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Items: 31

1.

The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543.

Showell HJ, Conklyn MJ, Alpert R, Hingorani GP, Wright KF, Smith MA, Stam E, Salter ED, Scampoli DN, Meltzer S, Reiter LA, Koch K, Piscopio AD, Cortina SR, Lopez-Anaya A, Pettipher ER, Milici AJ, Griffiths RJ.

J Pharmacol Exp Ther. 1998 Jun;285(3):946-54.

PMID:
9618393
2.

Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.

Kleinman EF, Campbell E, Giordano LA, Cohan VL, Jenkinson TH, Cheng JB, Shirley JT, Pettipher ER, Salter ED, Hibbs TA, DiCapua FM, Bordner J.

J Med Chem. 1998 Jan 29;41(3):266-70. No abstract available.

PMID:
9464356
3.

Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor.

Pettipher ER, Hibbs TA, Smith MA, Griffiths RJ.

Inflamm Res. 1997 Aug;46 Suppl 2:S135-6. No abstract available.

PMID:
9297548
5.
6.

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.

Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, Pettipher ER.

J Pharmacol Exp Ther. 1997 Feb;280(2):621-6.

PMID:
9023272
7.

2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo.

Faraci WS, Nagel AA, Verdries KA, Vincent LA, Xu H, Nichols LE, Labasi JM, Salter ED, Pettipher ER.

Br J Pharmacol. 1996 Nov;119(6):1101-8.

8.

Regulation of tumour necrosis factor production by adrenal hormones in vivo: insights into the antiinflammatory activity of rolipram.

Pettipher ER, Labasi JM, Salter ED, Stam EJ, Cheng JB, Griffiths RJ.

Br J Pharmacol. 1996 Apr;117(7):1530-4.

9.

Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.

Gladue RP, Carroll LA, Milici AJ, Scampoli DN, Stukenbrok HA, Pettipher ER, Salter ED, Contillo L, Showell HJ.

J Exp Med. 1996 Apr 1;183(4):1893-8.

11.

The in vitro and in vivo pharmacologic activity of the potent and selective leukotriene B4 receptor antagonist CP-105696.

Showell HJ, Pettipher ER, Cheng JB, Breslow R, Conklyn MJ, Farrell CA, Hingorani GP, Salter ED, Hackman BC, Wimberly DJ, et al.

J Pharmacol Exp Ther. 1995 Apr;273(1):176-84.

PMID:
7714764
12.

Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis.

Griffiths RJ, Pettipher ER, Koch K, Farrell CA, Breslow R, Conklyn MJ, Smith MA, Hackman BC, Wimberly DJ, Milici AJ, et al.

Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):517-21.

13.

(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.

Koch K, Melvin LS Jr, Reiter LA, Biggers MS, Showell HJ, Griffiths RJ, Pettipher ER, Cheng JB, Milici AJ, Breslow R, et al.

J Med Chem. 1994 Sep 30;37(20):3197-9. No abstract available.

PMID:
7932545
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20.

Cartilage proteoglycan depletion in acute and chronic antigen-induced arthritis.

Pettipher ER, Henderson B, Hardingham T, Ratcliffe A.

Arthritis Rheum. 1989 May;32(5):601-7.

PMID:
2785800
22.

Pathogenesis and treatment of chronic arthritis.

Pettipher ER.

Sci Prog. 1989;73(292 Pt 4):521-34. Review.

PMID:
2699674
24.

Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit.

Pettipher ER, Henderson B, Moncada S, Higgs GA.

Br J Pharmacol. 1988 Sep;95(1):169-76.

25.
26.

Studies on interleukin-1-induced arthritis.

Pettipher ER, Higgs GA, Henderson B.

Dev Biol Stand. 1988;69:111-4.

PMID:
3265673
27.

PAF-acether in chronic arthritis.

Pettipher ER, Higgs GA, Henderson B.

Agents Actions. 1987 Jun;21(1-2):98-103.

PMID:
3630862
28.

Mediators of rheumatoid arthritis.

Henderson B, Pettipher ER, Higgs GA.

Br Med Bull. 1987 Apr;43(2):415-28. Review. No abstract available.

PMID:
2825902
29.

Arthritogenic activity of interleukin 1.

Pettipher ER, Higgs GA, Henderson B.

Agents Actions. 1986 Dec;19(5-6):337-8. No abstract available.

PMID:
3493640
30.

Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.

Pettipher ER, Higgs GA, Henderson B.

Proc Natl Acad Sci U S A. 1986 Nov;83(22):8749-53.

31.

The synovial lining cell: biology and pathobiology.

Henderson B, Pettipher ER.

Semin Arthritis Rheum. 1985 Aug;15(1):1-32. Review. No abstract available.

PMID:
2994231

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