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Items: 1 to 50 of 58

1.

Synthetic Strategies for Dinucleotides Synthesis.

Appy L, Chardet C, Peyrottes S, Roy B.

Molecules. 2019 Nov 27;24(23). pii: E4334. doi: 10.3390/molecules24234334. Review.

2.

Synthesis of Substituted 5'-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73.

Ghoteimi R, Nguyen VT, Rahimova R, Grosjean F, Cros-Perrial E, Uttaro JP, Mathé C, Chaloin L, Jordheim LP, Peyrottes S.

ChemMedChem. 2019 Aug 6;14(15):1431-1443. doi: 10.1002/cmdc.201900348. Epub 2019 Jul 25.

PMID:
31264794
3.

Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.

Cheviet T, Lefebvre-Tournier I, Wein S, Peyrottes S.

J Med Chem. 2019 Sep 26;62(18):8365-8391. doi: 10.1021/acs.jmedchem.9b00182. Epub 2019 Apr 25.

PMID:
30964283
4.

Lead optimization and biological evaluation of fragment-based cN-II inhibitors.

Guillon R, Rahimova R, Preeti, Egron D, Rouanet S, Dumontet C, Aghajari N, Jordheim LP, Chaloin L, Peyrottes S.

Eur J Med Chem. 2019 Apr 15;168:28-44. doi: 10.1016/j.ejmech.2019.02.040. Epub 2019 Feb 14.

PMID:
30798051
5.

Straightforward Ball-Milling Access to Dinucleoside 5',5'-Polyphosphates via Phosphorimidazolide Intermediates.

Appy L, Depaix A, Bantreil X, Lamaty F, Peyrottes S, Roy B.

Chemistry. 2019 Feb 18;25(10):2477-2481. doi: 10.1002/chem.201805924. Epub 2019 Jan 21.

6.

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates.

Dumontet C, Peyrottes S, Rabeson C, Cros-Perrial E, Géant PY, Chaloin L, Jordheim LP.

Eur J Med Chem. 2018 Sep 5;157:1051-1055. doi: 10.1016/j.ejmech.2018.08.035. Epub 2018 Aug 17.

PMID:
30176535
7.

Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine.

Laux WH, Priet S, Alvarez K, Peyrottes S, Périgaud C.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618757636. doi: 10.1177/2040206618757636.

8.

Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface.

Rahimova R, Fontanel S, Lionne C, Jordheim LP, Peyrottes S, Chaloin L.

PLoS Comput Biol. 2018 Jan 29;14(1):e1005943. doi: 10.1371/journal.pcbi.1005943. eCollection 2018 Jan.

9.

Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens.

Moulin M, Alguacil J, Gu S, Mehtougui A, Adams EJ, Peyrottes S, Champagne E.

Cell Mol Life Sci. 2017 Dec;74(23):4353-4367. doi: 10.1007/s00018-017-2583-0. Epub 2017 Jul 1.

PMID:
28669030
10.

Water-Medium Synthesis of Nucleoside 5'-Polyphosphates.

Depaix A, Peyrottes S, Roy B.

Curr Protoc Nucleic Acid Chem. 2017 Jun 19;69:13.16.1-13.16.11. doi: 10.1002/cpnc.30.

PMID:
28628206
11.

Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells.

Puy JY, Jordheim LP, Cros-Perrial E, Dumontet C, Peyrottes S, Lefebvre-Tournier I.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 15;1053:101-110. doi: 10.1016/j.jchromb.2017.03.024. Epub 2017 Mar 24.

PMID:
28415014
12.

Evidence that oxidative dephosphorylation by the nonheme Fe(II), α-ketoglutarate:UMP oxygenase occurs by stereospecific hydroxylation.

Goswami A, Liu X, Cai W, Wyche TP, Bugni TS, Meurillon M, Peyrottes S, Perigaud C, Nonaka K, Rohr J, Van Lanen SG.

FEBS Lett. 2017 Feb;591(3):468-478. doi: 10.1002/1873-3468.12554. Epub 2017 Jan 25.

13.

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation.

Nguyen Van T, Hospital A, Lionne C, Jordheim LP, Dumontet C, Périgaud C, Chaloin L, Peyrottes S.

