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Items: 1 to 50 of 460

1.

Interaction of diazonamide A with tubulin.

Bai R, Cruz-Monserrate Z, Fenical W, Pettit GR, Hamel E.

Arch Biochem Biophys. 2019 Dec 9;680:108217. doi: 10.1016/j.abb.2019.108217. [Epub ahead of print]

PMID:
31830440
2.

Antineoplastic Agents. 606. The Betulastatins.

Pettit GR, Melody N, Chapuis JC.

J Nat Prod. 2018 Mar 23;81(3):458-464. doi: 10.1021/acs.jnatprod.7b00536. Epub 2018 Jan 5.

PMID:
29303263
3.

Antineoplastic Agents. 605. Isoquinstatins.

Pettit GR, Melody N, Chapuis JC.

J Nat Prod. 2018 Mar 23;81(3):451-457. doi: 10.1021/acs.jnatprod.7b00352. Epub 2017 Sep 19.

PMID:
28926240
4.

Antineoplastic Agents. 604. The Path of Quinstatin Derivatives to Antibody Drug Conjugates.

Pettit GR, Melody N, Chapuis JC.

J Nat Prod. 2017 Sep 22;80(9):2447-2452. doi: 10.1021/acs.jnatprod.7b00237. Epub 2017 Sep 12.

PMID:
28895394
5.

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors.

Pettit GR, Melody N, Chapuis JC.

J Nat Prod. 2017 Mar 24;80(3):692-698. doi: 10.1021/acs.jnatprod.6b01006. Epub 2017 Feb 17.

PMID:
28211277
6.

Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae.

Pettit GR, Ye Q, Herald DL, Knight JC, Hogan F, Melody N, Mukku VJ, Doubek DL, Chapuis JC.

J Nat Prod. 2016 Jun 24;79(6):1598-603. doi: 10.1021/acs.jnatprod.6b00107. Epub 2016 May 23.

PMID:
27214528
7.

Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications.

Pettit GR, Searcy JD, Tan R, Cragg GM, Melody N, Knight JC, Chapuis JC.

J Nat Prod. 2016 Mar 25;79(3):507-18. doi: 10.1021/acs.jnatprod.5b00873. Epub 2016 Mar 3.

PMID:
26938998
8.

The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.

Pettit GR, Xu JP, Chapuis JC, Melody N.

J Nat Prod. 2015 Jun 26;78(6):1446-50. doi: 10.1021/acs.jnatprod.5b00129. Epub 2015 Jun 4.

PMID:
26042639
9.

The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11.

Pettit GR, Moser BR, Herald DL, Knight JC, Chapuis JC, Zheng X.

J Nat Prod. 2015 May 22;78(5):1067-72. doi: 10.1021/np501033u. Epub 2015 Apr 27.

PMID:
25915559
10.

Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.

Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM.

J Nat Prod. 2015 Apr 24;78(4):896-900. doi: 10.1021/acs.jnatprod.5b00094. Epub 2015 Mar 26.

11.

Antineoplastic agents. 599. Total synthesis of dolastatin 16.

Pettit GR, Smith TH, Arce PM, Flahive EJ, Anderson CR, Chapuis JC, Xu JP, Groy TL, Belcher PE, Macdonald CB.

J Nat Prod. 2015 Mar 27;78(3):476-85. doi: 10.1021/np500925y. Epub 2015 Feb 17.

PMID:
25689568
12.

Antineoplastic agents. 600. From the South Pacific Ocean to the silstatins.

Pettit GR, Arce PM, Chapuis JC, Macdonald CB.

J Nat Prod. 2015 Mar 27;78(3):510-23. doi: 10.1021/np501004h. Epub 2015 Feb 17.

PMID:
25688575
13.

Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer.

Pettit GR, Melody N, Hempenstall F, Chapuis JC, Groy TL, Williams L.

J Nat Prod. 2014 Apr 25;77(4):863-72. doi: 10.1021/np400947d. Epub 2014 Apr 2.

14.

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG.

J Nat Prod. 2013 Sep 27;76(9):1668-78. doi: 10.1021/np400374w. Epub 2013 Sep 9.

15.

Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .

Pettit GR, Tang Y, Zhang Q, Bourne GT, Arm CA, Leet JE, Knight JC, Pettit RK, Chapuis JC, Doubek DL, Ward FJ, Weber C, Hooper JN.

J Nat Prod. 2013 Mar 22;76(3):420-4. doi: 10.1021/np300828y. Epub 2013 Feb 14.

16.

The cephalostatins. 22. synthesis of bis-steroidal pyrazine pyrones (1).

Pettit GR, Moser BR, Mendonça RF, Knight JC, Hogan F.

J Nat Prod. 2012 Jun 22;75(6):1063-9. doi: 10.1021/np300069z. Epub 2012 May 18.

17.

Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.

