee MO, Hobbs PD, Zhang XK, Dawson MI, Pfahl M.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5632-6. Erratum in: Proc Natl Acad Sci U S A 1994 Nov 22;91(24):11767.

34.

Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.

Zhang XK, Salbert G, Lee MO, Pfahl M.

Mol Cell Biol. 1994 Jun;14(6):4311-23.

35.

Vertebrate receptors: molecular biology, dimerization and response elements.

Pfahl M.

Semin Cell Biol. 1994 Apr;5(2):95-103. Review.

PMID:
8068887
36.

Recombinant human retinoic acid receptor beta. Binding of synthetic retinoids and transcriptional activation.

Lombardo A, Costa E, Chao WR, Toll L, Hobbs PD, Jong L, Lee MO, Pfahl M, Ely KR, Dawson MI.

J Biol Chem. 1994 Mar 11;269(10):7297-303.

37.

Molecular mechanisms of action for vitamin A-derived hormones.

Zhang XK, Pfahl M.

Prog Clin Biol Res. 1994;387:59-71. Review. No abstract available.

PMID:
7972260
38.

Nuclear retinoid receptors and their mechanism of action.

Pfahl M, Apfel R, Bendik I, Fanjul A, Graupner G, Lee MO, La-Vista N, Lu XP, Piedrafita J, Ortiz MA, et al.

Vitam Horm. 1994;49:327-82. Review. No abstract available.

PMID:
7810073
39.

Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching.

Lehmann JM, Zhang XK, Graupner G, Lee MO, Hermann T, Hoffmann B, Pfahl M.

Mol Cell Biol. 1993 Dec;13(12):7698-707.

40.
41.

Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.

Salbert G, Fanjul A, Piedrafita FJ, Lu XP, Kim SJ, Tran P, Pfahl M.

Mol Endocrinol. 1993 Oct;7(10):1347-56.

PMID:
8264664
42.

Nuclear receptor/AP-1 interaction.

Pfahl M.

Endocr Rev. 1993 Oct;14(5):651-8. Review. No abstract available.

PMID:
8262011
43.

Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.

Jong L, Lehmann JM, Hobbs PD, Harlev E, Huffman JC, Pfahl M, Dawson MI.

J Med Chem. 1993 Sep 3;36(18):2605-13.

PMID:
8410972
44.

Hetero- and homodimeric receptors in thyroid hormone and vitamin A action.

Zhang XK, Pfahl M.

Receptor. 1993 Fall;3(3):183-91. Review.

PMID:
8167569
45.

Signal transduction by retinoid receptors.

Pfahl M.

Skin Pharmacol. 1993;6 Suppl 1:8-16. Review.

PMID:
8142116
46.

V-erbA requires auxiliary proteins for dominant negative activity.

Hermann T, Hoffmann B, Piedrafita FJ, Zhang XK, Pfahl M.

Oncogene. 1993 Jan;8(1):55-65.

PMID:
8093812
47.

Retinoids selective for retinoid X receptor response pathways.

Lehmann JM, Jong L, Fanjul A, Cameron JF, Lu XP, Haefner P, Dawson MI, Pfahl M.

Science. 1992 Dec 18;258(5090):1944-6.

PMID:
1335166
48.

COUP orphan receptors are negative regulators of retinoic acid response pathways.

Tran P, Zhang XK, Salbert G, Hermann T, Lehmann JM, Pfahl M.

Mol Cell Biol. 1992 Oct;12(10):4666-76.

49.

A retinoic acid response element from the rat CRBPI promoter is activated by an RAR/RXR heterodimer.

Husmann M, Hoffmann B, Stump DG, Chytil F, Pfahl M.

Biochem Biophys Res Commun. 1992 Sep 30;187(3):1558-64.

PMID:
1339275
50.

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.

Zhang XK, Lehmann J, Hoffmann B, Dawson MI, Cameron J, Graupner G, Hermann T, Tran P, Pfahl M.

Nature. 1992 Aug 13;358(6387):587-91.

PMID:
1323763

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