Beilstein J Org Chem. 2016 Jul 18;12:1476-86. doi: 10.3762/bjoc.12.144. eCollection 2016.

14.

Recent Trends in Nucleotide Synthesis.

Roy B, Depaix A, Périgaud C, Peyrottes S.

Chem Rev. 2016 Jul 27;116(14):7854-97. doi: 10.1021/acs.chemrev.6b00174. Epub 2016 Jun 20. Review.

PMID:
27319940
15.

Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells.

Daguzan C, Moulin M, Kulyk-Barbier H, Davrinche C, Peyrottes S, Champagne E.

J Immunol. 2016 Mar 1;196(5):2219-29. doi: 10.4049/jimmunol.1501661. Epub 2016 Jan 27.

16.

Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.

Marton Z, Guillon R, Krimm I, Preeti, Rahimova R, Egron D, Jordheim LP, Aghajari N, Dumontet C, Périgaud C, Lionne C, Peyrottes S, Chaloin L.

J Med Chem. 2015 Dec 24;58(24):9680-96. doi: 10.1021/acs.jmedchem.5b01616. Epub 2015 Dec 7.

PMID:
26599519
17.

Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.

Jordheim LP, Puy JY, Cros-Perrial E, Peyrottes S, Lefebvre I, Périgaud C, Dumontet C.

Anal Bioanal Chem. 2015 Jul;407(19):5747-58. doi: 10.1007/s00216-015-8757-4. Epub 2015 May 22.

PMID:
25998135
18.

A chemical proteomics approach for the search of pharmacological targets of the antimalarial clinical candidate albitiazolium in Plasmodium falciparum using photocrosslinking and click chemistry.

Penarete-Vargas DM, Boisson A, Urbach S, Chantelauze H, Peyrottes S, Fraisse L, Vial HJ.

PLoS One. 2014 Dec 3;9(12):e113918. doi: 10.1371/journal.pone.0113918. eCollection 2014.

19.

²⁰¹Tl⁺-labelled Prussian blue nanoparticles as contrast agents for SPECT scintigraphy.

Perrier M, Busson M, Massasso G, Long J, Boudousq V, Pouget JP, Peyrottes S, Perigaud Ch, Porredon-Guarch C, de Lapuente J, Borras M, Larionova J, Guari Y.

Nanoscale. 2014 Nov 21;6(22):13425-9. doi: 10.1039/c4nr03044c.

PMID:
25283238
20.

Exploring prodrug approaches for albitiazolium and its analogues.

Peyrottes S, Caldarelli S, Wein S, Perigaud C, Vial H.

Curr Top Med Chem. 2014;14(14):1653-67.

PMID:
25116583
21.

New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.

Wein S, Tran Van Ba C, Maynadier M, Bordat Y, Perez J, Peyrottes S, Fraisse L, Vial HJ.

Antimicrob Agents Chemother. 2014 Sep;58(9):5519-27. doi: 10.1128/AAC.00040-14. Epub 2014 Jul 7.

22.

Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies.

Meurillon M, Marton Z, Hospital A, Jordheim LP, Béjaud J, Lionne C, Dumontet C, Périgaud C, Chaloin L, Peyrottes S.

Eur J Med Chem. 2014 Apr 22;77:18-37. doi: 10.1016/j.ejmech.2014.02.055. Epub 2014 Feb 24.

PMID:
24607586
23.

An alternative pathway to ribonucleoside β-hydroxyphosphonate analogues and related prodrugs.

Hospital A, Meurillon M, Peyrottes S, Périgaud C.

Org Lett. 2013 Sep 20;15(18):4778-81. doi: 10.1021/ol402143y. Epub 2013 Sep 9.

PMID:
24015803
24.

Montpellier Infectious Diseases (MID), 2nd annual meeting (2012).

Bastien P, Braun-Breton C, Chazal N, Devaux C, Foulongne V, Frank M, Hernandez JF, Kremer L, Lebrun M, Le Moing V, Leonetti JP, Lionne C, Peyrottes S.

Infect Genet Evol. 2013 Jun;16:450-4. doi: 10.1016/j.meegid.2013.01.019. Epub 2013 Feb 14.

PMID:
23416259
25.

New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation.

