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Items: 1 to 50 of 453

1.

Best practice in research - Overcoming common challenges in phytopharmacological research.

Heinrich M, Appendino G, Efferth T, Fürst R, Izzo AA, Kayser O, Pezzuto JM, Viljoen A.

J Ethnopharmacol. 2020 Jan 10;246:112230. doi: 10.1016/j.jep.2019.112230. Epub 2019 Sep 14. Review.

PMID:
31526860
2.

Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.

Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM.

J Nat Prod. 2019 Mar 22;82(3):492-499. doi: 10.1021/acs.jnatprod.8b00861. Epub 2019 Jan 16.

PMID:
30649869
3.

Resveratrol: Twenty Years of Growth, Development and Controversy.

Pezzuto JM.

Biomol Ther (Seoul). 2019 Jan 1;27(1):1-14. doi: 10.4062/biomolther.2018.176. Review.

4.

Synthesis and Structure-Activity Relationships of Tetrahydro-β-carboline Derivatives as Anticancer and Cancer-chemopreventive Agents.

Zhang M, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D.

Anticancer Res. 2018 Aug;38(8):4425-4433. doi: 10.21873/anticanres.12744.

PMID:
30061206
5.

Induction of NAD (P)H: Quinone reductase 1 (QR1) and antioxidant activities in vitro of 'Toranja Burarama' (Citrus maxima [Burm.] Merr.).

da Silva ES, Oliveira BG, Pereira ACH, Pimentel EF, Pezzuto JM, Lenz D, Kondratyuk TP, Andrade TU, Fronza M, Scherer R, Maia JF, Romão W, Alves FL, Ventura JA, Endringer DC.

Phytother Res. 2018 Oct;32(10):2059-2068. doi: 10.1002/ptr.6149. Epub 2018 Jul 12.

PMID:
29998488
6.

Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1.

Prior AM, Yu X, Park EJ, Kondratyuk TP, Lin Y, Pezzuto JM, Sun D.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5393-5399. doi: 10.1016/j.bmcl.2017.11.010. Epub 2017 Nov 6.

7.

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.

Cai YS, Sarotti AM, Gündisch D, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4630-4634. doi: 10.1016/j.bmcl.2017.09.021. Epub 2017 Sep 9.

PMID:
28927792
8.

NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462.

Li CS, Sarotti AM, Huang P, Dang UT, Hurdle JG, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S.

Sci Rep. 2017 Sep 5;7(1):10424. doi: 10.1038/s41598-017-10537-1.

9.
10.

Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis.

Youn UJ, Park EJ, Kondratyuk TP, Sripisut T, Laphookhieo S, Pezzuto JM, Chang LC.

Fitoterapia. 2016 Oct;114:92-97. doi: 10.1016/j.fitote.2016.08.012. Epub 2016 Aug 26.

PMID:
27575322
11.

Bruceantin inhibits multiple myeloma cancer stem cell proliferation.

Issa ME, Berndt S, Carpentier G, Pezzuto JM, Cuendet M.

Cancer Biol Ther. 2016 Sep;17(9):966-75. doi: 10.1080/15384047.2016.1210737. Epub 2016 Jul 19.

12.

Evidence supporting the conceptual framework of cancer chemoprevention in canines.

Kondratyuk TP, Adrian JA, Wright B, Park EJ, van Breemen RB, Morris KR, Pezzuto JM.

Sci Rep. 2016 May 24;6:26500. doi: 10.1038/srep26500.

13.

Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.

Sang-Ngern M, Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Wall MM, Ruf M, Lorch SE, Leong E, Pezzuto JM, Chang LC.

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2755-2759. doi: 10.1016/j.bmcl.2016.04.077. Epub 2016 Apr 26.

PMID:
27210437
14.

Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates.

Youn UJ, Park EJ, Kondratyuk TP, Sang-Ngern M, Wall MM, Wei Y, Pezzuto JM, Chang LC.

J Nat Prod. 2016 Jun 24;79(6):1508-13. doi: 10.1021/acs.jnatprod.5b00970. Epub 2016 May 19.

PMID:
27196335
15.

Endophytic fungi associated with Taxus fuana (West Himalayan Yew) of Pakistan: potential bio-resources for cancer chemopreventive agents.

Fatima N, Kondratyuk TP, Park EJ, Marler LE, Jadoon M, Qazi MA, Mehboob Mirza H, Khan I, Atiq N, Chang LC, Ahmed S, Pezzuto JM.

Pharm Biol. 2016 Nov;54(11):2547-2554. Epub 2016 May 9.

PMID:
27159021
16.

Litsea Species as Potential Antiviral Plant Sources.

Guan Y, Wang D, Tan GT, Van Hung N, Cuong NM, Pezzuto JM, Fong HH, Soejarto DD, Zhang H.

Am J Chin Med. 2016;44(2):275-90. doi: 10.1142/S0192415X16500166. Review.

PMID:
27080941
17.

Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β-hydroxywithanolide E isolated from Physalis peruviana.

Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM.

Mol Nutr Food Res. 2016 Jun;60(6):1482-500. doi: 10.1002/mnfr.201500977. Epub 2016 May 11.

PMID:
27006100
18.

Hedera nepalensis K. Koch: A Novel Source of Natural Cancer Chemopreventive and Anticancerous Compounds.

Jafri L, Saleem S, Kondrytuk TP, Haq IU, Ullah N, Pezzuto JM, Mirza B.

Phytother Res. 2016 Mar;30(3):447-53. doi: 10.1002/ptr.5546. Epub 2015 Dec 21.

PMID:
26692176
19.

Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents.

Cragg GM, Pezzuto JM.

Med Princ Pract. 2016;25 Suppl 2:41-59. doi: 10.1159/000443404. Epub 2015 Dec 17. Review.

20.

Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum.

Youn UJ, Sripisut T, Park EJ, Kondratyuk TP, Fatima N, Simmons CJ, Wall MM, Sun D, Pezzuto JM, Chang LC.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4719-4723. doi: 10.1016/j.bmcl.2015.08.063. Epub 2015 Aug 24.

PMID:
26343828
21.

Introduction to Resveratrol and Health: 3rd International Conference.

Vang O, Pezzuto JM.

Ann N Y Acad Sci. 2015 Aug;1348(1):v-vi. doi: 10.1111/nyas.12870. No abstract available.

PMID:
26315296
22.

A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells.

Chelsky ZL, Yue P, Kondratyuk TP, Paladino D, Pezzuto JM, Cushman M, Turkson J.

Mol Pharmacol. 2015 Sep;88(3):524-33. doi: 10.1124/mol.115.099093. Epub 2015 Jul 2.

23.

Synthesis, molecular docking and anticancer studies of peptides and iso-peptides.

Jabeen F, Panda SS, Kondratyuk TP, Park EJ, Pezzuto JM, Ihsan-ul-Haq, Hall CD, Katritzky AR.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2980-4. doi: 10.1016/j.bmcl.2015.05.020. Epub 2015 May 16.

PMID:
26048799
24.

Ferrocene incorporated selenoureas as anticancer agents.

Hussain RA, Badshah A, Pezzuto JM, Ahmed N, Kondratyuk TP, Park EJ.

J Photochem Photobiol B. 2015 Jul;148:197-208. doi: 10.1016/j.jphotobiol.2015.04.024. Epub 2015 May 1.

PMID:
25966308
25.

Academic pharmacy strikes Hawai'i. Part 2.

Pezzuto JM, Ma CS.

Hawaii J Med Public Health. 2015 Mar;74(3):120-8.

26.

The pharmacology of resveratrol in animals and humans.

Park EJ, Pezzuto JM.

Biochim Biophys Acta. 2015 Jun;1852(6):1071-113. doi: 10.1016/j.bbadis.2015.01.014. Epub 2015 Jan 31. Review.

27.

The Daniel K. Inouye College of Pharmacy scripts: Academic pharmacy strikes Hawai'i (part 1).

Pezzuto JM, Pezzuto MF.

Hawaii J Med Public Health. 2015 Jan;74(1):33-6.

28.

Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.

Parrish SM, Yoshida WY, Kondratyuk TP, Park EJ, Pezzuto JM, Kelly M, Williams PG.

J Nat Prod. 2014 Jul 25;77(7):1644-9. doi: 10.1021/np500256w. Epub 2014 Jul 3.

29.

Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.

García ME, Nicotra VE, Oberti JC, Ríos-Luci C, León LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padrón JM, Hueso-Falcón I, Estévez-Braun A.

Eur J Med Chem. 2014 Jul 23;82:68-81. doi: 10.1016/j.ejmech.2014.05.045. Epub 2014 May 20.

PMID:
24878636
30.

Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10.

Chai X, Youn UJ, Sun D, Dai J, Williams P, Kondratyuk TP, Borris RP, Davies J, Villanueva IG, Pezzuto JM, Chang LC.

J Nat Prod. 2014 Feb 28;77(2):227-33. doi: 10.1021/np4006635. Epub 2014 Feb 17.

31.

Bioactive compounds from Vitex leptobotrys.

Pan W, Liu K, Guan Y, Tan GT, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH, Zhang H.

J Nat Prod. 2014 Mar 28;77(3):663-7. doi: 10.1021/np400779v. Epub 2014 Jan 9.

32.

Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells.

Park EJ, Shen L, Sun D, Pezzuto JM.

J Nat Prod. 2014 Mar 28;77(3):527-35. doi: 10.1021/np400800h. Epub 2013 Dec 3.

33.

Resveratrol derivatives: a patent review (2009 - 2012).

Pezzuto JM, Kondratyuk TP, Ogas T.

Expert Opin Ther Pat. 2013 Dec;23(12):1529-46. doi: 10.1517/13543776.2013.834888. Epub 2013 Sep 16. Review.