Pettit GR, Tan R, Bao GH, Melody N, Doubek DL, Gao S, Chapuis JC, Williams L.

J Nat Prod. 2012 Apr 27;75(4):771-3. doi: 10.1021/np200862y. Epub 2012 Mar 13.

18.

Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.

Pettit GR, Rosenberg HJ, Dixon R, Knight JC, Hamel E, Chapuis JC, Pettit RK, Hogan F, Sumner B, Ain KB, Trickey-Platt B.

J Nat Prod. 2012 Mar 23;75(3):385-93. doi: 10.1021/np200797x. Epub 2012 Feb 10.

19.

Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis.

Lubahn C, Schaller JA, Shewmacker E, Wood C, Bellinger DL, Byron D, Melody N, Pettit GR, Lorton D.

Rheumatol Int. 2012 Dec;32(12):3751-60. doi: 10.1007/s00296-011-2217-z. Epub 2011 Dec 9.

PMID:
22159913
20.

The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1).

Pettit GR, Mendonça RF, Knight JC, Pettit RK.

J Nat Prod. 2011 Sep 23;74(9):1922-30. doi: 10.1021/np200411p. Epub 2011 Sep 7.

21.

Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.

Tanpure RP, Nguyen BL, Strecker TE, Aguirre S, Sharma S, Chaplin DJ, Siim BG, Hamel E, Lippert JW, Pettit GR, Trawick ML, Pinney KG.

J Nat Prod. 2011 Jul 22;74(7):1568-74. doi: 10.1021/np200104t. Epub 2011 Jun 30.

22.

Interactions of halichondrin B and eribulin with tubulin.

Bai R, Nguyen TL, Burnett JC, Atasoylu O, Munro MH, Pettit GR, Smith AB 3rd, Gussio R, Hamel E.

J Chem Inf Model. 2011 Jun 27;51(6):1393-404. doi: 10.1021/ci200077t. Epub 2011 May 13.

23.

Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units.

Pettit GR, Smith TH, Xu JP, Herald DL, Flahive EJ, Anderson CR, Belcher PE, Knight JC.

J Nat Prod. 2011 May 27;74(5):1003-8. doi: 10.1021/np100877h. Epub 2011 May 3.

24.

Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10.

Pettit GR, Hogan F, Toms S.

J Nat Prod. 2011 May 27;74(5):962-8. doi: 10.1021/np1007334. Epub 2011 May 2.

25.

Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10.

Prokopiou EM, Cooper PA, Pettit GR, Bibby MC, Shnyder SD.

Mol Med Rep. 2010 Mar-Apr;3(2):309-13. doi: 10.3892/mmr_00000256.

PMID:
21472238
26.

A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids.

Abi-Ghanem D, Lai X, Berghman LR, Horvat D, Li J, Romo D, Uddin MN, Kamano Y, Nogawa T, Xu JP, Pettit GR, Puschett JB.

J Immunoassay Immunochem. 2011;32(1):31-46. doi: 10.1080/15321819.2010.538107.

PMID:
21253968
27.

Antineoplastic agents 582. Part 1: Isolation and structure of a cyclobutane-type sesquiterpene cancer cell growth inhibitor from Coprinus cinereus (Coprinaceae).

Pettit GR, Meng Y, Pettit RK, Herald DL, Hogan F, Cichacz ZA.

Bioorg Med Chem. 2010 Jul 15;18(14):4879-83. doi: 10.1016/j.bmc.2010.06.023. Epub 2010 Jun 12.

28.

Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2.

Pettit GR, Quistorf PD, Fry JA, Herald DL, Hamel E, Chapuis JC.

J Nat Prod. 2009 May 22;72(5):876-83. doi: 10.1021/np800635h.

29.

Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa.

Pettit GR, Ye Q, Herald DL, Hogan F, Pettit RK.

J Nat Prod. 2010 Feb 26;73(2):164-6. doi: 10.1021/np9004689.

30.

An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins.

Pettit GR, Minardi MD, Hogan F, Price PM.

J Nat Prod. 2010 Mar 26;73(3):399-403. doi: 10.1021/np9004486.

31.

Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture.

Pettit RK, Pettit GR, Xu JP, Weber CA, Richert LA.

Planta Med. 2010 Mar;76(5):500-1. doi: 10.1055/s-0029-1240617. Epub 2009 Nov 25.

PMID:
19941263
32.

Antineoplastic agents. 556. Isolation and structure of Coprinastatin 1 from Coprinus cinereus.

Pettit GR, Meng Y, Pettit RK, Herald DL, Cichacz ZA, Doubek DL, Richert L.

J Nat Prod. 2010 Mar 26;73(3):388-92. doi: 10.1021/np900371j.

33.

Application of a high throughput Alamar blue biofilm susceptibility assay to Staphylococcus aureus biofilms.

Pettit RK, Weber CA, Pettit GR.

