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Items: 17

1.

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway.

Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM.

FASEB J. 2009 Nov;23(11):3819-28. doi: 10.1096/fj.09-134999. Epub 2009 Jul 22.

2.

BACE1 regulates voltage-gated sodium channels and neuronal activity.

Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM.

Nat Cell Biol. 2007 Jul;9(7):755-64. Epub 2007 Jun 18.

3.

Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin.

Haapasalo A, Kim DY, Carey BW, Turunen MK, Pettingell WH, Kovacs DM.

J Biol Chem. 2007 Mar 23;282(12):9063-72. Epub 2007 Jan 26.

4.

Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.

Zhang M, Haapasalo A, Kim DY, Ingano LA, Pettingell WH, Kovacs DM.

FASEB J. 2006 Jun;20(8):1176-8. Epub 2006 Apr 27.

PMID:
16645046
5.

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.

Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM.

J Biol Chem. 2005 Jun 17;280(24):23251-61. Epub 2005 Apr 14. Erratum in: J Biol Chem. 2005 Aug 19;280(33):29988.

6.

Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.

Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I, Tanzi RE, Kim TW.

J Biol Chem. 2000 May 12;275(19):14440-5.

7.

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.

Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE.

Science. 1997 Jul 18;277(5324):373-6.

8.

Isolation, characterization, and functional studies of rat liver iron regulatory protein 1.

Eisenstein RS, Barton HA, Pettingell WH Jr, Bomford AB.

Arch Biochem Biophys. 1997 Jul 1;343(1):81-91.

PMID:
9210649
9.

A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.

Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE.

Ann Neurol. 1997 Jun;41(6):809-13.

PMID:
9189043
10.

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells.

Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE.

J Biol Chem. 1997 Apr 25;272(17):11006-10.

11.

Familial Alzheimer's chromosome 14 mutations.

Wasco W, Pettingell WP, Jondro PD, Schmidt SD, Gurubhagavatula S, Rodes L, DiBlasi T, Romano DM, Guenette SY, Kovacs DM, et al.

Nat Med. 1995 Sep;1(9):848. No abstract available.

PMID:
7585193
12.

Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, et al.

Science. 1995 Aug 18;269(5226):973-7.

PMID:
7638622
13.

The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.

Bush AI, Pettingell WH Jr, de Paradis M, Tanzi RE, Wasco W.

J Biol Chem. 1994 Oct 28;269(43):26618-21.

14.

Rapid induction of Alzheimer A beta amyloid formation by zinc.

Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE.

Science. 1994 Sep 2;265(5177):1464-7.

PMID:
8073293
15.

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

Bush AI, Pettingell WH Jr, Paradis MD, Tanzi RE.

J Biol Chem. 1994 Apr 22;269(16):12152-8.

16.

Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.

Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W.

Genetica. 1993;91(1-3):255-63. Review.

PMID:
8125274
17.

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

Eisenstein RS, Garcia-Mayol D, Pettingell W, Munro HN.

Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):688-92.

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