Caldarelli SA, El Fangour S, Wein S, Tran van Ba C, Périgaud C, Pellet A, Vial HJ, Peyrottes S.

J Med Chem. 2013 Jan 24;56(2):496-509. doi: 10.1021/jm3014585. Epub 2013 Jan 4.

PMID:
23289711
26.

Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening.

Jordheim LP, Marton Z, Rhimi M, Cros-Perrial E, Lionne C, Peyrottes S, Dumontet C, Aghajari N, Chaloin L.

Biochem Pharmacol. 2013 Feb 15;85(4):497-506. doi: 10.1016/j.bcp.2012.11.024. Epub 2012 Dec 7.

PMID:
23220537
27.

Choline analogues in malaria chemotherapy.

Peyrottes S, Caldarelli S, Wein S, Périgaud C, Pellet A, Vial H.

Curr Pharm Des. 2012;18(24):3454-66. Review.

28.

Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.

Caldarelli SA, Hamel M, Duckert JF, Ouattara M, Calas M, Maynadier M, Wein S, Périgaud C, Pellet A, Vial HJ, Peyrottes S.

J Med Chem. 2012 May 24;55(10):4619-28. doi: 10.1021/jm3000328. Epub 2012 May 16.

PMID:
22591034
29.

Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues.

Gallier F, Lallemand P, Meurillon M, Jordheim LP, Dumontet C, Périgaud C, Lionne C, Peyrottes S, Chaloin L.

PLoS Comput Biol. 2011 Dec;7(12):e1002295. doi: 10.1371/journal.pcbi.1002295. Epub 2011 Dec 8.

30.

5',6'-nucleoside phosphonate analogues architecture: synthesis and comparative evaluation towards metabolic enzymes.

Gallier F, Alexandre JA, El Amri C, Deville-Bonne D, Peyrottes S, Périgaud C.

ChemMedChem. 2011 Jun 6;6(6):1094-106. doi: 10.1002/cmdc.201100068. Epub 2011 May 12.

PMID:
21567966
31.

Synthesis of 2',3'-dideoxynucleoside phosphoesters using H-phosphonate chemistry on soluble polymer support.

Crauste C, Périgaud C, Peyrottes S.

J Org Chem. 2011 Feb 4;76(3):997-1000. doi: 10.1021/jo1022958. Epub 2010 Dec 30.

PMID:
21192699
32.

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

Caldarelli SA, Boisbrun M, Alarcon K, Hamzé A, Ouattara M, Salom-Roig X, Maynadier M, Wein S, Peyrottes S, Pellet A, Calas M, Vial H.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3953-6. doi: 10.1016/j.bmcl.2010.05.001. Epub 2010 May 10.

PMID:
20605450
33.

Synthesis and evaluation of bis-thiazolium salts as potential antimalarial drugs.

Caldarelli SA, Duckert JF, Wein S, Calas M, Périgaud C, Vial H, Peyrottes S.

ChemMedChem. 2010 Jul 5;5(7):1102-9. doi: 10.1002/cmdc.201000097.

PMID:
20540062
34.

F1-adenosine triphosphatase displays properties characteristic of an antigen presentation molecule for Vgamma9Vdelta2 T cells.

Mookerjee-Basu J, Vantourout P, Martinez LO, Perret B, Collet X, Périgaud C, Peyrottes S, Champagne E.

J Immunol. 2010 Jun 15;184(12):6920-8. doi: 10.4049/jimmunol.0904024. Epub 2010 May 7.

35.

Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.

Wein S, Maynadier M, Tran Van Ba C, Cerdan R, Peyrottes S, Fraisse L, Vial H.

J Clin Microbiol. 2010 May;48(5):1651-60. doi: 10.1128/JCM.02250-09. Epub 2010 Mar 10.

36.

Insights into the soluble PEG-supported synthesis of cytosine-containing nucleoside 5'-mono-, di-, and triphosphates.

Crauste C, Périgaud C, Peyrottes S.

J Org Chem. 2009 Dec 4;74(23):9165-72. doi: 10.1021/jo901931z.

PMID:
19894748
37.

Separation of diastereoisomers of Ara-C phosphotriesters using solid phase extraction and HPLC for the study of their decomposition kinetic in cell extracts.

