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Items: 39

1.

TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.

Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F.

PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar.

2.

Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.

Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I.

FASEB J. 2018 Apr;32(4):1880-1890. doi: 10.1096/fj.201700571R. Epub 2018 Jan 5.

3.

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH.

Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.

4.

Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.

Kim YR, Volpert G, Shin KO, Kim SY, Shin SH, Lee Y, Sung SH, Lee YM, Ahn JH, Pewzner-Jung Y, Park WJ, Futerman AH, Park JW.

J Cell Mol Med. 2017 Dec;21(12):3565-3578. doi: 10.1111/jcmm.13267. Epub 2017 Jul 12.

5.

Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.

Volpert G, Ben-Dor S, Tarcic O, Duan J, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

J Cell Sci. 2017 Apr 15;130(8):1486-1493. doi: 10.1242/jcs.199968. Epub 2017 Mar 9.

6.

Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury.

Hubel E, Saroha A, Park WJ, Pewzner-Jung Y, Lavoie EG, Futerman AH, Bruck R, Fishman S, Dranoff JA, Shibolet O, Zvibel I.

Am J Pathol. 2017 Jan;187(1):122-133. doi: 10.1016/j.ajpath.2016.09.005. Epub 2016 Nov 11.

PMID:
27842214
7.

KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress.

Choi S, Kim JA, Li HY, Shin KO, Oh GT, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH.

Aging Cell. 2016 Oct;15(5):801-10. doi: 10.1111/acel.12502. Epub 2016 Jun 30.

8.

Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca) 1.1 upregulation.

Choi S, Kim JA, Kim TH, Li HY, Shin KO, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH.

Aging Cell. 2015 Dec;14(6):982-94. doi: 10.1111/acel.12388. Epub 2015 Aug 20.

9.

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.

Ali M, Saroha A, Pewzner-Jung Y, Futerman AH.

FEBS Lett. 2015 Aug 4;589(17):2213-7. doi: 10.1016/j.febslet.2015.06.045. Epub 2015 Jul 13.

10.

Development of pheochromocytoma in ceramide synthase 2 null mice.

Park WJ, Brenner O, Kogot-Levin A, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

Endocr Relat Cancer. 2015 Aug;22(4):623-32. doi: 10.1530/ERC-15-0058. Epub 2015 Jun 25.

11.

Ceramide and sphingosine in pulmonary infections.

Seitz AP, Grassmé H, Edwards MJ, Pewzner-Jung Y, Gulbins E.

Biol Chem. 2015 Jun;396(6-7):611-20. doi: 10.1515/hsz-2014-0285.

12.

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.

Barthelmes J, de Bazo AM, Pewzner-Jung Y, Schmitz K, Mayer CA, Foerch C, Eberle M, Tafferner N, Ferreirós N, Henke M, Geisslinger G, Futerman AH, Grösch S, Schiffmann S.

Brain Behav Immun. 2015 May;46:280-92. doi: 10.1016/j.bbi.2015.02.010. Epub 2015 Feb 16.

PMID:
25697397
13.

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell Metab. 2014 Nov 4;20(5):919. doi: 10.1016/j.cmet.2014.10.007. Epub 2014 Nov 4. No abstract available.

14.

CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell Metab. 2014 Oct 7;20(4):687-95. doi: 10.1016/j.cmet.2014.09.015. Erratum in: Cell Metab. 2014 Nov 4;20(5):919. Chaurasia, Bghagirath [corrected to Chaurasia, Bhagirath]. Erratum in: Cell Metab. 2014 Nov 4;20(5):919.

15.

Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.

Park WJ, Park JW, Merrill AH, Storch J, Pewzner-Jung Y, Futerman AH.

Biochim Biophys Acta. 2014 Dec;1841(12):1754-66. Erratum in: Biochim Biophys Acta. 2015 Jul;1851(7):996.

16.

Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity.

Rabinowich L, Fishman S, Hubel E, Thurm T, Park WJ, Pewzner-Jung Y, Saroha A, Erez N, Halpern Z, Futerman AH, Zvibel I.

J Hepatol. 2015 Jan;62(1):175-81. doi: 10.1016/j.jhep.2014.08.030. Epub 2014 Aug 27.

PMID:
25173968
17.

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.

Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E.

EMBO Mol Med. 2014 Sep;6(9):1205-14. doi: 10.15252/emmm.201404075.

18.

Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization.

Ali M, Fritsch J, Zigdon H, Pewzner-Jung Y, Schütze S, Futerman AH.

Cell Death Dis. 2013 Nov 21;4:e929. doi: 10.1038/cddis.2013.451.

19.

Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.

