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Items: 22

1.

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.

Tiacci E, Ladewig E, Schiavoni G, Penson A, Fortini E, Pettirossi V, Wang Y, Rosseto A, Venanzi A, Vlasevska S, Pacini R, Piattoni S, Tabarrini A, Pucciarini A, Bigerna B, Santi A, Gianni AM, Viviani S, Cabras A, Ascani S, Crescenzi B, Mecucci C, Pasqualucci L, Rabadan R, Falini B.

Blood. 2018 May 31;131(22):2454-2465. doi: 10.1182/blood-2017-11-814913. Epub 2018 Apr 12.

2.

Genomics of Hairy Cell Leukemia.

Tiacci E, Pettirossi V, Schiavoni G, Falini B.

J Clin Oncol. 2017 Mar 20;35(9):1002-1010. doi: 10.1200/JCO.2016.71.1556. Epub 2017 Feb 13. Review.

3.

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.

Martelli MP, Gionfriddo I, Mezzasoma F, Milano F, Pierangeli S, Mulas F, Pacini R, Tabarrini A, Pettirossi V, Rossi R, Vetro C, Brunetti L, Sportoletti P, Tiacci E, Di Raimondo F, Falini B.

Blood. 2015 May 28;125(22):3455-65. doi: 10.1182/blood-2014-11-611459. Epub 2015 Mar 20.

4.

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity.

Pettirossi V, Santi A, Imperi E, Russo G, Pucciarini A, Bigerna B, Schiavoni G, Fortini E, Spanhol-Rosseto A, Sportoletti P, Mannucci R, Martelli MP, Klein-Hitpass L, Falini B, Tiacci E.

Blood. 2015 Feb 19;125(8):1207-16. doi: 10.1182/blood-2014-10-603100. Epub 2014 Dec 5.

5.

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia.

Tiacci E, Schiavoni G, Martelli MP, Boveri E, Pacini R, Tabarrini A, Zibellini S, Santi A, Pettirossi V, Fortini E, Ascani S, Arcaini L, Inghirami G, Paulli M, Falini B.

Haematologica. 2013 Apr;98(4):635-9. doi: 10.3324/haematol.2012.078071. Epub 2013 Jan 24.

6.

Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.

Tiacci E, Pucciarini A, Bigerna B, Pettirossi V, Strozzini F, Martelli MP, Tabarrini A, Drexler HG, Falini B.

Blood. 2012 May 31;119(22):5332-3. doi: 10.1182/blood-2011-12-400374. No abstract available.

7.

Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy?

Falini B, Gionfriddo I, Cecchetti F, Ballanti S, Pettirossi V, Martelli MP.

Blood Rev. 2011 Nov;25(6):247-54. doi: 10.1016/j.blre.2011.06.001. Epub 2011 Jul 2. Review.

PMID:
21724308
8.

BRAF mutations in hairy-cell leukemia.

Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, Pucciarini A, Bigerna B, Pacini R, Wells VA, Sportoletti P, Pettirossi V, Mannucci R, Elliott O, Liso A, Ambrosetti A, Pulsoni A, Forconi F, Trentin L, Semenzato G, Inghirami G, Capponi M, Di Raimondo F, Patti C, Arcaini L, Musto P, Pileri S, Haferlach C, Schnittger S, Pizzolo G, Foà R, Farinelli L, Haferlach T, Pasqualucci L, Rabadan R, Falini B.

N Engl J Med. 2011 Jun 16;364(24):2305-15. doi: 10.1056/NEJMoa1014209. Epub 2011 Jun 11.

9.

Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.

Delfino DV, Spinicelli S, Pozzesi N, Pierangeli S, Velardi E, Bruscoli S, Martelli MP, Pettirossi V, Falchi L, Kang TB, Riccardi C.

Cell Death Differ. 2011 Jan;18(1):183-90. doi: 10.1038/cdd.2010.86. Epub 2010 Jul 30.

10.

CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice.

Martelli MP, Pettirossi V, Thiede C, Bonifacio E, Mezzasoma F, Cecchini D, Pacini R, Tabarrini A, Ciurnelli R, Gionfriddo I, Manes N, Rossi R, Giunchi L, Oelschlägel U, Brunetti L, Gemei M, Delia M, Specchia G, Liso A, Di Ianni M, Di Raimondo F, Falzetti F, Del Vecchio L, Martelli MF, Falini B.

