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Items: 28

1.

Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk.

Xue L, Fergusson J, Salimi M, Panse I, Ussher JE, Hegazy AN, Vinall SL, Jackson DG, Hunter MG, Pettipher R, Ogg G, Klenerman P.

J Allergy Clin Immunol. 2015 May;135(5):1358-66.e1-11. doi: 10.1016/j.jaci.2014.09.006. Epub 2014 Oct 19.

2.

Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459.

Pettipher R, Hunter MG, Perkins CM, Collins LP, Lewis T, Baillet M, Steiner J, Bell J, Payton MA.

Allergy. 2014 Sep;69(9):1223-32. doi: 10.1111/all.12451. Epub 2014 Jul 14.

PMID:
24866478
3.

Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis.

Straumann A, Hoesli S, Bussmann Ch, Stuck M, Perkins M, Collins LP, Payton M, Pettipher R, Hunter M, Steiner J, Simon HU.

Allergy. 2013 Mar;68(3):375-85. doi: 10.1111/all.12096. Epub 2013 Feb 5.

PMID:
23379537
4.

The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial.

Horak F, Zieglmayer P, Zieglmayer R, Lemell P, Collins LP, Hunter MG, Steiner J, Lewis T, Payton MA, Perkins CM, Pettipher R.

Allergy. 2012 Dec;67(12):1572-9. doi: 10.1111/all.12042. Epub 2012 Oct 1.

PMID:
23025511
5.

Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459.

Singh D, Cadden P, Hunter M, Pearce Collins L, Perkins M, Pettipher R, Townsend E, Vinall S, O'Connor B.

Eur Respir J. 2013 Jan;41(1):46-52. doi: 10.1183/09031936.00092111. Epub 2012 Apr 10.

6.

PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.

Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler JL, Ulven T, Heinemann A, Pettipher R, Kostenis E.

PLoS One. 2012;7(3):e33329. doi: 10.1371/journal.pone.0033329. Epub 2012 Mar 19.

7.

Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.

Pettipher R, Whittaker M.

J Med Chem. 2012 Apr 12;55(7):2915-31. doi: 10.1021/jm2013997. Epub 2012 Feb 13. Review. No abstract available.

PMID:
22224640
8.

Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.

Xue L, Barrow A, Fleming VM, Hunter MG, Ogg G, Klenerman P, Pettipher R.

J Immunol. 2012 Jan 15;188(2):694-702. doi: 10.4049/jimmunol.1102474. Epub 2011 Dec 14.

9.

Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.

Pettipher R, Vinall SL, Xue L, Speight G, Townsend ER, Gazi L, Whelan CJ, Armer RE, Payton MA, Hunter MG.

J Pharmacol Exp Ther. 2012 Feb;340(2):473-82. doi: 10.1124/jpet.111.187203. Epub 2011 Nov 21.

PMID:
22106101
10.

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma.

Barnes N, Pavord I, Chuchalin A, Bell J, Hunter M, Lewis T, Parker D, Payton M, Collins LP, Pettipher R, Steiner J, Perkins CM.

Clin Exp Allergy. 2012 Jan;42(1):38-48. doi: 10.1111/j.1365-2222.2011.03813.x. Epub 2011 Jul 15.

PMID:
21762224
11.

CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue.

Pérez-Novo CA, Holtappels G, Vinall SL, Xue L, Zhang N, Bachert C, Pettipher R.

Allergy. 2010 Mar;65(3):304-10. doi: 10.1111/j.1398-9995.2009.02204.x. Epub 2009 Oct 12.

PMID:
19839971
12.

Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway.

Xue L, Barrow A, Pettipher R.

J Immunol. 2009 Jun 15;182(12):7580-6. doi: 10.4049/jimmunol.0804090.

13.
14.

Antagonists of the prostaglandin D2 receptor CRTH2.

Pettipher R, Hansel TT.

Drug News Perspect. 2008 Jul-Aug;21(6):317-22. doi: 10.1358/dnp.2008.21.6.1246831. Review.

PMID:
18836589
15.

The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses.

Pettipher R.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S191-9. Epub 2007 Oct 29. Review.

17.

Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases.

Pettipher R, Hansel TT, Armer R.

Nat Rev Drug Discov. 2007 Apr;6(4):313-25. Review.

PMID:
17396136
18.
19.

Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.

Wettey FR, Xue L, Pettipher R.

Cytokine. 2006 Oct;36(1-2):29-34. Epub 2006 Dec 11.

PMID:
17161617
21.
22.

Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.

Armer RE, Ashton MR, Boyd EA, Brennan CJ, Brookfield FA, Gazi L, Gyles SL, Hay PA, Hunter MG, Middlemiss D, Whittaker M, Xue L, Pettipher R.

J Med Chem. 2005 Oct 6;48(20):6174-7.

PMID:
16190744
23.

Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model.

Pender SL, Chance V, Whiting CV, Buckley M, Edwards M, Pettipher R, MacDonald TT.

Gut. 2005 Aug;54(8):1114-20.

24.

Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies.

Pettipher R, Mangion J, Hunter MG, Mackay I.

Curr Opin Pharmacol. 2005 Aug;5(4):412-7. Review.

PMID:
15955737
25.

Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.

Gazi L, Gyles S, Rose J, Lees S, Allan C, Xue L, Jassal R, Speight G, Gamble V, Pettipher R.

Prostaglandins Other Lipid Mediat. 2005 Jan;75(1-4):153-67.

PMID:
15789622
26.

The application of genetics to the discovery of better medicines.

Pettipher R, Cardon LR.

Pharmacogenomics. 2002 Mar;3(2):257-63. Review.

PMID:
11972446
27.
28.

Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.

Pettipher R, Edwards J, Cruwys S, Jessup E, Beesley J, Henderson B.

Am J Pathol. 1990 Nov;137(5):1077-82.

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