Park WJ, Park JW, Erez-Roman R, Kogot-Levin A, Bame JR, Tirosh B, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.

J Biol Chem. 2013 Oct 25;288(43):30904-16. doi: 10.1074/jbc.M112.448852. Epub 2013 Sep 9.

20.

Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models.

Petrache I, Kamocki K, Poirier C, Pewzner-Jung Y, Laviad EL, Schweitzer KS, Van Demark M, Justice MJ, Hubbard WC, Futerman AH.

PLoS One. 2013 May 14;8(5):e62968. doi: 10.1371/journal.pone.0062968. Print 2013.

21.

Ceramide synthases: reexamining longevity.

Park JW, Pewzner-Jung Y.

Handb Exp Pharmacol. 2013;(215):89-107. doi: 10.1007/978-3-7091-1368-4_5. Review.

PMID:
23579451
22.

Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain.

Zigdon H, Kogot-Levin A, Park JW, Goldschmidt R, Kelly S, Merrill AH Jr, Scherz A, Pewzner-Jung Y, Saada A, Futerman AH.

J Biol Chem. 2013 Feb 15;288(7):4947-56. doi: 10.1074/jbc.M112.402719. Epub 2013 Jan 2.

23.

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.

Park JW, Park WJ, Kuperman Y, Boura-Halfon S, Pewzner-Jung Y, Futerman AH.

Hepatology. 2013 Feb;57(2):525-32. doi: 10.1002/hep.26015. Epub 2012 Dec 6.

PMID:
22911490
24.

Self-segregation of myelin membrane lipids in model membranes.

Yurlova L, Kahya N, Aggarwal S, Kaiser HJ, Chiantia S, Bakhti M, Pewzner-Jung Y, Ben-David O, Futerman AH, Brügger B, Simons M.

Biophys J. 2011 Dec 7;101(11):2713-20. doi: 10.1016/j.bpj.2011.10.026.

25.

Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.

Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH Jr, Prieto M, Futerman AH.

J Lipid Res. 2012 Mar;53(3):430-6. doi: 10.1194/jlr.M022715. Epub 2012 Jan 9.

26.

Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.

Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH.

J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24.

27.

A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy.

Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH.

J Biol Chem. 2010 Apr 2;285(14):10911-23. doi: 10.1074/jbc.M109.077610. Epub 2010 Jan 28.

28.

A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways.

Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brügger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH.

J Biol Chem. 2010 Apr 2;285(14):10902-10. doi: 10.1074/jbc.M109.077594. Epub 2010 Jan 28.

29.

Ceramide synthase 1 is regulated by proteasomal mediated turnover.

Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S.

Biochim Biophys Acta. 2009 Jul;1793(7):1218-27. doi: 10.1016/j.bbamcr.2009.04.006. Epub 2009 Apr 22.

30.

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches.

Sapoznikov A, Pewzner-Jung Y, Kalchenko V, Krauthgamer R, Shachar I, Jung S.

Nat Immunol. 2008 Apr;9(4):388-95. doi: 10.1038/ni1571. Epub 2008 Mar 2.

PMID:
18311142
31.

Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha.

Kacher Y, Golan A, Pewzner-Jung Y, Futerman AH.

Blood Cells Mol Dis. 2007 Jul-Aug;39(1):124-9. Epub 2007 May 7.

PMID:
17482853
32.

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis.

Pewzner-Jung Y, Ben-Dor S, Futerman AH.

J Biol Chem. 2006 Sep 1;281(35):25001-5. Epub 2006 Jun 22. Review. No abstract available.

33.

Caspase-8 serves both apoptotic and nonapoptotic roles.

Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D.

J Immunol. 2004 Sep 1;173(5):2976-84.

34.
35.

Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain.

Friedmann D, Yachimovich N, Mostoslavsky G, Pewzner-Jung Y, Ben-Yehuda A, Rajewsky K, Eilat D.

J Immunol. 1999 Apr 15;162(8):4406-16.

36.

B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain.

Pewzner-Jung Y, Friedmann D, Sonoda E, Jung S, Rajewsky K, Eilat D.

J Immunol. 1998 Nov 1;161(9):4634-45.

37.

Expression of an anti-DNA-associated VH gene in immunized and autoimmune mice.

Ash-Lerner A, Ginsberg-Strauss M, Pewzner-Jung Y, Desai DD, Marion TN, Eilat D.

J Immunol. 1997 Aug 1;159(3):1508-19.

PMID:
9233650
38.

B cell development under the condition of allelic inclusion.

Sonoda E, Pewzner-Jung Y, Schwers S, Taki S, Jung S, Eilat D, Rajewsky K.

Immunity. 1997 Mar;6(3):225-33.

39.

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