Foulon C, Tedou J, Peyrottes S, Perigaud C, Bonte JP, Vaccher C, Goossens JF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3475-81. doi: 10.1016/j.jchromb.2009.08.004. Epub 2009 Aug 7.

PMID:
19748325
38.

Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen.

Vantourout P, Mookerjee-Basu J, Rolland C, Pont F, Martin H, Davrinche C, Martinez LO, Perret B, Collet X, Périgaud C, Peyrottes S, Champagne E.

J Immunol. 2009 Sep 15;183(6):3848-57. doi: 10.4049/jimmunol.0901085. Epub 2009 Aug 26.

39.

Special feature of mixed phosphotriester derivatives of cytarabine.

Gouy MH, Jordheim LP, Lefebvre I, Cros E, Dumontet C, Peyrottes S, Périgaud C.

Bioorg Med Chem. 2009 Sep 1;17(17):6340-7. doi: 10.1016/j.bmc.2009.07.038. Epub 2009 Jul 23.

PMID:
19674903
40.
41.

Preparation, characterization and in vitro evaluation of a new nucleotide analogue prodrug cyclodextrin inclusion complexes.

Diab R, Jordheim LP, Degobert G, Peyrottes S, Périgaud C, Dumontet C, Fessi H.

J Nanosci Nanotechnol. 2009 Jan;9(1):295-300.

PMID:
19441310
42.

Development of a sensitive and selective LC/MS/MS method for the simultaneous determination of intracellular 1-beta-D-arabinofuranosylcytosine triphosphate (araCTP), cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in a human follicular lymphoma cell line.

Crauste C, Lefebvre I, Hovaneissian M, Puy JY, Roy B, Peyrottes S, Cohen S, Guitton J, Dumontet C, Perigaud C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1417-25. doi: 10.1016/j.jchromb.2009.02.071. Epub 2009 Mar 17.

PMID:
19328748
43.

Exploring synthetic routes to nucleoside alkynylphosphonates.

Meurillon M, Peyrottes S, Périgaud C.

Nucleic Acids Symp Ser (Oxf). 2008;(52):565-6. doi: 10.1093/nass/nrn286.

PMID:
18776505
44.

A step further in the SATE mononucleotide prodrug approach.

Peyrottes S, Villard AL, Coussot G, Augustijns P, Lefebvre I, Aubertin AM, Gosselin G, Périgaud C.

Nucleic Acids Symp Ser (Oxf). 2008;(52):539-40. doi: 10.1093/nass/nrn273.

PMID:
18776492
45.

Phenyl phosphotriester derivatives of AZT: variations upon the SATE moiety.

Villard AL, Coussot G, Lefebvre I, Augustijns P, Aubertin AM, Gosselin G, Peyrottes S, Périgaud C.

Bioorg Med Chem. 2008 Aug 1;16(15):7321-9. doi: 10.1016/j.bmc.2008.06.024. Epub 2008 Jun 18.

PMID:
18585917
46.

Chemistry of bisSATE mononucleotide prodrugs.

Peyrottes S, Périgaud C.

Curr Protoc Nucleic Acid Chem. 2007 Jun;Chapter 15:Unit 15.3. doi: 10.1002/0471142700.nc1503s29.

PMID:
18428973
47.

Improvement of the synthesis of sugar phosphonates using microwave irradiations.

Peyrottes S, Gallier F, Papillaud A, Béjaud J, Périgaud C.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1513-5.

PMID:
18066817
48.

Synthetic approaches to a mononucleotide prodrug of cytarabine.

Bazzanini R, Gouy MH, Peyrottes S, Gosselin G, Périgaud C, Manfredini S.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1635-49.

PMID:
16438040
49.

Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.

Jordheim LP, Cros E, Gouy MH, Galmarini CM, Peyrottes S, Mackey J, Perigaud C, Dumontet C.

Clin Cancer Res. 2004 Aug 15;10(16):5614-21.

50.

SATE pronucleotide approaches: an overview.

Peyrottes S, Egron D, Lefebvre I, Gosselin G, Imbach JL, Périgaud C.

Mini Rev Med Chem. 2004 May;4(4):395-408. Review.

PMID:
15134542

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