Blood. 2010 Nov 11;116(19):3907-22. doi: 10.1182/blood-2009-08-238899. Epub 2010 Jul 15.

11.

The EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues.

Sozzi G, Martelli MP, Conte D, Modena P, Pettirossi V, Pileri SA, Falini B.

Haematologica. 2009 Sep;94(9):1307-11. doi: 10.3324/haematol.2009.008045.

12.

EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues.

Martelli MP, Sozzi G, Hernandez L, Pettirossi V, Navarro A, Conte D, Gasparini P, Perrone F, Modena P, Pastorino U, Carbone A, Fabbri A, Sidoni A, Nakamura S, Gambacorta M, Fernández PL, Ramirez J, Chan JK, Grigioni WF, Campo E, Pileri SA, Falini B.

Am J Pathol. 2009 Feb;174(2):661-70. doi: 10.2353/ajpath.2009.080755. Epub 2009 Jan 15.

13.

A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF.

Bolli N, De Marco MF, Martelli MP, Bigerna B, Pucciarini A, Rossi R, Mannucci R, Manes N, Pettirossi V, Pileri SA, Nicoletti I, Falini B.

Leukemia. 2009 Mar;23(3):501-9. doi: 10.1038/leu.2008.326. Epub 2008 Nov 13.

PMID:
19005479
14.

A western blot assay for detecting mutant nucleophosmin (NPM1) proteins in acute myeloid leukaemia.

Martelli MP, Manes N, Liso A, Pettirossi V, Verducci Galletti B, Bigerna B, Pucciarini A, De Marco MF, Pallotta MT, Bolli N, Sborgia M, di Raimondo F, Fabbiano F, Meloni G, Specchia G, Martelli MF, Falini B.

Leukemia. 2008 Dec;22(12):2285-8. doi: 10.1038/leu.2008.149. Epub 2008 Jun 19. No abstract available.

PMID:
18563173
15.

Absence of nucleophosmin leukaemic mutants in B and T cells from AML with NPM1 mutations: implications for the cell of origin of NPMc+ AML.

Martelli MP, Manes N, Pettirossi V, Liso A, Pacini R, Mannucci R, Zei T, Bolli N, di Raimondo F, Specchia G, Nicoletti I, Martelli MF, Falini B.

Leukemia. 2008 Jan;22(1):195-8. Epub 2007 Jul 19. No abstract available.

PMID:
17637812
16.

Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas.

Falini B, Lenze D, Hasserjian R, Coupland S, Jaehne D, Soupir C, Liso A, Martelli MP, Bolli N, Bacci F, Pettirossi V, Santucci A, Martelli MF, Pileri S, Stein H.

Leukemia. 2007 Jul;21(7):1566-70. Epub 2007 Apr 19. No abstract available.

17.

HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation.

Della Fazia MA, Castelli M, Bartoli D, Pieroni S, Pettirossi V, Piobbico D, Viola-Magni M, Servillo G.

J Cell Sci. 2005 Jul 15;118(Pt 14):3185-94.

18.

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party.

N Engl J Med. 2005 Jan 20;352(3):254-66. Erratum in: N Engl J Med. 2005 Feb 17;352(7):740.

19.

Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI.

Tiacci E, Orvietani PL, Bigerna B, Pucciarini A, Corthals GL, Pettirossi V, Martelli MP, Liso A, Benedetti R, Pacini R, Bolli N, Pileri S, Pulford K, Gambacorta M, Carbone A, Pasquarello C, Scherl A, Robertson H, Sciurpi MT, Alunni-Bistocchi G, Binaglia L, Byrne JA, Falini B.

Blood. 2005 Apr 1;105(7):2812-20. Epub 2004 Dec 2.

20.

The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.

Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG.

Mol Cell Biol. 2002 Oct;22(20):7351-63.

21.

Differential expression of CD44 isoforms during liver regeneration in rats.

Della Fazia MA, Pettirossi V, Ayroldi E, Riccardi C, Magni MV, Servillo G.

J Hepatol. 2001 Apr;34(4):555-61.

PMID:
11394655
22.

Shc signaling in differentiating neural progenitor cells.

Conti L, Sipione S, Magrassi L, Bonfanti L, Rigamonti D, Pettirossi V, Peschanski M, Haddad B, Pelicci P, Milanesi G, Pelicci G, Cattaneo E.

Nat Neurosci. 2001 Jun;4(6):579-86.

PMID:
11369938

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