PMID:
24032623
34.

Vermelhotin, an anti-inflammatory agent, suppresses nitric oxide production in RAW 264.7 cells via p38 inhibition.

Pansanit A, Park EJ, Kondratyuk TP, Pezzuto JM, Lirdprapamongkol K, Kittakoop P.

J Nat Prod. 2013 Sep 27;76(9):1824-7. doi: 10.1021/np400565e. Epub 2013 Sep 9.

PMID:
24016057
35.

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.

Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang K, van Breemen RB, Pezzuto JM.

Eur J Med Chem. 2013 Oct;68:412-21. doi: 10.1016/j.ejmech.2013.07.052. Epub 2013 Aug 13.

PMID:
23994869
36.

Resveratrol analogs: promising chemopreventive agents.

Ogas T, Kondratyuk TP, Pezzuto JM.

Ann N Y Acad Sci. 2013 Jul;1290:21-9. doi: 10.1111/nyas.12196. Review.

PMID:
23855462
37.

Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.

Carlson S, Marler L, Nam SJ, Santarsiero BD, Pezzuto JM, Murphy BT.

Mar Drugs. 2013 Apr 3;11(4):1152-61. doi: 10.3390/md11041152.

38.

Retraction of: Li CM, Jiang WL, Zhu HB, Hou J. Antifibrotic effects of protocatechuic aldehyde on experimental liver fibrosis.

Pezzuto JM, Patel P.

Pharm Biol. 2013 May;51(5):675. doi: 10.3109/13880209.2013.782159. Epub 2013 Mar 19. No abstract available.

PMID:
23510404
39.

Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.

Conda-Sheridan M, Park EJ, Beck DE, Reddy PV, Nguyen TX, Hu B, Chen L, White JJ, van Breemen RB, Pezzuto JM, Cushman M.

J Med Chem. 2013 Mar 28;56(6):2581-605. doi: 10.1021/jm400026k. Epub 2013 Mar 8.

40.

Antioxidant marine products in cancer chemoprevention.

Park EJ, Pezzuto JM.

Antioxid Redox Signal. 2013 Jul 10;19(2):115-38. doi: 10.1089/ars.2013.5235. Epub 2013 Mar 19. Review.

PMID:
23397932
41.

Biologically active withanolides from Withania coagulans.

Ihsan-ul-Haq, Youn UJ, Chai X, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Mirza B, Pezzuto JM, Chang LC.

J Nat Prod. 2013 Jan 25;76(1):22-8. doi: 10.1021/np300534x. Epub 2013 Jan 14.

PMID:
23316950
42.

Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).

Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M.

Bioorg Med Chem. 2012 Dec 15;20(24):7030-9. doi: 10.1016/j.bmc.2012.10.006. Epub 2012 Oct 23.

43.

Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan.

Ihsan-ul-Haq, Mirza B, Kondratyuk TP, Park EJ, Burns BE, Marler LE, Pezzuto JM.

Pharm Biol. 2013 Mar;51(3):316-28. doi: 10.3109/13880209.2012.728612. Epub 2012 Nov 8.

PMID:
23137214
44.

Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors.

Yu X, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D.

Org Biomol Chem. 2012 Nov 28;10(44):8835-47. doi: 10.1039/c2ob26456k.

45.

Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells.

Archer CR, Groll M, Stein ML, Schellenberg B, Clerc J, Kaiser M, Kondratyuk TP, Pezzuto JM, Dudler R, Bachmann AS.

Biochemistry. 2012 Aug 28;51(34):6880-8. Epub 2012 Aug 17.

PMID:
22870914
46.

Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.

Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Tanamatayarat P, Wongwiwatthananukit S, Toyama O, Songsak T, Pezzuto JM, Chang LC.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62. doi: 10.1016/j.bmcl.2012.07.010. Epub 2012 Jul 15.

PMID:
22850207
47.

Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.

Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM.

ChemMedChem. 2012 Sep;7(9):1541-5. doi: 10.1002/cmdc.201200253. Epub 2012 Jul 30.

48.

Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.

Park EJ, Pezzuto JM, Jang KH, Nam SJ, Bucarey SA, Fenical W.

Nat Prod Commun. 2012 Jun;7(6):789-94.

49.

Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents.

Luqman S, Meena A, Singh P, Kondratyuk TP, Marler LE, Pezzuto JM, Negi AS.

Chem Biol Drug Des. 2012 Oct;80(4):616-24. doi: 10.1111/j.1747-0285.2012.01439.x. Epub 2012 Jul 25.

50.

Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.

Chen L, Conda-Sheridan M, Reddy PV, Morrell A, Park EJ, Kondratyuk TP, Pezzuto JM, van Breemen RB, Cushman M.

J Med Chem. 2012 Jun 28;55(12):5965-81. doi: 10.1021/jm3006806. Epub 2012 Jun 19.

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