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Items: 30

1.

Polarized AAVR expression determines infectivity by AAV gene therapy vectors.

Hamilton BA, Li X, Pezzulo AA, Abou Alaiwa MH, Zabner J.

Gene Ther. 2019 Jun;26(6):240-249. doi: 10.1038/s41434-019-0078-3. Epub 2019 Apr 8.

PMID:
30962536
2.

HSP90 inhibitor geldanamycin reverts IL-13- and IL-17-induced airway goblet cell metaplasia.

Pezzulo AA, Tudas RA, Stewart CG, Buonfiglio LGV, Lindsay BD, Taft PJ, Gansemer ND, Zabner J.

J Clin Invest. 2019 Feb 1;129(2):744-758. doi: 10.1172/JCI123524. Epub 2019 Jan 14.

3.

Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial.

Vargas Buonfiglio LG, Cano M, Pezzulo AA, Vanegas Calderon OG, Zabner J, Gerke AK, Comellas AP.

BMJ Open Respir Res. 2017 Jun 4;4(1):e000211. doi: 10.1136/bmjresp-2017-000211. eCollection 2017.

4.

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.

Bartlett JA, Ramachandran S, Wohlford-Lenane CL, Barker CK, Pezzulo AA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA, McCray PB Jr.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):845-854.

5.

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.

Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW.

Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059.

6.

Effects of vitamin D supplementation on alveolar macrophage gene expression: preliminary results of a randomized, controlled trial.

Gerke AK, Pezzulo AA, Tang F, Cavanaugh JE, Bair TB, Phillips E, Powers LS, Monick MM.

Multidiscip Respir Med. 2014 Mar 26;9(1):18. doi: 10.1186/2049-6958-9-18.

7.

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.

Abou Alaiwa MH, Beer AM, Pezzulo AA, Launspach JL, Horan RA, Stoltz DA, Starner TD, Welsh MJ, Zabner J.

J Cyst Fibros. 2014 Jul;13(4):373-7. doi: 10.1016/j.jcf.2013.12.006. Epub 2014 Jan 11.

8.

Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome.

Pezzulo AA, Kelly PH, Nassar BS, Rutland CJ, Gansemer ND, Dohrn CL, Costello AJ, Stoltz DA, Zabner J.

Appl Environ Microbiol. 2013 Oct;79(19):5936-41. doi: 10.1128/AEM.01752-13. Epub 2013 Jul 19.

9.

Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.

Bartlett JA, Albertolle ME, Wohlford-Lenane C, Pezzulo AA, Zabner J, Niles RK, Fisher SJ, McCray PB Jr, Williams KE.

Am J Physiol Lung Cell Mol Physiol. 2013 Aug 1;305(3):L256-66. doi: 10.1152/ajplung.00056.2013. Epub 2013 May 24.

10.

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.

Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA 4th, Hoffman EA, Chang EH, Zabner J, McCray PB Jr, Prather RS, Meyerholz DK, Welsh MJ.

J Clin Invest. 2013 Jun;123(6):2685-93. doi: 10.1172/JCI68867. Epub 2013 May 8.

11.

Coal fly ash impairs airway antimicrobial peptides and increases bacterial growth.

Borcherding JA, Chen H, Caraballo JC, Baltrusaitis J, Pezzulo AA, Zabner J, Grassian VH, Comellas AP.

PLoS One. 2013;8(2):e57673. doi: 10.1371/journal.pone.0057673. Epub 2013 Feb 28.

12.

Lentiviral vector gene transfer to porcine airways.

Sinn PL, Cooney AL, Oakland M, Dylla DE, Wallen TJ, Pezzulo AA, Chang EH, McCray PB Jr.

Mol Ther Nucleic Acids. 2012 Nov 27;1:e56. doi: 10.1038/mtna.2012.47.

13.

Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster.

Pezzulo AA, Hornick EE, Rector MV, Estin M, Reisetter AC, Taft PJ, Butcher SC, Carter AB, Manak JR, Stoltz DA, Zabner J.

PLoS One. 2012;7(8):e43777. doi: 10.1371/journal.pone.0043777. Epub 2012 Aug 30.

14.

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.

Pezzulo AA, Tang XX, Hoegger MJ, Abou Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB Jr, Welsh MJ, Zabner J.

Nature. 2012 Jul 4;487(7405):109-13. doi: 10.1038/nature11130.

15.

Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.

Chang EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR, Sieren JC, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB Jr, Stoltz DA, Welsh MJ, Zabner J.

Laryngoscope. 2012 Sep;122(9):1898-905. doi: 10.1002/lary.23392. Epub 2012 Jun 18.