Ann Clin Microbiol Antimicrob. 2009 Oct 27;8:28. doi: 10.1186/1476-0711-8-28.

34.

Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification.

Pettit GR, Melody N, Thornhill A, Knight JC, Groy TL, Herald CL.

J Nat Prod. 2009 Sep;72(9):1637-42. doi: 10.1021/np9002146.

35.

E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes.

Pettit RK, Pettit GR, Hamel E, Hogan F, Moser BR, Wolf S, Pon S, Chapuis JC, Schmidt JM.

Bioorg Med Chem. 2009 Sep 15;17(18):6606-12. doi: 10.1016/j.bmc.2009.07.076. Epub 2009 Aug 4.

PMID:
19709889
36.

In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.

Pettit RK, Weber CA, Lawrence SB, Pettit GR, Kean MJ, Cage GD.

J Med Microbiol. 2009 Sep;58(Pt 9):1203-6. doi: 10.1099/jmm.0.008268-0. Epub 2009 Jun 15.

37.
38.

Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs.

Pettit GR, Thornhill A, Melody N, Knight JC.

J Nat Prod. 2009 Mar 27;72(3):380-8. doi: 10.1021/np800608c.

PMID:
19228038
39.

Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris.

Pettit GR, Knight JC, Herald DL, Pettit RK, Hogan F, Mukku VJ, Hamblin JS, Dodson MJ, Chapuis JC.

J Nat Prod. 2009 Mar 27;72(3):366-71. doi: 10.1021/np800603u.

40.

Antineoplastic agents. 571. Total synthesis of bacillistatin 2.

Pettit GR, Hu S, Knight JC, Chapuis JC.

J Nat Prod. 2009 Mar 27;72(3):372-9. doi: 10.1021/np800607x.

41.

Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity.

Bai R, Edler MC, Bonate PL, Copeland TD, Pettit GR, Ludueña RF, Hamel E.

Mol Pharmacol. 2009 Jan;75(1):218-26. doi: 10.1124/mol.108.051110. Epub 2008 Oct 16.

42.

Role of Smac in cephalostatin-induced cell death.

Rudy A, López-Antón N, Barth N, Pettit GR, Dirsch VM, Schulze-Osthoff K, Rehm M, Prehn JH, Vogler M, Fulda S, Vollmar AM.

Cell Death Differ. 2008 Dec;15(12):1930-40. doi: 10.1038/cdd.2008.125. Epub 2008 Sep 19.

43.

Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug.

Pettit GR, Thornhill AJ, Moser BR, Hogan F.

J Nat Prod. 2008 Sep;71(9):1561-3. doi: 10.1021/np800179g. Epub 2008 Aug 27.

44.

Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.

Hall JJ, Sriram M, Strecker TE, Tidmore JK, Jelinek CJ, Kumar GD, Hadimani MB, Pettit GR, Chaplin DJ, Trawick ML, Pinney KG.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5146-9. doi: 10.1016/j.bmcl.2008.07.070. Epub 2008 Jul 24.

PMID:
18710804
45.

Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP.

Schyschka L, Rudy A, Jeremias I, Barth N, Pettit GR, Vollmar AM.

Leukemia. 2008 Sep;22(9):1737-45. doi: 10.1038/leu.2008.146. Epub 2008 Jun 12.

PMID:
18548102
46.

In vitro interactions of approved and experimental drugs against Candida drugs against Candida spp.

Repp KK, Hogan F, Pettit GR, Pettit RK.

J Chemother. 2008 Feb;20(1):137-9. No abstract available.

PMID:
18343758
47.

Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).

Pettit GR, Hogan F, Xu JP, Tan R, Nogawa T, Cichacz Z, Pettit RK, Du J, Ye QH, Cragg GM, Herald CL, Hoard MS, Goswami A, Searcy J, Tackett L, Doubek DL, Williams L, Hooper JN, Schmidt JM, Chapuis JC, Tackett DN, Craciunescu F.

J Nat Prod. 2008 Mar;71(3):438-44. doi: 10.1021/np700738k. Epub 2008 Mar 8.

PMID:
18327911
48.

Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.

Siles R, Ackley JF, Hadimani MB, Hall JJ, Mugabe BE, Guddneppanavar R, Monk KA, Chapuis JC, Pettit GR, Chaplin DJ, Edvardsen K, Trawick ML, Garner CM, Pinney KG.

J Nat Prod. 2008 Mar;71(3):313-20. doi: 10.1021/np070377j. Epub 2008 Feb 28.

PMID:
18303849
49.

Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug.

James C, Pettit GR, Nielsen OF, Jayakumar VS, Joe IH.

Spectrochim Acta A Mol Biomol Spectrosc. 2008 Oct;70(5):1208-16. doi: 10.1016/j.saa.2007.10.052. Epub 2007 Nov 21.

PMID:
18248845
50.

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