16.

CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia.

Li X, Comellas AP, Karp PH, Ernst SE, Moninger TO, Gansemer ND, Taft PJ, Pezzulo AA, Rector MV, Rossen N, Stoltz DA, McCray PB Jr, Welsh MJ, Zabner J.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L152-60. doi: 10.1152/ajplung.00116.2012. Epub 2012 May 25.

17.

Inhaled hypertonic saline in adults hospitalised for exacerbation of cystic fibrosis lung disease: a retrospective study.

Pezzulo AA, Stoltz DA, Hornick DB, Durairaj L.

BMJ Open. 2012 Apr 19;2(2):e000407. doi: 10.1136/bmjopen-2011-000407. Print 2012.

18.

In Situ Quantification of Glucose Concentration in Airway Surface Liquid With Functionalized ZnO Nanorod-Coated Microelectrodes.

Pezzulo AA, Asif MH, Willander M, Zabner J.

J Anal Bioanal Tech. 2011 Aug 12;S7(2). pii: 002.

19.

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.

Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB Jr, Zabner J, Welsh MJ, Stoltz DA.

Sci Transl Med. 2011 Mar 16;3(74):74ra24. doi: 10.1126/scitranslmed.3001868.

20.

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions.

Lorentzen D, Durairaj L, Pezzulo AA, Nakano Y, Launspach J, Stoltz DA, Zamba G, McCray PB Jr, Zabner J, Welsh MJ, Nauseef WM, Bánfi B.

Free Radic Biol Med. 2011 May 1;50(9):1144-50. doi: 10.1016/j.freeradbiomed.2011.02.013. Epub 2011 Feb 18.

21.

Glucose depletion in the airway surface liquid is essential for sterility of the airways.

Pezzulo AA, Gutiérrez J, Duschner KS, McConnell KS, Taft PJ, Ernst SE, Yahr TL, Rahmouni K, Klesney-Tait J, Stoltz DA, Zabner J.

PLoS One. 2011 Jan 20;6(1):e16166. doi: 10.1371/journal.pone.0016166.

22.

Do cell junction protein mutations cause an airway phenotype in mice or humans?

Chang EH, Pezzulo AA, Zabner J.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):202-20. doi: 10.1165/rcmb.2010-0498TR. Epub 2011 Feb 4. Review.

23.

Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia.

Chen JH, Stoltz DA, Karp PH, Ernst SE, Pezzulo AA, Moninger TO, Rector MV, Reznikov LR, Launspach JL, Chaloner K, Zabner J, Welsh MJ.

Cell. 2010 Dec 10;143(6):911-23. doi: 10.1016/j.cell.2010.11.029.

24.

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth.

Rogan MP, Reznikov LR, Pezzulo AA, Gansemer ND, Samuel M, Prather RS, Zabner J, Fredericks DC, McCray PB Jr, Welsh MJ, Stoltz DA.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20571-5. doi: 10.1073/pnas.1015281107. Epub 2010 Nov 8.

25.

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.

Pezzulo AA, Starner TD, Scheetz TE, Traver GL, Tilley AE, Harvey BG, Crystal RG, McCray PB Jr, Zabner J.

Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L25-31. doi: 10.1152/ajplung.00256.2010. Epub 2010 Oct 22.

26.

Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.

Meyerholz DK, Stoltz DA, Namati E, Ramachandran S, Pezzulo AA, Smith AR, Rector MV, Suter MJ, Kao S, McLennan G, Tearney GJ, Zabner J, McCray PB Jr, Welsh MJ.

Am J Respir Crit Care Med. 2010 Nov 15;182(10):1251-61. doi: 10.1164/rccm.201004-0643OC. Epub 2010 Jul 9.

27.

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.

Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA 4th, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ.

Sci Transl Med. 2010 Apr 28;2(29):29ra31. doi: 10.1126/scitranslmed.3000928.

28.

Pathology of gastrointestinal organs in a porcine model of cystic fibrosis.

Meyerholz DK, Stoltz DA, Pezzulo AA, Welsh MJ.

Am J Pathol. 2010 Mar;176(3):1377-89. doi: 10.2353/ajpath.2010.090849. Epub 2010 Jan 28.

29.

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.

Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ.

Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600.

30.

Beneficial effects of hydrocortisone and papaverine on a model of pulmonary embolism induced by autologous blood clots in isolated and perfused rabbit lungs.

Trejo HE, Urich D, Pezzulo AA, Caraballo JC, Gutiérrez J, Castro IJ, Centeno GR, Sánchez de León R.

Respirology. 2007 Nov;12(6):799-806.

PMID:
17986106

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